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Autophagy Volume 10, 2014 - Issue 7
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Basic Research Paper

Pathogenic role of BECN1/Beclin 1 in the development of amyotrophic lateral sclerosis

Melissa Nassif Biomedical Neuroscience Institute; Faculty of Medicine; University of Chile; Santiago, Chile; Center for Molecular Studies of the Cell (CEMC); Program of Cellular and Molecular Biology; Institute of Biomedical Sciences; University of Chile
,
Vicente Valenzuela Biomedical Neuroscience Institute; Faculty of Medicine; University of Chile; Santiago, Chile; Center for Molecular Studies of the Cell (CEMC); Program of Cellular and Molecular Biology; Institute of Biomedical Sciences; University of Chile
,
Diego Rojas-Rivera Biomedical Neuroscience Institute; Faculty of Medicine; University of Chile; Santiago, Chile; Center for Molecular Studies of the Cell (CEMC); Program of Cellular and Molecular Biology; Institute of Biomedical Sciences; University of Chile
,
René Vidal Biomedical Neuroscience Institute; Faculty of Medicine; University of Chile; Santiago, Chile; Neurounion Biomedical Foundation; Santiago, Chile
,
Soledad Matus Biomedical Neuroscience Institute; Faculty of Medicine; University of Chile; Santiago, Chile; Neurounion Biomedical Foundation; Santiago, Chile
,
Karen Castillo Biomedical Neuroscience Institute; Faculty of Medicine; University of Chile; Santiago, Chile; Center for Molecular Studies of the Cell (CEMC); Program of Cellular and Molecular Biology; Institute of Biomedical Sciences; University of Chile
,
Yerko Fuentealba Biomedical Neuroscience Institute; Faculty of Medicine; University of Chile; Santiago, Chile; Center for Molecular Studies of the Cell (CEMC); Program of Cellular and Molecular Biology; Institute of Biomedical Sciences; University of Chile
,
Guido Kroemer INSERM U848; Villejuif, France; Metabolomics and Cell Biology Platforms; Institut Gustave Roussy; Villejuif, France; Equipe 11 labellisée par la Ligue contre le Cancer; Centre de Recherche des Cordeliers; Paris, France; Pôle de Biologie; Hôpital Européen Georges Pompidou; Paris, France; Université Paris Descartes; Sorbonne Paris Cité; Paris, France
,
Beth Levine Department of Internal Medicine and Howard Hughes Medical Institute; UT Southwestern Medical Center; Dallas, TX USA
&
Claudio Hetz Biomedical Neuroscience Institute; Faculty of Medicine; University of Chile; Santiago, Chile; Center for Molecular Studies of the Cell (CEMC); Program of Cellular and Molecular Biology; Institute of Biomedical Sciences; University of Chile; Neurounion Biomedical Foundation; Santiago, Chile; Department of Immunology and Infectious Diseases; Harvard School of Public Health; Boston, MA USACorrespondence[email protected]
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Pages 1256-1271 | Received 10 Jul 2013, Accepted 04 Apr 2014, Published online: 12 May 2014

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Iris Grosjean, Barnabé Roméo, Marie-Angela Domdom, Amine Belaid, Grégoire D’Andréa, Nicolas Guillot, Romain K Gherardi, Jocelyn Gal, Gérard Milano, Charles Hugo Marquette, Rayjean J. Hung, Maria Teresa Landi, Younghun Han, Patrick Brest, Martin Von Bergen, Daniel J. Klionsky, Christopher I. Amos, Paul Hofman & Baharia Mograbi. (2022) Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases. Autophagy 18:11, pages 2519-2536.
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So Yeong Cheon, Hyunjeong Kim, David C. Rubinsztein & Jong Eun Lee. (2019) Autophagy, Cellular Aging and Age-related Human Diseases. Experimental Neurobiology 28:6, pages 643-657.
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Shifan Ma, Insiya Y. Attarwala & Xiang-Qun Xie. (2019) SQSTM1/p62: A Potential Target for Neurodegenerative Disease. ACS Chemical Neuroscience 10:5, pages 2094-2114.
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Maria Chiara Maiuri & Guido Kroemer. (2019) Therapeutic modulation of autophagy: which disease comes first?. Cell Death & Differentiation 26:4, pages 680-689.
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David Brenner, Kirsten Sieverding, Clara Bruno, Patrick Lüningschrör, Eva Buck, Simon Mungwa, Lena Fischer, Sarah J. Brockmann, Johannes Ulmer, Corinna Bliederhäuser, Clémentine E. Philibert, Takashi Satoh, Shizuo Akira, Séverine Boillée, Benjamin Mayer, Michael Sendtner, Albert C. Ludolph, Karin M. Danzer, Christian S. Lobsiger, Axel Freischmidt & Jochen H. Weishaupt. (2019) Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice . Journal of Experimental Medicine 216:2, pages 267-278.
Crossref
Charleen T. Chu. (2019) Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases. Neurobiology of Disease 122, pages 23-34.
Crossref
Ulfuara Shefa, NaYoung Jeong, InOk Song, Hyung-Joo Chung, Dokyoung Kim, Junyang Jung & Youngbuhm Huh. (2019) Mitophagy links oxidative stress conditions and neurodegenerative diseases. Neural Regeneration Research 14:5, pages 749.
Crossref
Stefan W. RyterDivya BhatiaMary E. Choi. (2019) Autophagy: A Lysosome-Dependent Process with Implications in Cellular Redox Homeostasis and Human Disease. Antioxidants & Redox Signaling 30:1, pages 138-159.
Crossref
Yan-Ming Wei & Bo Han. (2019) Beclin1 decreases the RIPA-insoluble fraction of amyotrophic lateral sclerosis-linked SOD1 mutant via autophagy. Neuroscience Letters 690, pages 106-111.
Crossref
Baris Bingol. (2018) Autophagy and lysosomal pathways in nervous system disorders. Molecular and Cellular Neuroscience 91, pages 167-208.
Crossref
Carlo Rodolfo, Silvia Campello & Francesco Cecconi. (2018) Mitophagy in neurodegenerative diseases. Neurochemistry International 117, pages 156-166.
Crossref
Yu Wang, Mingxue Song & Fuyong Song. (2018) Neuronal autophagy and axon degeneration. Cellular and Molecular Life Sciences 75:13, pages 2389-2406.
Crossref
Lili Xu, Jianjun Shen, Lina Yu, Jianliang Sun & Min Yan. (2018) Autophagy is involved in sevoflurane-induced developmental neurotoxicity in the developing rat brain. Brain Research Bulletin 140, pages 226-232.
Crossref
Athanasios Metaxakis, Christina Ploumi & Nektarios Tavernarakis. (2018) Autophagy in Age-Associated Neurodegeneration. Cells 7:5, pages 37.
Crossref
Maria A. Gonzalez Porras, Gary C. Sieck & Carlos B. Mantilla. (2018) Impaired Autophagy in Motor Neurons: A Final Common Mechanism of Injury and Death. Physiology 33:3, pages 211-224.
Crossref
José Manuel Matamala, Raul Arias-Carrasco, Carolina Sanchez, Markus Uhrig, Leslie Bargsted, Soledad Matus, Vinicius Maracaja-Coutinho, Sebastian Abarzua, Brigitte van Zundert, Renato Verdugo, Patricio Manque & Claudio Hetz. (2018) Genome-wide circulating microRNA expression profiling reveals potential biomarkers for amyotrophic lateral sclerosis. Neurobiology of Aging 64, pages 123-138.
Crossref
Abhishek Vats, Mandaville Gourie-Devi, Kavita Ahuja, Ankkita Sharma, Saima Wajid, Nirmal Kumar Ganguly & Vibha Taneja. (2018) Expression analysis of protein homeostasis pathways in the peripheral blood mononuclear cells of sporadic amyotrophic lateral sclerosis patients. Journal of the Neurological Sciences 387, pages 85-91.
Crossref
Rui Li, Xin Yi, Xiang Wei, Bo Huo, Xian Guo, Cai Cheng, Ze-Min Fang, Jing Wang, Xin Feng, Ping Zheng, Yun-Shu Su, Jackson Ferdinand Masau, Xue-Hai Zhu & Ding-Sheng Jiang. (2018) EZH2 inhibits autophagic cell death of aortic vascular smooth muscle cells to affect aortic dissection. Cell Death & Disease 9:2.
Crossref
Ju Hwan KimUy Dong SohnHyung-Gun KimHak Rim Kim. (2018) Exposure to 835 MHz RF-EMF decreases the expression of calcium channels, inhibits apoptosis, but induces autophagy in the mouse hippocampus. The Korean Journal of Physiology & Pharmacology 22:3, pages 277.
Crossref
Ju Hwan Kim, Da-Hyeon Yu, Hyo-Jeong Kim, Yang Hoon Huh, Seong-Wan Cho, Jin-Koo Lee, Hyung-Gun Kim & Hak Rim Kim. (2017) Exposure to 835 MHz radiofrequency electromagnetic field induces autophagy in hippocampus but not in brain stem of mice. Toxicology and Industrial Health 34:1, pages 23-35.
Crossref
Albert Lee, Stephanie L. Rayner, Serene S. L. Gwee, Alana De Luca, Hamideh Shahheydari, Vinod Sundaramoorthy, Audrey Ragagnin, Marco Morsch, Rowan Radford, Jasmin Galper, Sarah Freckleton, Bingyang Shi, Adam K. Walker, Emily K. Don, Nicholas J. Cole, Shu Yang, Kelly L. Williams, Justin J. Yerbury, Ian P. Blair, Julie D. Atkin, Mark P. Molloy & Roger S. Chung. (2017) Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy. Cellular and Molecular Life Sciences 75:2, pages 335-354.
Crossref
Zhiqiang Deng, Patricia Sheehan, Shi Chen & Zhenyu Yue. (2017) Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?. Molecular Neurodegeneration 12:1.
Crossref
Patrick Lüningschrör, Beyenech Binotti, Benjamin Dombert, Peter Heimann, Angel Perez-Lara, Carsten Slotta, Nadine Thau-Habermann, Cora R. von Collenberg, Franziska Karl, Markus Damme, Arie Horowitz, Isabelle Maystadt, Annette Füchtbauer, Ernst-Martin Füchtbauer, Sibylle Jablonka, Robert Blum, Nurcan Üçeyler, Susanne Petri, Barbara Kaltschmidt, Reinhard Jahn, Christian Kaltschmidt & Michael Sendtner. (2017) Plekhg5-regulated autophagy of synaptic vesicles reveals a pathogenic mechanism in motoneuron disease. Nature Communications 8:1.
Crossref
Leslie Bargsted, Danilo B. Medinas, Francisca Martínez Traub, Pablo Rozas, Natalia Muñoz, Melissa Nassif, Carolina Jerez, Alejandra Catenaccio, Felipe A. Court, Claudio Hetz & Soledad Matus. (2017) Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model. Scientific Reports 7:1.
Crossref
Danilo B. Medinas, Vicente Valenzuela & Claudio Hetz. (2017) Proteostasis disturbance in amyotrophic lateral sclerosis. Human Molecular Genetics 26:R2, pages R91-R104.
Crossref
Noam D. RudnickChristopher J. GriffeyPaolo GuarnieriValeria GerbinoXueyong WangJason A. PiersaintJuan Carlos TapiaMark M. RichTom Maniatis. (2017) Distinct roles for motor neuron autophagy early and late in the SOD1 G93A mouse model of ALS . Proceedings of the National Academy of Sciences 114:39.
Crossref
Nandini Ramesh & Udai Bhan Pandey. (2017) Autophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand. Frontiers in Molecular Neuroscience 10.
Crossref
Daniela Recabarren & Marcelo Alarcón. (2017) Gene networks in neurodegenerative disorders. Life Sciences 183, pages 83-97.
Crossref
Sylviane Muller, Susana Brun, Frédérique René, Jérôme de Sèze, Jean-Philippe Loeffler & Hélène Jeltsch-David. (2017) Autophagy in neuroinflammatory diseases. Autoimmunity Reviews 16:8, pages 856-874.
Crossref
Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Beth Levine, Douglas R. Green & Guido Kroemer. (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nature Reviews Drug Discovery 16:7, pages 487-511.
Crossref
Federica Rizzo, Agnese Ramirez, Claudia Compagnucci, Sabrina Salani, Valentina Melzi, Andreina Bordoni, Francesco Fortunato, Alessia Niceforo, Nereo Bresolin, Giacomo P. Comi, Enrico Bertini, Monica Nizzardo & Stefania Corti. (2017) Genome-wide RNA-seq of iPSC-derived motor neurons indicates selective cytoskeletal perturbation in Brown–Vialetto disease that is partially rescued by riboflavin. Scientific Reports 7:1.
Crossref
Ju Hwan KimDa-Hyeon YuHak Rim Kim. (2017) Activation of autophagy at cerebral cortex and apoptosis at brainstem are differential responses to 835 MHz RF-EMF exposure. The Korean Journal of Physiology & Pharmacology 21:2, pages 179.
Crossref
Eiichi Tokuda, Thomas Brännström, Peter M. Andersen & Stefan L. Marklund. (2016) Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase. Acta Neuropathologica Communications 4:1.
Crossref
Savina Apolloni, Paola Fabbrizio, Susanna Amadio & Cinzia Volonté. (2016) Actions of the antihistaminergic clemastine on presymptomatic SOD1-G93A mice ameliorate ALS disease progression. Journal of Neuroinflammation 13:1.
Crossref
Paula Garcia-Huerta, Paulina Troncoso-Escudero, Carolina Jerez, Claudio Hetz & Rene L. Vidal. (2016) The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases?. Brain Research 1649, pages 173-180.
Crossref
Maria A. Pabon, Kevin C. Ma & Augustine M. K. Choi. (2016) Autophagy and Obesity-Related Lung Disease. American Journal of Respiratory Cell and Molecular Biology 54:5, pages 636-646.
Crossref
Ju Hwan Kim, Yang Hoon Huh & Hak Rim Kim. (2016) Induction of Autophagy in the Striatum and Hypothalamus of Mice after 835 MHz Radiofrequency Exposure. PLOS ONE 11:4, pages e0153308.
Crossref
Mala V. Rao, Jabbar Campbell, Arti Palaniappan, Asok Kumar & Ralph A. Nixon. (2016) Calpastatin inhibits motor neuron death and increases survival of hSOD1 G93A mice . Journal of Neurochemistry 137:2, pages 253-265.
Crossref
Maria Sara Cipolat Mis, Simona Brajkovic, Emanuele Frattini, Alessio Di Fonzo & Stefania Corti. (2016) Autophagy in motor neuron disease: Key pathogenetic mechanisms and therapeutic targets. Molecular and Cellular Neuroscience 72, pages 84-90.
Crossref
Simona Rossi, Mauro Cozzolino & Maria Teresa Carrì. (2016) Old versus New Mechanisms in the Pathogenesis of ALS . Brain Pathology 26:2, pages 276-286.
Crossref
Yajing Peng, Mi Jin Kim, Rikki Hullinger, Kenneth J. O’Riordan, Corinna Burger, Mariana Pehar & Luigi Puglielli. (2016) Improved proteostasis in the secretory pathway rescues Alzheimer’s disease in the mouse. Brain 139:3, pages 937-952.
Crossref
Qin Xia, Hongfeng Wang, Zongbing Hao, Cheng Fu, Qingsong Hu, Feng Gao, Haigang Ren, Dong Chen, Junhai Han, Zheng Ying & Guanghui Wang. (2015) TDP ‐43 loss of function increases TFEB activity and blocks autophagosome–lysosome fusion . The EMBO Journal 35:2, pages 121-142.
Crossref
Sophie Pattingre. 2016. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging 165 174 .
Jae Keun Lee, Jin Hee Shin, Ji Eun Lee & Eui-Ju Choi. (2015) Role of autophagy in the pathogenesis of amyotrophic lateral sclerosis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852:11, pages 2517-2524.
Crossref
Rosie K. A. Bunton-Stasyshyn, Rachele A. Saccon, Pietro Fratta & Elizabeth M. C. Fisher. (2014) SOD1 Function and Its Implications for Amyotrophic Lateral Sclerosis Pathology. The Neuroscientist 21:5, pages 519-529.
Crossref
Deanna H. Morris, Calvin K. Yip, Yi Shi, Brian T. Chait & Qing Jun Wang. (2015) Beclin 1-Vps34 complex architecture: Understanding the nuts and bolts of therapeutic targets. Frontiers in Biology 10:5, pages 398-426.
Crossref
Beth Levine, Rong Liu, Xiaonan Dong & Qing Zhong. (2015) Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology. Trends in Cell Biology 25:9, pages 533-544.
Crossref
Davide Alessandro Basello & Anna Ivana Scovassi. (2015) Poly(ADP-ribosylation) and neurodegenerative disorders. Mitochondrion 24, pages 56-63.
Crossref
Sara Oliván, Ana Cristina Calvo, Samanta Gasco, María Jesús Muñoz, Pilar Zaragoza & Rosario Osta. (2015) Time-Point Dependent Activation of Autophagy and the UPS in SOD1G93A Mice Skeletal Muscle. PLOS ONE 10:8, pages e0134830.
Crossref
Dan-Jing Yang, Liang Zhu, Jie Ren, Rong-Jie Ma, Hongwen Zhu & Jun Xu. (2015) Dysfunction of autophagy as the pathological mechanism of motor neuron disease based on a patient-specific disease model. Neuroscience Bulletin 31:4, pages 445-451.
Crossref
Jihoon Nah, Junying Yuan & Yong-Keun Jung. (2015) Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach. Molecules and Cells 38:5, pages 381-389.
Crossref
V Nikoletopoulou, M-E Papandreou & N Tavernarakis. (2014) Autophagy in the physiology and pathology of the central nervous system. Cell Death & Differentiation 22:3, pages 398-407.
Crossref
Y Liu & B Levine. (2014) Autosis and autophagic cell death: the dark side of autophagy. Cell Death & Differentiation 22:3, pages 367-376.
Crossref
Markus Damme, Taina Suntio, Paul Saftig & Eeva-Liisa Eskelinen. (2014) Autophagy in neuronal cells: general principles and physiological and pathological functions. Acta Neuropathologica 129:3, pages 337-362.
Crossref
Melissa Nassif, Danilo Medinas, Karen Castillo, Camila Gherardelli & Claudio Hetz. 2015. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging 259 272 .
Leslie Bargsted, René L. Vidal, Claudio Hetz & Soledad Matus. 2015. Toxicity and Autophagy in Neurodegenerative Disorders. Toxicity and Autophagy in Neurodegenerative Disorders 63 78 .
René L. Vidal, Soledad Matus, Leslie Bargsted & Claudio Hetz. (2014) Targeting autophagy in neurodegenerative diseases. Trends in Pharmacological Sciences 35:11, pages 583-591.
Crossref

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