3,257
Views
37
CrossRef citations to date
0
Altmetric
Autophagic Punctum

Acetyl-coenzyme A

A metabolic master regulator of autophagy and longevity

, , , , , , , , , , , , , , & show all
Pages 1335-1337 | Received 13 Mar 2014, Accepted 15 Apr 2014, Published online: 15 May 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

David P. Enot, Mireia Niso-Santano, Sylvère Durand, Alexis Chery, Federico Pietrocola, Erika Vacchelli, Frank Madeo, Lorenzo Galluzzi & Guido Kroemer. (2015) Metabolomic analyses reveal that anti-aging metabolites are depleted by palmitate but increased by oleate in vivo. Cell Cycle 14:15, pages 2399-2407.
Read now
Guillermo Mariño, Federico Pietrocola, Frank Madeo & Guido Kroemer. (2014) Caloric restriction mimetics: natural/physiological pharmacological autophagy inducers. Autophagy 10:11, pages 1879-1882.
Read now

Articles from other publishers (35)

Liangbo Sun, Haojun Xiong, Lingxi Chen, Xufang Dai, Xiaojing Yan, Yaran Wu, Mingzhen Yang, Meihua Shan, Tao Li, Jie Yao, Wenbin Jiang, Haiyan He, Fengtian He & Jiqin Lian. (2022) Deacetylation of ATG4B promotes autophagy initiation under starvation. Science Advances 8:31.
Crossref
Rui Ling, Gong Chen, Xiang Tang, Na Liu, Yuepeng Zhou & Deyu Chen. (2022) Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development. Discover Oncology 13:1.
Crossref
Yan-Qin Feng, Jun-Jie Wang, Ming-Hao Li, Yu Tian, Ai-Hong Zhao, Lan Li, Massimo De Felici & Wei Shen. (2022) Impaired primordial follicle assembly in offspring ovaries from zearalenone-exposed mothers involves reduced mitochondrial activity and altered epigenetics in oocytes. Cellular and Molecular Life Sciences 79:5.
Crossref
Qin Zhang, Yulai Fang, Changjun Lv, Yanrong Zhu, Yufeng Xia, Zhifeng Wei & Yue Dai. (2022) Norisoboldine induces the development of Treg cells by promoting fatty acid oxidation‐mediated H3K27 acetylation of Foxp3. The FASEB Journal 36:4.
Crossref
TingTing Wu, Semo Jun, Eun-Ji Choi, Jiao Sun, Eun-Bi Yang, Hyun-Seo Lee, Sang-Yong Kim, Naima Ahmed Fahmi, Qibing Jiang, Wei Zhang, Jeongsik Yong, Jung-Hee Lee & Ho Jin You. (2022) 53BP1-ACLY-SLBP-coordinated activation of replication-dependent histone biogenesis maintains genomic integrity. Nucleic Acids Research 50:3, pages 1465-1483.
Crossref
Christos Koutouroushis & Oiendrila Sarkar. (2021) Role of Autophagy in Cardiovascular Disease and Aging. Cureus.
Crossref
Wei-Nan Guo & Chun-Ying Li. (2021) Linking Cellular Metabolism to Epigenetics in Melanoma. International Journal of Dermatology and Venereology 4:3, pages 168-173.
Crossref
Sylvère Durand, Claudia Grajeda-Iglesias, Fanny Aprahamian, Nitharsshini Nirmalathasan, Oliver Kepp & Guido Kroemer. 2021. Monitoring vesicular trafficking in cellular responses to stress - Part A. Monitoring vesicular trafficking in cellular responses to stress - Part A 137 156 .
Ioannis Skalidis, Christian Tüting & Panagiotis L. Kastritis. (2020) Unstructured regions of large enzymatic complexes control the availability of metabolites with signaling functions. Cell Communication and Signaling 18:1.
Crossref
John R. Moffett, Narayanan Puthillathu, Ranjini Vengilote, Diane M. Jaworski & Aryan M. Namboodiri. (2020) Acetate Revisited: A Key Biomolecule at the Nexus of Metabolism, Epigenetics and Oncogenesis—Part 1: Acetyl-CoA, Acetogenesis and Acyl-CoA Short-Chain Synthetases. Frontiers in Physiology 11.
Crossref
Maurizio D. Baroni, Sonia Colombo, Olivier Libens, Rani Pallavi, Marco Giorgio & Enzo Martegani. (2020) In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase. Apoptosis 25:9-10, pages 686-696.
Crossref
Angelina S. Gross, Andreas Zimmermann, Tobias Pendl, Sabrina Schroeder, Hannes Schoenlechner, Oskar Knittelfelder, Laura Lamplmayr, Ana Santiso, Andreas Aufschnaiter, Daniel Waltenstorfer, Sandra Ortonobes Lara, Sarah Stryeck, Christina Kast, Christoph Ruckenstuhl, Sebastian J. Hofer, Birgit Michelitsch, Martina Woelflingseder, Rolf Müller, Didac Carmona-Gutierrez, Tobias Madl, Sabrina Büttner, Kai-Uwe Fröhlich, Andrej Shevchenko & Tobias Eisenberg. (2019) Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK. Journal of Biological Chemistry 294:32, pages 12020-12039.
Crossref
Meng Li, Ying-Ling Chiang, Costas A. Lyssiotis, Matthew R. Teater, Jun Young Hong, Hao Shen, Ling Wang, Jing Hu, Hui Jing, Zhengming Chen, Neeraj Jain, Cihangir Duy, Sucharita J. Mistry, Leandro Cerchietti, Justin R. Cross, Lewis C. Cantley, Michael R. Green, Hening Lin & Ari M. Melnick. (2019) Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. Cancer Cell 35:6, pages 916-931.e9.
Crossref
David R. Zhou, Rawan Eid, Katie A. Miller, Eric Boucher, Craig A. Mandato & Michael T. Greenwood. (2019) Intracellular second messengers mediate stress inducible hormesis and Programmed Cell Death: A review. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1866:5, pages 773-792.
Crossref
Paméla Dakik, Younes Medkour, Karamat Mohammad & Vladimir I. Titorenko. (2019) Mechanisms Through Which Some Mitochondria-Generated Metabolites Act as Second Messengers That Are Essential Contributors to the Aging Process in Eukaryotes Across Phyla. Frontiers in Physiology 10.
Crossref
Zhuo Zhou, Yu Chen, Mengqi Jin, Jianqin He, Ayiding Guli, Chunlan Yan & Shiping Ding. (2018) Comprehensive Analysis of Lysine Acetylome Reveals a Site-Specific Pattern in Rapamycin-Induced Autophagy. Journal of Proteome Research 18:3, pages 865-877.
Crossref
Salvatore Chirumbolo, Antonio Vella & Geir Bjørklund. (2018) Quercetin Might Promote Autophagy in a Middle Cerebral Artery Occlusion-Mediated Ischemia Model: Comments on Fawad-Ali Shah et al.. Neurochemical Research 44:2, pages 297-300.
Crossref
Yingmei Zhang, Adam T. Whaley-Connell, James R. Sowers & Jun Ren. (2018) Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management. Pharmacology & Therapeutics 191, pages 1-22.
Crossref
Cristina-Sorina Cătană, Atanas G. Atanasov & Ioana Berindan-Neagoe. (2018) Natural products with anti-aging potential: Affected targets and molecular mechanisms. Biotechnology Advances 36:6, pages 1649-1656.
Crossref
Mahmoud AbdellatifSimon SedejDidac Carmona-GutierrezFrank MadeoGuido Kroemer. (2018) Autophagy in Cardiovascular Aging. Circulation Research 123:7, pages 803-824.
Crossref
Kartik Mani, Ali Javaheri & Abhinav Diwan. 2011. Comprehensive Physiology. Comprehensive Physiology 1639 1667 .
Matthew D.W. Piper & Linda Partridge. (2018) Drosophila as a model for ageing. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:9, pages 2707-2717.
Crossref
Liang-Yu Chen, Martin Lotz, Robert Terkeltaub & Ru Liu-Bryan. (2018) Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes. Journal of Biological Chemistry 293:31, pages 12259-12270.
Crossref
Geetika GargSandeep SinghAbhishek Kumar SinghSyed Ibrahim Rizvi. (2017) Antiaging Effect of Metformin on Brain in Naturally Aged and Accelerated Senescence Model of Rat. Rejuvenation Research 20:3, pages 173-182.
Crossref
Wai Yan Sun & Yu Wang. 2017. Nutrition and Functional Foods for Healthy Aging. Nutrition and Functional Foods for Healthy Aging 257 271 .
Pamela Dakik & Vladimir I. Titorenko. (2016) Communications between Mitochondria, the Nucleus, Vacuoles, Peroxisomes, the Endoplasmic Reticulum, the Plasma Membrane, Lipid Droplets, and the Cytosol during Yeast Chronological Aging. Frontiers in Genetics 7.
Crossref
Miguel A. AonSonia CortassaMagdalena JuhaszovaSteven J. Sollott. (2016) Mitochondrial health, the epigenome and healthspan. Clinical Science 130:15, pages 1285-1305.
Crossref
Marco Tomasetti, Federica Monaco, Nicola Manzella, Jakub Rohlena, Katerina Rohlenova, Sara Staffolani, Simona Gaetani, Veronica Ciarapica, Monica Amati, Massimo Bracci, Matteo Valentino, Jacob Goodwin, Maria Nguyen, Jaroslav Truksa, Margaryta Sobol, Pavel Hozak, Lan-Feng Dong, Lory Santarelli & Jiri Neuzil. (2016) MicroRNA-126 induces autophagy by altering cell metabolism in malignant mesothelioma. Oncotarget 7:24, pages 36338-36352.
Crossref
Ruba S. Deeb, Matthew S. Walters, Yael Strulovici-Barel, Qiuying Chen, Steven S. Gross & Ronald G. Crystal. (2016) Smoking-Associated Disordering of the Airway Basal Stem/Progenitor Cell Metabotype. American Journal of Respiratory Cell and Molecular Biology 54:2, pages 231-240.
Crossref
Rosa A. González-Polo, Elisa Pizarro-Estrella, Sokhna M. S. Yakhine-Diop, Mario Rodríguez-Arribas, Rubén Gómez-Sánchez, Ignacio Casado-Naranjo, José M. Bravo-San Pedro & José M. Fuentes. 2016. Autophagy Networks in Inflammation. Autophagy Networks in Inflammation 3 20 .
Leonardo Gatticchi, Ilaria Bellezza, Rachele Del Sordo, Matthew J. Peirce, Angelo Sidoni, Rita Roberti & Alba Minelli. (2015) The Tm7sf2 Gene Deficiency Protects Mice against Endotoxin-Induced Acute Kidney Injury. PLOS ONE 10:11, pages e0141885.
Crossref
Wei Xin, Xu Zhao, Lei Liu, Ying Xu, Zhaoping Li, Liyong Chen, Xiaojie Wang, Fan Yi & Qiang Wan. (2015) Acetyl-CoA carboxylase 2 suppression rescues human proximal tubular cells from palmitic acid induced lipotoxicity via autophagy. Biochemical and Biophysical Research Communications 463:3, pages 364-369.
Crossref
Jasmin Schiessl-Weyer, Pedro Roa, Franco Laccone, Britta Kluge, Alexander Tichy, Euripedes De Almeida Ribeiro, Rainer Prohaska, Peter Stoeter, Claudia Siegl & Ulrich Salzer. (2015) Acanthocytosis and the c.680 A>G Mutation in the PANK2 Gene: A Study Enrolling a Cohort of PKAN Patients from the Dominican Republic. PLOS ONE 10:4, pages e0125861.
Crossref
F Pietrocola, S Lachkar, D P Enot, M Niso-Santano, J M Bravo-San Pedro, V Sica, V Izzo, M C Maiuri, F Madeo, G Mariño & G Kroemer. (2014) Spermidine induces autophagy by inhibiting the acetyltransferase EP300. Cell Death & Differentiation 22:3, pages 509-516.
Crossref
Ryan A. Henry, Yin-Ming Kuo, Vikram Bhattacharjee, Timothy J. Yen & Andrew J. Andrews. (2014) Changing the Selectivity of p300 by Acetyl-CoA Modulation of Histone Acetylation. ACS Chemical Biology 10:1, pages 146-156.
Crossref