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Cancer Biology & Therapy Volume 12, 2011 - Issue 12
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Research Paper

Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells

Implications for preventing chemotherapy resistance

Ying-Hui Ko The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Departments of Stem Cell Biology & Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA
,
Zhao Lin The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Departments of Stem Cell Biology & Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA
,
Neal Flomenberg The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Department of Medical Oncology
,
Richard G. Pestell The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Departments of Stem Cell Biology & Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Department of Medical Oncology
,
Anthony Howell Manchester Breast Center & Breakthrough Breast Cancer Research Unit; Paterson Institute for Cancer Research; School of Cancer; Enabling Sciences and Technology; Manchester Academic Health Science Center; University of Manchester; Manchester, UK
,
Federica Sotgia The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Departments of Stem Cell Biology & Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Manchester Breast Center & Breakthrough Breast Cancer Research Unit; Paterson Institute for Cancer Research; School of Cancer; Enabling Sciences and Technology; Manchester Academic Health Science Center; University of Manchester; Manchester, UK
,
Michael P. Lisanti The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Departments of Stem Cell Biology & Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Manchester Breast Center & Breakthrough Breast Cancer Research Unit; Paterson Institute for Cancer Research; School of Cancer; Enabling Sciences and Technology; Manchester Academic Health Science Center; University of Manchester; Manchester, UK; Department of Medical OncologyCorrespondence[email protected]
&
Ubaldo E. Martinez-Outschoorn The Jefferson Stem Cell Biology and Regenerative Medicine Center; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Departments of Stem Cell Biology & Regenerative Medicine and Cancer Biology; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA; Department of Medical OncologyCorrespondence[email protected]
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Pages 1085-1097 | Received 28 Sep 2011, Accepted 07 Nov 2011, Published online: 15 Dec 2011

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Lin Chen, Kunzi Zhang, Jian Sun, Jingtong Tang & Jianping Zhou. (2021) Development and Validation of an Autophagy-Stroma-Based Microenvironment Gene Signature for Risk Stratification in Colorectal Cancer. OncoTargets and Therapy 14, pages 3503-3515.
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Ji Geng, Xiao Yuan, Mingzhen Wei, Junchao Wu & Zheng-Hong Qin. (2018) The diverse role of TIGAR in cellular homeostasis and cancer. Free Radical Research 52:11-12, pages 1240-1249.
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Rosa Sanchez-Alvarez, Ubaldo E. Martinez-Outschoorn, Zhao Lin, Rebecca Lamb, James Hulit, Anthony Howell, Federica Sotgia, Emanuel Rubin & Michael P. Lisanti. (2013) Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism. Cell Cycle 12:2, pages 289-301.
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Edward Henry Mathews & Leon Liebenberg. (2012) Complexity of metabolic cancer control. Cancer Biology & Therapy 13:8, pages 585-585.
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Chris Albanese, Fabiana S. Machado & Herbert B. Tanowitz. (2011) Glutamine and the tumor microenvironment. Cancer Biology & Therapy 12:12, pages 1098-1100.
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