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Research Paper

Polymorphisms in the hypoxia-inducible factor-1α gene confer susceptibility to pancreatic cancer

Pages 383-387 | Received 04 Mar 2011, Accepted 07 Jun 2011, Published online: 01 Sep 2011

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Mert Erkan, Metin Kurtoglu & Jorg Kleeff. (2016) The role of hypoxia in pancreatic cancer: a potential therapeutic target?. Expert Review of Gastroenterology & Hepatology 10:3, pages 301-316.
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Lori A Erickson, W Edward Highsmith$suffix/text()$suffix/text(), Peiwen Fei & Jun Zhang. (2015) Targeting the hypoxia pathway to treat pancreatic cancer. Drug Design, Development and Therapy 9, pages 2029-2031.
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Jihui Hao. (2015) HIF-1 is a critical target of pancreatic cancer. OncoImmunology 4:9.
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Yanwei Ye, Min Wang, Shuang Hu, Yingqiang Shi, Xiefu Zhang, Ye Zhou, Chunlin Zhao, Guojun Wang, Jianguo Wen & Hong Zong. (2014) Hypoxia-Inducible Factor-1α C1772T Polymorphism and Cancer Risk: A Meta-Analysis Including 18,334 Subjects. Cancer Investigation 32:4, pages 126-135.
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Articles from other publishers (33)

Lan Wang, Ming Li, Tiantian Dong, Yuanyuan Li, Ci Yin & Fang Nie. (2023) Pancreatic Ductal Adenocarcinoma: The Characteristics of Contrast-Enhanced Ultrasound Are Correlated with the Hypoxic Microenvironment. Diagnostics 13:20, pages 3270.
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Zaid Z Akkoub & Omar F Khabour. (2023) Association between P582S <i>HIF-1A</i> gene polymorphism and hematological parameters among women: A cross-sectional study. Electronic Journal of General Medicine 20:5, pages em508.
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Amani A. Abdelgalil, Rehan Monir, Mohamed Elmetwally, Maivel H. Ghattas, Fagr B. Bazeed, Noha M. Mesbah, Dina M. Abo-Elmatty & Eman T. Mehanna. (2023) The Relation of VEGFA, VEGFR2, VEGI, and HIF1A Genetic Variants and Their Serum Protein Levels with Breast Cancer in Egyptian Patients. Biochemical Genetics.
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Zhuo-Miao Ye, Li-Juan Li, Ming-Bo Luo, Hong-Yuan Qing, Jing-Hui Zheng, Chi Zhang, Yun-Xin Lu & You-Ming Tang. (2020) A systematic review and network meta-analysis of single nucleotide polymorphisms associated with pancreatic cancer risk. Aging 12:24, pages 25256-25274.
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Hong-Yan Li, Tianbiao Zhou, Wenshan Lin, Shujun Lin & Hongzhen Zhong. (2019) Association of hypoxia-inducible factor-1α (HIF1α) 1790G/A gene polymorphism with renal cell carcinoma and prostate cancer susceptibility: a meta-analysis. BMC Medical Genetics 20:1.
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Haotian Wang, Rujiang Jia, Tiansuo Zhao, Xin Li, Mingxiao Lang, Chungen Lan, Hongwei Wang, Zengxun Li, Bodong Zhou, Liangliang Wu, Yan Sun, Xiuchao Wang, He Ren & Jihui Hao. (2019) HIF-1α mediates tumor-nerve interactions through the up-regulation of GM-CSF in pancreatic ductal adenocarcinoma. Cancer Letters 453, pages 10-20.
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Sivakamasundari Pichu, Selvaraj Vimalraj, Jayalalitha Sathiyamoorthy & Vijay Viswanathan. (2018) Association of hypoxia inducible factor-1 alpha exon 12 mutation in diabetic patients with and without diabetic foot ulcer. International Journal of Biological Macromolecules 119, pages 833-837.
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Wu Wang, Bu-Qiang Wu, Guang-Bin Chen, Yong Zhou, Zhao-Hua Li, Jian-Liang Zhang, Yin-Lu Ding, Peng Zhang & Jin-Qing Wang. (2018) Hypoxia-inducible factor-1α rs11549465 C>T and rs11549467 G>A gene polymorphisms are associated with an increased risk of digestive cancers in Asians. Journal of Cancer Research and Therapeutics 14:Suppl 1, pages S46-S53.
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I. Gladek, J. Ferdin, S. Horvat, G. A. Calin & T. Kunej. (2017) HIF1A gene polymorphisms and human diseases: Graphical review of 97 association studies . Genes, Chromosomes and Cancer 56:6, pages 439-452.
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Mariana Burgos & Rodrigo Cabrera. (2017) Influencia del polimorfismo rs11549465 de HIF-1α en los niveles de hemoglobina y lactato en pacientes de cirugía cardiovascular. Revista de la Facultad de Medicina 65:2, pages 253-260.
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Vito Longo, Oronzo Brunetti, Antonio Gnoni, Stefano Cascinu, Giampietro Gasparini, Vito Lorusso, Domenico Ribatti & Nicola Silvestris. (2016) Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue. Oncotarget 7:36, pages 58649-58658.
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Xiuchao Wang, He Ren, Tiansuo Zhao, Weidong Ma, Jie Dong, Shengjie Zhang, Wen Xin, Shengyu Yang, Li Jia & Jihui Hao. (2016) Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes. Oncotarget 7:12, pages 13717-13729.
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Md. T Anam, Alokta Ishika, Md. B Hossain & Jesmin. (2015) A meta-analysis of hypoxia inducible factor 1-alpha (HIF1A) gene polymorphisms: association with cancers. Biomarker Research 3:1.
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Zhi-Hai Ni, Xian-Jun Liang, Jing-Gang Mo, Yi Zhang, Jian-Hua Liang, Yu-Sha Yang, Yong Zhou, Zhao-Hua Li, Jian-Liang Zhang, Yin-Lu Ding, Peng Zhang & Jin-Qing Wang. (2015) Associations of hypoxia inducible factor-1α gene polymorphisms with susceptibility to digestive tract cancers: a case–control study and meta-analysis. Genes & Genomics 37:11, pages 931-938.
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Ana I. Belo, Sandra J. van Vliet, Andreas Maus, Lisa C. Laan, Tessa D. Nauta, Pieter Koolwijk, Boris Tefsen & Irma van Die. (2015) Hypoxia inducible factor 1α down regulates cell surface expression of α1,2‐fucosylated glycans in human pancreatic adenocarcinoma cells. FEBS Letters 589:18, pages 2359-2366.
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Xu Guo, Deyang Li, Yibing Chen, Jiaze An, Kan Wang, Zhuding Xu, Zhinan Chen & Jinliang Xing. (2015) SNP rs2057482 in HIF1A gene predicts clinical outcome of aggressive hepatocellular carcinoma patients after surgery. Scientific Reports 5:1.
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Xiao Sun. (2015) HIF-1α -1790G>A polymorphism significantly increases the risk of digestive tract cancer: A meta-analysis. World Journal of Gastroenterology 21:5, pages 1641.
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Sarika Sharma, Ruhi Kapahi, Vasudha Sambyal, Kamlesh Guleria, Mridu Manjari, Meena Sudan, Manjit Singh Uppal & Neeti Rajan Singh. (2014) No Association of Hypoxia Inducible Factor-1α Gene Polymorphisms with Breast Cancer in North-West Indians. Asian Pacific Journal of Cancer Prevention 15:22, pages 9973-9978.
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Yuqiao Zhou, Lin Lin, Yun Wang, Xin Jin, Xin Zhao, Dongjuan Liu, Ting Hu, Lu Jiang, Hongxia Dan, Xin Zeng, Jing Li, Jiayi Wang & Qianming Chen. (2014) The association between hypoxia-inducible factor-1 α gene G1790A polymorphism and cancer risk: a meta-analysis of 28 case–control studies. Cancer Cell International 14:1.
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Qing Yan, Pin Chen, Songtao Wang, Ning Liu, Peng Zhao & Aihua Gu. (2014) Association between HIF-1α C1772T/G1790A polymorphisms and cancer susceptibility: an updated systematic review and meta-analysis based on 40 case-control studies. BMC Cancer 14:1.
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Liang Yi, Xuwei Hou, Ji Zhou, Lunshan Xu, Qing Ouyang, Hong Liang, Zhaocong Zheng, Hongjie Chen & Minhui Xu. (2014) HIF-1α Genetic Variants and Protein Expression Confer the Susceptibility and Prognosis of Gliomas. NeuroMolecular Medicine 16:3, pages 578-586.
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Gang Wu, Wen-Feng Yan, Yuan-Zeng Zhu & Pei-Chun Sun. (2014) Hypoxia-inducible factor-1α (HIF-1α) C1772T polymorphism significantly contributes to the risk of malignancy from a meta-analysis. Tumor Biology 35:5, pages 4113-4122.
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Boya Liu, Qingchun Liu, Yang Song, Xiaofei Li, Yunjie Wang, Shaogui Wan, Zhipei Zhang & Haichuan Su. (2014) Polymorphisms of HIF1A gene are associated with prognosis of early stage non-small-cell lung cancer patients after surgery. Medical Oncology 31:4.
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Xi Yang, Chi Zhang, Hong-Cheng Zhu, Qin Qin, Lian-Jun Zhao, Jia Liu, Li-Ping Xu, Qu Zhang, Jing Cai, Jian-Xin Ma, Hong-Yan Cheng & Xin-Chen Sun. (2013) HIF-1? P582S and A588T polymorphisms and digestive system cancer risk?a meta-analysis. Tumor Biology 35:3, pages 2825-2830.
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Xin Hu, Yuan Fang, Jun Zheng, Yazhou He, Xin Zan, Sen Lin, Xi Li, Hao Li & Chao You. (2013) The association between HIF-1α polymorphism and cancer risk: a systematic review and meta-analysis. Tumor Biology 35:2, pages 903-916.
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Zhi-Jun Dai. (2014) Associations Between C1772T Polymorphism in Hypoxia-Inducible Factor-1? Gene and Breast Cancer: A Meta-Analysis.. Medical Science Monitor 20, pages 2578-2583.
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Yanwei Ye, Min Wang, Jingjing Li, Yingqiang ShiXiefu Zhang, Ye ZhouChunlin Zhao & Jianguo Wen. (2018) Hypoxia-Inducible Factor-1α G Polymorphism and the Risk of Cancer: A Meta-Analysis. Tumori Journal 100:6, pages e257-e265.
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Pengfei He, Qi Han, Jiajia Liu, Dongjuan Liu, Xin Zhao, Ting Hu, Lu Jiang, Hongxia Dan, Xin Zeng, Jing Li, Jiayi Wang & Qianming Chen. (2013) The Association between Hypoxia-Inducible Factor-1 ? Gene C1772T Polymorphism and Cancer Risk: A Meta-Analysis of 37 Case-Control Studies. PLoS ONE 8:12, pages e83441.
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Xi Yang, Hong-Cheng Zhu, Chi Zhang, Qin Qin, Jia Liu, Li-Ping Xu, Lian-Jun Zhao, Qu Zhang, Jing Cai, Jian-Xin Ma, Hong-Yan Cheng & Xin-Chen Sun. (2013) HIF-1α 1772 C/T and 1790 G/A Polymorphisms Are Significantly Associated with Higher Cancer Risk: An Updated Meta-Analysis from 34 Case-Control Studies. PLoS ONE 8:11, pages e80396.
Crossref
He Ren, Tiansuo Zhao, Junwei Sun, Xiuchao Wang, Jingcheng Liu, Song Gao, Ming Yu & Jihui Hao. (2013) The CX3CL1/CX3CR1 reprograms glucose metabolism through HIF-1 pathway in pancreatic adenocarcinoma. Journal of Cellular Biochemistry 114:11, pages 2603-2611.
Crossref
Xin Hu, Sen Lin, Jun Zheng, Rui Guo, Hao Li & Chao You. (2013) Clinicopathological significance of hypoxia-inducible factor-1 alpha polymorphisms in cancers: evidence from a meta-analysis. Tumor Biology 34:5, pages 2477-2487.
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Qian Zhang, Yan Chen, Bin Zhang, Bin Shi, Wenjun Weng, Zhipeng Chen, Nannan Guo, Yibing Hua & Lingjun Zhu. (2013) Hypoxia-Inducible Factor-1? Polymorphisms and Risk of Cancer Metastasis: A Meta-Analysis. PLoS ONE 8:8, pages e70961.
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Pankaj K. Singh, Randall E. Brand & Kamiya Mehla. (2012) MicroRNAs in pancreatic cancer metabolism. Nature Reviews Gastroenterology & Hepatology 9:6, pages 334-344.
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