1,233
Views
124
CrossRef citations to date
0
Altmetric
Review

EpCAM: A New Therapeutic Target for an Old Cancer Antigen

Pages 320-325 | Published online: 20 Mar 2003

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Zhen-Jie Wu, Jia-Chang Tan, Xiong Qin, Bin Liu & Zhen-Chao Yuan. (2018) Significance of circulating tumor cells in osteosarcoma patients treated by neoadjuvant chemotherapy and surgery. Cancer Management and Research 10, pages 3333-3339.
Read now
Se Hee Park, Ah-Young Kim, Sang Hoon Ma, Hyun Min Kim, Hyung Sik Kang, Jin-Soo Maeng, Kisung Ko, In Sik Chung & Young Hee Joung. (2015) Purification of human carcinoma antigen GA733-2 expressed in Escherichia coli and production of its polyclonal antibody in rabbit. Animal Cells and Systems 19:3, pages 188-193.
Read now
Silke Petsch, Olivier Gires, Dominik Rüttinger, Sabine Denzel, Sandra Lippold, Patrick A. Baeuerle & Andreas Wolf. (2011) Concentrations of EpCAM ectodomain as found in sera of cancer patients do not significantly impact redirected lysis and T-cell activation by EpCAM/CD3-bispecific BiTE antibody MT110 . mAbs 3:1, pages 31-37.
Read now
Jean-Emmanuel Kurtz & Patrick Dufour. (2010) Adecatumumab: an anti-EpCAM monoclonal antibody, from the bench to the bedside. Expert Opinion on Biological Therapy 10:6, pages 951-958.
Read now
Eleni Andreopoulou & Massimo Cristofanilli. (2010) Circulating tumor cells as prognostic marker in metastatic breast cancer. Expert Review of Anticancer Therapy 10:2, pages 171-177.
Read now
Imke Atreya & Markus F Neurath. (2008) Immune cells in colorectal cancer: prognostic relevance and therapeutic strategies. Expert Review of Anticancer Therapy 8:4, pages 561-572.
Read now

Articles from other publishers (118)

Lanuza A.P. Faccioli, Marlon Lemos Dias, Ricardo Martins-Santos, Bruno Diaz Paredes, Christina Maeda Takiya & Regina Coeli dos Santos Goldenberg. 2024. Resident Stem Cells and Regenerative Therapy. Resident Stem Cells and Regenerative Therapy 23 51 .
Xuewei Zhao, Ruixia Zhao, Yang Feng, Zuchun Qiu, Xue Bai, Danying Zhang, Yujuan Zhou, Hongming Fang, Niu Liu, Lirong Chen, Chenshuang Jia, Yue Yuan, Xinyao Li, Wei Duan, Guochao Nie & Yingchun Hou. (2023) The roles EpCAM plays to enhance the malignancy of gastric cancer. Journal of Cancer Research and Clinical Oncology 149:11, pages 8495-8505.
Crossref
Vita Golubovskaya, John Sienkiewicz, Jinying Sun, Yanwei Huang, Liang Hu, Hua Zhou, Hizkia Harto, Shirley Xu, Robert Berahovich, Walter Bodmer & Lijun Wu. (2023) mRNA-Lipid Nanoparticle (LNP) Delivery of Humanized EpCAM-CD3 Bispecific Antibody Significantly Blocks Colorectal Cancer Tumor Growth. Cancers 15:10, pages 2860.
Crossref
Shuang Li, Zhiguang Wang, Xiaoxiao Lin, Yalan Bian & Liqun Chen. (2023) Exo I signal amplification of a DNA hydrogel film combined with capillary self-driven action for EpCAM detection. The Analyst.
Crossref
Sabine Alebrand, Christian Freese, Janis Stiefel, Arnold Maria Raem & Michael Baßler. 2023. Immunoassays. Immunoassays 389 410 .
Elijah N. McCool, Tian Xu, Wenrong Chen, Nicole C. Beller, Scott M. NolanAmanda B. Hummon, Xiaowen Liu & Liangliang Sun. (2022) Deep top-down proteomics revealed significant proteoform-level differences between metastatic and nonmetastatic colorectal cancer cells. Science Advances 8:51.
Crossref
Se Hee Park, Kon-Young Ji, Seo Young Park, Hyun Min Kim, Sang Hoon Ma, Ju Hui Do, Hyuno Kang, Hyung Sik Kang, Doo-Byoung Oh, Jae Sung Shim & Young Hee Joung. (2022) Immunotherapeutic effects of recombinant colorectal cancer antigen produced in tomato fruits. Scientific Reports 12:1.
Crossref
Min Wang, Wei Cai, Ai-Jun Yang, Chen-Yu Wang, Chen-Li Zhang, Wei Liu, Xiao-Feng Xie, Yuan-Yuan Gong, Ying-Ying Zhao, Wen-Cheng Wu, Quan Zhou, Chan-Yuan Zhao, Jing-Fei Dong & Min Li. (2022) Gastric cancer cell-derived extracellular vesicles disrupt endothelial integrity and promote metastasis. Cancer Letters 545, pages 215827.
Crossref
Bhavani Shankar Maradani, Sowmya Parameswaran & Krishnakumar Subramanian. (2022) Development and characterization of DNA aptamer against Retinoblastoma by Cell-SELEX. Scientific Reports 12:1.
Crossref
Samjhana Shrestha, Asmita Banstola, Jee-Heon Jeong, Ji Hae Seo & Simmyung Yook. (2022) Targeting Cancer Stem Cells: Therapeutic and diagnostic strategies by the virtue of nanoparticles. Journal of Controlled Release 348, pages 518-536.
Crossref
Yisha Zhang, David Lim, Zuchao Cai, Junxuan Peng, Beidi Jia, Guoliang Chu, Fengmei Zhang, Chao Dong & Zhihui Feng. (2022) Valproic acid counteracts polycyclic aromatic hydrocarbons (PAHs)-induced tumorigenic effects by regulating the polarization of macrophages. Ecotoxicology and Environmental Safety 241, pages 113779.
Crossref
Sara Eskandarinezhad, Irshad Ahmad Wani, Mohammad Nourollahileilan, Ajit Khosla & Tokeer Ahmad. (2022) Review—Metal and Metal Oxide Nanoparticles/Nanocomposites as Electrochemical Biosensors for Cancer Detection. Journal of The Electrochemical Society 169:4, pages 047504.
Crossref
Elham Kalantari, Tahereh Taheri, Saba Fata, Maryam Abolhasani, Mitra Mehrazma, Zahra Madjd & Mojgan Asgari. (2022) Significant co-expression of putative cancer stem cell markers, EpCAM and CD166, correlates with tumor stage and invasive behavior in colorectal cancer. World Journal of Surgical Oncology 20:1.
Crossref
Davinder Singh, Divya Dheer, Abhilash Samykutty & Ravi Shankar. (2021) Antibody drug conjugates in gastrointestinal cancer: From lab to clinical development. Journal of Controlled Release 340, pages 1-34.
Crossref
Jianling Wang, Lihua Sui, Jia Huang, Lu Miao, Yubing Nie, Kuansong Wang, Zhichun Yang, Qiong Huang, Xue Gong, Yayun Nan & Kelong Ai. (2021) MoS2-based nanocomposites for cancer diagnosis and therapy. Bioactive Materials 6:11, pages 4209-4242.
Crossref
Abu Tayab Moin, Bishajit Sarkar, Md Asad Ullah, Yusha Araf, Nafisa Ahmed & Bashudev Rudra. (2021) In silico assessment of EpCAM transcriptional expression and determination of the prognostic biomarker for human lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Biochemistry and Biophysics Reports 27, pages 101074.
Crossref
Jinlong Kong, Yang Liu, Xiangbin Du, Kaiqun Wang, Weiyi Chen, Di Huang, Yan Wei & Haiyang Mao. (2021) Effect of cell-nanostructured substrate interactions on the capture efficiency of HeLa cells. Biomedical Materials 16:3, pages 035011.
Crossref
Kun Xu, Wenwen Zhang, Cong Wang, Longfei Hu, Runtian Wang, Cenzhu Wang, Lin Tang, Guohua Zhou, Bingjie Zou, Hui Xie, Jinhai Tang & Xiaoxiang Guan. (2021) Integrative analyses of scRNA-seq and scATAC-seq reveal CXCL14 as a key regulator of lymph node metastasis in breast cancer. Human Molecular Genetics 30:5, pages 370-380.
Crossref
Se Hee Park, Kon-Young Ji, Hyun Min Kim, Sang Hoon Ma, Seo Young Park, Ju Hui Do, Doo-Byoung Oh, Hyung Sik Kang, Jae Sung Shim & Young Hee Joung. (2021) Optimization of the human colorectal carcinoma antigen GA733-2 production in tobacco plants. Plant Biotechnology Reports 15:1, pages 55-67.
Crossref
Abd-Elgawad Radi & Maha Ragaa Abd-Ellatief. (2021) Electrochemical Aptasensors: Current Status and Future Perspectives. Diagnostics 11:1, pages 104.
Crossref
Mahmood Barani, Muhammad Bilal, Abbas Rahdar, Rabia Arshad, Arun Kumar, Hamed Hamishekar & George Z. Kyzas. (2021) Nanodiagnosis and nanotreatment of colorectal cancer: an overview. Journal of Nanoparticle Research 23:1.
Crossref
Preye Agbana, Min Jae Lee, Piotr Rychahou, Kyung-Bo Kim & Younsoo Bae. (2020) Ternary Polypeptide Nanoparticles with Improved Encapsulation, Sustained Release, and Enhanced In Vitro Efficacy of Carfilzomib. Pharmaceutical Research 37:11.
Crossref
Lia Walcher, Ann-Kathrin Kistenmacher, Huizhen Suo, Reni Kitte, Sarah Dluczek, Alexander Strauß, André-René Blaudszun, Tetyana Yevsa, Stephan Fricke & Uta Kossatz-Boehlert. (2020) Cancer Stem Cells—Origins and Biomarkers: Perspectives for Targeted Personalized Therapies. Frontiers in Immunology 11.
Crossref
Leili Saeednejad Zanjani, Zahra Madjd, Ulrika Axcrona, Maryam Abolhasani, Arezoo Rasti, Mojgan Asgari, Øystein Fodstad & Yvonne Andersson. (2020) Cytoplasmic expression of B7-H3 and membranous EpCAM expression are associated with higher grade and survival outcomes in patients with clear cell renal cell carcinoma. Annals of Diagnostic Pathology 46, pages 151483.
Crossref
Alejandro Kayum Jiménez‐Zenteno & Aline Cerf. (2019) Liquid Biopsy Based on Circulating Cancer‐Associated Cells: Bridging the Gap from an Emerging Concept to a Mainstream Tool in Precision Medicine. Advanced Biosystems 4:2.
Crossref
Zhiquan Liang, Ziwen Lu, Yafei Zhang, Dongsheng Shang, Ruyan Li, Lanlan Liu, Zhicong Zhao, Peishan Zhang, Qiong Lin, Chunlai Feng, Yibang Zhang, Peng Liu, Zhigang Tu & Hanqing Liu. (2019) Targeting Membrane Receptors of Ovarian Cancer Cells for Therapy. Current Cancer Drug Targets 19:6, pages 449-467.
Crossref
Riccardo Giampieri, Francesco Piva, Giulia Occhipinti, Alessandro Bittoni, Alessandra Righetti, Silvia Pagliaretta, Alberto Murrone, Francesca Bianchi, Consuelo Amantini, Matteo Giulietti, Giulia Ricci, Giovanni Principato, Giorgio Santoni, Rossana Berardi & Stefano Cascinu. (2019) Clinical impact of different exosomes’ protein expression in pancreatic ductal carcinoma patients treated with standard first line palliative chemotherapy. PLOS ONE 14:5, pages e0215990.
Crossref
Fangchao Cui, Jian Ji, Jiadi Sun, Jun Wang, Haiming Wang, Yinzhi Zhang, Hong Ding, Yong Lu, Dan Xu & Xiulan Sun. (2019) A novel magnetic fluorescent biosensor based on graphene quantum dots for rapid, efficient, and sensitive separation and detection of circulating tumor cells. Analytical and Bioanalytical Chemistry 411:5, pages 985-995.
Crossref
Bárbara Sousa, Ana Sofia Ribeiro & Joana Paredes. 2019. Stem Cells Heterogeneity in Cancer. Stem Cells Heterogeneity in Cancer 83 103 .
Matthew Neave, Robyn Hall, Nina Huang, Kenneth McColl, Peter Kerr, Marion Hoehn, Jennifer Taylor & Tanja Strive. (2018) Robust Innate Immunity of Young Rabbits Mediates Resistance to Rabbit Hemorrhagic Disease Caused by Lagovirus Europaeus GI.1 But Not GI.2. Viruses 10:9, pages 512.
Crossref
Yuki Goto & Hiroaki Suga. (2018) Artificial In Vitro Biosynthesis Systems for the Development of Pseudo-Natural Products . Bulletin of the Chemical Society of Japan 91:3, pages 410-419.
Crossref
Zeid A. Nima, Ahmed M. Alwbari, Vijayalakshmi Dantuluri, Rabab N. Hamzah, Natasha Sra, Pooja Motwani, Konstantinos Arnaoutakis, Rebecca A. Levy, Amani F. Bohliqa, Dmitry Nedosekin, Vladimir P. Zharov, Issam Makhoul & Alexandru S. Biris. (2017) Targeting nano drug delivery to cancer cells using tunable, multi-layer, silver-decorated gold nanorods. Journal of Applied Toxicology 37:12, pages 1370-1378.
Crossref
Mohammad Javad Dehghan Esmatabadi, Fatemeh Movahedi Motlagh, Azadeh Etemadzadeh & Samira Hajigholami. (2017) The Most Well - known Markers of CSCs and Their Role in Growth of Tumors, Drug Resistance and Metastasis. Journal of Human Genetics and Genomics 2:1.
Crossref
Vasanthakumar S, Sasikala P, Padma M, Balachandar V, Venkatesh B & Ganesan S. (2017) EpCAM as a novel therapeutic target for hepatocellular carcinoma. Journal of Oncological Sciences 3:2, pages 71-76.
Crossref
Jingyu Shi, Jing Lyu, Feng Tian & Mo Yang. (2017) A fluorescence turn-on biosensor based on graphene quantum dots (GQDs) and molybdenum disulfide (MoS2) nanosheets for epithelial cell adhesion molecule (EpCAM) detection. Biosensors and Bioelectronics 93, pages 182-188.
Crossref
N V Sankpal, T P Fleming, P K Sharma, H J Wiedner & W E Gillanders. (2017) A double-negative feedback loop between EpCAM and ERK contributes to the regulation of epithelial–mesenchymal transition in cancer. Oncogene 36:26, pages 3706-3717.
Crossref
Salvatore Vitale, Antonio Laganà, Stella Capriglione, Roberto Angioli, Valentina La Rosa, Salvatore Lopez, Gaetano Valenti, Fabrizio Sapia, Giuseppe Sarpietro, Salvatore Butticè, Carmelo Tuscano, Daniele Fanale, Alessandro Tropea & Diego Rossetti. (2017) Target Therapies for Uterine Carcinosarcomas: Current Evidence and Future Perspectives. International Journal of Molecular Sciences 18:5, pages 1100.
Crossref
Susanna W. L. de Geus, Leonora S. F. Boogerd, Rutger-Jan Swijnenburg, J. Sven D. Mieog, Willemieke S. F. J. Tummers, Hendrica A. J. M. Prevoo, Cornelis F. M. Sier, Hans Morreau, Bert A. Bonsing, Cornelis J. H. van de Velde, Alexander L. Vahrmeijer & Peter J. K. Kuppen. (2016) Selecting Tumor-Specific Molecular Targets in Pancreatic Adenocarcinoma: Paving the Way for Image-Guided Pancreatic Surgery. Molecular Imaging and Biology 18:6, pages 807-819.
Crossref
Lin Shi, Kai Wang & Yong Yang. (2016) Adhesion-based tumor cell capture using nanotopography. Colloids and Surfaces B: Biointerfaces 147, pages 291-299.
Crossref
T Shibata, H Uchida, T Shiroyama, Y Okubo, T Suzuki, H Ikeda, M Yamaguchi, Y Miyagawa, T Fukuhara, J B Cohen, J C Glorioso, T Watabe, H Hamada & H Tahara. (2016) Development of an oncolytic HSV vector fully retargeted specifically to cellular EpCAM for virus entry and cell-to-cell spread. Gene Therapy 23:6, pages 479-488.
Crossref
Jose I. Varillas & Z. Hugh Fan. 2016. Circulating Tumor Cells. Circulating Tumor Cells 401 422 .
Jeong-Hwan Lee, Lu Qiao, Mee Ryoung Song & Kisung Ko. (2016) Murine response studies of insect cell (Sf9) expressed recombinant colorectal cancer vaccine candidate using surface plasmon resonance studies. Entomological Research 46:1, pages 5-14.
Crossref
Stefania Bellone, Jonathan Black, Diana P. English, Carlton L. Schwab, Salvatore Lopez, Emiliano Cocco, Elena Bonazzoli, Federica Predolini, Francesca Ferrari, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz & Alessandro D. Santin. (2016) Solitomab, an EpCAM/CD3 bispecific antibody construct (BiTE), is highly active against primary uterine serous papillary carcinoma cell lines in?vitro. American Journal of Obstetrics and Gynecology 214:1, pages 99.e1-99.e8.
Crossref
Francesca Ferrari, Stefania Bellone, Jonathan Black, Carlton L. Schwab, Salvatore Lopez, Emiliano Cocco, Elena Bonazzoli, Federica Predolini, Gulden Menderes, Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz & Alessandro D. Santin. (2015) Solitomab, an EpCAM/CD3 bispecific antibody construct (BiTE®), is highly active against primary uterine and ovarian carcinosarcoma cell lines in vitro. Journal of Experimental & Clinical Cancer Research 34:1.
Crossref
Kazuhiro Iwasaki, Yuki Goto, Takayuki Katoh, Taro Yamashita, Shuichi Kaneko & Hiroaki Suga. (2015) A Fluorescent Imaging Probe Based on a Macrocyclic Scaffold That Binds to Cellular EpCAM. Journal of Molecular Evolution 81:5-6, pages 210-217.
Crossref
Nihal G. Maremanda, Kislay Roy, Rupinder K. Kanwar, Vidyarani Shyamsundar, Vijayalakshmi Ramshankar, Arvind Krishnamurthy, Subramanian Krishnakumar & Jagat R. Kanwar. (2015) Quick chip assay using locked nucleic acid modified epithelial cell adhesion molecule and nucleolin aptamers for the capture of circulating tumor cells. Biomicrofluidics 9:5.
Crossref
Yo Seph Park, Jeong-Hwan Lee, Jin-Yeon Park, Han Sung Hwang, Martin Zenke, Dong Wook Han, Young Sun Kang, Kisung Ko & Kinarm Ko. (2015) Functionality of insect-cell-derived colorectal cancer vaccine candidate protein EpCAM-Fc in human dendritic cells. Entomological Research 45:3, pages 162-166.
Crossref
Annie R.A. McDougall, Mary Tolcos, Stuart B. Hooper, Timothy J. Cole & Megan J. Wallace. (2015) Trop2 : From development to disease . Developmental Dynamics 244:2, pages 99-109.
Crossref
Diana P. English, Stefania Bellone, Carlton L. Schwab, Dana M. Roque, Salvatore Lopez, Ileana Bortolomai, Emiliano Cocco, Elena Bonazzoli, Sudeshna Chatterjee, Elena Ratner, Dan-Arin Silasi, Masoud Azodi, Peter E. Schwartz, Thomas J. Rutherford & Alessandro D. Santin. (2015) Solitomab, an epithelial cell adhesion molecule/CD3 bispecific antibody (BiTE), is highly active against primary chemotherapy-resistant ovarian cancer cell lines in vitro and fresh tumor cells ex vivo. Cancer 121:3, pages 403-412.
Crossref
Deuk-Su Kim, Lu Qiao, Kyung-Jin Lee & Kisung Ko. (2015) Optimization of colorectal cancer vaccine candidate protein GA733-Fc expression in a baculovirus-insect cell system . Entomological Research 45:1, pages 39-48.
Crossref
Olivier Gires & Nikolas H. Stoecklein. (2014) Dynamic EpCAM expression on circulating and disseminating tumor cells: causes and consequences. Cellular and Molecular Life Sciences 71:22, pages 4393-4402.
Crossref
Nathan Yoganathan. (2014) Development of novel oncology biomarkers for cancer. BMC Proceedings 8:S4.
Crossref
Zeid A. Nima, Meena Mahmood, Yang Xu, Thikra Mustafa, Fumiya Watanabe, Dmitry A. Nedosekin, Mazen A. Juratli, Tariq Fahmi, Ekaterina I. Galanzha, John P. Nolan, Alexei G. Basnakian, Vladimir P. Zharov & Alexandru S. Biris. (2014) Circulating tumor cell identification by functionalized silver-gold nanorods with multicolor, super-enhanced SERS and photothermal resonances. Scientific Reports 4:1.
Crossref
Pengfei Zhang, Bizhi Shi, Huiping Gao, Hua Jiang, Juan Kong, Jin Yan, Xiaorong Pan, Kesang Li, Pengwei Zhang, Ming Yao, Shengli Yang, Jianren Gu, Hongyang Wang & Zonghai Li. (2013) An EpCAM/CD3 bispecific antibody efficiently eliminates hepatocellular carcinoma cells with limited galectin-1 expression. Cancer Immunology, Immunotherapy 63:2, pages 121-132.
Crossref
Jeffrey F.W. Keuren, Johannes J.M.L. Hoffmann & Mathie P.G. Leers. (2014) Immunological screening for tumor cells in serous body fluids has added value with the CELL-DYN Sapphire. Clinical Chemistry and Laboratory Medicine (CCLM) 52:2.
Crossref
A K Rud, E Borgen, G M Mælandsmo, K Flatmark, H Le, D Josefsen, I Solvoll, C B Schirmer, Å Helland, L Jørgensen, O T Brustugun, Ø Fodstad & K Boye. (2013) Clinical significance of disseminated tumour cells in non-small cell lung cancer. British Journal of Cancer 109:5, pages 1264-1270.
Crossref
Masahiro Yasunaga, Shino Manabe, David Tarin & Yasuhiro Matsumura. (2013) Tailored immunoconjugate therapy depending on a quantity of tumor stroma. Cancer Science 104:2, pages 231-237.
Crossref
Christina M. Takiya, Bruno Diaz Paredes, Luiz Fernando Quintanilha de Mesquita, Grazielle Suhett Dias, Lanuza Alaby Pinheiro Faccioli, Taro Takami, Shuji Terai, Isao Sakaida & Regina Coeli dos Santos Goldenberg. 2013. Resident Stem Cells and Regenerative Therapy. Resident Stem Cells and Regenerative Therapy 177 203 .
Min Hu, Lan Jian, Liyuan Zhang, Jiang Zheng, Yonghe You, Jieqiong Deng, Hua Li & Yifeng Zhou. (2012) Functional polymorphism in the EpCAM gene is associated with occurrence and advanced disease status of cervical cancer in Chinese population. Molecular Biology Reports 39:7, pages 7303-7309.
Crossref
Gerhard Moldenhauer, Alexei V. Salnikov, Sandra L?ttgau, Ingrid Herr, Jan Anderl & Heinz Faulstich. (2012) Therapeutic Potential of Amanitin-Conjugated Anti-Epithelial Cell Adhesion Molecule Monoclonal Antibody Against Pancreatic Carcinoma. JNCI: Journal of the National Cancer Institute 104:8, pages 622-634.
Crossref
E. Andreopoulou, L.‐Y. Yang, K. M. Rangel, J. M. Reuben, L. Hsu, S. Krishnamurthy, V. Valero, H. A. Fritsche & M. Cristofanilli. (2011) Comparison of assay methods for detection of circulating tumor cells in metastatic breast cancer: AdnaGen AdnaTest BreastCancer Select/Detect™ versus Veridex CellSearch™ system. International Journal of Cancer 130:7, pages 1590-1597.
Crossref
Carlo Patriarca, Roberto Maria Macchi, Anja K. Marschner & Hakan Mellstedt. (2012) Epithelial cell adhesion molecule expression (CD326) in cancer: A short review. Cancer Treatment Reviews 38:1, pages 68-75.
Crossref
Katya Hekimian, Ernst-Ludwig Stein, Ulrich Pachmann & Katharina Pachmann. (2012) Demasking of epithelial cell adhesion molecule (EpCAM) on circulating epithelial tumor cells by Tween®20 treatment in breast cancer patients. Clinical Chemistry and Laboratory Medicine 50:4.
Crossref
Naoto Shirasu, Hiromi Yamada, Hirotomo Shibaguchi, Motomu Kuroki & Masahide Kuroki. (2012) Molecular Characterization of a Fully Human Chimeric T-Cell Antigen Receptor for Tumor-Associated Antigen EpCAM. Journal of Biomedicine and Biotechnology 2012, pages 1-7.
Crossref
Zhe Lu, Kyung-Jin Lee, Yingxue Shao, Jeong-Hwan Lee, Yangkang So, Young-Kug Choo, Doo-Byoung Oh, Kyung-A Hwang, Seung Han Oh, Yeon Soo Han & Kisung Ko. (2012) Expression of GA733-Fc Fusion Protein as a Vaccine Candidate for Colorectal Cancer in Transgenic Plants. Journal of Biomedicine and Biotechnology 2012, pages 1-11.
Crossref
György BerencsiIIIIII & Katalin N. Szomor. 2012. Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis. Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis 281 333 .
Johannes Meller, Torsten Liersch, Birgit Meller, Kia Homayounfar & Carsten-Oliver Sahlmann. 2014. Therapeutic Nuclear Medicine. Therapeutic Nuclear Medicine 639 661 .
Masahiro Yasunaga, Shino Manabe, David Tarin & Yasuhiro Matsumura. (2011) Cancer-Stroma Targeting Therapy by Cytotoxic Immunoconjugate Bound to the Collagen 4 Network in the Tumor Tissue. Bioconjugate Chemistry 22:9, pages 1776-1783.
Crossref
H Akita, H Nagano, Y Takeda, H Eguchi, H Wada, S Kobayashi, S Marubashi, M Tanemura, H Takahashi, H Ohigashi, Y Tomita, O Ishikawa, M Mori & Y Doki. (2011) Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity. Oncogene 30:31, pages 3468-3476.
Crossref
Esma Saâda, Philippe Follana, Fréderic Peyrade, Véronique Mari & Éric François. (2011) Physiopathologie et prise en charge des ascites malignes réfractaires. Bulletin du Cancer 98:6, pages 679-687.
Crossref
Sarah Shigdar, Jia Lin, Yan Yu, Mile Pastuovic, Ming Wei & Wei Duan. (2011) RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule. Cancer Science 102:5, pages 991-998.
Crossref
Marleen van Oosten, Lucia M.A. Crane, Joost Bart, Fijs W. van Leeuwen & Gooitzen M. van Dam. (2011) Selecting Potential Targetable Biomarkers for Imaging Purposes in Colorectal Cancer Using TArget Selection Criteria (TASC): A Novel Target Identification Tool. Translational Oncology 4:2, pages 71-82.
Crossref
Lan Jiang, Chun Zhang, Yinyan Li, Xiao Yu, Jian Zheng, Ping Zou, Yuting Li, Xiaonong Bin, Jiachun Lu & Yifeng Zhou. (2010) A non-synonymous polymorphism Thr115Met in the EpCAM gene is associated with an increased risk of breast cancer in Chinese population. Breast Cancer Research and Treatment 126:2, pages 487-495.
Crossref
Alma Ortiz-Plata, Karina Moreno-Leyva, Mario López-Gómez, Sandra Santos-Salinas, Aurora Sánchez-García & Martha Lilia Tena-Suck. (2010) Epithelial cell adhesion molecule expression in pituitary adenomas: an immunohistochemical study. Annals of Diagnostic Pathology 14:6, pages 418-424.
Crossref
Christine E. Richter, Emiliano Cocco, Stefania Bellone, Dan-Arin Silasi, Dominik Rüttinger, Masoud Azodi, Peter E. Schwartz, Thomas J. Rutherford, Sergio Pecorelli & Alessandro D. Santin. (2010) High-grade, chemotherapy-resistant ovarian carcinomas overexpress epithelial cell adhesion molecule (EpCAM) and are highly sensitive to immunotherapy with MT201, a fully human monoclonal anti-EpCAM antibody. American Journal of Obstetrics and Gynecology 203:6, pages 582.e1-582.e7.
Crossref
Ashley Cimino, Marc Halushka, Peter Illei, Xinyan Wu, Saraswati Sukumar & Pedram Argani. (2009) Epithelial cell adhesion molecule (EpCAM) is overexpressed in breast cancer metastases. Breast Cancer Research and Treatment 123:3, pages 701-708.
Crossref
Chih‐Yung Yang, Chi‐Hung Lin & Jeng‐Kai Jiang. (2010) Early relapse in a rectal cancer patient: Possible implication of circulating cancer stem cell. Journal of Surgical Oncology 102:2, pages 196-197.
Crossref
Valerie Y. Ng, Sheu Ngo Ang, Jia Xin Chan & Andre B.H. Choo. (2010) Characterization of Epithelial Cell Adhesion Molecule as a Surface Marker on Undifferentiated Human Embryonic Stem Cells  . Stem Cells 28:1, pages 29-35.
Crossref
Sabine Denzel, Dorothea Maetzel, Brigitte Mack, Carola Eggert, Gabriele Bärr & Olivier Gires. (2009) Initial activation of EpCAM cleavage viacell-to-cell contact. BMC Cancer 9:1.
Crossref
Edmund J. Gosselin, Constantine Bitsaktsis, Ying Li & Bibiana V. Iglesias. (2009) Fc receptor-targeted mucosal vaccination as a novel strategy for the generation of enhanced immunity against mucosal and non-mucosal pathogens. Archivum Immunologiae et Therapiae Experimentalis 57:5, pages 311-323.
Crossref
Alexei V. Salnikov, Ariane Groth, Anja Apel, Georgios Kallifatidis, Benjamin M. Beckermann, Akmal Khamidjanov, Eduard Ryschich, Markus W. Büchler, Ingrid Herr & Gerhard Moldenhauer. (2009) Targeting of cancer stem cell marker EpCAM by bispecific antibody EpCAMxCD3 inhibits pancreatic carcinoma. Journal of Cellular and Molecular Medicine 13:9b, pages 4023-4033.
Crossref
Minoru Tanaka, Mayuko Okabe, Kaori Suzuki, Yoshiko Kamiya, Yuko Tsukahara, Shigeru Saito & Atsushi Miyajima. (2009) Mouse hepatoblasts at distinct developmental stages are characterized by expression of EpCAM and DLK1: Drastic change of EpCAM expression during liver development. Mechanisms of Development 126:8-9, pages 665-676.
Crossref
Bárbara González, Sabine Denzel, Brigitte Mack, Marcus Conrad & Olivier Gires. (2009) EpCAM Is Involved in Maintenance of the Murine Embryonic Stem Cell Phenotype. Stem Cells 27:8, pages 1782-1791.
Crossref
Mayuko OkabeYuko TsukaharaMinoru TanakaKaori SuzukiShigeru SaitoYoshiko KamiyaTohru TsujimuraKoji NakamuraAtsushi Miyajima. (2009) Potential hepatic stem cells reside in EpCAM+ cells of normal and injured mouse liver. Development 136:11, pages 1951-1960.
Crossref
Barbara Seliger & Olivier Gires. 2009. Tumor‐Associated Antigens. Tumor‐Associated Antigens 63 78 .
Patrick A. Baeuerle & Gert Riethmueller. 2009. Tumor‐Associated Antigens. Tumor‐Associated Antigens 179 200 .
Narendra V. Sankpal, Michael W. Willman, Timothy P. Fleming, John D. Mayfield & William E. Gillanders. (2009) Transcriptional Repression of Epithelial Cell Adhesion Molecule Contributes to p53 Control of Breast Cancer Invasion. Cancer Research 69:3, pages 753-757.
Crossref
Shine-Gwo Shiah, Long-Chang Chang, Kang-Yu Tai, Ghien-Hsing Lee, Cheng-Wen Wu & Yi-Shing Shieh. (2009) The involvement of promoter methylation and DNA methyltransferase-1 in the regulation of EpCAM expression in oral squamous cell carcinoma. Oral Oncology 45:1, pages e1-e8.
Crossref
Robert O. Dillman. 2009. Principles of Cancer Biotherapy. Principles of Cancer Biotherapy 303 406 .
Rohit G. Saldanha, Ning Xu, Mark P. Molloy, Duncan A. Veal & Mark S. Baker. (2008) Differential Proteome Expression Associated with Urokinase Plasminogen Activator Receptor (uPAR) Suppression in Malignant Epithelial Cancer. Journal of Proteome Research 7:11, pages 4792-4806.
Crossref
K Maaser & J Borlak. (2008) A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators. British Journal of Cancer 99:10, pages 1635-1643.
Crossref
Robert Brodzik, Sergei Spitsin, Max Golovkin, Katarzyna Bandurska, Carla Portocarrero, Monika Okulicz, Zenon Steplewski & Hilary Koprowski. (2007) Plant-derived EpCAM antigen induces protective anti-cancer response. Cancer Immunology, Immunotherapy 57:3, pages 317-323.
Crossref
Jens Rauch & Olivier Gires. (2008) SEREX, Proteomex, AMIDA, and beyond: Serological screening technologies for target identification. PROTEOMICS – Clinical Applications 2:3, pages 355-371.
Crossref
B. Györffy, M. Dietel, T. Fekete & H. Lage. (2008) A snapshot of microarray-generated gene expression signatures associated with ovarian carcinoma. International Journal of Gynecologic Cancer 18:6, pages 1215-1233.
Crossref
Barry L. Ziober, Michael G. Mauk, Erica M. Falls, Zongyuan Chen, Amy F. Ziober & Haim H. Bau. (2008) Lab-on-a-chip for oral cancer screening and diagnosis. Head & Neck 30:1, pages 111-121.
Crossref
M. Hou, M. Andersson, C. Zheng, A. Sundblad, O. Soder & K. Jahnukainen. (2007) Decontamination of leukemic cells and enrichment of germ cells from testicular samples from rats with Roser's T-cell leukemia by flow cytometric sorting. Reproduction 134:6, pages 767-779.
Crossref
C Paret, D Hildebrand, J Weitz, A Kopp-Schneider, A Kuhn, A Beer, R Hautmann & M Zöller. (2007) C4.4A as a candidate marker in the diagnosis of colorectal cancer. British Journal of Cancer 97:8, pages 1146-1156.
Crossref
Olivia Aranha & Al B. Benson. (2007) Adjuvant therapy for Colon Cancer. Current Gastroenterology Reports 9:5, pages 415-421.
Crossref
P Ruf, O Gires, M Jäger, K Fellinger, J Atz & H Lindhofer. (2007) Characterisation of the new EpCAM-specific antibody HO-3: implications for trifunctional antibody immunotherapy of cancer. British Journal of Cancer 97:3, pages 315-321.
Crossref
Sebastian Kuhn, Moritz Koch, Tobias Nübel, Markus Ladwein, Dalibor Antolovic, Pamela Klingbeil, Dagmar Hildebrand, Gerhard Moldenhauer, Lutz Langbein, Werner W. Franke, Jürgen Weitz & Margot Zöller. (2007) A Complex of EpCAM, Claudin-7, CD44 Variant Isoforms, and Tetraspanins Promotes Colorectal Cancer Progression. Molecular Cancer Research 5:6, pages 553-567.
Crossref
K-Y Tai, S-G Shiah, Y-S Shieh, Y-R Kao, C-Y Chi, E Huang, H-S Lee, L-C Chang, P-C Yang & C-W Wu. (2007) DNA methylation and histone modification regulate silencing of epithelial cell adhesion molecule for tumor invasion and progression. Oncogene 26:27, pages 3989-3997.
Crossref
Edmond Changkyun Park, Tadayoshi Hayata, Ken W.Y. Cho & Jin‐Kwan Han. (2007) Xenopus cDNA microarray identification of genes with endodermal organ expression . Developmental Dynamics 236:6, pages 1633-1649.
Crossref
O Toutirais, A Gervais, F Cabillic, M Le Gallo, A Coudrais, J Levêque, V Catros-Quemener & N Genetet. (2007) Effects of CD40 binding on ovarian carcinoma cell growth and cytokine production in vitro . Clinical and Experimental Immunology 149:2, pages 372-377.
Crossref
Sara E. Perry, Philip Robinson, Alan Melcher, Philip Quirke, Hans-J?rg B?hring, Graham P. Cook & G. Eric Blair. (2007) Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells. FEBS Letters 581:6, pages 1137-1142.
Crossref
P. Markus DecKert. 2007. Handbook of Therapeutic Antibodies. Handbook of Therapeutic Antibodies 592 672 .
Duane A. Sewell, Chao-Xing Yuan & Erle Robertson. (2007) Proteomic Signatures in Laryngeal Squamous Cell Carcinoma. ORL 69:2, pages 77-84.
Crossref
Nikolas H Stoecklein, Annika Siegmund, Peter Scheunemann, Andreas M Luebke, Andreas Erbersdobler, Pablo E Verde, Claus F Eisenberger, Matthias Peiper, Alexander Rehders, Jan Schulte am Esch, Wolfram Trudo Knoefel & Stefan B Hosch. (2006) Ep-CAM expression in squamous cell carcinoma of the esophagus: a potential therapeutic target and prognostic marker. BMC Cancer 6:1.
Crossref
François Le Naour, Magali André, Claude Boucheix & Eric Rubinstein. (2006) Membrane microdomains and proteomics: Lessons from tetraspanin microdomains and comparison with lipid rafts. PROTEOMICS 6:24, pages 6447-6454.
Crossref
Al B. BensonIIIIII. (2006) New Approaches to the Adjuvant Therapy of Colon Cancer. The Oncologist 11:9, pages 973-980.
Crossref
Christian Ensinger, Roswitha Kremser, Rupert Prommegger, Gilbert Spizzo & Kurt W. Schmid. (2006) EpCAM Overexpression in Thyroid Carcinomas. Journal of Immunotherapy 29:5, pages 569-573.
Crossref
François Le Naour, Magali André, Céline Greco, Martine Billard, Bernard Sordat, Jean-François Emile, François Lanza, Claude Boucheix & Eric Rubinstein. (2006) Profiling of the Tetraspanin Web of Human Colon Cancer Cells. Molecular & Cellular Proteomics 5:5, pages 845-857.
Crossref
Leonardo Elia, Carmela Mennuni, Mariangela Storto, Silvia Podda, Francesco Calvaruso, Valentina Salucci, Luigi Aurisicchio, Alessia Scarito, Gennaro Ciliberto, Nicola La Monica & Fabio Palombo. (2006) Genetic vaccines against Ep-CAM break tolerance to self in a limited subset of subjects: Initial identification of predictive biomarkers. European Journal of Immunology 36:5, pages 1337-1349.
Crossref
Sonja Offner, Robert Hofmeister, Andrea Romaniuk, Peter Kufer & Patrick A. Baeuerle. (2006) Induction of regular cytolytic T cell synapses by bispecific single-chain antibody constructs on MHC class I-negative tumor cells. Molecular Immunology 43:6, pages 763-771.
Crossref
Daosong Xu & Martin E. Hemler. (2005) Metabolic Activation-related CD147-CD98 Complex. Molecular & Cellular Proteomics 4:8, pages 1061-1071.
Crossref
Markus Münz, Reinhard Zeidler & Olivier Gires. (2005) The tumour-associated antigen EpCAM upregulates the fatty acid binding protein E-FABP. Cancer Letters 225:1, pages 151-157.
Crossref
Rosalyn D. Blumenthal, Lou Osorio, Marianne K. Hayes, Ivan D. Horak, Hans J. Hansen & David M. Goldenberg. (2004) Carcinoembryonic antigen antibody inhibits lung metastasis and augments chemotherapy in a human colonic carcinoma xenograft. Cancer Immunology, Immunotherapy 54:4, pages 315-327.
Crossref
T. K. Hoffmann, T. L. Whiteside & H. Bier. (2005) Plattenepithelkarzinome des Kopf-Hals-BereichsSquamous cell carcinoma of the head and neck. HNO 53:3, pages 285-298.
Crossref
Xin Xie. (2005) Expression pattern of epithelial cell adhesion molecule on normal and malignant colon tissues. World Journal of Gastroenterology 11:3, pages 344.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.