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Cancer Biology & Therapy Volume 13, 2012 - Issue 9
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Research Paper

Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling

M. Danielle Bareford Department of Neurosurgery; Virginia Commonwealth University; Richmond, VA USA
,
Hossein A. Hamed Department of Neurosurgery; Virginia Commonwealth University; Richmond, VA USA
,
Jeremy Allegood Department of Biochemistry and Molecular Biology; Virginia Commonwealth University; Richmond, VA USA
,
Nichola Cruickshanks Department of Neurosurgery; Virginia Commonwealth University; Richmond, VA USA
,
Andrew Poklepovic Department of Medicine; Virginia Commonwealth University; Richmond, VA USA
,
Margaret A. Park Department of Biochemistry and Molecular Biology; Virginia Commonwealth University; Richmond, VA USA
,
Besim Ogretmen Department of Biochemistry and Molecular Biology; Medical University of South Carolina; Charleston, SC USA
,
Sarah Spiegel Department of Biochemistry and Molecular Biology; Virginia Commonwealth University; Richmond, VA USA
,
Steven Grant Department of Medicine; Virginia Commonwealth University; Richmond, VA USA
&
Paul Dent Department of Neurosurgery; Virginia Commonwealth University; Richmond, VA USACorrespondence[email protected]
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Pages 793-803 | Received 15 Feb 2012, Accepted 29 Apr 2012, Published online: 07 Jun 2012

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Nichola Cruickshanks, Jane L Roberts, M Danielle Bareford, Mehrad Tavallai, Andrew Poklepovic, Laurence Booth, Sarah Spiegel & Paul Dent. (2015) Differential regulation of autophagy and cell viability by ceramide species. Cancer Biology & Therapy 16:5, pages 733-742.
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Laurence Booth, Jane L Roberts, Adam Conley, Nichola Cruickshanks, Thomas Ridder, Steven Grant, Andrew Poklepovic & Paul Dent. (2014) HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells. Cancer Biology & Therapy 15:3, pages 305-316.
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Paul Dent. (2013) ERK plays the baddie (again). Cancer Biology & Therapy 14:11, pages 997-998.
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Paul Dent. (2013) Ceramide in the prostate. Cancer Biology & Therapy 14:10, pages 881-882.
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Articles from other publishers (23)

Andrew Poklepovic, Sarah Gordon, Danielle A. Shafer, John D. Roberts, Prithviraj Bose, Charles E. GeyerJr.Jr., William P. McGuire, Mary Beth Tombes, Ellen Shrader, Katie Strickler, Maria Quigley, Wen Wan, Maciej Kmieciak, H. Davis Massey, Laurence Booth, Richard G. Moran & Paul Dent. (2016) Phase I study of pemetrexed with sorafenib in advanced solid tumors. Oncotarget 7:27, pages 42625-42638.
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Laurence Booth, Jane L. Roberts, Andrew Poklepovic & Paul Dent. (2023) Autophagy as a therapeutic mechanism to kill drug-resistant cancer cells. Anti-Cancer Drugs.
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Paola Antonia Corsetto, Stefania Zava, Angela Maria Rizzo & Irma Colombo. (2023) The Critical Impact of Sphingolipid Metabolism in Breast Cancer Progression and Drug Response. International Journal of Molecular Sciences 24:3, pages 2107.
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Jean-Marie Sontag, Diana Schuhmacher, Goce Taleski, Anthony Jordan, Sarah Khan, Alexander Hoffman, Rey J. Gomez, Matthew D. Mazalouskas, Steven K. Hanks, Benjamin W. Spiller, Estelle Sontag & Brian E. Wadzinski. (2022) A new paradigm for regulation of protein phosphatase 2A function via Src and Fyn kinase–mediated tyrosine phosphorylation. Journal of Biological Chemistry 298:8, pages 102248.
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Jun Hu, Jing Hu, Wenrui Wu, Yufei Qin, Junjie Fu, Chao Liu, Peter H. Seeberger & Jian Yin. (2022) Bimodal Treatment of Hepatocellular Carcinoma by Targeted Minimally Interventional Photodynamic/Chemotherapy Using Glyco-Covalent-Organic Frameworks-Guided Porphyrin/Sorafenib. Acta Biomaterialia 148, pages 206-217.
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E.C. Dacol, S. Wang, Y. Chen & A.P. Lepique. (2021) The interaction of SET and protein phosphatase 2A as target for cancer therapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1876:1, pages 188578.
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Sebastian Brachtendorf, Khadija El-Hindi & Sabine Grösch. (2019) WITHDRAWN: Ceramide synthases in cancer therapy and chemoresistance. Progress in Lipid Research, pages 100992.
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Sebastian Brachtendorf, Khadija El-Hindi & Sabine Grösch. (2019) Ceramide synthases in cancer therapy and chemoresistance. Progress in Lipid Research 74, pages 160-185.
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Buuvee Bayarkhangai, Suzan Noureldin, Liting Yu, Na Zhao, Yaru Gu, Hanmei Xu & Changying Guo. (2018) A comprehensive and perspective view of oncoprotein SET in cancer . Cancer Medicine 7:7, pages 3084-3094.
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Henan Zhao, Duojiao Li, Baojing Zhang, Yan Qi, Yunpeng Diao, Yuhong Zhen & Xiaohong Shu. (2017) PP2A as the Main Node of Therapeutic Strategies and Resistance Reversal in Triple-Negative Breast Cancer. Molecules 22:12, pages 2277.
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Ion Cristóbal, Blanca Torrejón, Javier Martínez-Useros, Juan Madoz-Gurpide, Federico Rojo & Jesús García-Foncillas. (2017) PP2A regulates signaling through hormonal receptors in breast cancer with important therapeutic implications. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1868:2, pages 435-438.
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ZHILIN QI, SHIMEI QI, LIN GUI & LEI SHEN. (2016) β-arrestin2 regulates TRAIL-induced HepG2 cell apoptosis via the Src-extracellular signal-regulated signaling pathway. Molecular Medicine Reports 14:1, pages 263-270.
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Laurence Booth, Jane L. Roberts, Mehrad Tavallai, John Chuckalovcak, Daniel K. Stringer, Antonis E. Koromilas, David L. Boone, William P. McGuire, Andrew Poklepovic & Paul Dent. (2016) [Pemetrexed + Sorafenib] lethality is increased by inhibition of ERBB1/2/3-PI3K-NFκB compensatory survival signaling. Oncotarget 7:17, pages 23608-23632.
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Laurence Booth, Jane L. Roberts, Mehrad Tavallai, Timothy Webb, Daniel Leon, Jesse Chen, William P. McGuire, Andrew Poklepovic & Paul Dent. (2016) The afatinib resistance of in vivo generated H1975 lung cancer cell clones is mediated by SRC/ERBB3/c-KIT/c-MET compensatory survival signaling . Oncotarget 7:15, pages 19620-19630.
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Baharan Fekry, Amin Esmaeilniakooshkghazi, Sergey A. Krupenko & Natalia I. Krupenko. (2016) Ceramide Synthase 6 Is a Novel Target of Methotrexate Mediating Its Antiproliferative Effect in a p53-Dependent Manner. PLOS ONE 11:1, pages e0146618.
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Erman Salih Istifli & Mehmet Topaktaş. (2015) In vitro genotoxicity and cytotoxicity of a particular combination of pemetrexed and cefixime in human peripheral blood lymphocytes. SpringerPlus 4:1.
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Yan Wang, Yuechen Zhan, Rong Xu, Rongguang Shao, Jiandong Jiang & Zhen Wang. (2015) Src mediates extracellular signal-regulated kinase 1/2 activation and autophagic cell death induced by cardiac glycosides in human non-small cell lung cancer cell lines. Molecular Carcinogenesis 54:S1, pages E26-E34.
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Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy & Faisal Thayyullathil. (2015) Tumor suppressive functions of ceramide: evidence and mechanisms. Apoptosis 20:5, pages 689-711.
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Raúl Rincón, Ion Cristóbal, Sandra Zazo, Oriol Arpí, Silvia Menéndez, Rebeca Manso, Ana Lluch, Pilar Eroles, Ana Rovira, Joan Albanell, Jesús García-Foncillas, Juan Madoz-Gúrpide & Federico Rojo. (2015) PP2A inhibition determines poor outcome and doxorubicin resistance in early breast cancer and its activation shows promising therapeutic effects. Oncotarget 6:6, pages 4299-4314.
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Yongxi Tong, Haijun Huang & Hongying Pan. (2015) Inhibition of MEK/ERK activation attenuates autophagy and potentiates pemetrexed-induced activity against HepG2 hepatocellular carcinoma cells. Biochemical and Biophysical Research Communications 456:1, pages 86-91.
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Benjamin Newcomb & Yusuf A. Hannun. 2015. Bioactive Sphingolipids in Cancer Biology and Therapy. Bioactive Sphingolipids in Cancer Biology and Therapy 81 106 .
Hossein A. Hamed, Seyedmehrad Tavallai, Steven Grant, Andrew Poklepovic & Paul Dent. (2015) Sorafenib/Regorafenib and Lapatinib Interact to kill CNS Tumor Cells. Journal of Cellular Physiology 230:1, pages 131-139.
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Andrew Thorburn, Douglas H. Thamm & Daniel L. Gustafson. (2014) Autophagy and Cancer Therapy. Molecular Pharmacology 85:6, pages 830-838.
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