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Cancer Biology & Therapy Volume 13, 2012 - Issue 11
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Research Paper

Perifosine enhances mTORC1-targeted cancer therapy by activation of GSK3β in NSCLC cells

Zhuo Ma Department of Pharmacology; Nanjing Medical University; Nanjing, Jiangsu, China
,
Lingjun Zhu Department of Oncology; The First Affiliated Hospital of Nanjing Medical University; Nanjing, Jiangsu, China
,
Xuan Luo Department of Pharmacology; Nanjing Medical University; Nanjing, Jiangsu, China
,
Sulan Zhai Department of Pharmacology; Nanjing Medical University; Nanjing, Jiangsu, China
,
Ping Li Department of Pharmacology; Nanjing Medical University; Nanjing, Jiangsu, China
&
Xuerong Wang Department of Pharmacology; Nanjing Medical University; Nanjing, Jiangsu, ChinaCorrespondence[email protected]
Pages 1009-1017 | Received 20 Feb 2012, Accepted 04 Jun 2012, Published online: 24 Jul 2012

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Min Li, Hongling Chen, Tong Sun, Zhuo Ma, Xi Chen, Dandan Wu, Wenbin Huang & Xuerong Wang. (2020) p70S6K Promotes Acquired Resistance of Erlotinib Through Induction of Epithelial-Mesenchymal Transition in Non-Small Cell Lung Carcinoma. OncoTargets and Therapy 13, pages 5257-5270.
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Zhongyuan Gao, Ting Yuan, Xiao Zhou, Ping Ni, Geng Sun, Ping Li, Zhixiang Cheng & Xuerong Wang. (2018) Targeting BRD4 proteins suppresses the growth of NSCLC through downregulation of eIF4E expression. Cancer Biology & Therapy 19:5, pages 407-415.
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Ting Yuan, Ping Ni, Zuhao Zhang, Dandan Wu, Geng Sun, Haijun Zhang, Baoan Chen, Xuerong Wang & Zhixiang Cheng. (2022) Targeting BET proteins inhibited the growth of non‐small cell lung carcinoma through downregulation of Met expression. Cell Biology International 47:3, pages 622-633.
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Yuting Meng, Xixi Qian, Li Zhao, Nan Li, Shengjie Wu, Baoan Chen, Tong Sun & Xuerong Wang. (2021) Trichostatin A downregulates bromodomain and extra-terminal proteins to suppress osimertinib resistant non-small cell lung carcinoma. Cancer Cell International 21:1.
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Dandan Wu, Jie Cheng, Geng Sun, Shengjie Wu, Min Li, Zhongyuan Gao, Sulan Zhai, Ping Li, Dongming Su & Xuerong Wang. (2016) p70S6K promotes IL-6-induced epithelial-mesenchymal transition and metastasis of head and neck squamous cell carcinoma. Oncotarget 7:24, pages 36539-36550.
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Zhenguo Sun, Zhou Wang, Xiangyan Liu & Dong Wang. (2015) New development of inhibitors targeting the PI3K/AKT/mTOR pathway in personalized treatment of non-small-cell lung cancer. Anti-Cancer Drugs 26:1, pages 1-14.
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Haitao Meng, Yingming Jin, Hui Liu, Liangshun You, Chunmei Yang, Xue Yang & Wenbin Qian. (2013) SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt. Journal of Hematology & Oncology 6:1.
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SONG LIANG, RENHUA GUO, ZHIHONG ZHANG, DONGXIAO LIU, HAO XU, ZEKUAN XU, XUERONG WANG & LI YANG. (2013) Upregulation of the eIF4E signaling pathway contributes to the progression of gastric cancer, and targeting eIF4E by perifosine inhibits cell growth. Oncology Reports 29:6, pages 2422-2430.
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Wim J. van Blitterswijk & Marcel Verheij. (2013) Anticancer mechanisms and clinical application of alkylphospholipids. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1831:3, pages 663-674.
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