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Cancer Biology & Therapy Volume 13, 2012 - Issue 13
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Research Paper

Oridonin in combination with imatinib exerts synergetic anti-leukemia effect in Ph+ acute lymphoblastic leukemia cells in vitro by inhibiting activation of LYN/mTOR signaling pathway

Yong Guo Department of Hematology; State Key Laboratory of Biotherapy and Cancer Center; West China Hospital of Sichuan University; Sichuan, China
,
Qingqing Shan Department of Hematology; State Key Laboratory of Biotherapy and Cancer Center; West China Hospital of Sichuan University; Sichuan, China
,
Yuping Gong Department of Hematology; State Key Laboratory of Biotherapy and Cancer Center; West China Hospital of Sichuan University; Sichuan, ChinaCorrespondence[email protected]
,
Juan Lin Department of Hematology; State Key Laboratory of Biotherapy and Cancer Center; West China Hospital of Sichuan University; Sichuan, China
,
Xi Yang Department of Hematology; State Key Laboratory of Biotherapy and Cancer Center; West China Hospital of Sichuan University; Sichuan, China
&
Ruiqing Zhou Department of Hematology; State Key Laboratory of Biotherapy and Cancer Center; West China Hospital of Sichuan University; Sichuan, China
Pages 1244-1254 | Received 14 Oct 2011, Accepted 22 May 2012, Published online: 16 Aug 2012

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Bili Wang, Can Shen, Yang Li, Ting Zhang, Hui Huang, Jun Ren, Zhengjun Hu, Jian Xu & Bin Xu. (2019) Oridonin overcomes the gemcitabine resistant PANC-1/Gem cells by regulating GST pi and LRP/1 ERK/JNK signalling. OncoTargets and Therapy 12, pages 5751-5765.
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Matthew Ku, Meaghan Wall, Ruth N. MacKinnon, Carl R. Walkley, Louise E. Purton, Constantine Tam, David Izon, Lynda Campbell, Heung-Chin Cheng & Harshal Nandurkar. (2015) Src family kinases and their role in hematological malignancies. Leukemia & Lymphoma 56:3, pages 577-586.
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Mikhail V Blagosklonny. (2013) Selective anti-cancer agents as anti-aging drugs. Cancer Biology & Therapy 14:12, pages 1092-1097.
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Weiyan Cheng, Chuanhui Huang, Weifeng Ma, Xin Tian & Xiaojian Zhang. (2018) Recent Development of Oridonin Derivatives with Diverse Pharmacological Activities. Mini-Reviews in Medicinal Chemistry 19:2, pages 114-124.
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Zhang Yi-wen, Bao Mei-hua, Lou Xiao-ya, Cheng Yu, Yu Jing & Zhou Hong-hao. (2018) Effects of Oridonin on Hepatic Cytochrome P450 Expression and Activities in PXR-Humanized Mice. Biological and Pharmaceutical Bulletin 41:5, pages 707-712.
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Brice Ayissi Owona & Herman J. Schluesener. (2015) Molecular Insight in the Multifunctional Effects of Oridonin. Drugs in R&D 15:3, pages 233-244.
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Faya M. Millimouno, Jia Dong, Liu Yang, Jiang Li & Xiaomeng Li. (2014) Targeting Apoptosis Pathways in Cancer and Perspectives with Natural Compounds from Mother Nature. Cancer Prevention Research 7:11, pages 1081-1107.
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Yan-Yan Wang, Yan-Fang Lv, Lu Lu & Li Cai. (2014) Oridonin inhibits mTOR signaling and the growth of lung cancer tumors. Anti-Cancer Drugs 25:10, pages 1192-1200.
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Dian-Lei Liu, He-Qi Bu, Hai-Min Jin, Jin-Feng Zhao, Ye Li & Hai Huang. (2014) Enhancement of the effects of gemcitabine against pancreatic cancer by oridonin via the mitochondrial caspase-dependent signaling pathway. Molecular Medicine Reports.
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Xi Yang, Guangcui He, Yuping Gong, Bohui Zheng, Fangfang Shi, Rui Shi & Xiaojing Yang. (2014) Mammalian target of rapamycin inhibitor rapamycin enhances anti‐leukemia effect of imatinib on P h + acute lymphoblastic leukemia cells . European Journal of Haematology 92:2, pages 111-120.
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Lu Wang, Shengpeng Wang, Ruie Chen, Yanping Wang, Hui Li, Yitao Wang & Meiwan Chen. (2014) Oridonin Loaded Solid Lipid Nanoparticles Enhanced Antitumor Activity in MCF-7 Cells. Journal of Nanomaterials 2014, pages 1-11.
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