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Cancer Biology & Therapy Volume 15, 2014 - Issue 2
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Research Paper

MLS-2384, a new 6-bromoindirubin derivative with dual JAK/Src kinase inhibitory activity, suppresses growth of diverse cancer cells

Lucy Liu Beckman Research Institute; City of Hope Comprehensive Cancer Center; Duarte, CA USACorrespondence[email protected] [email protected]
,
Nicolas Gaboriaud Pharmacognosy and Natural Products Chemistry; University of Athens; Athens, Greece
,
Konstantina Vougogianopoulou Pharmacognosy and Natural Products Chemistry; University of Athens; Athens, Greece
,
Yan Tian Beckman Research Institute; City of Hope Comprehensive Cancer Center; Duarte, CA USA
,
Jun Wu Beckman Research Institute; City of Hope Comprehensive Cancer Center; Duarte, CA USA
,
Wei Wen Beckman Research Institute; City of Hope Comprehensive Cancer Center; Duarte, CA USA
,
Leandros Skaltsounis Pharmacognosy and Natural Products Chemistry; University of Athens; Athens, Greece
&
Richard Jove Vaccine & Gene Therapy Institute of Florida; Port St. Lucie, FL USACorrespondence[email protected] [email protected]
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Pages 178-184 | Received 15 Jul 2013, Accepted 06 Oct 2013, Published online: 01 Nov 2013

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Lihong Chen, Jinhua Wang, Jianbo Wu, Qiaomei Zheng & Jifen Hu. (2018) Indirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathway. Drug Design, Development and Therapy 12, pages 3335-3342.
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Nicolas Gaboriaud-Kolar, Konstantina Vougogiannopoulou & Alexios-Leandros Skaltsounis. (2015) Indirubin derivatives: a patent review (2010 – present). Expert Opinion on Therapeutic Patents 25:5, pages 583-593.
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Articles from other publishers (21)

立群 高. (2023) Research Progress in the Regulation of JAK/STAT3 Pathway in Chinese Medicine to Treat Ovarian Cancer. Traditional Chinese Medicine 12:01, pages 215-220.
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Jeongchan Lee, Joonwon Kim, Hyun Kim, HyunA Park, Jin Young Kim, Eun‐Jung Kim, Yung‐Hun Yang, Kwon‐Young Choi & Byung‐Gee Kim. (2022) Constructing multi‐enzymatic cascade reactions for selective production of 6‐bromoindirubin from tryptophan in Escherichia coli . Biotechnology and Bioengineering 119:10, pages 2938-2949.
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Pei Shen, Yezhi Wang, Xiangxiang Jia, Pengfei Xu, Lian Qin, Xi Feng, Zhiyu Li & Zhixia Qiu. (2022) Dual-target Janus kinase (JAK) inhibitors: Comprehensive review on the JAK-based strategies for treating solid or hematological malignancies and immune-related diseases. European Journal of Medicinal Chemistry 239, pages 114551.
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Chakrabhavi Dhananjaya Mohan, Shobith Rangappa, Habbanakuppe D. Preetham, S. Chandra Nayaka, Vijai K. Gupta, Salundi Basappa, Gautam Sethi & Kanchugarakoppal S. Rangappa. (2022) Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature. Seminars in Cancer Biology 80, pages 157-182.
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Jiaqi Zhu, Peter Langer, Claas Ulrich & Jürgen Eberle. (2021) Crucial Role of Reactive Oxygen Species (ROS) for the Proapoptotic Effects of Indirubin Derivatives in Cutaneous SCC Cells. Antioxidants 10:10, pages 1514.
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Igor A. Schepetkin, Mark B. Plotnikov, Andrei I. Khlebnikov, Tatiana M. Plotnikova & Mark T. Quinn. (2021) Oximes: Novel Therapeutics with Anticancer and Anti-Inflammatory Potential. Biomolecules 11:6, pages 777.
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Feng Song, Yunqiang Bian, Jing Liu, Zhenghua Li, Li Zhao, Junman Fang, Yonghong Lai & Meng Zhou. (2021) Indole Alkaloids, Synthetic Dimers and Hybrids with Potential In Vivo Anticancer Activity. Current Topics in Medicinal Chemistry 21:5, pages 377-403.
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Manlio Tolomeo & Antonio Cascio. (2021) The Multifaced Role of STAT3 in Cancer and Its Implication for Anticancer Therapy. International Journal of Molecular Sciences 22:2, pages 603.
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Aliaa M. Mohassab, Heba A. Hassan, Dalia Abdelhamid & Mohamed Abdel-Aziz. (2020) STAT3 transcription factor as target for anti-cancer therapy. Pharmacological Reports 72:5, pages 1101-1124.
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Chin-Jui Wu, Vignesh Sundararajan, Bor-Ching Sheu, Ruby Yun-Ju Huang & Lin-Hung Wei. (2019) Activation of STAT3 and STAT5 Signaling in Epithelial Ovarian Cancer Progression: Mechanism and Therapeutic Opportunity. Cancers 12:1, pages 24.
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Haeri Lee, Ae Jin Jeong & Sang-Kyu Ye. (2019) Highlighted STAT3 as a potential drug target for cancer therapy. BMB Reports 52:7, pages 415-423.
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Veselina Zhivkova, Felix Kiecker, Peter Langer & Jürgen Eberle. (2019) Crucial role of reactive oxygen species (ROS) for the proapoptotic effects of indirubin derivative DKP-073 in melanoma cells. Molecular Carcinogenesis 58:2, pages 258-269.
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Meixuan Chen, Barbara Pockaj, Mariacarla Andreozzi, Michael T. Barrett, Sri Krishna, Seron Eaton, Ruifang Niu & Karen S. Anderson. (2018) JAK2 and PD-L1 Amplification Enhance the Dynamic Expression of PD-L1 in Triple-negative Breast Cancer. Clinical Breast Cancer 18:5, pages e1205-e1215.
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Nicolas Gaboriaud-Kolar, Vasillios Myrianthopoulos, Konstantina Vougogiannopoulou, Panagiotis Gerolymatos, David A. Horne, Richard Jove, Emmanuel Mikros, Sangkil Nam & Alexios-Leandros Skaltsounis. (2016) Natural-Based Indirubins Display Potent Cytotoxicity toward Wild-Type and T315I-Resistant Leukemia Cell Lines. Journal of Natural Products 79:10, pages 2464-2471.
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Byung-Hak Kim, Eun Hee Yi & Sang-Kyu Ye. (2016) Signal transducer and activator of transcription 3 as a therapeutic target for cancer and the tumor microenvironment. Archives of Pharmacal Research 39:8, pages 1085-1099.
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Steffanie L. Furtek, Donald S. Backos, Christopher J. Matheson & Philip Reigan. (2016) Strategies and Approaches of Targeting STAT3 for Cancer Treatment. ACS Chemical Biology 11:2, pages 308-318.
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Xiaowei Huo, Yonghong Liao, Yu Tian, Li Gao & Li Cao. (2016) Zeylenone promotes apoptosis in chronic myelogenous leukemia-derived K562 cells by a mechanism involving Jak2 and Src kinase. RSC Advances 6:115, pages 114096-114108.
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Uddalak Bharadwaj, Moses M. Kasembeli & David J. Tweardy. 2016. STAT Inhibitors in Cancer. STAT Inhibitors in Cancer 95 161 .
Martina Broecker-Preuss, Nina Becher-Boveleth, Susanne Gall, Katrin Rehmann, Susann Schenke & Klaus Mann. (2015) Induction of atypical cell death in thyroid carcinoma cells by the indirubin derivative 7-bromoindirubin-3′-oxime (7BIO). Cancer Cell International 15:1.
Crossref
Jian Wu, Wen-Ying Lu & Lei-Lei Cui. (2015) Inhibitory Effect of Curcumin on Invasion of Skin Squamous Cell Carcinoma A431 Cells. Asian Pacific Journal of Cancer Prevention 16:7, pages 2813-2818.
Crossref
Mohamed Hassan. (2014) Hepatitis C virus-mediated angiogenesis: Molecular mechanisms and therapeutic strategies. World Journal of Gastroenterology 20:42, pages 15467.
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