Citations (41)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (2)
Jun Liu, Junshik Hong, Kwang-Sung Ahn, Junhyeok Go, Heejoo Han, Jihyun Park, Dongchan Kim, Hyejoo Park, Youngil Koh, Dong-Yeop Shin & Sung-Soo Yoon. (2019) ERK-dependent IL-6 positive feedback loop mediates resistance against a combined treatment using danusertib and BKM120 in Burkitt lymphoma cell lines. Leukemia & Lymphoma 60:10, pages 2532-2540.
Read now
Read now
Paul Dent. (2014) Crosstalk between ERK, AKT, and cell survival. Cancer Biology & Therapy 15:3, pages 245-246.
Read now
Read now
Articles from other publishers (39)
Yuqing Qian, Siyu Zhou, Jiayi Li, Mingyuan Ma, Huanwen Chen, Yin Cao, Yuxiang Zhang, Chaoyu Sun, Kang Li, Yizhao Liu, Shutong Dai, Mingtao Ao, Meijuan Fang, Zhen Wu & Mingdong Li. (2023) Discovery of 4-((3,4-dichlorophenyl)amino)-2-methylquinolin-6-ol derivatives as EGFR and HDAC dual inhibitors. European Journal of Pharmacology 960, pages 176114.
Crossref
Crossref
Shayan Khozooei, Soundaram Veerappan & Mahmoud Toulany. (2023) YB-1 activating cascades as potential targets in KRAS-mutated tumors. Strahlentherapie und Onkologie 199:12, pages 1110-1127.
Crossref
Crossref
Jakub Szymczyk, Aleksandra Czyrek, Jacek Otlewski & Malgorzata Zakrzewska. (2023) FGF1 Protects MCF-7 Cells against Taltobulin through Both the MEKs/ERKs and PI3K/AKT Signaling Pathway. Biomedicines 11:7, pages 1856.
Crossref
Crossref
Shuyu Liu, Dawei Sun, Richard Butler & Emma L. Rawlins. (2023) RTK signalling promotes epithelial columnar cell shape and apical junction maintenance in human lung progenitor cells. Development 150:11.
Crossref
Crossref
Marianna Sirico, Alberto D’Angelo, Caterina Gianni, Chiara Casadei, Filippo Merloni & Ugo De Giorgi. (2023) Current State and Future Challenges for PI3K Inhibitors in Cancer Therapy. Cancers 15:3, pages 703.
Crossref
Crossref
Mahmoud Toulany. (2023) Targeting K-Ras-mediated DNA damage response in radiation oncology: Current status, challenges and future perspectives. Clinical and Translational Radiation Oncology 38, pages 6-14.
Crossref
Crossref
Muddenahalli Srinivasa Sudhanva, Gurusamy Hariharasudhan, Semo Jun, Gwanwoo Seo, Radhakrishnan Kamalakannan, Hyun Hee Kim & Jung-Hee Lee. (2022) MicroRNA-145 Impairs Classical Non-Homologous End-Joining in Response to Ionizing Radiation-Induced DNA Double-Strand Breaks via Targeting DNA-PKcs. Cells 11:9, pages 1509.
Crossref
Crossref
Usuma Jermnak, Wachiraphan Supsavhad, Sunee Kunakornsawat, Tassanee Jaroensong, Piyajit Watcharasit, Daranee Visitnonthachai, Selapoom Pairor & Napasorn Phaochoosak. (2021)
Anti‐cancer potentials of
Gynura procumbens
leaves extract against two canine mammary cancer cell lines
. Veterinary Medicine and Science 8:1, pages 69-84.
Crossref
Crossref
Yan He, Miao Miao Sun, Guo Geng Zhang, Jing Yang, Kui Sheng Chen, Wen Wen Xu & Bin Li. (2021) Targeting PI3K/Akt signal transduction for cancer therapy. Signal Transduction and Targeted Therapy 6:1.
Crossref
Crossref
Qiong Wu, Tian-yi Liu, Bai-chun Hu, Xiang Li, Yu-ting Wu, Xiao-tong Sun, Xiao-wen Jiang, Shu Wang, Xiao-chun Qin, Huai-wei Ding & Qing-chun Zhao. (2021) CK-3, A Novel Methsulfonyl Pyridine Derivative, Suppresses Hepatocellular Carcinoma Proliferation and Invasion by Blocking the PI3K/AKT/mTOR and MAPK/ERK Pathways. Frontiers in Oncology 11.
Crossref
Crossref
Xin-Xing Li, Xiaoting Zheng, Zhenjie Liu, Qiongming Xu, Hongzhen Tang, Jianfang Feng, Shilin Yang, Chi Teng Vong, Hongwei Gao & Yitao Wang. (2020) Cryptotanshinone from Salvia miltiorrhiza Bunge (Danshen) inhibited inflammatory responses via TLR4/MyD88 signaling pathway. Chinese Medicine 15:1.
Crossref
Crossref
Kai Chen, Zhongjun Shang, Ai-lin Dai & Pei-ling Dai. (2020) Novel PI3K/Akt/mTOR pathway inhibitors plus radiotherapy: Strategy for non-small cell lung cancer with mutant RAS gene. Life Sciences 255, pages 117816.
Crossref
Crossref
Diana Zamora-Olivares, Tamer S. Kaoud, Lingyu Zeng, Jacey R. Pridgen, Deborah L. Zhuang, Yakndara E. Ekpo, Jessica R. Nye, Mitchell Telles, Eric V. Anslyn & Kevin N. Dalby. (2019) Quantification of ERK Kinase Activity in Biological Samples Using Differential Sensing. ACS Chemical Biology 15:1, pages 83-92.
Crossref
Crossref
Thomas B. Davis, Mingli Yang, Heiman Wang, Changgong Lee, Timothy J. Yeatman & W. Jack Pledger. (2019) PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC. Oncotarget 10:63, pages 6768-6780.
Crossref
Crossref
Hai-Zhou Wu, Jia-Qi Xiao, Song-Shu Xiao & Yan Cheng. (2019) KRAS: A Promising Therapeutic Target for Cancer Treatment. Current Topics in Medicinal Chemistry 19:23, pages 2081-2097.
Crossref
Crossref
Hassan Bjeije, Bahram Mohammad Soltani, Mehrdad Behmanesh & Mohammad Reza Zali. (2019) YWHAE long non-coding RNA competes with miR-323a-3p and miR-532-5p through activating K-Ras/Erk1/2 and PI3K/Akt signaling pathways in HCT116 cells. Human Molecular Genetics 28:19, pages 3219-3231.
Crossref
Crossref
Mahmoud Toulany. (2019) Targeting DNA Double-Strand Break Repair Pathways to Improve Radiotherapy Response. Genes 10:1, pages 25.
Crossref
Crossref
Asuman Demiroglu-Zergeroglu, Nurettin Ayvali, Gulseren Turhal, Hurmuz Ceylan & Sultan Nacak Baytas. (2018)
Investigation of potent anticarcinogenic activity of 1, 3-diarylpyrazole acrylamide derivatives
in vitro
. Journal of Pharmacy and Pharmacology 70:12, pages 1619-1629.
Crossref
Crossref
Tianhang Wang, Jiling Cheng, Shuyu Wang, Xudong Wang, Hongquan Jiang, Yueqing Yang, Ying Wang, Chunting Zhang, Weiwei Liang & Honglin Feng. (2018) α-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis. Brain Research Bulletin 140, pages 299-310.
Crossref
Crossref
Pratap Karki, Peter Hong, James JohnsonJr.Jr., Edward Pajarillo, Deok-Soo Son, Michael Aschner & Eunsook Y. Lee. (2017) Arundic Acid Increases Expression and Function of Astrocytic Glutamate Transporter EAAT1 Via the ERK, Akt, and NF-κB Pathways. Molecular Neurobiology 55:6, pages 5031-5046.
Crossref
Crossref
Nina T. Solberg, Jo Waaler, Kaja Lund, Line Mygland, Petter A. Olsen & Stefan Krauss. (2018) TANKYRASE Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting β-CATENIN and AKT Signaling in Colorectal Cancer. Molecular Cancer Research 16:3, pages 543-553.
Crossref
Crossref
Katharina Mueck, Simone Rebholz, Mozhgan Harati, H. Rodemann & Mahmoud Toulany. (2017) Akt1 Stimulates Homologous Recombination Repair of DNA Double-Strand Breaks in a Rad51-Dependent Manner. International Journal of Molecular Sciences 18:11, pages 2473.
Crossref
Crossref
Mahmoud Toulany, Julia Maier, Mari Iida, Simone Rebholz, Marina Holler, Astrid Grottke, Manfred Jüker, Deric L Wheeler, Ulrich Rothbauer & H Peter Rodemann. (2017) Akt1 and Akt3 but not Akt2 through interaction with DNA-PKcs stimulate proliferation and post-irradiation cell survival of K-RAS-mutated cancer cells. Cell Death Discovery 3:1.
Crossref
Crossref
Ingeborg Elisabeth Cernaj. (2016) Simultaneous dual targeting of Par-4 and G6PD: a promising new approach in cancer therapy? Quintessence of a literature review on survival requirements of tumor cells. Cancer Cell International 16:1.
Crossref
Crossref
Yun-Xin Lu, Dong-Liang Chen, De-Shen Wang, Le-Zong Chen, Hai-Yu Mo, Hui Sheng, Long Bai, Qi-Nian Wu, Hong-En Yu, Dan Xie, Jing-Ping Yun, Zhao-Lei Zeng, Feng Wang, Huai-Qiang Ju & Rui-Hua Xu. (2016) Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway. Cell Death & Disease 7:10, pages e2432-e2432.
Crossref
Crossref
Mahmoud Toulany, Mari Iida, Simone Keinath, Firdevs F. Iyi, Katharina Mueck, Birgit Fehrenbacher, Wael Y. Mansour, Martin Schaller, Deric L. Wheeler & H. Peter Rodemann. (2016)
Dual targeting of PI3K and MEK enhances the radiation response of
K-RAS
mutated non-small cell lung cancer
. Oncotarget 7:28, pages 43746-43761.
Crossref
Crossref
NICOLE M. JONES, MATTHEW R. ROWE, PETER R. SHEPHERD & MELANIE J. McCONNELL. (2016) Targeted inhibition of dominant PI3-kinase catalytic isoforms increase expression of stem cell genes in glioblastoma cancer stem cell models. International Journal of Oncology 49:1, pages 207-216.
Crossref
Crossref
Shaofang Wu, Shuzhen Wang, Siyuan Zheng, Roel Verhaak, Dimpy Koul & W.K. Alfred Yung. (2016) MSK1-Mediated β-Catenin Phosphorylation Confers Resistance to PI3K/mTOR Inhibitors in Glioblastoma. Molecular Cancer Therapeutics 15:7, pages 1656-1668.
Crossref
Crossref
Cholpon S. Djuzenova, Vanessa Fiedler, Astrid Katzer, Konstanze Michel, Stefanie Deckert, Heiko Zimmermann, Vladimir L. Sukhorukov & Michael Flentje. (2016) Dual PI3K- and mTOR-inhibitor PI-103 can either enhance or reduce the radiosensitizing effect of the Hsp90 inhibitor NVP-AUY922 in tumor cells: The role of drug-irradiation schedule. Oncotarget 7:25, pages 38191-38209.
Crossref
Crossref
Marina Holler, Astrid Grottke, Katharina Mueck, Julia Manes, Manfred Jücker, H. Peter Rodemann & Mahmoud Toulany. (2016) Dual Targeting of Akt and mTORC1 Impairs Repair of DNA Double-Strand Breaks and Increases Radiation Sensitivity of Human Tumor Cells. PLOS ONE 11:5, pages e0154745.
Crossref
Crossref
Paul Toren, Soojin Kim, Fraser Johnson & Amina Zoubeidi. (2016) Combined AKT and MEK Pathway Blockade in Pre-Clinical Models of Enzalutamide-Resistant Prostate Cancer. PLOS ONE 11:4, pages e0152861.
Crossref
Crossref
Janaina Fernandes. (2016) Oncogenes: The Passport for Viral Oncolysis through PKR Inhibition. Biomarkers in Cancer 8, pages BIC.S33378.
Crossref
Crossref
Mahmoud Toulany. 2016. Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment. Strategies to Enhance the Therapeutic Ratio of Radiation as a Cancer Treatment
253
287
.
Ji‑Cheng Tantai, Yao Zhang & Heng Zhao. (2015) Heterophyllin B inhibits the adhesion and invasion of ECA‑109 human esophageal carcinoma cells by targeting PI3K/AKT/β‑catenin signaling. Molecular Medicine Reports.
Crossref
Crossref
Mahmoud Toulany & H. Peter Rodemann. (2015) Phosphatidylinositol 3-kinase/Akt signaling as a key mediator of tumor cell responsiveness to radiation. Seminars in Cancer Biology 35, pages 180-190.
Crossref
Crossref
Harrison Cash, Sujay Shah, Ellen Moore, Andria Caruso, Ravindra Uppaluri, Carter Van Waes & Clint Allen. (2015) mTOR and MEK1/2 inhibition differentially modulate tumor growth and the immune microenvironment in syngeneic models of oral cavity cancer. Oncotarget 6:34, pages 36400-36417.
Crossref
Crossref
Shiyi Yu, Xiuxiu Cai, Chenxi Wu, Lele Wu, Yuzhi Wang, Yan Liu, Zhenghong Yu, Sheng Qin, Fei Ma, Jean Paul Thiery & Liming Chen. (2014) Adhesion glycoprotein CD44 functions as an upstream regulator of a network connecting ERK, AKT and Hippo-YAP pathways in cancer progression. Oncotarget 6:5, pages 2951-2965.
Crossref
Crossref
Jin Li, Yiming Lai, Yi Cao, Tao Du, Lexiang Zeng, Ganping Wang, Xianju Chen, Jieqing Chen, Yongsheng Yu, Simin Zhang, Yiming Zhang, Hai Huang & Zhenghui Guo. (2015) SHARPIN overexpression induces tumorigenesis in human prostate cancer LNCaP, DU145 and PC-3 cells via NF-κB/ERK/Akt signaling pathway. Medical Oncology 32:2.
Crossref
Crossref
Heng-Yi Wang, Sheng-Li Yang, Hui-Fang Liang & Chang-Hai Li. (2014) HBx Protein Promotes Oval Cell Proliferation by Up-Regulation of Cyclin D1 via Activation of the MEK/ERK and PI3K/Akt Pathways. International Journal of Molecular Sciences 15:3, pages 3507-3518.
Crossref
Crossref