Citations (39)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (2)
S. Nandi, P. Kumar, S.A. Amin, T. Jha & S. Gayen. (2021) First molecular modelling report on tri-substituted pyrazolines as phosphodiesterase 5 (PDE5) inhibitors through classical and machine learning based multi-QSAR analysis. SAR and QSAR in Environmental Research 32:11, pages 917-939.
Read now
Read now
Timothy Webb, Jori Carter, Jane L Roberts, Andrew Poklepovic, William P McGuire, Laurence Booth & Paul Dent. (2015) Celecoxib enhances [sorafenib + sildenafil] lethality in cancer cells and reverts platinum chemotherapy resistance . Cancer Biology & Therapy 16:11, pages 1660-1670.
Read now
Read now
Articles from other publishers (37)
Ruiyang Ren, Chenyi Xiong, Runyu Ma, Yixuan Wang, Tianyang Yue, Jiayun Yu & Bin Shao. (2023) The recent progress of myeloid‐derived suppressor cell and its targeted therapies in cancers. MedComm 4:4.
Crossref
Crossref
Arun SamiduraiLei XiAnindita DasRakesh C. Kukreja. (2023) Beyond Erectile Dysfunction: cGMP-Specific Phosphodiesterase 5 Inhibitors for Other Clinical Disorders. Annual Review of Pharmacology and Toxicology 63:1, pages 585-615.
Crossref
Crossref
Pan Zhao, Yao Shen, Mengyang Li, Hanjun Dan, Zhiming Zhao & Jian Zhang. (2022) Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Tadalafil in Colorectal Cancer. Frontiers in Pharmacology 13.
Crossref
Crossref
Mehdi Sanati, Samaneh Aminyavari, Hamid Mollazadeh, Bahram Bibak, Elmira Mohtashami & Amir R. Afshari. (2022) How do phosphodiesterase-5 inhibitors affect cancer? A focus on glioblastoma multiforme. Pharmacological Reports 74:2, pages 323-339.
Crossref
Crossref
Parul Sharma, Navneet Singh & Siddharth Sharma. (2021) ATP binding cassette transporters and cancer: revisiting their controversial role. Pharmacogenomics 22:18, pages 1211-1235.
Crossref
Crossref
Mohammad Salemizadeh Parizi, Fatemeh Salemizadeh Parizi, Saeed Abdolhosseini, Shohreh Vanaei, Ali Manzouri & Farnoosh Ebrahimzadeh. (2021) Myeloid-derived suppressor cells (MDSCs) in brain cancer: challenges and therapeutic strategies. Inflammopharmacology 29:6, pages 1613-1624.
Crossref
Crossref
Arun Samidurai, Lei Xi, Anindita Das, Audra N. Iness, Navin G. Vigneshwar, Pin-Lan Li, Dinender K. Singla, Sakthivel Muniyan, Surinder K. Batra & Rakesh C. Kukreja. (2021) Role of phosphodiesterase 1 in the pathophysiology of diseases and potential therapeutic opportunities. Pharmacology & Therapeutics 226, pages 107858.
Crossref
Crossref
Amira M AboYoussef, Marwa M Khalaf, Marina N Malak & Mohamed A Hamzawy. (2021) Repurposing of sildenafil as antitumour; induction of cyclic guanosine monophosphate/protein kinase G pathway, caspase-dependent apoptosis and pivotal reduction of Nuclear factor kappa light chain enhancer of activated B cells in lung cancer. Journal of Pharmacy and Pharmacology 73:8, pages 1080-1091.
Crossref
Crossref
Senthilnath Lakshmanachetty, Joselyn Cruz-Cruz, Eric Hoffmeyer, Allison P. Cole & Siddhartha S. Mitra. (2021) New Insights into the Multifaceted Role of Myeloid-Derived Suppressor Cells (MDSCs) in High-Grade Gliomas: From Metabolic Reprograming, Immunosuppression, and Therapeutic Resistance to Current Strategies for Targeting MDSCs. Cells 10:4, pages 893.
Crossref
Crossref
Rabah Iratni & Mohammed Akli Ayoub. (2021) Sildenafil in Combination Therapy against Cancer: A Literature Review. Current Medicinal Chemistry 28:11, pages 2248-2259.
Crossref
Crossref
Jiun-I Lai, Yu-Jhen Tseng, Ming-Huang Chen, Chi-Ying F. Huang & Peter Mu-Hsin Chang. (2020) Clinical Perspective of FDA Approved Drugs With P-Glycoprotein Inhibition Activities for Potential Cancer Therapeutics. Frontiers in Oncology 10.
Crossref
Crossref
Laurence Booth, Jane L. Roberts, Cameron West, Daniel Von Hoff & Paul Dent. (2020) GZ17‐6.02 initiates DNA damage causing autophagosome‐dependent HDAC degradation resulting in enhanced anti‐PD1 checkpoint inhibitory antibody efficacy. Journal of Cellular Physiology 235:11, pages 8098-8113.
Crossref
Crossref
Jui-Ling Hsu, Wohn-Jenn Leu, Lih-Ching Hsu, Chen-Hsun Ho, Shih-Ping Liu & Jih-Hwa Guh. (2020) Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling. Frontiers in Oncology 10.
Crossref
Crossref
Cristina Antinozzi, Paolo Sgrò & Luigi Di Luigi. (2020) Advantages of Phosphodiesterase Type 5 Inhibitors in the Management of Glucose Metabolism Disorders: A Clinical and Translational Issue. International Journal of Endocrinology 2020, pages 1-8.
Crossref
Crossref
Romina Armando, Diego Mengual G�mez & Daniel Gomez. (2020) New drugs are not enough‑drug repositioning in oncology: An update. International Journal of Oncology.
Crossref
Crossref
Barbara Wenzel, Jianrong Liu, Sladjana Dukic-Stefanovic, Winnie Deuther-Conrad, Rodrigo Teodoro, Friedrich-Alexander Ludwig, Jean-Michel Chezal, Emmanuel Moreau, Peter Brust & Aurelie Maisonial-Besset. (2019) Targeting cyclic nucleotide phosphodiesterase 5 (PDE5) in brain: Toward the development of a PET radioligand labeled with fluorine-18. Bioorganic Chemistry 86, pages 346-362.
Crossref
Crossref
I. A. Tyuzikov, A. V. Smirnov, L. V. Smirnova & I. V. Lesnikova. (2019) Non-classical effects of sildenafil in clinical medicine: an interdisciplinary approach. Medical Council:21, pages 192-202.
Crossref
Crossref
Juliette Servante, Jasper Estranero, Lisethe Meijer, Rob Layfield & Richard Grundy. (2018) Chemical modulation of autophagy as an adjunct to chemotherapy in childhood and adolescent brain tumors. Oncotarget 9:81, pages 35266-35277.
Crossref
Crossref
Kunyu Shen, David W. Johnson, David A. Vesey, Michael A. McGuckin & Glenda C. Gobe. (2017) Role of the unfolded protein response in determining the fate of tumor cells and the promise of multi-targeted therapies. Cell Stress and Chaperones 23:3, pages 317-334.
Crossref
Crossref
Ting Peng, Jun Gong, Yongzhe Jin, Yanping Zhou, Rongsheng Tong, Xin Wei, Lan Bai & Jianyou Shi. (2018) Inhibitors of phosphodiesterase as cancer therapeutics. European Journal of Medicinal Chemistry 150, pages 742-756.
Crossref
Crossref
Jane L. Roberts, Andrew Poklepovic & Laurence Booth. (2017) Curcumin interacts with sildenafil to kill GI tumor cells via endoplasmic reticulum stress and reactive oxygen/ nitrogen species. Oncotarget 8:59, pages 99451-99469.
Crossref
Crossref
Ines Barone, Cinzia Giordano, Daniela Bonofiglio, Sebastiano Andò & Stefania Catalano. (2017) Phosphodiesterase type 5 and cancers: progress and challenges. Oncotarget 8:58, pages 99179-99202.
Crossref
Crossref
Melih Dagdeviren. 2017. Nitric Oxide Synthase - Simple Enzyme-Complex Roles. Nitric Oxide Synthase - Simple Enzyme-Complex Roles.
Traci R. Tuttle, Vinita Takiar, Bhavna Kumar, Pawan Kumar & Nira Ben-Jonathan. (2017) Soluble guanylate cyclase stimulators increase sensitivity to cisplatin in head and neck squamous cell carcinoma cells. Cancer Letters 389, pages 33-40.
Crossref
Crossref
Valeriana Cesarini, Maurizio Martini, Lucia Ricci Vitiani, Giovanni Luca Gravina, Silvia Di Agostino, Grazia Graziani, Quintino Giorgio D'Alessandris, Roberto Pallini, Luigi M Larocca, Pellegrino Rossi, Emmanuele A Jannini & Susanna Dolci. (2017) Type 5 phosphodiesterase regulates glioblastoma multiforme aggressiveness and clinical outcome. Oncotarget 8:8, pages 13223-13239.
Crossref
Crossref
Ramin Saravani, Hamid Reza Galavi & Ali Shahraki. (2017)
Inhibition of Phosphodiesterase 5 and Increasing the Level of Cyclic Guanosine 3′,5′ Monophosphate by Hydroalcoholic
Achillea wilhelmsii
C. Koch Extract in Human Breast Cancer Cell Lines MCF-7 and MDA-Mb-468
. Breast Cancer: Basic and Clinical Research 11, pages 117822341769017.
Crossref
Crossref
Kunyu Shen, David W. Johnson & Glenda C. Gobe. (2016) The role of cGMP and its signaling pathways in kidney disease. American Journal of Physiology-Renal Physiology 311:4, pages F671-F681.
Crossref
Crossref
Tareq Saleh, Laurie Cuttino & David A. Gewirtz. (2016) Autophagy is not uniformly cytoprotective: a personalized medicine approach for autophagy inhibition as a therapeutic strategy in non-small cell lung cancer. Biochimica et Biophysica Acta (BBA) - General Subjects 1860:10, pages 2130-2136.
Crossref
Crossref
Naihua Liu, Liu Mei, Xueying Fan, Chao Tang, Xing Ji, Xinhua Hu, Wei Shi, Yu Qian, Musaddique Hussain, Junsong Wu, Chaojun Wang, Shaoqiang Lin & Ximei Wu. (2016) Phosphodiesterase 5/protein kinase G signal governs stemness of prostate cancer stem cells through Hippo pathway. Cancer Letters 378:1, pages 38-50.
Crossref
Crossref
Anindita Das, David Durrant, Clint Mitchell, Paul Dent, Surinder K. Batra & Rakesh C. Kukreja. (2015) Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95. Oncotarget 7:4, pages 4399-4413.
Crossref
Crossref
Jane L. Roberts, Mehrad Tavallai, Aida Nourbakhsh, Abigail Fidanza, Tanya Cruz‐Luna, Elizabeth Smith, Paul Siembida, Pascale Plamondon, Kelly A. Cycon, Christopher D. Doern, Laurence Booth & Paul Dent. (2015) GRP78/Dna K Is a Target for Nexavar/Stivarga/Votrient in the Treatment of Human Malignancies, Viral Infections and Bacterial Diseases. Journal of Cellular Physiology 230:10, pages 2552-2578.
Crossref
Crossref
Mehrad Tavallai, Hossein A. Hamed, Jane L. Roberts, Nichola Cruickshanks, John Chuckalovcak, Andrew Poklepovic, Laurence Booth & Paul Dent. (2015) Nexavar/Stivarga and Viagra Interact to Kill Tumor Cells. Journal of Cellular Physiology 230:9, pages 2281-2298.
Crossref
Crossref
Laurence Booth, Jane L. Roberts, Mehrad Tavallai, Aida Nourbakhsh, John Chuckalovcak, Jori Carter, Andrew Poklepovic & Paul Dent. (2015) OSU-03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood-Brain Barrier: Implications for Anti-Cancer Therapies. Journal of Cellular Physiology 230:8, pages 1982-1998.
Crossref
Crossref
Laurence Booth, Jane L. Roberts, Devin R. Cash, Seyedmehrad Tavallai, Sophonie Jean, Abigail Fidanza, Tanya Cruz‐Luna, Paul Siembiba, Kelly A. Cycon, Cynthia N. Cornelissen & Paul Dent. (2015) GRP78/BiP/HSPA5/Dna K is a universal therapeutic target for human disease. Journal of Cellular Physiology 230:7, pages 1661-1676.
Crossref
Crossref
Laurence Booth, Jane L. Roberts, Nichola Cruickshanks, Seyedmehrad Tavallai, Timothy Webb, Peter Samuel, Adam Conley, Brittany Binion, Harold F. Young, Andrew Poklepovic, Sarah Spiegel & Paul Dent. (2015) PDE5 Inhibitors Enhance Celecoxib Killing in Multiple Tumor Types. Journal of Cellular Physiology 230:5, pages 1115-1127.
Crossref
Crossref
Laurence BoothJane L. RobertsPaul Dent. (2015) HSPA5/Dna K May Be a Useful Target for Human Disease Therapies. DNA and Cell Biology 34:3, pages 153-158.
Crossref
Crossref
Anindita Das, David Durrant, Fadi N. Salloum, Lei Xi & Rakesh C. Kukreja. (2015) PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer. Pharmacology & Therapeutics 147, pages 12-21.
Crossref
Crossref