Cancer Biology & Therapy, Volume 15, Issue 6 (2014)

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Cancer Biology & Therapy, Volume 15, Issue 6 (2014)

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Commentary

Article Commentary
Met in lung cancer
Paul Dent
Pages: 653-654
Published online: 11 Mar 2014
AbstractforMet in lung cancer | Full Text | References | PDF (104.8 KB)
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Review

Review Article
The emerging roles of ARID1A in tumor suppression
Ren-Chin Wu, Tian-Li Wang & Ie-Ming Shih
Pages: 655-664
Published online: 11 Mar 2014
AbstractforThe emerging roles of ARID1A in tumor suppression | Full Text | References | PDF (1.5 MB)
  • 6934 Views
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Review Article
Melanoma immunotherapy
Martina Sanlorenzo, Igor Vujic, Christian Posch, Akshay Dajee, Adam Yen, Sarasa Kim, Michelle Ashworth, Michael D Rosenblum, Alain Algazi, Simona Osella-Abate, Pietro Quaglino, Adil Daud & Susanna Ortiz-Urda
Pages: 665-674
Published online: 20 Mar 2014
AbstractforMelanoma immunotherapy | Full Text | References | PDF (1.7 MB)
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Journal Club

Article Commentary
Low pH reprograms somatic murine cells into pluripotent stem cells
A novel technique with therapeutic implications
Jonathan S Williams, Ying Xiao & Isaac Brownell
Pages: 675-677
Published online: 11 Mar 2014
AbstractforLow pH reprograms somatic murine cells into pluripotent stem cells | Full Text | References | PDF (667.2 KB)
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Bedside to Bench Report

Article
Activity of abiraterone in rechallenging two AR-expressing salivary gland adenocarcinomas, resistant to androgen-deprivation therapy
Laura D Locati, Federica Perrone, Barbara Cortelazzi, Martina Imbimbo, Paolo Bossi, Paolo Potepan, Enrico Civelli, Gaetana Rinaldi, Pasquale Quattrone, Lisa Licitra & Silvana Pilotti
Pages: 678-682
Published online: 11 Mar 2014
AbstractforActivity of abiraterone in rechallenging two AR-expressing salivary gland adenocarcinomas, resistant to androgen-deprivation therapy | Full Text | References | PDF (3.7 MB)
  • 1090 Views
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Article
Application of a telomerase-based circulating tumor cell (CTC) assay in bladder cancer patients receiving postoperative radiation therapy
A case study
Melody Ju, Gary D Kao, David Steinmetz, Sanjay Chandrasekaran, Stephen M Keefe, Thomas J Guzzo, John P Christodouleas, Stephen M Hahn & Jay F Dorsey
Pages: 683-687
Published online: 11 Mar 2014
AbstractforApplication of a telomerase-based circulating tumor cell (CTC) assay in bladder cancer patients receiving postoperative radiation therapy | Full Text | References | PDF (1.3 MB)
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Clinical Study

Article
dCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer
A dual-institutional follow-up with the RTOG 9704 trial
Florencia McAllister, Danielle M Pineda, Masaya Jimbo, Shruti Lal, Richard A Burkhart, Jennifer Moughan, Kathryn A Winter, Kotb Abdelmohsen, Myriam Gorospe, Ana de Jesus Acosta, Rachana H Lankapalli, Jordan M Winter, Charles J Yeo, Agnieska K Witkiewicz, Christine A Iacobuzio-Donahue, Daniel Laheru & Jonathan R Brody
Pages: 688-698
Published online: 11 Mar 2014
AbstractfordCK expression correlates with 5-fluorouracil efficacy and HuR cytoplasmic expression in pancreatic cancer | Full Text | References | PDF (1.7 MB) | Supplemental
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Article
Aspirin improves outcome in high risk prostate cancer patients treated with radiation therapy
Corbin D Jacobs, Stephen G Chun, Jingsheng Yan, Xian-Jin Xie, David A Pistenmaa, Raquibul Hannan, Yair Lotan, Claus G Roehrborn, Kevin S Choe & D W Nathan Kim
Pages: 699-706
Published online: 21 Mar 2014
AbstractforAspirin improves outcome in high risk prostate cancer patients treated with radiation therapy | Full Text | References | PDF (899 KB)
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Article
Pegylated liposomal doxorubicin in the management of ovarian cancer
A systematic review and metaanalysis of randomized trials
Nicoletta Staropoli, Domenico Ciliberto, Cirino Botta, Lucia Fiorillo, Anna Grimaldi, Stefania Lama, Michele Caraglia, Angela Salvino, Pierfrancesco Tassone & Pierosandro Tagliaferri
Pages: 707-720
Published online: 21 Mar 2014
AbstractforPegylated liposomal doxorubicin in the management of ovarian cancer | Full Text | References | PDF (3.8 MB)
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Research Paper

Article
A novel lead compound CM-118
Antitumor activity and new insight into the molecular mechanism and combination therapy strategy in c-Met- and ALK-dependent cancers
Lanfang Meng, Mengjun Shu, Yaqing Chen, Dexiao Yang, Qun He, Hui Zhao, Zhiyong Feng, Chris Liang & Ker Yu
Pages: 721-734
Published online: 11 Mar 2014
AbstractforA novel lead compound CM-118 | Full Text | References | PDF (3.4 MB)
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Article
High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism
Alessandra Cirillo, Anna Di Salle, Orsolina Petillo, Mariarosa AB Melone, Giovanna Grimaldi, Alfredo Bellotti, Giovanni Torelli, Maria Serena de’ Santi, Giovanna Cantatore, Alfredo Marinelli, Umberto Galderisi & Gianfranco Peluso
Pages: 735-741
Published online: 11 Mar 2014
AbstractforHigh grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism | Full Text | References | PDF (1,002.6 KB) | Supplemental
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Article
Limited efficacy of specific HDAC6 inhibition in urothelial cancer cells
Lorena Rosik, Günter Niegisch, Ute Fischer, Manfred Jung, Wolfgang Arthur Schulz & Michèle Janine Hoffmann
Pages: 742-757
Published online: 11 Mar 2014
AbstractforLimited efficacy of specific HDAC6 inhibition in urothelial cancer cells | Full Text | References | PDF (5.4 MB)
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Article
PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells
Jane L Roberts, Laurence Booth, Adam Conley, Nichola Cruickshanks, Mark Malkin, Rakesh C Kukreja, Steven Grant, Andrew Poklepovic & Paul Dent
Pages: 758-767
Published online: 20 Mar 2014
AbstractforPDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells | Full Text | References | PDF (1.6 MB)
  • 1734 Views
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Article
Characterization of rare transforming KRAS mutations in sporadic colorectal cancer
Joanna HM Tong, Raymond WM Lung, Frankie MC Sin, Peggy PY Law, Wei Kang, Anthony WH Chan, Brigette BY Ma, Tony WC Mak, Simon SM Ng & Ka Fai To
Pages: 768-776
Published online: 18 Mar 2014
AbstractforCharacterization of rare transforming KRAS mutations in sporadic colorectal cancer | Full Text | References | PDF (1.4 MB)
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Article
RAD50 targeting impairs DNA damage response and sensitizes human breast cancer cells to cisplatin therapy
Ali Flores-Pérez, Lourdes E Rafaelli, Nayeli Ramírez-Torres, Elena Aréchaga-Ocampo, Sara Frías, Silvia Sánchez, Laurence A Marchat, Alfredo Hidalgo-Miranda, Valeria Quintanar-Jurado, Sergio Rodríguez-Cuevas, Verónica Bautista-Piña, Ángeles Carlos-Reyes & César López-Camarillo
Pages: 777-788
Published online: 18 Mar 2014
AbstractforRAD50 targeting impairs DNA damage response and sensitizes human breast cancer cells to cisplatin therapy | Full Text | References | PDF (2.7 MB)
  • 1376 Views
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Article
Systemic inflammation promotes lung metastasis via E-selectin upregulation in mouse breast cancer model
Man Jiang, Xiaoya Xu, Yuli Bi, Jiying Xu, Chengyong Qin & Mingyong Han
Pages: 789-796
Published online: 21 Mar 2014
AbstractforSystemic inflammation promotes lung metastasis via E-selectin upregulation in mouse breast cancer model | Full Text | References | PDF (2 MB)
  • 1580 Views
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Article
Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro
Giulia Marvaso, Agnese Barone, Nicola Amodio, Lavinia Raimondi, Valter Agosti, Emanuela Altomare, Valerio Scotti, Angela Lombardi, Roberto Bianco, Cataldo Bianco, Michele Caraglia, Pierfrancesco Tassone & Pierosandro Tagliaferri
Pages: 797-805
Published online: 21 Mar 2014
AbstractforSphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro | Full Text | References | PDF (1.9 MB)
  • 1483 Views
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Article
MALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway
Xiang-Song Wu, Xu-An Wang, Wen-Guang Wu, Yun-Ping Hu, Mao-Lan Li, Qian Ding, Hao Weng, Yi-Jun Shu, Tian-Yu Liu, Lin Jiang, Yang Cao, Run-Fa Bao, Jia-Sheng Mu, Zhu-Jun Tan, Feng Tao & Ying-Bin Liu
Pages: 806-814
Published online: 21 Mar 2014
AbstractforMALAT1 promotes the proliferation and metastasis of gallbladder cancer cells by activating the ERK/MAPK pathway | Full Text | References | PDF (2.6 MB)
  • 2593 Views
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Article
Multiple lesions in receptor tyrosine kinase pathway determine glioblastoma response to pan-ERBB inhibitor PF-00299804 and PI3K/mTOR dual inhibitor PF-05212384
Yanni Zhu & Khalid Shah
Pages: 815-822
Published online: 21 Mar 2014
AbstractforMultiple lesions in receptor tyrosine kinase pathway determine glioblastoma response to pan-ERBB inhibitor PF-00299804 and PI3K/mTOR dual inhibitor PF-05212384 | Full Text | References | PDF (1.4 MB) | Supplemental
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