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Research Paper

CDK4 inhibition and doxorubicin mediate breast cancer cell apoptosis through Smad3 and survivin

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Pages 1301-1311 | Received 16 Jun 2014, Accepted 22 Jun 2014, Published online: 09 Jul 2014

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Joseph T. Decker, Pridvi Kandagatla, Lei Wan, Regan Bernstein, Jeffrey A. Ma, Lonnie D. Shea & Jacqueline S. Jeruss. (2020) Cyclin E overexpression confers resistance to trastuzumab through noncanonical phosphorylation of SMAD3 in HER2+ breast cancer. Cancer Biology & Therapy 21:11, pages 994-1004.
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Khuloud Bajbouj, Jasmin Shafarin & Mawieh Hamad. (2019) Estrogen-dependent disruption of intracellular iron metabolism augments the cytotoxic effects of doxorubicin in select breast and ovarian cancer cells. Cancer Management and Research 11, pages 4655-4668.
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Jacqueline S Jeruss. (2023) The Promise of Ongoing Discovery and Growth: 10 Years after Receiving the Jacobson Promising Investigator Award. Journal of the American College of Surgeons 237:5, pages 788-792.
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Sruthi Sritharan, Sampurna Guha, Snoopy Hazarika & Nageswaran Sivalingam. (2022) Meta analysis of bioactive compounds, miRNA, siRNA and cell death regulators as sensitizers to doxorubicin induced chemoresistance. Apoptosis 27:9-10, pages 622-646.
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Satyam Rajput, Kaivalya A. Deo, Tanmay Mathur, Giriraj Lokhande, Kanwar Abhay Singh, Yuxiang Sun, Daniel L. Alge, Abhishek Jain, Tapasree Roy Sarkar & Akhilesh K. Gaharwar. (2022) 2D Nanosilicate for additive manufacturing: Rheological modifier, sacrificial ink and support bath. Bioprinting 25, pages e00187.
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You Li, Zhen Qin, Fengli Zhang & Shang‐Tian Yang. (2021) Two‐color fluorescent proteins reporting survivin regulation in breast cancer cells for high throughput drug screening. Biotechnology and Bioengineering 119:3, pages 1004-1017.
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Mengyao Qin, Yu Xin, Yong Bian, Xuan Yang, Tao Xi & Jing Xiong. (2022) Phosphorylation-Induced Ubiquitination and Degradation of PXR through CDK2-TRIM21 Axis. Cells 11:2, pages 264.
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V. Divya & V.L. Pushpa. (2021) High-throughput virtual screening followed by in vitro investigation to identify new lead inhibitors of Cyclin Dependent Kinase 4. Journal of Molecular Graphics and Modelling 109, pages 108020.
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Joseph T. Decker, Jeffrey A. Ma, Lonnie D. Shea & Jacqueline S. Jeruss. (2021) Implications of TGFβ Signaling and CDK Inhibition for the Treatment of Breast Cancer. Cancers 13:21, pages 5343.
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Alexandra Daks, Victoria Mamontova, Olga Fedorova, Alexey Petukhov, Oleg Shuvalov, Sergey Parfenyev, Sofia Netsvetay, Aigul Venina, Alena Kizenko, Evgeny Imyanitov & Nickolai Barlev. (2021) Set7/9 controls proliferation and genotoxic drug resistance of NSCLC cells. Biochemical and Biophysical Research Communications 572, pages 41-48.
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Aparna Padhye, Jessica M. Konen, B. Leticia Rodriguez, Jared J. Fradette, Joshua K. Ochieng, Lixia Diao, Jing Wang, Wei Lu, Luisa S. Solis, Harsh Batra, Maria G. Raso, Michael D. Peoples, Rosalba Minelli, Alessandro Carugo, Christopher A. Bristow & Don L. Gibbons. (2021) Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer. JCI Insight 6:17.
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Reyhaneh Farghadani, Maryam Seifaddinipour, Jayakumar Rajarajeswaran, Mahmood Ameen Abdulla, Najihah Binti Mohd Hashim, Si Lay Khaing & Nur’ain Binti Salehen. (2019) In vivo acute toxicity evaluation and in vitro molecular mechanism study of antiproliferative activity of a novel indole Schiff base β -diiminato manganese III complex in hormone-dependent and triple negative breast cancer cells . PeerJ 7, pages e7686.
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Poliana Camila Marinello, Carolina Panis, Thamara Nishida Xavier Silva, Renata Binato, Eliana Abdelhay, Juliana Alves Rodrigues, André Luiz Mencalha, Natália Medeiros Dias Lopes, Rodrigo Cabral Luiz, Rubens Cecchini & Alessandra Lourenço Cecchini. (2019) Metformin prevention of doxorubicin resistance in MCF-7 and MDA-MB-231 involves oxidative stress generation and modulation of cell adaptation genes. Scientific Reports 9:1.
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Xin Xin, Yongqi Wu, Ru Zang & Shang-Tian Yang. (2019) A fluorescent 3D cell culture assay for high throughput screening of cancer drugs down-regulating survivin. Journal of Biotechnology 289, pages 80-87.
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Yong-Zhi Zhou, Chu-Zhong Li, Hua Gao & Ya-Zhuo Zhang. (2018) The Effects of Smad3 on Adrenocorticotropic Hormone–Secreting Pituitary Adenoma Development, Cell Proliferation, Apoptosis, and Hormone Secretion. World Neurosurgery 114, pages e329-e337.
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Flaviana Alves Dos Santos, Michelly Cristiny Pereira, Tiago Bento de Oliveira, Francisco Jaime Bezerra Mendonça Junior, Maria do Carmo Alves de Lima, Marina Galdino da Rocha Pitta, Ivan da Rocha Pitta, Moacyr Jesus Barreto de Melo Rêgo & Maira Galdino da Rocha Pitta. (2018) Anticancer properties of thiophene derivatives in breast cancer MCF-7 cells. Anti-Cancer Drugs 29:2, pages 157-166.
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Shreyas S. Rao, Jenna Stoehr, Danijela Dokic, Lei Wan, Joseph T. Decker, Kristine Konopka, Alexandra L. Thomas, Jia Wu, Virginia G. Kaklamani, Lonnie D. Shea & Jacqueline S. Jeruss. (2017) Synergistic effect of eribulin and CDK inhibition for the treatment of triple negative breast cancer. Oncotarget 8:48, pages 83925-83939.
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Virginia G. Kaklamani, Jacqueline S. Jeruss, Elisha Hughes, Kalliopi Siziopikou, Kirsten M. Timms, Alexander Gutin, Victor Abkevich, Zaina Sangale, Cara Solimeno, Krystal L. Brown, Joshua Jones, Anne-Renee Hartman, Caitlin Meservey, Borko Jovanovic, Irene Helenowski, Seema A. Khan, Kevin Bethke, Nora Hansen, Regina Uthe, Sara Giordano, Steven Rosen, Kent Hoskins, Jamie Von Roenn, Sarika Jain, Vamsi Parini & William Gradishar. (2015) Phase II neoadjuvant clinical trial of carboplatin and eribulin in women with triple negative early-stage breast cancer (NCT01372579). Breast Cancer Research and Treatment 151:3, pages 629-638.
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