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Leticia Muñoz-Hernando, Jose L Muñoz-Gonzalez, Laura Marqueta-Marques, Carmen Alvarez-Conejo, Álvaro Tejerizo-García, Gregorio Lopez-Gonzalez, Emilia Villegas-Muñoz, Angel Martin-Jimenez & Jesús S Jiménez-López. (2015) Endometriosis: alternative methods of medical treatment. International Journal of Women's Health 7, pages 595-603.
Read now
Read now
XinHong Guo, XinXin Zhang, Ling Ye, Ying Zhang, Rui Ding, YongWei Hao, YaLin Zhao, ZhenZhong Zhang & Yun Zhang. (2014) Inhalable microspheres embedding chitosan-coated PLGA nanoparticles for 2-methoxyestradiol. Journal of Drug Targeting 22:5, pages 421-427.
Read now
Read now
Xinhong Guo, Qian Mei, Yabing Xing, Ling Ye, Hongling Zhang, Xiufang Shi & Zhenzhong Zhang. (2012) Preparation and cytotoxicity of poly (DL-lactide-co-glycolide) microspheres encapsulating 2-methoxyestradiol. Drug Delivery 19:3, pages 143-148.
Read now
Read now
Guohua Xia, Baoan Chen, Jiahua Ding, Chong Gao, Huixia Lu, Zeye Shao, Feng Gao & Xuemei Wang. (2011) Effect of magnetic Fe3O4 nanoparticles with 2-methoxyestradiol on the cell-cycle progression and apoptosis of myelodysplastic syndrome cells. International Journal of Nanomedicine 6, pages 1921-1927.
Read now
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April L. Risinger & Susan L. Mooberry. (2011) Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel. Cell Cycle 10:13, pages 2162-2171.
Read now
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Jung-Kyo Cho, Ki-Yun Hong, Jung Won Park, Han-Kwang Yang & Soo-Chang Song. (2011) Injectable delivery system of 2-methoxyestradiol for breast cancer therapy using biodegradable thermosensitive poly(organophosphazene) hydrogel. Journal of Drug Targeting 19:4, pages 270-280.
Read now
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Danielle G Smith, Tapiwanashe Magwere & Susan A Burchill. (2011) Oxidative stress and therapeutic opportunities: focus on the Ewing’s sarcoma family of tumors. Expert Review of Anticancer Therapy 11:2, pages 229-249.
Read now
Read now
Robert O Carlson. (2008) New tubulin targeting agents currently in clinical development. Expert Opinion on Investigational Drugs 17:5, pages 707-722.
Read now
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Articles from other publishers (108)
Paulina Bastian, Lucyna Konieczna, Jarosław Dulski, Agnieszka Daca, Dagmara Jacewicz, Agata Płoska, Narcyz Knap, Jarosław Sławek, Tomasz Bączek, Leszek Kalinowski, Joanna Drzeżdżon, Anna Roszmann, Mariusz Belka & Magdalena Górska-Ponikowska. (2023) 2-Methoxyestradiol and Hydrogen Peroxide as Promising Biomarkers in Parkinson’s Disease. Molecular Neurobiology.
Crossref
Crossref
Yifat Koren Carmi, Hazem Khamaisi, Rina Adawi, Eden Noyman, Jacob Gopas & Jamal Mahajna. (2023) Secreted Soluble Factors from Tumor-Activated Mesenchymal Stromal Cells Confer Platinum Chemoresistance to Ovarian Cancer Cells. International Journal of Molecular Sciences 24:9, pages 7730.
Crossref
Crossref
Simona Camero, Matteo Cassandri, Silvia Pomella, Luisa Milazzo, Francesca Vulcano, Antonella Porrazzo, Giovanni Barillari, Cinzia Marchese, Silvia Codenotti, Miriam Tomaciello, Rossella Rota, Alessandro Fanzani, Francesca Megiorni & Francesco Marampon. (2022) Radioresistance in rhabdomyosarcomas: Much more than a question of dose. Frontiers in Oncology 12.
Crossref
Crossref
Paulina Bastian, Jaroslaw Dulski, Anna Roszmann, Dagmara Jacewicz, Alicja Kuban-Jankowska, Jaroslaw Slawek, Michal Wozniak & Magdalena Gorska-Ponikowska. (2021) Regulation of Mitochondrial Dynamics in Parkinson’s Disease—Is 2-Methoxyestradiol a Missing Piece?. Antioxidants 10:2, pages 248.
Crossref
Crossref
Olagoke Zacchaeus Olatunde, Jianping Yong & Canzhong Lu. (2021) The Progress of the Anticancer Agents Related to the Microtubules Target. Mini-Reviews in Medicinal Chemistry 20:20, pages 2165-2192.
Crossref
Crossref
Svetlana N. Morozkina & Alexander G. Shavva. 2020. Chemistry and Biological Activity of Steroids. Chemistry and Biological Activity of Steroids.
Magdalena Gorska-Ponikowska, Alicja Kuban-Jankowska, Antonella Marino Gammazza, Agnieszka Daca, Justyna M. Wierzbicka, Michal A. Zmijewski, Hue H. Luu, Michal Wozniak & Francesco Cappello. (2020) The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model. International Journal of Molecular Sciences 21:2, pages 616.
Crossref
Crossref
Li-Xin Sheng, Jiang-Yu Zhang, Li Li, Xiao Xie, Xiao-An Wen & Ke-Guang Cheng. (2020) Design, Synthesis, and Evaluation of Novel 2-Methoxyestradiol Derivatives as Apoptotic Inducers through an Intrinsic Apoptosis Pathway. Biomolecules 10:1, pages 123.
Crossref
Crossref
Rustelle Janse van Vuuren, Mandie Botes, Tamarin Jurgens, Anna Margaretha Joubert & Iman van den Bout. (2019) Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization. Cancer Cell International 19:1.
Crossref
Crossref
Anna Kamm, Paulina Przychodzen, Alicja Kuban-Jankowska, Dagmara Jacewicz, Aleksandra M. Dabrowska, Stephan Nussberger, Michal Wozniak & Magdalena Gorska-Ponikowska. (2019) Nitric oxide and its derivatives in the cancer battlefield. Nitric Oxide 93, pages 102-114.
Crossref
Crossref
Anna Kamm, Paulina Przychodzeń, Alicja Kuban–Jankowska, Antonella Marino Gammazza, Francesco Cappello, Agnieszka Daca, Michał A. Żmijewski, Michał Woźniak & Magdalena Górska–Ponikowska. (2019) 2-Methoxyestradiol and Its Combination with a Natural Compound, Ferulic Acid, Induces Melanoma Cell Death via Downregulation of Hsp60 and Hsp90. Journal of Oncology 2019, pages 1-12.
Crossref
Crossref
Seyed-Omar Zaraei, Abduelmula R. Abduelkarem, Hanan S. Anbar, Sara Kobeissi, Miami Mohammad, Aya Ossama & Mohammed I. El-Gamal. (2019) Sulfamates in drug design and discovery: Pre-clinical and clinical investigations. European Journal of Medicinal Chemistry 179, pages 257-271.
Crossref
Crossref
Ananya Pal, Hsin Yao Chiu & Reshma Taneja. (2019) Genetics, epigenetics and redox homeostasis in rhabdomyosarcoma: Emerging targets and therapeutics. Redox Biology 25, pages 101124.
Crossref
Crossref
Andrea Poch, Felipe Villanelo, Soledad Henriquez, Paulina Kohen, Alex Muñoz, Jerome F. StraussIIIIII & Luigi Devoto. (2019) Molecular modelling predicts that 2-methoxyestradiol disrupts HIF function by binding to the PAS-B domain. Steroids 144, pages 21-29.
Crossref
Crossref
Thikryat Neamatallah, Ashraf B. Abdel-Naim, Basma G. Eid & Atif Hasan. (2018) 2-Methoxyestradiol attenuates liver fibrosis in mice: implications for M2 macrophages. Naunyn-Schmiedeberg's Archives of Pharmacology 392:3, pages 381-391.
Crossref
Crossref
Nora al-Kazaale, Phuong T. Tran, Farhad Haidari, Eirik Johansson Solum, Sandra Liekens, Peter Vervaeke, Ingebrigt Sylte, Jing-Jy Cheng, Anders Vik & Trond Vidar Hansen. (2018) Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol. Steroids 136, pages 47-55.
Crossref
Crossref
Lie Yao, Xiang Zou, Chen Jin, Jie Fan, Zhongyi Guo, Quanjun Lin, Ji Li & Deliang Fu. (2018) The roles of ID-1 in human pancreatic ductal adenocarcinoma and the therapeutic effects of 2-methoxyestradiol. Carcinogenesis 39:5, pages 728-737.
Crossref
Crossref
Xiang Zou, Li Zhang, Jie Yuan, Chunjie Yang, Zehan Wu, Jianping Song, Wei Zhu, Ying Mao & Liang Chen. (2017) Endogenous hormone 2-methoxyestradiol suppresses venous hypertension-induced angiogenesis through up- and down-regulating p53 and id-1. Journal of Cellular and Molecular Medicine.
Crossref
Crossref
Koen Van Gansbeke, Eirik Johansson Solum, Sandra Liekens, Anders Vik & Trond Vidar Hansen. (2017) Regioselective monoalkylation of 17?-estradiol for the synthesis of cytotoxic estrogens. Steroids 124, pages 54-59.
Crossref
Crossref
R.R. Massaro, F. Faião-Flores, V.W. Rebecca, S. Sandri, D.K. Alves-Fernandes, P.C. Pennacchi, K.S.M. Smalley & S.S. Maria-Engler. (2017) Inhibition of proliferation and invasion in 2D and 3D models by 2-methoxyestradiol in human melanoma cells. Pharmacological Research 119, pages 242-250.
Crossref
Crossref
Michelle Helen Visagie, Iman van den Bout & Anna Margaretha Joubert. (2017) A bis-sulphamoylated estradiol derivative induces ROS-dependent cell cycle abnormalities and subsequent apoptosis. PLOS ONE 12:4, pages e0176006.
Crossref
Crossref
Sasidhar Eda, Ramakrishna Vadde & Rajeswari Jinka. 2017. Role of Transcription Factors in Gastrointestinal Malignancies. Role of Transcription Factors in Gastrointestinal Malignancies
131
159
.
Xu Wang, Chun Liu, Liucheng Wu & Shunxing Zhu. (2016) Potent ameliorating effect of Hypoxia-inducible factor 1α (HIF-1α) antagonist YC-1 on combined allergic rhinitis and asthma syndrome (CARAS) in Rats. European Journal of Pharmacology 788, pages 343-350.
Crossref
Crossref
Xiang Zou, Liangfu Zhou, Wei Zhu, Ying Mao & Liang Chen. (2016) Effectiveness of 2-methoxyestradiol in alleviating angiogenesis induced by intracranial venous hypertension. Journal of Neurosurgery 125:3, pages 746-753.
Crossref
Crossref
Soledad Henríquez, Paulina Kohen, Xia Xu, Timothy D. Veenstra, Alex Muñoz, Wilder A. Palomino, Jerome F. StraussIIIIII & Luigi Devoto. (2016) Estrogen metabolites in human corpus luteum physiology: differential effects on angiogenic activity. Fertility and Sterility 106:1, pages 230-237.e1.
Crossref
Crossref
Fei Long, Loubin Si, Xiao Long, Bob Yang, Xiaojun Wang & Fuquan Zhang. (2015)
2
ME
2 increase radiation‐induced apoptosis of keloid fibroblasts by targeting
HIF
‐1α
in vitro
. Australasian Journal of Dermatology 57:2.
Crossref
Crossref
Kulvinder Kochar Kaur & Gautam Allahbadia. (2016) An Update on Pathophysiology and Medical Management of Endometriosis. Advances in Reproductive Sciences 04:02, pages 53-73.
Crossref
Crossref
Han Lin, Xian Jiang, Huaqiang Zhu, Wenjing Jiang, Xuesong Dong, Haiquan Qiao, Xueying Sun & Hongchi Jiang. (2015) 2ME2 inhibits the activated hypoxia-inducible pathways by cabozantinib and enhances its efficacy against medullary thyroid carcinoma. Tumor Biology 37:1, pages 381-391.
Crossref
Crossref
Yuli Qian, Ahmad Sherbini, Bahar Matin, Yanli Zhao, John Castellot & David J Greenblatt. (2015) Inhibition of 2-methoxyestradiol glucuronidation by probenecid. Journal of Pharmacy and Pharmacology 67:11, pages 1585-1592.
Crossref
Crossref
Mark P. Thomas & Barry V. L. Potter. (2015)
Discovery and Development of the Aryl
O
-Sulfamate Pharmacophore for Oncology and Women’s Health
. Journal of Medicinal Chemistry 58:19, pages 7634-7658.
Crossref
Crossref
Smreti Vasudevan, Sannu Ann Thomas, Krishnankutty C. Sivakumar, Reena J. Komalam, Keerthi V. Sreerekha, Kallikat N. Rajasekharan & Suparna Sengupta. (2015) Diaminothiazoles evade multidrug resistance in cancer cells and xenograft tumour models and develop transient specific resistance: understanding the basis of broad-spectrum versus specific resistance. Carcinogenesis 36:8, pages 883-893.
Crossref
Crossref
Magdalena Gorska, Alicja Kuban-Jankowska, Michal Zmijewski, Antonella Marino Gammazza, Francesco Cappello, Maciej Wnuk, Monika Gorzynik, Iwona Rzeszutek, Agnieszka Daca, Anna Lewinska & Michal Wozniak. (2015) DNA strand breaks induced by nuclear hijacking of neuronal NOS as an anti-cancer effect of 2-methoxyestradiol. Oncotarget 6:17, pages 15449-15463.
Crossref
Crossref
Arvind S. Negi, Yashveer Gautam, Sarfaraz Alam, Debabrata Chanda, Suaib Luqman, Jayanta Sarkar, Feroz Khan & Rituraj Konwar. (2015) Natural antitubulin agents: Importance of 3,4,5-trimethoxyphenyl fragment. Bioorganic & Medicinal Chemistry 23:3, pages 373-389.
Crossref
Crossref
Eirik Johansson Solum, Jing-Jy Cheng, Ingebrigt Sylte, Anders Vik & Trond Vidar Hansen. (2015) Synthesis, biological evaluation and molecular modeling of new analogs of the anti-cancer agent 2-methoxyestradiol: potent inhibitors of angiogenesis. RSC Advances 5:41, pages 32497-32504.
Crossref
Crossref
Li Ma, Guangxin Li, Huaqiang Zhu, Xuesong Dong, Dali Zhao, Xian Jiang, Jie Li, Haiquan Qiao, Shaobin Ni & Xueying Sun. (2014) 2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2. Cancer Letters 355:1, pages 96-105.
Crossref
Crossref
Eirik Johansson Solum, Jing-Jy Cheng, Irene B. S?rvik, Ragnhild E. Paulsen, Anders Vik & Trond Vidar Hansen. (2014) Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: Inhibitors of tubulin and angiogenesis. European Journal of Medicinal Chemistry 85, pages 391-398.
Crossref
Crossref
Mauricio P. Pinto, Rodolfo A. Medina & Gareth I. Owen. (2014) 2-Methoxyestradiol and Disorders of Female Reproductive Tissues. Hormones and Cancer 5:5, pages 274-283.
Crossref
Crossref
Eirik Johansson Solum, Anders Vik & Trond Vidar Hansen. (2014) Synthesis, cytotoxic effects and tubulin polymerization inhibition of 1,4-disubstituted 1,2,3-triazole analogs of 2-methoxyestradiol. Steroids 87, pages 46-53.
Crossref
Crossref
Erzsébet Mernyák, Johanna Szabó, Ildikó Bacsa, Judit Huber, Gyula Schneider, Renáta Minorics, Noémi Bózsity, István Zupkó, Mónika Varga, Zsolt Bikádi, Eszter Hazai & János Wölfling. (2014) Syntheses and antiproliferative effects of d-homo- and d-secoestrones. Steroids 87, pages 128-136.
Crossref
Crossref
Magdalena Gorska, Alicja Kuban-Jankowska, Michal Zmijewski, Monika Gorzynik, Michal Szkatula & Michal Wozniak. (2014) Neuronal Nitric Oxide Synthase Induction in the Antitumorigenic and Neurotoxic Effects of 2-Methoxyestradiol. Molecules 19:9, pages 13267-13281.
Crossref
Crossref
Colin E. EvansSteven P. GroverJulia HumphriesPrakash SahaAnant P. PatelAshish S. PatelOliver T. LyonsMatt WalthamBijan ModaraiAlberto Smith. (2014) Antiangiogenic Therapy Inhibits Venous Thrombus Resolution. Arteriosclerosis, Thrombosis, and Vascular Biology 34:3, pages 565-570.
Crossref
Crossref
Carrie R. Muh, Shweta Joshi, Alok R. Singh, Santosh Kesari, Donald L. Durden & Milan T. Makale. (2013) PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. Journal of Neuro-Oncology 116:1, pages 89-97.
Crossref
Crossref
Eddy Pasquier, Maria Kavallaris & Nicolas Andre. 2014. Metronomic Chemotherapy. Metronomic Chemotherapy
69
90
.
Chris Brede & Vinod Labhasetwar. (2013) Applications of Nanoparticles in the Detection and Treatment of Kidney Diseases. Advances in Chronic Kidney Disease 20:6, pages 454-465.
Crossref
Crossref
Paulina Kohen, Soledad Henríquez, Candy Rojas, Phillip M. Gerk, Wilder A. Palomino, Jerome F. StraussIIIIII & Luigi Devoto. (2013) 2-Methoxyestradiol in the human corpus luteum throughout the luteal phase and its influence on lutein cell steroidogenesis and angiogenic activity. Fertility and Sterility 100:5, pages 1397-1404.e1.
Crossref
Crossref
Ravi Shankar, Abhilash Samykutty, Corinne Riggin, Sneha Kannan, Ursula Wenzel & Rohit Kolhatkar. (2013) Cathepsin B Degradable Star-Shaped Peptidic Macromolecules for Delivery of 2-Methoxyestradiol. Molecular Pharmaceutics 10:10, pages 3776-3788.
Crossref
Crossref
Avudaiappan Maran, Mahrokh Dadsetan, Colleen M. Buenz, Kristen L. Shogren, Lichun Lu & Michael J. Yaszemski. (2013) Hydrogel‐PLGA delivery system prolongs 2‐methoxyestradiol‐mediated anti‐tumor effects in osteosarcoma cells. Journal of Biomedical Materials Research Part A 101A:9, pages 2491-2499.
Crossref
Crossref
Angela JainMichael V. Seiden. (2013) Rare Epithelial Tumors Arising in or near the Ovary: A Review of the Risk Factors, Presentation, and Future Treatment Direction for Ovarian Clear Cell and Mucinous Carcinoma. American Society of Clinical Oncology Educational Book:33, pages e200-e204.
Crossref
Crossref
Sarah K Burroughs, Stefan Kaluz, Danzhu Wang, Ke Wang, Erwin G Van Meir & Binghe Wang. (2013) Hypoxia inducible factor pathway inhibitors as anticancer therapeutics. Future Medicinal Chemistry 5:5, pages 553-572.
Crossref
Crossref
J. Peng, X. Xu, B. E. Mace, L. A. Vanderveer, L. R. Workman, M. J. Slifker, P. M. Sullivan, T. D. Veenstra & M. L. Clapper. (2012) Estrogen metabolism within the lung and its modulation by tobacco smoke. Carcinogenesis 34:4, pages 909-915.
Crossref
Crossref
Suman Kambhampati, Roger A. Rajewski, Mehmet Tanol, Inamul Haque, Amlan Das, Snigdha Banerjee, Saheli Jha, Douglas Burns, Emma Borrego-Diaz, Peter J. Van Veldhuizen & Sushanta K. Banerjee. (2013) A Second-Generation 2-Methoxyestradiol Prodrug Is Effective against Barrett's Adenocarcinoma in a Mouse Xenograft Model. Molecular Cancer Therapeutics 12:3, pages 255-263.
Crossref
Crossref
Maoquan Zhou, Adel Hamza, Chang-Guo Zhan & Jon S. Thorson. (2013) Assessing the Regioselectivity of OleD-Catalyzed Glycosylation with a Diverse Set of Acceptors. Journal of Natural Products 76:2, pages 279-286.
Crossref
Crossref
Hazem Ali, Gokhan Kilic, Kathleen Vincent, Massoud Motamedi & Erik Rytting. (2013) Nanomedicine for uterine leiomyoma therapy. Therapeutic Delivery 4:2, pages 161-175.
Crossref
Crossref
?gnes Ber?nyi, Ren?ta Minorics, Zolt?n Iv?nyi, Imre Ocsovszki, Eszter Ducza, Hubert Thole, Josef Messinger, J?nos W?lfling, Gerg? M?ty?n, Erzs?bet Merny?k, ?va Frank, Gyula Schneider & Istv?n Zupk?. (2013) Synthesis and investigation of the anticancer effects of estrone-16-oxime ethers in vitro. Steroids 78:1, pages 69-78.
Crossref
Crossref
M.W. Laschke & M.D. Menger. (2012) Anti-angiogenic treatment strategies for the therapy of endometriosis. Human Reproduction Update 18:6, pages 682-702.
Crossref
Crossref
Francisco Machado-Linde, Pablo Pelegrin, Maria L. Sanchez-Ferrer, Josefa Leon, Pedro Cascales & Juan J. Parrilla. (2012) 2-Methoxyestradiol in the Pathophysiology of Endometriosis: Focus on Angiogenesis and Therapeutic Potential. Reproductive Sciences 19:10, pages 1018-1029.
Crossref
Crossref
Beth A. Drzewiecki, Govindaraj Anumanthan, Heidi A. Penn, Stacy T. Tanaka, John C. Thomas, Mark C. Adams, John W. BrockIIIIII, John C. PopeIVIV, Robert J. Matusik, Simon Hayward & Douglass B. Clayton. (2012) Modulation of the Hypoxic Response Following Partial Bladder Outlet Obstruction. The Journal of Urology 188:4, pages 1549-1554.
Crossref
Crossref
Ren?ta Minorics, No?mi B?zsity, J?nos W?lfling, Erzs?bet Merny?k, Gyula Schneider, ?rp?d M?rki, George Falkay, Imre Ocsovszki & Istv?n Zupk?. (2012) Antiproliferative effect of normal and 13-epi-d-homoestrone and their 3-methyl ethers on human reproductive cancer cell lines. The Journal of Steroid Biochemistry and Molecular Biology 132:1-2, pages 168-175.
Crossref
Crossref
Hye Joung Choi & Bao Ting Zhu. (2012) Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1823:8, pages 1306-1315.
Crossref
Crossref
Hongbo Min, Gautam S. Ghatnekar, Angela V. Ghatnekar, Xiaohong You, Min Bu, Xinyi Guo, Shizhong Bu, Bo Shen & Qin Huang. (2011) 2‐Methoxyestradiol induced bax phosphorylation and apoptosis in human retinoblastoma cells via p38 MAPK activation. Molecular Carcinogenesis 51:7, pages 576-585.
Crossref
Crossref
Sivaramakrishna Koganti, Russell Snyder & Thomas Thekkumkara. (2012) Pharmacologic Effects of 2-Methoxyestradiol on Angiotensin Type 1 Receptor Down-Regulation in Rat Liver Epithelial and Aortic Smooth Muscle Cells. Gender Medicine 9:2, pages 76-93.
Crossref
Crossref
Justine Yang Bruce, Jens Eickhoff, Roberto Pili, Theodore Logan, Michael Carducci, Jamie Arnott, Anthony Treston, George Wilding & Glenn Liu. (2010) A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate. Investigational New Drugs 30:2, pages 794-802.
Crossref
Crossref
Xinhong Guo, Yabing Xing, Qian Mei, Hongling Zhang, Zhenzhong Zhang & Fude Cui. (2012) Preparation and cytotoxicity of 2-methoxyestradiol-loaded solid lipid nanoparticles. Anti-Cancer Drugs 23:2, pages 185-190.
Crossref
Crossref
Jennifer S. Carew, Juan A. Esquivel, Claudia M. Espitia, Christoph M. Schultes, Marcel Mülbaier, Joe D. Lewis, Bernd Janssen, Francis J. Giles & Steffan T. Nawrocki. (2012) ELR510444 Inhibits Tumor Growth and Angiogenesis by Abrogating HIF Activity and Disrupting Microtubules in Renal Cell Carcinoma. PLoS ONE 7:1, pages e31120.
Crossref
Crossref
Boris A. Gorshkov, Marina A. Zemskova, Alexander D. Verin & Natalia V. Bogatcheva. (2012) Taxol alleviates 2-methoxyestradiol-induced endothelial permeability. Vascular Pharmacology 56:1-2, pages 56-63.
Crossref
Crossref
Natalia V. Bogatcheva, Marina A. Zemskova, Boris A. Gorshkov, Kyung Mi Kim, Gregory A. Daglis, Christophe Poirier & Alexander D. Verin. (2011) Ezrin, Radixin, and Moesin Are Phosphorylated in Response to 2-Methoxyestradiol and Modulate Endothelial Hyperpermeability. American Journal of Respiratory Cell and Molecular Biology 45:6, pages 1185-1194.
Crossref
Crossref
Matthew H. Kulke, Jennifer A. Chan, Jeffrey A. Meyerhardt, Andrew X. Zhu, Thomas A. Abrams, Lawrence S. Blaszkowsky, Eileen Regan, Carolyn Sidor & Charles S. Fuchs. (2010) A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors. Cancer Chemotherapy and Pharmacology 68:2, pages 293-300.
Crossref
Crossref
Henrik ten Freyhaus, Markus Dagnell, Maike Leuchs, Marius Vantler, Eva M. Berghausen, Evren Caglayan, Norbert Weissmann, Bhola K. Dahal, Ralph T. Schermuly, Arne Östman, Kai Kappert & Stephan Rosenkranz. (2011) Hypoxia Enhances Platelet-derived Growth Factor Signaling in the Pulmonary Vasculature by Down-Regulation of Protein Tyrosine Phosphatases. American Journal of Respiratory and Critical Care Medicine 183:8, pages 1092-1102.
Crossref
Crossref
Svetlana Verenich & Phillip M. Gerk. (2010) Therapeutic Promises of 2-Methoxyestradiol and Its Drug Disposition Challenges. Molecular Pharmaceutics 7:6, pages 2030-2039.
Crossref
Crossref
Marisol Quezada, Jorge Diaz, Soledad Henriquez, Maria Loreto Bravo, Evelyn Aranda, Barbara Oliva, Manuel Villalon, Sumie Kato, Mauricio A. Cuello, Jan J. Brosens, Carol A. Lange & Gareth I. Owen. (2010) 2-Methoxyestradiol Inhibits Progesterone-Dependent Tissue Factor Expression and Activity in Breast Cancer Cells. Hormones and Cancer 1:3, pages 117-126.
Crossref
Crossref
Eddy Pasquier, Snega Sinnappan, Marcia A. Munoz & Maria Kavallaris. (2010) ENMD-1198, a New Analogue of 2-Methoxyestradiol, Displays Both Antiangiogenic and Vascular-Disrupting Properties. Molecular Cancer Therapeutics 9:5, pages 1408-1418.
Crossref
Crossref
Suman Kambhampati, Snigdha Banerjee, Kakali Dhar, Smita Mehta, Inamul Haque, Gopal Dhar, Monami Majumder, Gibanananda Ray, Peter J. Vanveldhuizen & Sushanta K. Banerjee. (2010) 2-Methoxyestradiol Inhibits Barrett's Esophageal Adenocarcinoma Growth and Differentiation through Differential Regulation of the β-Catenin–E-Cadherin Axis. Molecular Cancer Therapeutics 9:3, pages 523-534.
Crossref
Crossref
Harald Seeger & Alfred O. Mueck. (2010) Are estradiol metabolites involved in gynaecological carcinogenesis?. Hormone Molecular Biology and Clinical Investigation 1:3.
Crossref
Crossref
Jeanny B. Aragon-Ching & William Dahut. 2010. Drug Management of Prostate Cancer. Drug Management of Prostate Cancer
225
232
.
Pramod C. RathTapas Mukhopadhyay. (2009)
p53
Gene Expression and 2-Methoxyestradiol Treatment Differentially Induce Nuclear Factor Kappa B Activation in Human Lung Cancer Cells with Different p53 Phenotypes
. DNA and Cell Biology 28:12, pages 615-623.
Crossref
Crossref
Daniela Matei, Jeanne Schilder, Gregory Sutton, Susan Perkins, Tim Breen, Check Quon & Carolyn Sidor. (2009) Activity of 2 methoxyestradiol (Panzem® NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: A Hoosier Oncology Group trial. Gynecologic Oncology 115:1, pages 90-96.
Crossref
Crossref
April L. Risinger, Francis J. Giles & Susan L. Mooberry. (2009) Microtubule dynamics as a target in oncology. Cancer Treatment Reviews 35:3, pages 255-261.
Crossref
Crossref
Amye J. Tevaarwerk, Kyle D. Holen, Dona B. Alberti, Carolyn Sidor, Jamie Arnott, Check Quon, George Wilding & Glenn Liu. (2009) Phase I Trial of 2-Methoxyestradiol NanoCrystal Dispersion in Advanced Solid Malignancies. Clinical Cancer Research 15:4, pages 1460-1465.
Crossref
Crossref
M F C Parsons, P A Foster, S K Chander, R Jhalli, S P Newman, M P Leese, B V L Potter, A Purohit & M J Reed. (2008) The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer. British Journal of Cancer 99:9, pages 1433-1441.
Crossref
Crossref
S. Huerta-Yepez, G.J. Baay-Guzman, R. Garcia-Zepeda, R. Hernandez-Pando, M.I. Vega, C. Gonzalez-Bonilla & B. Bonavida. (2008) 2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse model. Clinical Immunology 129:2, pages 313-324.
Crossref
Crossref
Giovanna Pitarresi, Giuseppe Tripodo, Rossella Calabrese, Emanuela Fabiola Craparo, Mariano Licciardi & Gaetano Giammona. (2008) Hydrogels for Potential Colon Drug Release by Thiol-ene Conjugate Addition of a New Inulin Derivative. Macromolecular Bioscience 8:10, pages 891-902.
Crossref
Crossref
Siddhartha Kar, Meifang Wang & Brian I. Carr. (2008) 2-Methoxyestradiol inhibits hepatocellular carcinoma cell growth by inhibiting Cdc25 and inducing cell cycle arrest and apoptosis. Cancer Chemotherapy and Pharmacology 62:5, pages 831-840.
Crossref
Crossref
Hiroshi Hirata, Yuji Hinoda, Naoko Okayama, Yutaka Suehiro, Ken Kawamoto, Nobuyuki Kikuno, Joseph T. Rabban, Lee-May Chen & Rajvir Dahiya. (2008)
COMT
polymorphisms affecting protein expression are risk factors for endometrial cancer
. Molecular Carcinogenesis 47:10, pages 768-774.
Crossref
Crossref
Wanqiu Chen, Vikram Jadhav, Jiping Tang & John H. Zhang. (2008) HIF-1α inhibition ameliorates neonatal brain injury in a rat pup hypoxic–ischemic model. Neurobiology of Disease 31:3, pages 433-441.
Crossref
Crossref
Aaron P. Brown, Deborah E. Citrin & Kevin A. Camphausen. (2008) Clinical biomarkers of angiogenesis inhibition. Cancer and Metastasis Reviews 27:3, pages 415-434.
Crossref
Crossref
Paul A. Foster, Yaik T. Ho, Simon P. Newman, Philip G. Kasprzyk, Mathew P. Leese, Barry V. L. Potter, Michael J. Reed & Atul Purohit. (2007) 2-MeOE2bisMATE and 2-EtE2bisMATE induce cell cycle arrest and apoptosis in breast cancer xenografts as shown by a novel ex vivo technique. Breast Cancer Research and Treatment 111:2, pages 251-260.
Crossref
Crossref
Theresa M. LaVallee, Patricia A. Burke, Glenn M. Swartz, Ernest Hamel, Gregory E. Agoston, Jamshed Shah, Lita Suwandi, Art D. Hanson, William E. Fogler, Carolyn F. Sidor & Anthony M. Treston. (2008)
Significant antitumor activity
in vivo
following treatment with the microtubule agent ENMD-1198
. Molecular Cancer Therapeutics 7:6, pages 1472-1482.
Crossref
Crossref
Andrew C. Issekutz & Kusum Sapru. (2008) Modulation of adjuvant arthritis in the rat by 2-methoxyestradiol: An effect independent of an anti-angiogenic action. International Immunopharmacology 8:5, pages 708-716.
Crossref
Crossref
Nicola J. Mabjeesh, Alexander Shefler, Sharon Amir & Haim Matzkin. (2008) Potentiation of 2‐Methoxyestradiol‐Induced cytotoxicity by blocking endothelin A receptor in prostate cancer cells. The Prostate 68:6, pages 679-689.
Crossref
Crossref
Mathew P. Leese, Fabrice L. Jourdan, Keira Gaukroger, Mary F. Mahon, Simon P. Newman, Paul A. Foster, Chloe Stengel, Sandra Regis-Lydi, Eric Ferrandis, Anna Di Fiore, Giuseppina De Simone, Claudiu T. Supuran, Atul Purohit, Michael J. Reed & Barry V. L. Potter. (2008) Structure–Activity Relationships of C-17 Cyano-Substituted Estratrienes as Anticancer Agents. Journal of Medicinal Chemistry 51:5, pages 1295-1308.
Crossref
Crossref
Jyh-Ming Chow, Chien-Ru Liu, Che-Pin Lin, Chun-Nin Lee, Yun-Chih Cheng, Shufan Lin & H. Eugene Liu. (2008) Downregulation of c-Myc determines sensitivity to 2-methoxyestradiol–induced apoptosis in human acute myeloid leukemia. Experimental Hematology 36:2, pages 140-148.
Crossref
Crossref
Simon P. Newman, Paul A. Foster, Chloe Stengel, Joanna M. Day, Yaik T. Ho, Jean-Gabriel Judde, Myriam Lassalle, Gregoire Prevost, Mathew P. Leese, Barry V.L. Potter, Michael J. Reed & Atul Purohit. (2008)
STX140 Is Efficacious
In vitro
and
In vivo
in Taxane-Resistant Breast Carcinoma Cells
. Clinical Cancer Research 14:2, pages 597-606.
Crossref
Crossref
Michael Höpfner, Detlef Schuppan & Hans Scherübl. (2008) Treatment of gastrointestinal neuroendocrine tumors with inhibitors of growth factor receptors and their signaling pathways: Recent advances and future perspectives. World Journal of Gastroenterology 14:16, pages 2461.
Crossref
Crossref
Jeanny B. Aragon-Ching & William L. Dahut. (2008) The Role of Angiogenesis Inhibitors in Prostate Cancer. The Cancer Journal 14:1, pages 20-25.
Crossref
Crossref
Lyudmila A. Vereshchagina, Orit Scharf & A. Dimitrios Colevas. 2008. The Role of Microtubules in Cell Biology, Neurobiology, and Oncology. The Role of Microtubules in Cell Biology, Neurobiology, and Oncology
421
478
.
S P Newman, P A Foster, Y T Ho, J M Day, B Raobaikady, P G Kasprzyk, M P Leese, B V L Potter, M J Reed & A Purohit. (2007) The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers. British Journal of Cancer 97:12, pages 1673-1682.
Crossref
Crossref
Allison B. Edsall, Gregory E. Agoston, Anthony M. Treston, Stacy M. Plum, Robert H. McClanahan, Tian-Sheng Lu, Wei Song & Mark Cushman. (2007) Synthesis and in Vivo Antitumor Evaluation of 2-Methoxyestradiol 3-Phosphate, 17-Phosphate, and 3,17-Diphosphate. Journal of Medicinal Chemistry 50:26, pages 6700-6705.
Crossref
Crossref
Heng-Liang Lin, Muh-Hwa Yang, Chew-Wun Wu, Po-Min Chen, Yi-Ping Yang, Yue-Ru Chu, Chung-Lan Kao, Hung-Hai Ku, Jen-Fan Lo, Jing-Ping Liou, Chin-Wen Chi & Shih-Hwa Chiou. (2007) 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer. International Journal of Cancer 121:11, pages 2547-2555.
Crossref
Crossref
S. Vincent Rajkumar, Paul G. Richardson, Martha Q. Lacy, Angela Dispenzieri, Philip R. Greipp, Thomas E. Witzig, Robert Schlossman, Carolyn F. Sidor, Kenneth C. Anderson & Morie A. Gertz. (2007) Novel Therapy with 2-Methoxyestradiol for the Treatment of Relapsed and Plateau Phase Multiple Myeloma. Clinical Cancer Research 13:20, pages 6162-6167.
Crossref
Crossref
I Durán, R Salazar, O Casanovas, V Arrazubi, E Vilar, L.L. Siu, J Yao & J Tabernero. (2007) New drug development in digestive neuroendocrine tumors. Annals of Oncology 18:8, pages 1307-1313.
Crossref
Crossref
Iljung Lee, Yearn Seong Choe, Kyung-Ho Jung, Kyung-Han Lee, Joon Young Choi, Yong Choi & Byung-Tae Kim. (2007) 2-[methyl-11C]Methoxyestradiol: synthesis, evaluation and pharmacokinetics for in vivo studies on angiogenesis. Nuclear Medicine and Biology 34:6, pages 625-631.
Crossref
Crossref
Miao-rong SHE, Jing-gao LI, Kun-yuan GUO, Wei LIN, Xin DU & Xin-qing NIU. (2007) Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2-methoxyestradiol. Acta Pharmacologica Sinica 28:7, pages 1037-1044.
Crossref
Crossref
Nehal J. Lakhani, Alex Sparreboom, X.i.a. Xu, Timothy D. Veenstra, Jürgen Venitz, William L. Dahut & William D. Figg. (2007) Characterization of in vitro and in vivo metabolic pathways of the investigational anticancer agent, 2‐methoxyestradiol. Journal of Pharmaceutical Sciences 96:7, pages 1821-1831.
Crossref
Crossref
S K Chander, P A Foster, M P Leese, S P Newman, B V L Potter, A Purohit & M J Reed. (2007) In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol. British Journal of Cancer 96:9, pages 1368-1376.
Crossref
Crossref
Natalia V. Bogatcheva, Djanybek Adyshev, Bolot Mambetsariev, Nurgul Moldobaeva & Alexander D. Verin. (2007) Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction. American Journal of Physiology-Lung Cellular and Molecular Physiology 292:2, pages L487-L499.
Crossref
Crossref
Rajendra Bhati, Yesim Gökmen-Polar, George W. SledgeJr.Jr., Cheng Fan, Harikrishna Nakshatri, David Ketelsen, Christoph H. Borchers, Michael J. Dial, Cam Patterson & Nancy Klauber-DeMore. (2007) 2-Methoxyestradiol Inhibits the Anaphase-Promoting Complex and Protein Translation in Human Breast Cancer Cells. Cancer Research 67:2, pages 702-708.
Crossref
Crossref
Taisaku Funakoshi, Amy E. Birsner & Robert J. D'Amato. (2006) Antiangiogenic effect of oral 2-methoxyestradiol on choroidal neovascularization in mice. Experimental Eye Research 83:5, pages 1102-1107.
Crossref
Crossref
Nehal Lakhani, Alex Sparreboom, Jürgen Venitz, William L. Dahut & William D. Figg. (2006) Plasma protein binding of the investigational anticancer agent 2-methoxyestradiol. Anti-Cancer Drugs 17:8, pages 977-983.
Crossref
Crossref