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Research Paper

The tetramerization domain of p53 is required for efficient BAK oligomerization

Pages 1576-1583 | Published online: 01 Oct 2007

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Cédric Castrogiovanni, Marie Vandaudenard, Béranger Waterschoot, Olivier De Backer & Patrick Dumont. (2015) Decrease of mitochondrial p53 during late apoptosis is linked to its dephosphorylation on serine 20. Cancer Biology & Therapy 16:9, pages 1296-1307.
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Anna Budina-Kolomets, Robert D Hontz, Julia Pimkina & Maureen E Murphy. (2013) A conserved domain in exon 2 coding for the human and murine ARF tumor suppressor protein is required for autophagy induction. Autophagy 9:10, pages 1553-1565.
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Julia Pimkina & Maureen E. Murphy. (2011) Interaction of the ARF tumor suppressor with cytosolic HSP70 contributes to its autophagy function. Cancer Biology & Therapy 12:6, pages 503-509.
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Articles from other publishers (24)

David Stieg, Kaitlyn Casey & Maureen E. Murphy. (2023) p53 Oligomerization Domain Mutants: A New Class of Mutants That Retain “License to Kill”. Cancer Discovery 13:5, pages 1046-1048.
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Lev Zavileyskiy & Victoria Bunik. (2022) Regulation of p53 Function by Formation of Non-Nuclear Heterologous Protein Complexes. Biomolecules 12:2, pages 327.
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Chrisanta Harakandi, Lauraine Nininahazwe, Haiwei Xu, Bingrui Liu, Chenghua He, Yi-Chao Zheng & Hang Zhang. (2021) Recent advances on the intervention sites targeting USP7-MDM2-p53 in cancer therapy. Bioorganic Chemistry 116, pages 105273.
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Abiodun Anifowose, Ayodeji A. Agbowuro, Xiaoxiao Yang & Binghe Wang. (2020) Anticancer strategies by upregulating p53 through inhibition of its ubiquitination by MDM2. Medicinal Chemistry Research 29:7, pages 1105-1121.
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Cédric Castrogiovanni, Béranger Waterschoot, Olivier De Backer & Patrick Dumont. (2017) Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. Cell Death & Differentiation 25:1, pages 190-203.
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Bodo C. Melnik. (2017) Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer. Nutrition & Metabolism 14:1.
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Vladimir Uversky. (2016) p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure–Function Continuum Concept. International Journal of Molecular Sciences 17:11, pages 1874.
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Xian Zhang, Chien-Feng Li, Ling Zhang, Ching-Yuan Wu, Lixia Han, Guoxiang Jin, Abdol Hossein Rezaeian, Fei Han, Chunfang Liu, Chuan Xu, Xiaohong Xu, Chih-Yang Huang, Fuu-Jen Tsai, Chang-Hai Tsai, Kounosuke Watabe & Hui-Kuan Lin. (2016) TRAF6 Restricts p53 Mitochondrial Translocation, Apoptosis, and Tumor Suppression. Molecular Cell 64:4, pages 803-814.
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Rui Kamada, Yu Toguchi, Takao Nomura, Toshiaki Imagawa & Kazuyasu Sakaguchi. (2016) Tetramer formation of tumor suppressor protein p53: Structure, function, and applications. Biopolymers 106:4, pages 598-612.
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Karina J. Matissek, Abood Okal, Mohanad Mossalam & Carol S. Lim. (2014) Delivery of a Monomeric p53 Subdomain with Mitochondrial Targeting Signals from Pro-Apoptotic Bak or Bax. Pharmaceutical Research 31:9, pages 2503-2515.
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Thuy-Ai Nguyen, Daniel Menendez, Michael A. Resnick & Carl W. Anderson. (2014) Mutant TP53 Posttranslational Modifications: Challenges and Opportunities. Human Mutation 35:6, pages 738-755.
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Julia C. Liu, Paul H. Lerou & Galit Lahav. (2014) Stem cells: balancing resistance and sensitivity to DNA damage. Trends in Cell Biology 24:5, pages 268-274.
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Yingjuan Qian, Yong-Sam Jung & Xinbin Chen. (2012) Differentiated embryo-chondrocyte expressed gene 1 regulates p53-dependent cell survival versus cell death through macrophage inhibitory cytokine-1. Proceedings of the National Academy of Sciences 109:28, pages 11300-11305.
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Angelina V. Vaseva, Natalie D. Marchenko, Kyungmin Ji, Stella E. Tsirka, Sonja Holzmann & Ute M. Moll. (2012) p53 Opens the Mitochondrial Permeability Transition Pore to Trigger Necrosis. Cell 149:7, pages 1536-1548.
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Mohanad Mossalam, Karina J. Matissek, Abood Okal, Jonathan E. Constance & Carol S. Lim. (2012) Direct Induction of Apoptosis Using an Optimal Mitochondrially Targeted p53. Molecular Pharmaceutics 9:5, pages 1449-1458.
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Chris Zhiyi Zhang, Haitao Zhang, Jingping Yun, George Gong Chen & Paul Bo San Lai. (2012) Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo. Biochemical Pharmacology 83:9, pages 1278-1289.
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Michela Muscolini, Elisa Montagni, Vanessa Palermo, Silvia Di Agostino, Wei Gu, Salma Abdelmoula-Souissi, Cristina Mazzoni, Giovanni Blandino & Loretta Tuosto. (2011) The Cancer-associated K351N Mutation Affects the Ubiquitination and the Translocation to Mitochondria of p53 Protein. Journal of Biological Chemistry 286:46, pages 39693-39702.
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Daniel Speidel. (2010) Transcription-independent p53 apoptosis: an alternative route to death. Trends in Cell Biology 20:1, pages 14-24.
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Yosef Buganim & Varda Rotter. (2009) p53: Balancing tumour suppression and implications for the clinic. European Journal of Cancer 45, pages 217-234.
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G.V. Sherbet. (2009) Metastasis promoter S100A4 is a potentially valuable molecular target for cancer therapy. Cancer Letters 280:1, pages 15-30.
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Anna-Maria G. Psarra & Constantine E. Sekeris. (2009) Glucocorticoid receptors and other nuclear transcription factors in mitochondria and possible functions. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1787:5, pages 431-436.
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Julia Pimkina, Olivier Humbey, Jack T. Zilfou, Michal Jarnik & Maureen E. Murphy. (2009) ARF Induces Autophagy by Virtue of Interaction with Bcl-xl. Journal of Biological Chemistry 284:5, pages 2803-2810.
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Olivier Humbey, Julia Pimkina, Jack T. Zilfou, Michal Jarnik, Carmen Dominguez-Brauer, Darren J. Burgess, Christine M. Eischen & Maureen E. Murphy. (2008) The ARF Tumor Suppressor Can Promote the Progression of Some Tumors. Cancer Research 68:23, pages 9608-9613.
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J. I-Ju Leu & Donna L. George. (2007) Hepatic IGFBP1 is a prosurvival factor that binds to BAK, protects the liver from apoptosis, and antagonizes the proapoptotic actions of p53 at mitochondria. Genes & Development 21:23, pages 3095-3109.
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