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Research Paper

c-Myb oncoprotein is an essential target of the dleu2 tumor suppressor microRNA cluster

Pages 1758-1764 | Published online: 01 Nov 2008

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M. Ahmad Chaudhry, Bridget Kreger & Romaica A. Omaruddin. (2010) Transcriptional modulation of micro-RNA in human cells differing in radiation sensitivity. International Journal of Radiation Biology 86:7, pages 569-583.
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Vivian P. Wagner, Colin D. Bingle & Lynne Bingle. (2022) MYB-NFIB fusion transcript in adenoid cystic carcinoma: Current state of knowledge and future directions. Critical Reviews in Oncology/Hematology 176, pages 103745.
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Shu Wen Lim, Kennet JunKai Tan, Osman Mohd Azuraidi, Maran Sathiya, Ee Chen Lim, Kok Song Lai, Wai-Sum Yap & Nik Abd Rahman Nik Mohd Afizan. (2021) Functional and structural analysis of non-synonymous single nucleotide polymorphisms (nsSNPs) in the MYB oncoproteins associated with human cancer. Scientific Reports 11:1.
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Dingyu Hu, Wenjun Shao, Li Liu, Yanyan Wang, Shunling Yuan, Zhaoping Liu, Jing Liu & Ji Zhang. (2021) Intricate crosstalk between MYB and noncoding RNAs in cancer. Cancer Cell International 21:1.
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Eri Shibata, Kei-ichi Morita, Kou Kayamori, Shoichiro Tange, Hiroki Shibata, Yosuke Harazono, Yasuyuki Michi, Tohru Ikeda, Hiroyuki Harada, Issei Imoto & Tetsuya Yoda. (2021) Detection of novel fusion genes by next-generation sequencing-based targeted RNA sequencing analysis in adenoid cystic carcinoma of head and neck. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 132:4, pages 426-433.
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Annika K. Wefers, Damian Stichel, Daniel Schrimpf, Roland Coras, Mélanie Pages, Arnault Tauziède-Espariat, Pascale Varlet, Daniel Schwarz, Figen Söylemezoglu, Ute Pohl, José Pimentel, Jochen Meyer, Ekkehard Hewer, Anna Japp, Abhijit Joshi, David E. Reuss, Annekathrin Reinhardt, Philipp Sievers, M. Belén Casalini, Azadeh Ebrahimi, Kristin Huang, Christian Koelsche, Hu Liang Low, Olinda Rebelo, Dina Marnoto, Albert J. Becker, Ori Staszewski, Michel Mittelbronn, Martin Hasselblatt, Jens Schittenhelm, Edmund Cheesman, Ricardo Santos de Oliveira, Rosane Gomes P. Queiroz, Elvis Terci Valera, Volkmar H. Hans, Andrey Korshunov, Adriana Olar, Keith L. Ligon, Stefan M. Pfister, Zane Jaunmuktane, Sebastian Brandner, Ruth G. Tatevossian, David W. Ellison, Thomas S. Jacques, Mrinalini Honavar, Eleonora Aronica, Maria Thom, Felix Sahm, Andreas von Deimling, David T. W. Jones, Ingmar Blumcke & David Capper. (2019) Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course. Acta Neuropathologica 139:1, pages 193-209.
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Kylee Morrison, Mark Manzano, Kevin Chung, Matthew J. Schipma, Elizabeth T. Bartom & Eva Gottwein. (2019) The Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family. Cell Reports 29:10, pages 2961-2969.e6.
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Ting Liu, Zhenru Xu, Daming Ou, Jing Liu & Ji Zhang. (2018) The miR‐15a/16 gene cluster in human cancer: A systematic review. Journal of Cellular Physiology 234:5, pages 5496-5506.
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Bo Yu, Lusu Yao, Cuiqiao Liu, Lina Tang & Tao Xing. (2019) Upregulation of microRNA‑16 alters the response to inhaled β‑agonists in patients with asthma though modulating expression of ADRB2. Molecular Medicine Reports.
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Shiri Klein, Michal Abraham, Baruch Bulvik, Elia Dery, Ido D. Weiss, Neta Barashi, Rinat Abramovitch, Hanna Wald, Yaniv Harel, Devorah Olam, Lola Weiss, Katia Beider, Orly Eizenberg, Ori Wald, Eithan Galun, Yaron Pereg & Amnon Peled. (2018) CXCR4 Promotes Neuroblastoma Growth and Therapeutic Resistance through miR-15a/16-1–Mediated ERK and BCL2/Cyclin D1 Pathways. Cancer Research 78:6, pages 1471-1483.
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Tina Catela Ivkovic, Gjendine Voss, Helena Cornella & Yvonne Ceder. (2017) microRNAs as cancer therapeutics: A step closer to clinical application. Cancer Letters 407, pages 113-122.
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Ryan P. Sullivan, Jeffrey W. Leong, Stephanie E. Schneider, Aaron R. Ireland, Melissa M. Berrien-Elliott, Anvita Singh, Timothy Schappe, Brea A. Jewell, Veronika Sexl & Todd A. Fehniger. (2015) MicroRNA-15/16 Antagonizes Myb To Control NK Cell Maturation . The Journal of Immunology 195:6, pages 2806-2817.
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E Mets, J Van der Meulen, G Van Peer, M Boice, P Mestdagh, I Van de Walle, T Lammens, S Goossens, B De Moerloose, Y Benoit, N Van Roy, E Clappier, B Poppe, J Vandesompele, H-G Wendel, T Taghon, P Rondou, J Soulier, P Van Vlierberghe & F Speleman. (2014) MicroRNA-193b-3p acts as a tumor suppressor by targeting the MYB oncogene in T-cell acute lymphoblastic leukemia. Leukemia 29:4, pages 798-806.
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Jennifer Laudadio & Anthony N. Snow. 2015. Molecular Oncology Testing for Solid Tumors. Molecular Oncology Testing for Solid Tumors 303 339 .
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S Kasar, C Underbayev, Y Yuan, M Hanlon, S Aly, H Khan, V Chang, M Batish, T Gavrilova, F Badiane, H Degheidy, G Marti & E Raveche. (2013) Therapeutic implications of activation of the host gene (Dleu2) promoter for miR-15a/16-1 in chronic lymphocytic leukemia. Oncogene 33:25, pages 3307-3315.
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James N. PsathasPatrick J. DoonanPichai Raman, Bruce D. FreedmanAndy J. Minn & Andrei Thomas-Tikhonenko. (2013) The Myc-miR-17-92 axis amplifies B-cell receptor signaling via inhibition of ITIM proteins: a novel lymphomagenic feed-forward loop. Blood 122:26, pages 4220-4229.
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M. Ahmad Chaudhry, Romaica A. Omaruddin, Christopher D. Brumbaugh, Muhammad A. Tariq & Nader Pourmand. (2013) Identification of radiation-induced microRNA transcriptome by next-generation massively parallel sequencing. Journal of Radiation Research 54:5, pages 808-822.
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Brittany C. Parker, Matti J. Annala, David E. Cogdell, Kirsi J. Granberg, Yan Sun, Ping Ji, Xia Li, Joy Gumin, Hong Zheng, Limei Hu, Olli Yli-Harja, Hannu Haapasalo, Tapio Visakorpi, Xiuping Liu, Chang-gong Liu, Raymond Sawaya, Gregory N. Fuller, Kexin Chen, Frederick L. Lang, Matti Nykter & Wei Zhang. (2013) The tumorigenic FGFR3-TACC3 gene fusion escapes miR-99a regulation in glioblastoma. Journal of Clinical Investigation.
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Muller Fabbri. (2012) TLRs as miRNA Receptors. Cancer Research 72:24, pages 6333-6337.
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Yao Yuan, Siddha Kasar, Chingiz Underbayev, Daniel Vollenweider, Erica Salerno, Sergei V. Kotenko & Elizabeth Raveche. (2012) Role of microRNA-15a in autoantibody production in interferon-augmented murine model of lupus. Molecular Immunology 52:2, pages 61-70.
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M. A. Chaudhry & R. A. Omaruddin. (2012) Differential regulation of MicroRNA expression in irradiated and bystander cells. Molecular Biology 46:4, pages 569-578.
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M. Ahmad Chaudhry, Romaica A. Omaruddin, Bridget Kreger, Sonia M. de Toledo & Edouard I. Azzam. (2012) Micro RNA responses to chronic or acute exposures to low dose ionizing radiation. Molecular Biology Reports 39:7, pages 7549-7558.
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Martin A Rivas, Leandro Venturutti, Yi-Wen Huang, Roxana Schillaci, Tim Hui-Ming Huang & Patricia V Elizalde. (2012) Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development. Breast Cancer Research 14:3.
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Elaine Y. Chung, James N. Psathas, Duonan Yu, Yimei Li, Mitchell J. Weiss & Andrei Thomas-Tikhonenko. (2012) CD19 is a major B cell receptor–independent activator of MYC-driven B-lymphomagenesis. Journal of Clinical Investigation 122:6, pages 2257-2266.
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Chingiz Underbayev, Siddha Kasar, Yao Yuan & Elizabeth Raveche. (2012) MicroRNAs and Induced Pluripotent Stem Cells for Human Disease Mouse Modeling. Journal of Biomedicine and Biotechnology 2012, pages 1-7.
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Jun-ichi Satoh. 2012. Systems Biology in Cancer Research and Drug Discovery. Systems Biology in Cancer Research and Drug Discovery 247 266 .
Louis B BrillIIII, William A Kanner, André Fehr, Ywonne Andrén, Christopher A Moskaluk, Thomas Löning, Göran Stenman & Henry F FriersonJrJr. (2011) Analysis of MYB expression and MYB-NFIB gene fusions in adenoid cystic carcinoma and other salivary neoplasms. Modern Pathology 24:9, pages 1169-1176.
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Elena Sotillo & Andrei Thomas-Tikhonenko. (2011) Shielding the messenger (RNA): microRNA-based anticancer therapies. Pharmacology & Therapeutics 131:1, pages 18-32.
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Jochen Imig, Natalie Motsch, Jia Yun Zhu, Stephanie Barth, Michal Okoniewski, Tanja Reineke, Marianne Tinguely, Alberto Faggioni, Pankaj Trivedi, Gunter Meister, Christoph Renner & Friedrich A. Grässer. (2011) microRNA profiling in Epstein–Barr virus-associated B-cell lymphoma. Nucleic Acids Research 39:5, pages 1880-1893.
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Feriyl Bhaijee, Dominique J. Pepper, Karen T. Pitman & Diana Bell. (2011) New developments in the molecular pathogenesis of head and neck tumors: a review of tumor-specific fusion oncogenes in mucoepidermoid carcinoma, adenoid cystic carcinoma, and NUT midline carcinoma. Annals of Diagnostic Pathology 15:1, pages 69-77.
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Vijay G. Sankaran, Tobias F. Menne, Danilo ŠćepanovićJo-Anne Vergilio, Peng JiJinkuk KimPrathapan ThiruStuart H. Orkin, Eric S. Lander & Harvey F. Lodish. (2011) MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proceedings of the National Academy of Sciences 108:4, pages 1519-1524.
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Ruth G. Tatevossian, Bo Tang, James Dalton, Tim Forshew, Andrew R. Lawson, Jing Ma, Geoff Neale, Sheila A. Shurtleff, Simon Bailey, Amar Gajjar, Suzanne J. Baker, Denise Sheer & David W. Ellison. (2010) MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas. Acta Neuropathologica 120:6, pages 731-743.
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Michael Dews, Jamie L. Fox, Stacy Hultine, Prema Sundaram, Wenge Wang, Yingqiu Y. Liu, Emma Furth, Gregory H. Enders, Wafik El-Deiry, Janell M. Schelter, Michele A. Cleary & Andrei Thomas-Tikhonenko. (2010) The Myc–miR-17∼92 Axis Blunts TGFβ Signaling and Production of Multiple TGFβ-Dependent Antiangiogenic Factors. Cancer Research 70:20, pages 8233-8246.
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Sjur Reppe, Hilde Refvem, Vigdis T. Gautvik, Ole K. Olstad, Per I. Høvring, Finn P. Reinholt, Marit Holden, Arnoldo Frigessi, Rune Jemtland & Kaare M. Gautvik. (2010) Eight genes are highly associated with BMD variation in postmenopausal Caucasian women. Bone 46:3, pages 604-612.
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E. Maria C. Ohlsson Teague, Cristin G. Print & M. Louise Hull. (2010) The role of microRNAs in endometriosis and associated reproductive conditions. Human Reproduction Update 16:2, pages 142-165.
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Mikael Lerner, Masako Harada, Jakob Lovén, Juan Castro, Zadie Davis, David Oscier, Marie Henriksson, Olle Sangfelt, Dan Grandér & Martin M. Corcoran. (2009) DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1. Experimental Cell Research 315:17, pages 2941-2952.
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Nora Bandi, Samuel Zbinden, Mathias Gugger, Marlene Arnold, Verena Kocher, Lara Hasan, Andreas Kappeler, Thomas Brunner & Erik Vassella. (2009) miR-15a and miR-16 Are Implicated in Cell Cycle Regulation in a Rb-Dependent Manner and Are Frequently Deleted or Down-regulated in Non–Small Cell Lung Cancer . Cancer Research 69:13, pages 5553-5559.
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Olesya Chayka, Daisy Corvetta, Michael Dews, Alessandro E. Caccamo, Izabela Piotrowska, Giorgia Santilli, Sian Gibson, Neil J. Sebire, Nourredine Himoudi, Michael D. Hogarty, John Anderson, Saverio Bettuzzi, Andrei Thomas-Tikhonenko & Arturo Sala. (2009) Clusterin, a Haploinsufficient Tumor Suppressor Gene in Neuroblastomas. JNCI: Journal of the National Cancer Institute 101:9, pages 663-677.
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