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Research Paper

Gamma-radiation (GR) triggers a unique gene expression profile associated with cell death compared to proton radiation (PR) in mice in vivo

Pages 2023-2033 | Published online: 01 Dec 2008

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Agnieszka Panek, Justyna Miszczyk & Jan Swakoń. (2018) Biological effects and inter-individual variability in peripheral blood lymphocytes of healthy donors exposed to 60 MeV proton radiotherapeutic beam. International Journal of Radiation Biology 94:12, pages 1085-1094.
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Johannes Müller, Christian Neubert, Cläre von Neubeck, Michael Baumann, Mechthild Krause, Wolfgang Enghardt, Rebecca Bütof, Antje Dietrich & Armin Lühr. (2017) Proton radiography for inline treatment planning and positioning verification of small animals. Acta Oncologica 56:11, pages 1399-1405.
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Niklas Finnberg, Chris Wambi, Ann Kennedy & Wafik S. El-Deiry. (2013) The effects of antioxidants on gene expression following gamma-radiation (GR) and proton radiation (PR) in mice in vivo. Cell Cycle 12:14, pages 2241-2247.
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Shubhankar Suman, Igor Shuryak, Bhaskar Kallakury, David J. Brenner, Albert J. FornaceJr.Jr., Michael D. Johnson & Kamal Datta. (2020) Protons Show Greater Relative Biological Effectiveness for Mammary Tumorigenesis with Higher ERα- and HER2-Positive Tumors Relative to γ-rays in APCMin/+ Mice. International Journal of Radiation Oncology*Biology*Physics 107:1, pages 202-211.
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Yoko Hirabayashi. (2014) Radiation-induced, cell cycle-related gene expression in aging hematopoietic stem cells: enigma of their recovery. Annals of the New York Academy of Sciences 1310:1, pages 69-73.
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Jonathan D. Grant & Joe Y. Chang. (2014) Proton-Based Stereotactic Ablative Radiotherapy in Early-Stage Non-Small-Cell Lung Cancer. BioMed Research International 2014, pages 1-7.
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Swati Girdhani, Rainer Sachs & Lynn Hlatky. (2013) Biological Effects of Proton Radiation: What We Know and Don't Know. Radiation Research 179:3, pages 257-272.
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Yoko Hirabayashi & Tohru Inoue. 2012. Toxicology and Epigenetics. Toxicology and Epigenetics 475 510 .
Swati Girdhani, Clare Lamont, Philip Hahnfeldt, Amir Abdollahi & Lynn Hlatky. (2012) Proton Irradiation Suppresses Angiogenic Genes and Impairs Cell Invasion and Tumor Growth. Radiation Research 178:1, pages 33.
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A.R. Kennedy & X.S. Wan. (2011) Countermeasures for space radiation induced adverse biologic effects. Advances in Space Research 48:9, pages 1460-1479.
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Mitsuko L. Yamamoto, Kurt Hafer, Ramune Reliene, Sheila Fleming, Owen Kelly, Katrin Hacke & Robert H. Schiestl. (2011) Effects of 1 GeV/nucleon 56 Fe Particles on Longevity, Carcinogenesis and Neuromotor Ability in Atm -Deficient Mice . Radiation Research 175:2, pages 231-239.
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