Citations (65)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (2)
Yizeng Yang & Jonathan P. Katz. (2016) KLF4 is downregulated but not mutated during human esophageal squamous cell carcinogenesis and has tumor stage-specific functions. Cancer Biology & Therapy 17:4, pages 422-429.
Read now
Read now
NichelleC. Whitlock & Seung
Joon Baek. (2012) The Anticancer Effects of Resveratrol: Modulation of Transcription Factors. Nutrition and Cancer 64:4, pages 493-502.
Read now
Read now
Articles from other publishers (63)
Xiaoming Zhang, Weijia Wang, Chunlei Lu & Haifeng Zhang. (2023) KLF4 suppresses the proliferation of perihilar cholangiocarcinoma by negatively regulating GDF15 and phosphorylating AKT. Oncology Reports 50:6.
Crossref
Crossref
Zhihong He, Jie He & Keping Xie. (2023) KLF4 transcription factor in tumorigenesis. Cell Death Discovery 9:1.
Crossref
Crossref
Tingzeng Wang, Okkyung Rho, Fernando Eguiarte‐Solomon & John DiGiovanni. (2022) Twist1 as a target for prevention of cutaneous squamous cell carcinoma. Molecular Carcinogenesis 62:1, pages 62-76.
Crossref
Crossref
Nader Salari, Shabnam Rasoulpoor, Shna Rasoulpoor, Kamran Mansouri, Shamarina Shohaimi & Masoud Mohammadi. (2022) The Role of Krüppel-like Factor 4 (KLF4) Gene in Breast Cancer Tissue Samples: A Systematic Review and Meta-analysis. Indian Journal of Gynecologic Oncology 20:1.
Crossref
Crossref
Shuo Yang, Ting FengHong Li. (2021)
KLF5
, a Novel Therapeutic Target in Squamous Cell Carcinoma
. DNA and Cell Biology 40:12, pages 1503-1512.
Crossref
Crossref
Patrick M. Mulvaney, Paul R. Massey, Kenneth K. Yu, Jack E. Drinan & Chryslayne D. Schmults. (2021) Differential Molecular Expression Patterns Associated with Metastasis in Cutaneous Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. Journal of Investigative Dermatology 141:9, pages 2161-2169.
Crossref
Crossref
María Luisa Paparella, Dario Martin Ferri, Krissya María Villegas & Ana Rosa Raimondi. (2021) Quantitative analysis of KLF4 and SOX2 expression in oral carcinomas reveals independent association with oral tongue subsite location and histological grade. Cancer Biomarkers 32:1, pages 37-48.
Crossref
Crossref
Shweta Arora, Prithvi Singh, Shaniya Ahmad, Tanveer Ahmad, Ravins Dohare, Saleh A. Almatroodi, Faris Alrumaihi, Arshad Husain Rahmani & Mansoor Ali Syed. (2021) Comprehensive Integrative Analysis Reveals the Association of KLF4 with Macrophage Infiltration and Polarization in Lung Cancer Microenvironment. Cells 10:8, pages 2091.
Crossref
Crossref
Amelia J. Hodges, Nicholas O. Hudson & Bethany A. Buck-Koehntop. (2020) Cys2His2 Zinc Finger Methyl-CpG Binding Proteins: Getting a Handle on Methylated DNA. Journal of Molecular Biology 432:6, pages 1640-1660.
Crossref
Crossref
Maria Tsompana, Christian Gluck, Isha Sethi, Ishita Joshi, Jonathan Bard, Norma J. Nowak, Satrajit Sinha & Michael J. Buck. (2019) Reactivation of super-enhancers by KLF4 in human Head and Neck Squamous Cell Carcinoma. Oncogene 39:2, pages 262-277.
Crossref
Crossref
Elizabeth K. EadyHelen D. BraschJennifer de JonghReginald W. MarshSwee T. TanTinte Itinteang. (2019) Expression of Embryonic Stem Cell Markers in Microcystic Lymphatic Malformation. Lymphatic Research and Biology 17:5, pages 496-503.
Crossref
Crossref
Sabrina P. Koh, Helen D. Brasch, Jennifer de Jongh, Tinte Itinteang & Swee T. Tan. (2019) Cancer stem cell subpopulations in moderately differentiated head and neck cutaneous squamous cell carcinoma. Heliyon 5:8, pages e02257.
Crossref
Crossref
Niaz Mahmood & Shafaat A. Rabbani. (2019) DNA Methylation Readers and Cancer: Mechanistic and Therapeutic Applications. Frontiers in Oncology 9.
Crossref
Crossref
Xiangyuan Chen, Xiaowei Ding, Qichao Wu, Jie Qi, Minmin Zhu & Changhong Miao. (2019) Monomethyltransferase SET8 facilitates hepatocellular carcinoma growth by enhancing aerobic glycolysis. Cell Death & Disease 10:4.
Crossref
Crossref
Yong Cui, Guanlong Li, Xin Zhang, Fangfang Dai & Rongxiang Zhang. (2018) Increased MALAT1 expression contributes to cisplatin resistance in non‑small cell lung cancer. Oncology Letters.
Crossref
Crossref
Yunlu Jia, Xiaogang Ying, Jichun Zhou, Yongxia Chen, Xiao Luo, Shudu Xie, Qin chuan Wang, Wenxian Hu & Linbo Wang. (2018) The novel KLF4/PLAC8 signaling pathway regulates lung cancer growth. Cell Death & Disease 9:6.
Crossref
Crossref
Qinqin Zhou, Dejun Fan, Kejun Huang, Xiuting Chen, Yufeng Chen & Qingyun Mai. (2018) Activation of KLF4 expression by small activating RNA promotes migration and invasion in colorectal epithelial cells. Cell Biology International 42:4, pages 495-503.
Crossref
Crossref
Xiaoli Ding, Tianyu Zhong, Lixia Jiang, Junyun Huang, Yu Xia & Rong Hu. (2018) miR-25 enhances cell migration and invasion in non-small-cell lung cancer cells via ERK signaling pathway by inhibiting KLF4. Molecular Medicine Reports.
Crossref
Crossref
Mingyue Liu, Xiqing Li, Ke-Zheng Peng, Tianhui Gao, Yao Cui, Ning Ma, Yun Zhou & Guiqin Hou. (2018) Subcellular localization of Klf4 in non-small cell lung cancer and its clinical significance. Biomedicine & Pharmacotherapy 99, pages 480-485.
Crossref
Crossref
Bede van Schaijik, Paul F Davis, Agadha C Wickremesekera, Swee T Tan & Tinte Itinteang. (2018) Subcellular localisation of the stem cell markers OCT4, SOX2, NANOG, KLF4 and c-MYC in cancer: a review. Journal of Clinical Pathology 71:1, pages 88-91.
Crossref
Crossref
Undraga Schagdarsurengin, Angela Lammert, Natalie Schunk, Diana Sheridan, Stefan Gattenloehner, Klaus Steger, Florian Wagenlehner & Temuujin Dansranjavin. (2017) Impairment of IGF2 gene expression in prostate cancer is triggered by epigenetic dysregulation of IGF2-DMR0 and its interaction with KLF4. Cell Communication and Signaling 15:1.
Crossref
Crossref
Xiqing Li, Zhunlan Zhao, Xiaoling Zhang, Sheng Yang, Xia Lin, Xinglong Yang, Xiaolin Lin, Junwen Shi, Shengchun Wang, Wentao Zhao, Jing Li, Fei Gao, Mingyue Liu, Ning Ma, Weiren Luo, Kaitai Yao, Yan Sun, Shengjun Xiao, Dong Xiao & Junshuang Jia. (2017) Klf4 reduces stemness phenotype, triggers mesenchymal-epithelial transition (MET)-like molecular changes, and prevents tumor progression in nasopharygeal carcinoma. Oncotarget 8:55, pages 93924-93941.
Crossref
Crossref
Amr M. Ghaleb & Vincent W. Yang. (2017) Krüppel-like factor 4 (KLF4): What we currently know. Gene 611, pages 27-37.
Crossref
Crossref
Xiang Song, Yue‑Ming Xing, Wei Wu, Guo‑Hua Cheng, Feng Xiao, Gang Jin, Ying Liu & Xin Zhao. (2017) Expression of Kr�ppel‑like factor 4 in breast cancer tissues and its effects on the proliferation of breast cancer MDA‑MB‑231 cells. Experimental and Therapeutic Medicine.
Crossref
Crossref
Wei-Cheng Tseng, Cheng-Wei Chuang, Muh-Hwa Yang, Chin-Chen Pan & Der-Cherng Tarng. (2016) Krüppel-like factor 4 is a novel prognostic predictor for urothelial carcinoma of bladder and it regulates TWIST1-mediated epithelial-mesenchymal transition. Urologic Oncology: Seminars and Original Investigations 34:11, pages 485.e15-485.e24.
Crossref
Crossref
Xiong XiaoNan LiDapeng ZhangBo YangHongmei GuoYuemin Li. (2016) Generation of Induced Pluripotent Stem Cells with Substitutes for Yamanaka's Four Transcription Factors. Cellular Reprogramming 18:5, pages 281-297.
Crossref
Crossref
Wenxian Hu, Yunlu Jia, Xiangsheng Xiao, Kezhen Lv, Yongxia Chen, Linbo Wang, Xiao Luo, Tianze Liu, Wenbin Li, Yixin Li, Changlin Zhang, Zhenglong Yu, Wenlin Huang, Bing Sun & Wu-guo Deng. (2016) KLF4 downregulates hTERT expression and telomerase activity to inhibit lung carcinoma growth. Oncotarget 7:33, pages 52870-52887.
Crossref
Crossref
Marie Fadous‑Khalif�, Nijez Aloulou, Majida Jalbout, Joseph Hadchity, Georges Aftimos, Fran�ois Paris & Elie Hadchity. (2016) Kr�ppel-like factor 4: A new potential biomarker of lung cancer. Molecular and Clinical Oncology.
Crossref
Crossref
Hongcheng Sun, Huamei Tang, Dacheng Xie, Zhiliang Jia, Zhenyu Ma, Daoyan Wei, Lopa Mishra, Yong Gao, Shaojiang Zheng, Keping Xie & Zhihai Peng. (2016) Krüppel-like Factor 4 Blocks Hepatocellular Carcinoma Dedifferentiation and Progression through Activation of Hepatocyte Nuclear Factor-6. Clinical Cancer Research 22:2, pages 502-512.
Crossref
Crossref
Tomomi Yoda, Keely May McNamara, Yasuhiro Miki, Yoshiaki Onodera, Kiyoshi Takagi, Yasuhiro Nakamura, Takanori Ishida, Takashi Suzuki, Noriaki Ohuchi & Hironobu Sasano. (2015) KLF15 in breast cancer: a novel tumor suppressor?. Cellular Oncology 38:3, pages 227-235.
Crossref
Crossref
Alberto Martin, Fernando Salvador, Gema Moreno‐Bueno, Alfredo Floristán, Cristina Ruiz‐Herguido, Eva P Cuevas, Saleta Morales, Vanesa Santos, Katalin Csiszar, Pierre Dubus, Jody J Haigh, Anna Bigas, Francisco Portillo & Amparo Cano. (2015) Lysyl oxidase‐like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression. The EMBO Journal 34:8, pages 1090-1109.
Crossref
Crossref
Yuqing He, Kang Zeng, Xibao Zhang, Qiaolin Chen, Jiang Wu, Hong Li, Yong Zhou, Gustavo Glusman, Jared Roach, Alton Etheridge, Shizhen Qing, Qiang Tian, Inyoul Lee, Xin Tian, Xiaoning Wang, Zhihua Wu, Leroy Hood, Yuanlin Ding & Kai Wang. (2015) A Gain-of-Function Mutation in TRPV3 Causes Focal Palmoplantar Keratoderma in a Chinese Family. Journal of Investigative Dermatology 135:3, pages 907-909.
Crossref
Crossref
Ning Wang, Zhi-Wen Xu & Kun-Hao Wang. (2015) Systematical Analysis of Cutaneous Squamous Cell Carcinoma Network of microRNAs, Transcription Factors, and Target and Host Genes. Asian Pacific Journal of Cancer Prevention 15:23, pages 10355-10361.
Crossref
Crossref
Y Huang, J Chen, C Lu, J Han, G Wang, C Song, S Zhu, C Wang, G Li, J Kang & J Wang. (2014) HDAC1 and Klf4 interplay critically regulates human myeloid leukemia cell proliferation. Cell Death & Disease 5:10, pages e1491-e1491.
Crossref
Crossref
Yu-Tang Tung, Tung-Chou Tsai, Yueh-Hsiung Kuo, Chih-Ching Yen, Jheng-Yue Sun, Wen-Hui Chang, Hsiao-Ling Chen & Chuan-Mu Chen. (2014) Comparison of solid-state-cultured and wood-cultured Antrodia camphorata in anti-inflammatory effects using NF-κB/luciferase inducible transgenic mice. Phytomedicine 21:12, pages 1708-1716.
Crossref
Crossref
H-L Chen, Y-T Tung, C-L Tsai, C-W Lai, Z-L Lai, H-C Tsai, Y-L Lin, C-H Wang & C-M Chen. (2013) Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice. International Journal of Obesity 38:9, pages 1172-1179.
Crossref
Crossref
José Manuel Naranjo GómezJose Fernando Val BernalPilar García ArranzServando Lazuén FernándezJose Javier Gómez Roman. (2014) Alterations in the Expression of p53, KLF4, and p21 in Neuroendocrine Lung Tumors. Archives of Pathology & Laboratory Medicine 138:7, pages 936-942.
Crossref
Crossref
Hui-Ting Hsu, Pei-Ru Wu, Chih-Jung Chen, Li-Sung Hsu, Chung-Min Yeh, Ming-Tai Hsing, Yi-Shan Chiang, Ming-Tsung Lai & Kun-Tu Yeh. (2014) High Cytoplasmic Expression of Krüppel-like Factor 4 Is an Independent Prognostic Factor of Better Survival in Hepatocellular Carcinoma. International Journal of Molecular Sciences 15:6, pages 9894-9906.
Crossref
Crossref
Agata M. Wasik, Jerzy Grabarek, Aleksandar Pantovic, Artur Cieślar-Pobuda, Hamid R. Asgari, Caspar Bundgaard-Nielsen, Mehrdad Rafat, Ian M.C. Dixon, Saeid Ghavami & Marek J. Łos. 2014.
167
203
.
Hsu-Chung Liu, Shun-Yuan Pai, Winston TK Cheng, Hsiao-Ling Chen, Tung-Chou Tsai, Shang-Hsun Yang & Chuan-Mu Chen. (2013) Ingestion of milk containing the Dp2 peptide, a dust mite allergen, protects mice from allergic airway inflammation and hyper-responsiveness. Allergy, Asthma & Clinical Immunology 9:1.
Crossref
Crossref
Li-Sung Hsu, Chien-Pin Chan, Chih-Jung Chen, Shu-Hui Lin, Ming-Tsung Lai, Jeng-Dong Hsu, Kun-Tu Yeh & Maw-Soan Soon. (2013) Decreased Kruppel-like factor 4 (KLF4) expression may correlate with poor survival in gastric adenocarcinoma. Medical Oncology 30:4.
Crossref
Crossref
Chih-Jie ShenChiao-Chieh LinPerng-Chih ShenWinston T.K. ChengHsiao-Ling ChenTsung-Chou ChangShyh-Shyan LiuChuan-Mu Chen. (2013) Imprinted Genes and Satellite Loci Are Differentially Methylated in Bovine Somatic Cell Nuclear Transfer Clones. Cellular Reprogramming 15:5, pages 413-424.
Crossref
Crossref
Erlin Song, Xin Ma, Hongzhao Li, Peng Zhang, Dong Ni, Weihao Chen, Yu Gao, Yang Fan, Haigang Pang, Taoping Shi, Qiang Ding, Baojun Wang, Yu Zhang & Xu Zhang. (2013) Attenuation of Krüppel-Like Factor 4 Facilitates Carcinogenesis by Inducing G1/S Phase Arrest in Clear Cell Renal Cell Carcinoma. PLoS ONE 8:7, pages e67758.
Crossref
Crossref
Xiaoping Guo & Yongmin Tang. (2012) KLF4 translation level is associated with differentiation stage of different pediatric leukemias in both cell lines and primary samples. Clinical and Experimental Medicine 13:2, pages 99-107.
Crossref
Crossref
XIN YIN, YI-WEI LI, JIAN-JUN JIN, YIN ZHOU, ZHENG-GANG REN, SHUANG-JIAN QIU & BO-HENG ZHANG. (2013) The clinical and prognostic implications of pluripotent stem cell gene expression in hepatocellular carcinoma. Oncology Letters 5:4, pages 1155-1162.
Crossref
Crossref
Yu-Tang Tung, Hsiao-Ling Chen, Chih-Ching Yen, Po-Ying Lee, Hsin-Chung Tsai, Ming-Fong Lin & Chuan-Mu Chen. (2013) Bovine lactoferrin inhibits lung cancer growth through suppression of both inflammation and expression of vascular endothelial growth factor. Journal of Dairy Science 96:4, pages 2095-2106.
Crossref
Crossref
Clémentine Le Magnen, Lukas Bubendorf, Christian Ruiz, Inti Zlobec, Alexander Bachmann, Michael Heberer, Giulio C. Spagnoli, Stephen Wyler & Chantal Mengus. (2013) Klf4 transcription factor is expressed in the cytoplasm of prostate cancer cells. European Journal of Cancer 49:4, pages 955-963.
Crossref
Crossref
Shu-Yi Yang, Hui-Min Wang, Tai-Wen Wu, Yi-Ju Chen, Jeng-Jer Shieh, Ju-Hwa Lin, Tsing-Fen Ho, Ren-Jie Luo, Chung-Yi Chen & Chia-Che Chang. (2013)
Subamolide B Isolated from Medicinal Plant
Cinnamomum subavenium
Induces Cytotoxicity in Human Cutaneous Squamous Cell Carcinoma Cells through Mitochondrial and CHOP-Dependent Cell Death Pathways
. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-13.
Crossref
Crossref
Yu-Tang Tung, Hsiao-Ling Chen, Hsin-Chung Tsai, Shang-Hsun Yang, Yi-Chun Chang & Chuan-Mu Chen. (2013)
Therapeutic Potential of Andrographolide Isolated from the Leaves of
Andrographis paniculata
Nees for Treating Lung Adenocarcinomas
. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-8.
Crossref
Crossref
Jiun-Yu Chen, Hsiao-Ling Chen, Ju-Chien Cheng, Hung-Jen Lin, Yu-Tang Tung, Chia-Fan Lin & Chuan-Mu Chen. (2012) A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation. Journal of Ethnopharmacology 142:3, pages 811-818.
Crossref
Crossref
Chih-Jung Chen, Li-Sung Hsu, Shu-Hui Lin, Mu-Kuan Chen, Hsin-Kai Wang, Jeng-Dong Hsu, Huei Lee & Kun-Tu Yeh. (2012) Loss of nuclear expression of Krüppel-like factor 4 is associated with poor prognosis in patients with oral cancer. Human Pathology 43:7, pages 1119-1125.
Crossref
Crossref
Juan Li, Hai Zheng, Junfeng Wang, Fang Yu, Rebecca J. Morris, Timothy C. Wang, Shiang Huang & Walden Ai. (2012) Expression of Kruppel-Like Factor KLF4 in Mouse Hair Follicle Stem Cells Contributes to Cutaneous Wound Healing. PLoS ONE 7:6, pages e39663.
Crossref
Crossref
Yu-Tang Tung, Hsiao-Ling Chen, Cheng-Wei Lai, Chih-Jie Shen, Yi-Wen Lai & Chuan-Mu Chen. (2011) Curcumin reduces pulmonary tumorigenesis in vascular endothelial growth factor (VEGF)-overexpressing transgenic mice. Molecular Nutrition & Food Research 55:7, pages 1036-1043.
Crossref
Crossref
Shyh-Kuan Tai, Muh-Hwa Yang, Shyue-Yih Chang, Yung-Chi Chang, Wing-Yin Li, Tung-Lung Tsai, Yi-Fen Wang, Pen-Yuan Chu & Shie-Liang Hsieh. (2011) Persistent Krüppel-like factor 4 expression predicts progression and poor prognosis of head and neck squamous cell carcinoma. Cancer Science 102:4, pages 895-902.
Crossref
Crossref
Woo Jin Choi, Sung Hwan Youn, Jung Ho Back, Saebomi Park, Eun Joo Park, Kwang Joong Kim, Hye Rim Park, Arianna L. Kim & Kwang Ho Kim. (2010) The role of KLF4 in UVB-induced murine skin tumor development and its correlation with cyclin D1, p53, and p21Waf1/Cip1 in epithelial tumors of the human skin. Archives of Dermatological Research 303:3, pages 191-200.
Crossref
Crossref
N Cordani, S Pozzi, E Martynova, D Fanoni, S Borrelli, D Alotto, C Castagnoli, E Berti, M A Viganò & R Mantovani. (2010) Mutant p53 subverts p63 control over KLF4 expression in keratinocytes. Oncogene 30:8, pages 922-932.
Crossref
Crossref
Nichelle C. Whitlock, Jae Hoon Bahn, Seong-Ho Lee, Thomas E. Eling & Seung Joon Baek. (2011) Resveratrol-Induced Apoptosis Is Mediated by Early Growth Response-1, Krüppel-Like Factor 4, and Activating Transcription Factor 3. Cancer Prevention Research 4:1, pages 116-127.
Crossref
Crossref
Nobuyuki Ehira, Hiroyuki Oshiumi, Misako Matsumoto, Takeshi Kondo, Masahiro Asaka & Tsukasa Seya. (2010) An embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma. Journal of Experimental & Clinical Cancer Research 29:1.
Crossref
Crossref
Beth B. McConnell & Vincent W. Yang. (2010) Mammalian Krüppel-Like Factors in Health and Diseases. Physiological Reviews 90:4, pages 1337-1381.
Crossref
Crossref
Che-Ming Hung, Shinn-Chih Wu, Chih-Ching Yen, Ming-Fong Lin, Yi-Wen Lai, Yu-Tang Tung, Hsiao-Ling Chen & Chuan-Mu Chen. (2010) Porcine lactoferrin as feedstuff additive elevates avian immunity and potentiates vaccination. BioMetals 23:3, pages 579-587.
Crossref
Crossref
Che-Ming Hung, Chia-Chou Yeh, Hsiao-Ling Chen, Cheng-Wei Lai, Meng-Fu Kuo, Ming-Hsien Yeh, Willie Lin, Ming-Yu Tu, Hsu-Chen Cheng & Chuan-Mu Chen. (2010) Porcine lactoferrin administration enhances peripheral lymphocyte proliferation and assists infectious bursal disease vaccination in native chickens. Vaccine 28:16, pages 2895-2902.
Crossref
Crossref
Marie-Pier Tétreault & Jonathan P. Katz. 2009. The Biology of Krüppel-like Factors. The Biology of Krüppel-like Factors
107
119
.
Vincent W. Yang. 2009. The Biology of Krüppel-like Factors. The Biology of Krüppel-like Factors
205
219
.