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Research Paper

Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo

Pages 1418-1426 | Published online: 01 Sep 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

Jane Huang, Wayne Fairbrother & John C Reed. (2015) Therapeutic targeting of Bcl-2 family for treatment of B-cell malignancies. Expert Review of Hematology 8:3, pages 283-297.
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Shadia Zaman, Rui Wang & Varsha Gandhi. (2014) Targeting the apoptosis pathway in hematologic malignancies. Leukemia & Lymphoma 55:9, pages 1980-1992.
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Kumudha Balakrishnan, Sumesh Aggarwal, William Wierda & Varsha Gandhi. (2013) Bax and Bak are required for apogossypolone, a BH3-mimetic, induced apoptosis in chronic lymphocytic leukemia cells. Leukemia & Lymphoma 54:5, pages 1097-1100.
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Qiang Liu & Hong-Gang Wang. (2012) Anti-cancer drug discovery and development. Communicative & Integrative Biology 5:6, pages 557-565.
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Naval Bajwa, Chenzhong Liao & Zaneta Nikolovska-Coleska. (2012) Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review. Expert Opinion on Therapeutic Patents 22:1, pages 37-55.
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Articles from other publishers (27)

Abdul Shukkur Ebrahim, Mustapha Kandouz, Allison Liddane, Hussam Sabbagh, Yuning Hou, Chunying Li & Ayad Al-Katib. (2016) PNT2258, a novel deoxyribonucleic acid inhibitor, induces cell cycle arrest and apoptosis via a distinct mechanism of action: a new class of drug for non-Hodgkin's lymphoma. Oncotarget 7:27, pages 42374-42384.
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Yuling Li, Jinfeng Qu, Lu Liu, Yu Sun, Junhua Zhang, Sai Han & Youzhong Zhang. (2022) Apogossypolone Inhibits Cell Proliferation and Epithelial-Mesenchymal Transition in Cervical Cancer via Activating DKK3. Frontiers in Oncology 12.
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Clemente Batista Soares Neto, Aparecido Almeida Conceição, Taísa Godoy Gomes, Jose Antonio de Aquino Ribeiro, Raquel Bombarda Campanha, Paulo Augusto Vianna Barroso, Antony Enis Virginio Machado, Simone Mendonça, Felix Gonçalves De Siqueira & Robert Neil Gerard Miller. (2020) A Comparison of Physical, Chemical, Biological and Combined Treatments for Detoxification of Free Gossypol in Crushed Whole Cottonseed. Waste and Biomass Valorization 12:7, pages 3965-3975.
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Mei Lan Tan, Shahrul Bariyah Sahul Hamid, Muhammad Asyraf Abduraman & Heng Kean Tan. 2020. Cancer Immunology. Cancer Immunology 307 353 .
Aarti Anantram & Mariam Degani. (2019) Targeting cancer's Achilles’ heel: role of BCL-2 inhibitors in cellular senescence and apoptosis. Future Medicinal Chemistry 11:17, pages 2287-2312.
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Shu Yang, Yujia Mao, Huijun Zhang, Yan Xu, Jing An & Ziwei Huang. (2019) The chemical biology of apoptosis: Revisited after 17 years. European Journal of Medicinal Chemistry 177, pages 63-75.
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Jana Mihalyova, Tomas Jelinek, Katerina Growkova, Matous Hrdinka, Michal Simicek & Roman Hajek. (2018) Venetoclax: A new wave in hematooncology. Experimental Hematology 61, pages 10-25.
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Alma Abou Samra, Aude Robert, Crystal Gov, Loëtitia Favre, Laure Eloy, Eric Jacquet, Jérôme Bignon, Joëlle Wiels, Sandy Desrat & Fanny Roussi. (2018) Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A. European Journal of Medicinal Chemistry 148, pages 26-38.
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Yuzhi Lu, Jun Li, Chun-E Dong, Jian Huang, Hai-Bing Zhou & Wei Wang. (2017) Recent advances in gossypol derivatives and analogs: a chemistry and biology view. Future Medicinal Chemistry 9:11, pages 1243-1275.
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Jeremy L. Yap, Lijia Chen, Maryanna E. Lanning & Steven Fletcher. (2016) Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules. Journal of Medicinal Chemistry 60:3, pages 821-838.
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Mark P.A. Luna-Vargas & Jerry Edward Chipuk. (2016) Physiological and Pharmacological Control of BAK, BAX, and Beyond. Trends in Cell Biology 26:12, pages 906-917.
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TIANXIAO LI, GANG YUAN, LIN ZHANG, LIJUN YE, SHUXIA LI, YUHUA FAN & JIAN SUN. (2015) ApoG2 inhibits the antiapoptotic protein, Mcl-1, and induces mitochondria-dependent apoptosis in human colorectal cancer cells. Molecular Medicine Reports 12:5, pages 6976-6984.
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Laura Vela & Isabel Marzo. (2015) Bcl-2 family of proteins as drug targets for cancer chemotherapy: the long way of BH3 mimetics from bench to bedside. Current Opinion in Pharmacology 23, pages 74-81.
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Ke Li, Hao Liu, Wei Gao, Mu Chen, Yun Zeng, Jiajun Liu, Liang Xu & Daocheng Wu. (2015) Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. Biomaterials 39, pages 131-144.
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Mei Lan Tan, Heng Kean Tan & Tengku Sifzizul Tengku Muhammad. 2015. Cancer Immunology. Cancer Immunology 209 242 .
Kumudha Balakrishnan & Varsha Gandhi. (2013) Bcl-2 antagonists: a proof of concept for CLL therapy. Investigational New Drugs 31:5, pages 1384-1394.
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Jing Xin, Yonghua Zhan, Muhan Liu, Hao Hu, Limin Xia, Yongzhan Nie, Kaichun Wu, Jimin Liang & Jie Tian. (2013) ApoG2 induces ER stress-dependent apoptosis in gastric cancer cells in vitro and its real-time evaluation by bioluminescence imaging in vivo. Cancer Letters 336:2, pages 260-269.
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P Cheng, Z Ni, X Dai, B Wang, W Ding, A Rae Smith, L Xu, D Wu, F He & J Lian. (2013) The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma cells. Cell Death & Disease 4:2, pages e489-e489.
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J. Xin, Y.H. Zhan, L.M. Xia, H.W. Zhu, Y.Z. Nie, J.M. Liang & J. Tian. (2013) ApoG2 as the most potent gossypol derivatives inhibits cell growth and induces apoptosis on gastric cancer cells. Biomedicine & Pharmacotherapy 67:1, pages 88-95.
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Victor Y. Yazbeck & Daniel E. Johnson. 2013. Cell Death Signaling in Cancer Biology and Treatment. Cell Death Signaling in Cancer Biology and Treatment 231 253 .
Hongxia Lin, Murugesan K. Gounder, Joseph R. Bertino, Ah-Ng Tony Kong, Robert S. DiPaola & Mark N. Stein. (2012) A validated HPLC assay for the determination of R-(−)-gossypol in human plasma and its application in clinical pharmacokinetic studies. Journal of Pharmaceutical and Biomedical Analysis 66, pages 371-375.
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Ashiq Masood, Asfar S. Azmi & Ramzi M. Mohammad. (2011) Small Molecule Inhibitors of Bcl-2 Family Proteins for Pancreatic Cancer Therapy. Cancers 3:2, pages 1527-1549.
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V Pavet, M M Portal, J C Moulin, R Herbrecht & H Gronemeyer. (2010) Towards novel paradigms for cancer therapy. Oncogene 30:1, pages 1-20.
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Sophie Dupire & Bertrand Coiffier. (2010) Targeted treatment and new agents in diffuse large B cell lymphoma. International Journal of Hematology 92:1, pages 12-24.
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Zhang Xianqing, Huang Xiaofeng, Mu Shijie, Chen Rui, An Qunxing, Xia Aijun & Wu Daocheng. (2009) Inhibitory effect of a new gossypol derivative apogossypolone (ApoG2) on xenograft of human prostate cancer cell line PC-3. Journal of Medical Colleges of PLA 24:5, pages 274-282.
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G. Basini, S. Bussolati, L. Baioni & F. Grasselli. (2009) Gossypol, a polyphenolic aldehyde from cotton plant, interferes with swine granulosa cell function. Domestic Animal Endocrinology 37:1, pages 30-36.
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Mei Lan Tan, Jer Ping Ooi, Nawfal Ismail, Ahmed Ismail Hassan Moad & Tengku Sifzizul Tengku Muhammad. (2009) Programmed Cell Death Pathways and Current Antitumor Targets. Pharmaceutical Research 26:7, pages 1547-1560.
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