928
Views
65
CrossRef citations to date
0
Altmetric
Research Paper

ADAM17 promotes breast cancer cell malignant phenotype through EGFR-PI3K-AKT activation

Pages 1045-1054 | Published online: 01 Jun 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Monika Gooz. (2010) ADAM-17: the enzyme that does it all. Critical Reviews in Biochemistry and Molecular Biology 45:2, pages 146-169.
Read now
Francis Robert & Jerry Pelletier. (2009) Translation initiation: a critical signalling node in cancer. Expert Opinion on Therapeutic Targets 13:11, pages 1279-1293.
Read now

Articles from other publishers (62)

Dong Hoon Shin, Jeong Yeon Jo, Minyoung Choi, Kyung-Hee Kim, Young-Ki Bae & Sang Soo Kim. (2023) Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer. Experimental & Molecular Medicine 55:10, pages 2220-2237.
Crossref
Yi Jin & Daqing Jiang. (2023) GATA6-AS1 via Sponging miR-543 to Regulate PTEN/AKT Signaling Axis Suppresses Cell Proliferation and Migration in Gastric Cancer. Mediators of Inflammation 2023, pages 1-19.
Crossref
Dario Van Meenen, Annika Doege, Emily Alefeld, André Haase, Manfred Beier, Tobias Kiefer, Eva Biewald, Klaus Metz, Oliver Dräger, Maike Anna Busch & Nicole Dünker. (2022) ADAM10 and ADAM17—Novel Players in Retinoblastoma Carcinogenesis. International Journal of Molecular Sciences 23:20, pages 12621.
Crossref
Ning Wang, Ying Yu, Rongjiang Wang, Yu Chen & Jianer Tang. (2022) mRNA-Modified FUS/NRF2 Signalling Inhibits Ferroptosis and Promotes Prostate Cancer Growth. Computational and Mathematical Methods in Medicine 2022, pages 1-11.
Crossref
Guoqin Zhu, Jie Liu, Yuan Wang, Naixin Jia, Weiyi Wang, Junhui Zhang, Yi Liang, Hao Tian & Jiaping Zhang. (2021) ADAM17 Mediates Hypoxia-Induced Keratinocyte Migration via the p38/MAPK Pathway. BioMed Research International 2021, pages 1-11.
Crossref
Yanjun Zhou, Jonas S. Heitmann, Korbinian N. Kropp, Martina Hinterleitner, André Koch, Andreas D. Hartkopf, Helmut R. Salih, Clemens Hinterleitner & Stefanie Maurer. (2021) Regulation of Platelet-Derived ADAM17: A Biomarker Approach for Breast Cancer?. Diagnostics 11:7, pages 1188.
Crossref
Guang Yang, Mengying Cui, Weibo Jiang, Jiyao Sheng, Yongsheng Yang & Xuewen Zhang. (2021) Molecular switch in human diseases-disintegrin and metalloproteinases, ADAM17. Aging 13:12, pages 16859-16872.
Crossref
Debasmita Mukhopadhyay, Nour AlSawaftah & Ghaleb A. Husseini. (2020) Identification of Novel MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating the EGFR-ADAM17 Axis: An In Silico Analysis . ACS Pharmacology & Translational Science 4:1, pages 396-399.
Crossref
Behrad Darvishi, Saeedeh Boroumandieh, Keivan Majidzadeh-A, Malihe Salehi, Fereshteh Jafari & Leila Farahmand. (2020) The role of activated leukocyte cell adhesion molecule (ALCAM) in cancer progression, invasion, metastasis and recurrence: A novel cancer stem cell marker and tumor-specific prognostic marker. Experimental and Molecular Pathology 115, pages 104443.
Crossref
Mohamed I Saad, Louise McLeod, Liang Yu, Hiromichi Ebi, Saleela Ruwanpura, Irit Sagi, Stefan Rose-John & Brendan J Jenkins. (2020) The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis. Carcinogenesis 41:4, pages 527-538.
Crossref
Yuduo Guo, Xin He, Mingshan Zhang, Yanming Qu, Chunyu Gu, Ming Ren, Haoran Wang, Weihai Ning, Junfa Li, Chunjiang Yu & Hongwei Zhang. (2020) Reciprocal control of ADAM17/EGFR/Akt signaling and miR-145 drives GBM invasiveness. Journal of Neuro-Oncology 147:2, pages 327-337.
Crossref
Victoria H. Wu & J. Silvio Gutkind. 2020. Improving the Therapeutic Ratio in Head and Neck Cancer. Improving the Therapeutic Ratio in Head and Neck Cancer 317 334 .
Michael P. Menden, Dennis Wang, Mike J. Mason, Bence Szalai, Krishna C. Bulusu, Yuanfang Guan, Thomas Yu, Jaewoo Kang, Minji Jeon, Russ Wolfinger, Tin Nguyen, Mikhail Zaslavskiy, In Sock Jang, Zara Ghazoui, Mehmet Eren Ahsen, Robert Vogel, Elias Chaibub Neto, Thea Norman, Eric K. Y. Tang, Mathew J. Garnett, Giovanni Y. Di Veroli, Stephen Fawell, Gustavo Stolovitzky, Justin Guinney, Jonathan R. Dry & Julio Saez-Rodriguez. (2019) Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen. Nature Communications 10:1.
Crossref
Jiawei Chen, Chongxian Hou, Zongtai Zheng, Han Lin, Guangzhao Lv & Dong Zhou. (2019) Identification of Secreted Phosphoprotein 1 (SPP1) as a Prognostic Factor in Lower-Grade Gliomas. World Neurosurgery 130, pages e775-e785.
Crossref
Saad, Rose-John & Jenkins. (2019) ADAM17: An Emerging Therapeutic Target for Lung Cancer. Cancers 11:9, pages 1218.
Crossref
Bao-Juan Zhang & Chang-Xiu Yuan. (2019) Effects of ADAM2 silencing on isoflurane-induced cognitive dysfunction via the P13K/Akt signaling pathway in immature rats. Biomedicine & Pharmacotherapy 109, pages 217-225.
Crossref
Konstantina Kyriakopoulou, Elena Kefali, Zoi Piperigkou, Heba Bassiony & Nikos K. Karamanos. (2018) Advances in targeting epidermal growth factor receptor signaling pathway in mammary cancer. Cellular Signalling 51, pages 99-109.
Crossref
Martin Veit, Katharina Isabelle Koyro, Björn Ahrens, Florian Bleibaum, Martin Munz, Hagen Rövekamp, Jörg Andrä, Rainer Schreiber, Karl Kunzelmann, Anselm Sommer, Sucharit Bhakdi & Karina Reiss. (2018) Anoctamin-6 regulates ADAM sheddase function. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1865:11, pages 1598-1610.
Crossref
Xiao-Feng Yin, Qiong Zhang, Zhuo-Yu Chen, Hai-Fang Wang, Xin Li, Hong-Xia Wang, Hai-Xia Li, Chun-Min Kang, Shuai Chu, Kai-Fei Li, Yao Li & Yu-Rong Qiu. (2018) NLRP3 in human glioma is correlated with increased WHO grade, and regulates cellular proliferation, apoptosis and metastasis via epithelial-mesenchymal transition and the PTEN/AKT signaling pathway. International Journal of Oncology.
Crossref
Nina Hedemann, Christoph Rogmans, Susanne Sebens, Daniela Wesch, Manuel Reichert, Dirk Schmidt-Arras, Hans-Heinrich Oberg, Ulrich Pecks, Marion van Mackelenbergh, Jörg Weimer, Norbert Arnold, Nicolai Maass & Dirk O. Bauerschlag. (2018) ADAM17 inhibition enhances platinum efficiency in ovarian cancer. Oncotarget 9:22, pages 16043-16058.
Crossref
Allison E. Schafer & Burns C. Blaxall. (2017) G Protein Coupled Receptor-mediated Transactivation of Extracellular Proteases. Journal of Cardiovascular Pharmacology 70:1, pages 10-15.
Crossref
Hong-Qing Xi, Ke-Cheng Zhang, Ji-Yang Li, Jian-Xin Cui, Yun-He Gao, Bo Wei, Dongsheng Huang & Lin Chen. (2017) RNAi-mediated inhibition of Lgr5 leads to decreased angiogenesis in gastric cancer. Oncotarget 8:19, pages 31581-31591.
Crossref
Alexandros NicolaouZhen ZhaoBernd H. NorthoffKristina SassAndreas HerbstAlexander KohlmaierAthena ChalarisChristian WolfrumChristian WeberSabine SteffensStefan Rose-JohnDaniel TeupserLesca M. Holdt. (2017) Adam17 Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice . Arteriosclerosis, Thrombosis, and Vascular Biology 37:2, pages 247-257.
Crossref
Rebeca Kawahara, Daniela Campos Granato, Sami Yokoo, Romênia Ramos Domingues, Daniel Maragno Trindade & Adriana Franco Paes Leme. (2017) Mass spectrometry-based proteomics revealed Glypican-1 as a novel ADAM17 substrate. Journal of Proteomics 151, pages 53-65.
Crossref
Eva Vacas, Laura Muñoz-Moreno, Pedro L. Valenzuela, Juan C. Prieto, Andrew V. Schally, María J. Carmena & Ana M. Bajo. (2016) Growth hormone-releasing hormone induced transactivation of epidermal growth factor receptor in human triple-negative breast cancer cells. Peptides 86, pages 153-161.
Crossref
Hongyu Shen, Liangpeng Li, Siying Zhou, Dandan Yu, Sujin Yang, Xiu Chen, Dandan Wang, Shanliang Zhong, Jianhua Zhao & Jinhai Tang. (2016) The role of ADAM17 in tumorigenesis and progression of breast cancer. Tumor Biology 37:12, pages 15359-15370.
Crossref
Xiangchao Meng, Baoshan Hu, Mohammad Hossain, Guofu Chen, Ying Sun & Xuepeng Zhang. (2016) ADAM17-siRNA inhibits MCF-7 breast cancer through EGFR-PI3K-AKT activation. International Journal of Oncology.
Crossref
D. Aydin, A. Bilici, D. Yavuzer, U. Kefeli, A. Tan, O. Ercelep, A. Mert, S. Yuksel, M. Ozcelik, D. Isik, H. Surmeli, H. Odabasi & M. Aliustaoglu. (2015) Prognostic significance of ADAM17 expression in patients with gastric cancer who underwent curative gastrectomy. Clinical and Translational Oncology 17:8, pages 604-611.
Crossref
Yong Lu, Michael Chopp, Xuguang Zheng, Mark Katakowski, Ding Wang, Elise Fraser, Monique Nguyen & Feng Jiang. (2014) Overexpression of miR‑145 in U87 cells reduces glioma cell malignant phenotype and promotes survival after in vivo implantation. International Journal of Oncology.
Crossref
Esak Lee, Seung Jae Lee, Jacob E. Koskimaki, Zheyi Han, Niranjan B. Pandey & Aleksander S. Popel. (2014) Inhibition of breast cancer growth and metastasis by a biomimetic peptide. Scientific Reports 4:1.
Crossref
Yuwu Liu, Chang Wu, Ying Wang, Sailan Wen, Junpu Wang, Zhihong Chen, Qiongqiong He & Deyun Feng. (2014) MicroRNA-145 inhibits cell proliferation by directly targeting ADAM17 in hepatocellular carcinoma. Oncology Reports.
Crossref
Sean W. Harshman, Michael E. Hoover, Chengsi Huang, Owen E. Branson, Sarah B. Chaney, Carolyn M. Cheney, Thomas J. Rosol, Charles L. Shapiro, Vicki H. Wysocki, Kay Huebner & Michael A. Freitas. (2014) Histone H1 Phosphorylation in Breast Cancer. Journal of Proteome Research 13:5, pages 2453-2467.
Crossref
XIAOHONG LV, YANG LI, MING QIAN, CHENGYUAN MA, HONGYU JING, ZHONGMEI WEN & DONGHUA QIAN. (2014) ADAM17 silencing suppresses the migration and invasion of non-small cell lung cancer. Molecular Medicine Reports 9:5, pages 1935-1940.
Crossref
Xue-wei Yang, Long-juan Zhang, Xiao-hui Huang, Lian-zhou Chen, Qiao Su, Wen-tao Zeng, Wen Li & Qian Wang. (2014) miR-145 suppresses cell invasion in hepatocellular carcinoma cells: miR-145 targets ADAM17. Hepatology Research 44:5, pages 551-559.
Crossref
Rebeca Kawahara, Renato Niyama Lima, Romênia R. Domingues, Bianca Alves Pauletti, Gabriela V. Meirelles, Michelle Assis, Ana Carolina Migliorini Figueira & Adriana Franco Paes Leme. (2014) Deciphering the Role of the ADAM17-Dependent Secretome in Cell Signaling. Journal of Proteome Research 13:4, pages 2080-2093.
Crossref
Peter A. Forsyth, Niveditha Krishna, Samuel Lawn, J. Gerardo Valadez, Xiaotao Qu, David A. Fenstermacher, Michelle Fournier, Lisa Potthast, Prakash Chinnaiyan, Geoffrey T. Gibney, Michele Zeinieh, Philip A. Barker, Bruce D. Carter, Michael K. Cooper & Rajappa S. Kenchappa. (2014) p75 Neurotrophin Receptor Cleavage by α- and γ-Secretases Is Required for Neurotrophin-mediated Proliferation of Brain Tumor-initiating Cells. Journal of Biological Chemistry 289:12, pages 8067-8085.
Crossref
Yi-Te Chen, Chun-Han Hou, Sheng-Mou Hou & Ju-Fang Liu. (2014) The Effects of Amphiregulin Induced MMP-13 Production in Human Osteoarthritis Synovial Fibroblast. Mediators of Inflammation 2014, pages 1-12.
Crossref
Stephen L. Rego, Rachel S. Helms & Didier Dréau. (2013) Tumor necrosis factor-alpha-converting enzyme activities and tumor-associated macrophages in breast cancer. Immunologic Research 58:1, pages 87-100.
Crossref
BING ZHAO & MENGCAI HU. (2013) Gallic acid reduces cell viability, proliferation, invasion and angiogenesis in human cervical cancer cells. Oncology Letters 6:6, pages 1749-1755.
Crossref
Yun-Jeong Jeong, Hyun-Ji Cho, Junji Magae, In-Kyu Lee, Keun-Gyu Park & Young-Chae Chang. (2013) Ascofuranone suppresses EGF-induced HIF-1α protein synthesis by inhibition of the Akt/mTOR/p70S6K pathway in MDA-MB-231 breast cancer cells. Toxicology and Applied Pharmacology 273:3, pages 542-550.
Crossref
Pachiyappan Kamarajan, Jae M Shin, Xu Qian, Bibiana Matte, Joey Yizhou Zhu & Yvonne L. Kapila. (2013) ADAM 17‐mediated CD 44 cleavage promotes orasphere formation or stemness and tumorigenesis in HNSCC . Cancer Medicine 2:6, pages 793-802.
Crossref
Ming-Qing Gao, Baek Gil Kim, Suki Kang, Yoon Pyo Choi, Joo-Heon Yoon & Nam Hoon Cho. (2013) Human breast cancer-associated fibroblasts enhance cancer cell proliferation through increased TGF-α cleavage by ADAM17. Cancer Letters 336:1, pages 240-246.
Crossref
Xiang-jun Wang, Chang-wei Feng & Min Li. (2013) ADAM17 mediates hypoxia-induced drug resistance in hepatocellular carcinoma cells through activation of EGFR/PI3K/Akt pathway. Molecular and Cellular Biochemistry 380:1-2, pages 57-66.
Crossref
Joachim Gr�tzinger. (2013) The disintegrin domain of ADAM17 antagonises fibroblast‑carcinoma cell interactions. International Journal of Oncology.
Crossref
Ahmad Trad, Hinrich P. Hansen, Mohammad Shomali, Matthias Peipp, Katja Klausz, Nina Hedemann, Kosuke Yamamoto, André Mauermann, Christine Desel, Inken Lorenzen, Hilmar Lemke, Stefan Rose-John & Joachim Grötzinger. (2012) ADAM17-overexpressing breast cancer cells selectively targeted by antibody–toxin conjugates. Cancer Immunology, Immunotherapy 62:3, pages 411-421.
Crossref
Zhang-Xuan Shou, Xue Jin & Zhong-Sheng Zhao. (2012) Upregulated Expression of ADAM17 Is a Prognostic Marker for Patients With Gastric Cancer. Annals of Surgery 256:6, pages 1014-1022.
Crossref
Harry Bulstrode, Louise M. Jones, Elodie J. Siney, Jessica M. Sampson, Andreas Ludwig, William P. Gray & Sandrine Willaime-Morawek. (2012) A-Disintegrin and Metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells. Cancer Letters 326:1, pages 79-87.
Crossref
Arindam Banerjee, Zheng-Sheng Wu, Peng-Xu Qian, Jian Kang, Dong-Xu Liu, Tao Zhu & Peter E. Lobie. (2012) ARTEMIN Promotes De Novo Angiogenesis in ER Negative Mammary Carcinoma through Activation of TWIST1-VEGF-A Signalling. PLoS ONE 7:11, pages e50098.
Crossref
Feng Jiang. (2012) MiR-145 reduces ADAM17 expression and inhibits in vitro migration and invasion of glioma cells. Oncology Reports.
Crossref
T Rzymski, A Petry, D Kračun, F Rieß, L Pike, A L Harris & A Görlach. (2011) The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress. Oncogene 31:31, pages 3621-3634.
Crossref
Frances M. Richards, Christopher J. Tape, Duncan I. Jodrell & Gillian Murphy. (2012) Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model In Vivo. PLoS ONE 7:7, pages e40597.
Crossref
Kosuke Yamamoto, Ahmad Trad, Anja Baumgart, Linda Hüske, Inken Lorenzen, Athena Chalaris, Joachim Grötzinger, Tobias Dechow, Jürgen Scheller & Stefan Rose-John. (2012) A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells. Biochemical Journal 445:1, pages 135-144.
Crossref
Sheng-Jun Liao, Yuan-Hong Zhou, Ye Yuan, Dong Li, Feng-Hua Wu, Qi Wang, Jian-Hua Zhu, Bin Yan, Jing-Jing Wei, Gui-Mei Zhang & Zuo-Hua Feng. (2011) Triggering of Toll-like receptor 4 on metastatic breast cancer cells promotes αvβ3-mediated adhesion and invasive migration. Breast Cancer Research and Treatment 133:3, pages 853-863.
Crossref
Xuguang Zheng, Feng Jiang, Mark Katakowski, Yong Lu & Michael Chopp. (2011) ADAM17 promotes glioma cell malignant phenotype. Molecular Carcinogenesis 51:2, pages 150-164.
Crossref
Ping Lin, Xicai Sun, Tian Feng, Haifeng Zou, Ying Jiang, Zijun Liu, Dandan Zhao & Xiaoguang Yu. (2011) ADAM17 regulates prostate cancer cell proliferation through mediating cell cycle progression by EGFR/PI3K/AKT pathway. Molecular and Cellular Biochemistry 359:1-2, pages 235-243.
Crossref
Masami Nozaki. (2011) Heparin-binding epidermal growth factor-like growth factor is a potent regulator of invasion activity in oral squamous cell carcinoma. Oncology Reports.
Crossref
Michael J Duffy, Maeve Mullooly, Norma O'Donovan, Sumainizah Sukor, John Crown, Aisling Pierce & Patricia M McGowan. (2011) The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?. Clinical Proteomics 8:1.
Crossref
Ahmad Trad, Nina Hedemann, Mohammad Shomali, Verena Pawlak, Joachim Grötzinger & Inken Lorenzen. (2011) Development of sandwich ELISA for detection and quantification of human and murine a disintegrin and metalloproteinase17. Journal of Immunological Methods 371:1-2, pages 91-96.
Crossref
Kyoungmi KimSandra L. TaylorSheila GantiLining GuoMichael V. OsierRobert H. Weiss. (2011) Urine Metabolomic Analysis Identifies Potential Biomarkers and Pathogenic Pathways in Kidney Cancer. OMICS: A Journal of Integrative Biology 15:5, pages 293-303.
Crossref
Irina Nazarenko, Marcel Jenny, Jana Keil, Cornelia Gieseler, Karen Weisshaupt, Jalid Sehouli, Stefan Legewie, Lena Herbst, Wilko Weichert, Silvia Darb-Esfahani, Manfred Dietel, Reinhold Schäfer, Florian Ueberall & Christine Sers. (2010) Atypical Protein Kinase C ζ Exhibits a Proapoptotic Function in Ovarian Cancer. Molecular Cancer Research 8:6, pages 919-934.
Crossref
Monika L. Burness, Tatyana A. Grushko & Olufunmilayo I. Olopade. (2010) Epidermal Growth Factor Receptor in Triple-Negative and Basal-Like Breast Cancer. The Cancer Journal 16:1, pages 23-32.
Crossref
Mark Katakowski, Feng Jiang, XuGuang Zheng, Jorge A. Gutierrez, Alexandra Szalad & Michael Chopp. (2009) Tumorigenicity of cortical astrocyte cell line induced by the protease ADAM17. Cancer Science 100:9, pages 1597-1604.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.