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Venugopal Chenna, Chaoxin Hu & SaeedR. Khan. (2014) Synthesis and cytotoxicity studies of Hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agents. Journal of Environmental Science and Health, Part A 49:6, pages 641-647.
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Matthew Kyle Hadden. (2013) Hedgehog pathway inhibitors: a patent review (2009 – present). Expert Opinion on Therapeutic Patents 23:3, pages 345-361.
Read now
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Syed F Zafar, Ganji Purnachandra Nagaraju & Bassel El-Rayes. (2012) Developing histone deacetylase inhibitors in the therapeutic armamentarium of pancreatic adenocarcinoma. Expert Opinion on Therapeutic Targets 16:7, pages 707-718.
Read now
Read now
Nelson S. Yee, Robert D. Brown, Min Sun Lee, Weiqiang Zhou, Chris Jensen, Henning Gerke & Rosemary K. Yee. (2012) TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma. Cancer Biology & Therapy 13:8, pages 592-599.
Read now
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Swapna Asuthkar, Jasti S Rao & Christopher S Gondi. (2012) Drugs in preclinical and early-stage clinical development for pancreatic cancer. Expert Opinion on Investigational Drugs 21:2, pages 143-152.
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Weiqiang Zhou, I-Chau Liang & Nelson S. Yee. (2011) Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer. Cancer Biology & Therapy 11:7, pages 659-670.
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Stephen G. Chun & Nelson S. Yee. (2010) Werner syndrome as a hereditary risk factor for exocrine pancreatic cancer. Cancer Biology & Therapy 10:5, pages 430-437.
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Articles from other publishers (47)
Z. Lahmar, E. Ahmed, A. Fort, I. Vachier, A. Bourdin & A. Bergougnoux. (2022) Hedgehog pathway and its inhibitors in chronic obstructive pulmonary disease (COPD). Pharmacology & Therapeutics 240, pages 108295.
Crossref
Crossref
Delphine Quatannens, Yannick Verhoeven, Peter Van Dam, Filip Lardon, Hans Prenen, Geert Roeyen, Marc Peeters, Evelien L.J. Smits & Jonas Van Audenaerde. (2022) Targeting hedgehog signaling in pancreatic ductal adenocarcinoma. Pharmacology & Therapeutics 236, pages 108107.
Crossref
Crossref
Christian Vay, Shahrooz Babaei, Sami-Alexander Safi, Levent Dizdar, Alexander Rehders, Lena Haeberle, Christoph Roderburg, Sven H. Loosen, Irene Esposito, Wolfram T. Knoefel & Andreas Krieg. (2022) Clinicopathological and Prognostic Value of Survivin Expression in Surgically Resected Pancreatic Ductal Adenocarcinoma. Cancers 14:14, pages 3494.
Crossref
Crossref
Xue-Song Xiang, Peng-Cheng Li, Wen-Quan Wang & Liang Liu. (2022) Histone deacetylases: A novel class of therapeutic targets for pancreatic cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1877:1, pages 188676.
Crossref
Crossref
Maryam Fallah, Amirhossein Davoodvandi, Shahin Nikmanzar, Sarehnaz Aghili, Seyed Mohammad Ali Mirazimi, Michael Aschner, Amir Rashidian, Michael R. Hamblin, Mohsen Chamanara, Navid Naghsh & Hamed Mirzaei. (2021) Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. Biomedicine & Pharmacotherapy 142, pages 112024.
Crossref
Crossref
Zong-Ting Gu, Zong-Ze Li & Cheng-feng Wang. (2021) Advances in research of extracellular mechanisms underlying gemcitabine resistance in pancreatic cancer. World Chinese Journal of Digestology 29:8, pages 421-434.
Crossref
Crossref
Kıvanç Görgülü, Kalliope N. Diakopoulos, Ezgi Kaya-Aksoy, Katrin J. Ciecielski, Jiaoyu Ai, Marina Lesina & Hana Algül. (2020) The Role of Autophagy in Pancreatic Cancer: From Bench to the Dark Bedside. Cells 9:4, pages 1063.
Crossref
Crossref
Ferdinando Maria Milazzo, Loredana Vesci, Anna Maria Anastasi, Caterina Chiapparino, Antonio Rosi, Giuseppe Giannini, Maurizio Taddei, Elena Cini, Valentina Faltoni, Elena Petricci, Gianfranco Battistuzzi, Laura Salvini, Valeria Carollo & Rita De Santis. (2020) ErbB2 Targeted Epigenetic Modulation: Anti-tumor Efficacy of the ADC Trastuzumab-HDACi ST8176AA1. Frontiers in Oncology 9.
Crossref
Crossref
Ishita Tandon, Asawari Waghmode & Nilesh Kumar Sharma. (2019) Cancer Stem Cells Equipped with Powerful Hedgehog Signaling and Better Epigenetic Memory: Avenues to Look for Cancer Therapeutics. Current Cancer Drug Targets 19:11, pages 877-884.
Crossref
Crossref
Boya Zhang, Lei Yang, Hua Wang, Ming Liu, Xiuxia Zhang, Meiling Liu, Jing Shen, Zhipeng Liu, Zhuo Zhao & Yuan Zhang. (2019) RTCA Monitors the Inhibitory Effect of SWCNTs on the Proliferation of human liver cancer HepG2 cells. IOP Conference Series: Materials Science and Engineering 563:5, pages 052070.
Crossref
Crossref
Xiaochun Dong, Chenglin Wang, Zhongjian Chen & Weili Zhao. (2018) Overcoming the resistance mechanisms of Smoothened inhibitors. Drug Discovery Today 23:3, pages 704-710.
Crossref
Crossref
Victor Tang, Kevin Otto & Warren SeeringDonna M. Brennan-Crispi & Sarah E. Millar. 2018. Executive Decision Synthesis. Executive Decision Synthesis
121
157
.
Chen Liang, Si Shi, Qingcai Meng, Dingkong Liang, Shunrong Ji, Bo Zhang, Yi Qin, Jin Xu, Quanxing Ni & Xianjun Yu. (2017) Complex roles of the stroma in the intrinsic resistance to gemcitabine in pancreatic cancer: where we are and where we are going. Experimental & Molecular Medicine 49:12, pages e406-e406.
Crossref
Crossref
Jodie F. Hay, Katrina Lappin, Fabio Liberante, Laura M. Kettyle, Kyle B. Matchett, Alexander Thompson & Ken I. Mills. (2017) Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy. Oncotarget 8:40, pages 67891-67903.
Crossref
Crossref
Parthasarathy Seshacharyulu, Michael J Baine, Joshua J Souchek, Melanie Menning, Sukhwinder Kaur, Ying Yan, Michel M. Ouellette, Maneesh Jain, Chi Lin & Surinder K. Batra. (2017) Biological determinants of radioresistance and their remediation in pancreatic cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1868:1, pages 69-92.
Crossref
Crossref
Yi Qin, Zhi-Wei Liao, Jing-Yan Luo, Wen-Zhe Wu, An-Shang Lu, Pu-Xia Su, Bing-Quan Lai & Xiao-Xiao Wang. (2016) Functional characterization of TRPM7 in nasopharyngeal carcinoma and its knockdown effects on tumorigenesis. Tumor Biology 37:7, pages 9273-9283.
Crossref
Crossref
Rajesh Singh, James W. LillardJr.Jr. & Shailesh Singh. 2016. Epigenetic Advancements in Cancer. Epigenetic Advancements in Cancer
27
63
.
Yoav Binenbaum, Shorook Na’ara & Ziv Gil. (2015) Gemcitabine resistance in pancreatic ductal adenocarcinoma. Drug Resistance Updates 23, pages 55-68.
Crossref
Crossref
Wan Feng, Dawei Cai, Bin Zhang, Guochun Lou & Xiaoping Zou. (2015) Combination of HDAC inhibitor TSA and silibinin induces cell cycle arrest and apoptosis by targeting survivin and cyclinB1/Cdk1 in pancreatic cancer cells. Biomedicine & Pharmacotherapy 74, pages 257-264.
Crossref
Crossref
Mehdi H. Shahi, Idoya Zazpe, Mohammad Afzal, Subrata Sinha, Robert B. Rebhun, B?rbara Mel?ndez, Juan A. Rey & Javier S. Castresana. (2014) Epigenetic regulation of human hedgehog interacting protein in glioma cell lines and primary tumor samples. Tumor Biology 36:4, pages 2383-2391.
Crossref
Crossref
Wan Feng, Bin Zhang, Dawei Cai & Xiaoping Zou. (2014) Therapeutic potential of histone deacetylase inhibitors in pancreatic cancer. Cancer Letters 347:2, pages 183-190.
Crossref
Crossref
Hui Fan, Xuechun Lu, Xiaohui Wang, Yang Liu, Bo Guo, Yan Zhang, Wenying Zhang, Jing Nie, Kaichao Feng, Meixia Chen, Yajing Zhang, Yao Wang, Fengxia Shi, Xiaobing Fu, Hongli Zhu & Weidong Han. (2014) Low-Dose Decitabine-Based Chemoimmunotherapy for Patients with Refractory Advanced Solid Tumors: A Phase I/II Report. Journal of Immunology Research 2014, pages 1-14.
Crossref
Crossref
Tapati Mazumdar, Ranjodh Sandhu, Maha Qadan, Jennifer DeVecchio, Victoria Magloire, Akwasi Agyeman, Bibo Li & Janet A. Houghton. (2013) Hedgehog Signaling Regulates Telomerase Reverse Transcriptase in Human Cancer Cells. PLoS ONE 8:9, pages e75253.
Crossref
Crossref
Deobrat Dixit, Ruchi Ghildiyal, Nikhil Ponnor Anto, Sourav Ghosh, Vivek Sharma & Ellora Sen. (2013) Guggulsterone sensitizes glioblastoma cells to Sonic hedgehog inhibitor SANT-1 induced apoptosis in a Ras/NFκB dependent manner. Cancer Letters 336:2, pages 347-358.
Crossref
Crossref
Nelson S. YeeAbid A. KaziRosemary K. Yee. (2013) Translating Discovery in Zebrafish Pancreatic Development to Human Pancreatic Cancer: Biomarkers, Targets, Pathogenesis, and Therapeutics. Zebrafish 10:2, pages 132-146.
Crossref
Crossref
Carole Y. Perrot, Delphine Javelaud & Alain Mauviel. (2013) Overlapping activities of TGF-β and Hedgehog signaling in cancer: Therapeutic targets for cancer treatment. Pharmacology & Therapeutics 137:2, pages 183-199.
Crossref
Crossref
Yong An, Baobao Cai, Jianmin Chen, Nan Lv, Jie Yao, Xiaofeng Xue, Min Tu, Dong Tang, Jishu Wei, Kuirong Jiang, Junli Wu, Qiang Li, Wentao Gao & Yi Miao. (2013) MAP3K10 promotes the proliferation and decreases the sensitivity of pancreatic cancer cells to gemcitabine by upregulating Gli-1 and Gli-2. Cancer Letters 329:2, pages 228-235.
Crossref
Crossref
. 2013. Therapeutic Strategies in Cancer Biology and Pathology. Therapeutic Strategies in Cancer Biology and Pathology
217
288
.
Nelson S. Yee & Rosemary K. Yee. 2013. New Advances on Disease Biomarkers and Molecular Targets in Biomedicine. New Advances on Disease Biomarkers and Molecular Targets in Biomedicine
75
84
.
Nelson S. Yee. 2013. Impact of Genetic Targets on Cancer Therapy. Impact of Genetic Targets on Cancer Therapy
91
143
.
Curt Balch & Kenneth P. Nephew. 2013. Epigenetic Alterations in Oncogenesis. Epigenetic Alterations in Oncogenesis
285
311
.
Guan Wang, Jing He, Jianyun Zhao, Wenting Yun, Chengzhi Xie, Jeffrey W. Taub, Asfar Azmi, Ramzi M. Mohammad, Yan Dong, Wei Kong, Yingjie Guo & Yubin Ge. (2012) Class I and Class II Histone Deacetylases Are Potential Therapeutic Targets for Treating Pancreatic Cancer. PLoS ONE 7:12, pages e52095.
Crossref
Crossref
Jun Xia, Changjie Chen, Zhiwen Chen, Lucio Miele, Fazlul H. Sarkar & Zhiwei Wang. (2012) Targeting pancreatic cancer stem cells for cancer therapy. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1826:2, pages 385-399.
Crossref
Crossref
Nelson S. Yee, Weiqiang Zhou, Minsun Lee & Rosemary K. Yee. (2012) Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma. Cancer Letters 318:1, pages 99-105.
Crossref
Crossref
Nelson S. Yee, Weiqiang Zhou, Stephen G. Chun, I-Chau Liang & Rosemary K. Yee. (2012) Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer. Biology Open 1:4, pages 295-307.
Crossref
Crossref
Nelson S. Yee, Ada S. Chan, Julian D. Yee & Rosemary K. Yee. (2012) TRPM7 and TRPM8 Ion Channels in Pancreatic Adenocarcinoma: Potential Roles as Cancer Biomarkers and Targets. Scientifica 2012, pages 1-8.
Crossref
Crossref
Nelson S. Yee, Weiqiang Zhou & I-Chau Liang. (2011) Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer. Disease Models & Mechanisms 4:2, pages 240-254.
Crossref
Crossref
Yee Hong Chia & Cynthia X. Ma. (2010) Hedgehog Pathway Inhibitors: Potential Applications in Breast Cancer. Current Breast Cancer Reports 3:1, pages 15-23.
Crossref
Crossref
Wolfgang Hagmann, Ralf Faissner, Martina Schnölzer, Matthias Löhr & Ralf Jesnowski. (2010) Membrane Drug Transporters and Chemoresistance in Human Pancreatic Carcinoma. Cancers 3:1, pages 106-125.
Crossref
Crossref
Hidemi Rikiishi. (2010) Possible Role of Autophagy in the Treatment of Pancreatic Cancer with Histone Deacetylase Inhibitors. Cancers 2:4, pages 2026-2043.
Crossref
Crossref
Nelson S. Yee, Weiqiang Zhou & Minsun Lee. (2010) Transient receptor potential channel TRPM8 is over-expressed and required for cellular proliferation in pancreatic adenocarcinoma. Cancer Letters 297:1, pages 49-55.
Crossref
Crossref
Donald J. AbrahamRobertson Graeme. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery
223
294
.
Günter Schneider, Oliver H. Krämer, Petra Fritsche, Susanne Schüler, Roland M. Schmid & Dieter Saur. (2010) Targeting histone deacetylases in pancreatic ductal adenocarcinoma. Journal of Cellular and Molecular Medicine 14:6a, pages 1255-1263.
Crossref
Crossref
Gianluca Canettieri, Lucia Di Marcotullio, Azzura Greco, Sonia Coni, Laura Antonucci, Paola Infante, Laura Pietrosanti, Enrico De Smaele, Elisabetta Ferretti, Evelina Miele, Marianna Pelloni, Giuseppina De Simone, Emilia Maria Pedone, Paola Gallinari, Alessandra Giorgi, Christian Steinkühler, Luigi Vitagliano, Carlo Pedone, M. Eugenià Schinin, Isabella Screpanti & Alberto Gulino. (2010) Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation. Nature Cell Biology 12:2, pages 132-142.
Crossref
Crossref
Yongming Li, Xia Li & Bin Guo. (2010) Chemopreventive Agent 3,3′-Diindolylmethane Selectively Induces Proteasomal Degradation of Class I Histone Deacetylases. Cancer Research 70:2, pages 646-654.
Crossref
Crossref
Liyun Sang, James M. Roberts & Hilary A. Coller. (2010) Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. Trends in Molecular Medicine 16:1, pages 17-26.
Crossref
Crossref
Zakaria Mohamed Lahmar, Engi Ahmed, Aurélie Fort, Isabelle Vachier, Arnaud Bourdin & Anne Bergougnoux. (2022) Hedgehog Pathway and its Inhibitors in Chronic Obstructive Pulmonary Disease (COPD). SSRN Electronic Journal.
Crossref
Crossref