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Research Paper

A novel and selective membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor reduces cancer cell motility and tumor growth

Pages 2362-2370 | Published online: 15 Dec 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Thomas Fischer & Rainer Riedl. (2021) Challenges with matrix metalloproteinase inhibition and future drug discovery avenues. Expert Opinion on Drug Discovery 16:1, pages 75-88.
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Vishnu Mohan, Dalit Talmi-Frank, Valeria Arkadash, Niv Papo & Irit Sagi. (2016) Matrix metalloproteinase protein inhibitors: highlighting a new beginning for metalloproteinases in medicine. Metalloproteinases in Medicine 3, pages 31-47.
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Desiree E. Mendes, Annie Wong-On-Wing & Clifford E. Berkman. (2016) Phosphoramidate-based peptidomimetic inhibitors of membrane type-1 matrix metalloproteinase. Journal of Enzyme Inhibition and Medicinal Chemistry 31:1, pages 167-171.
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Suvi-Tuuli Vilen, Juho Suojanen, Fidel Salas, Juha Risteli, Merja Ylipalosaari, Outi Itkonen, Hannu Koistinen, Marc Baumann, Ulf-Håkan Stenman, Timo Sorsa, Tuula Salo & Pia Nyberg. (2012) Trypsin-2 Enhances Carcinoma Invasion by Processing Tight Junctions and Activating ProMT1-MMP. Cancer Investigation 30:8, pages 583-592.
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Articles from other publishers (35)

Md.Maruf Hasan, Abu Rashed Md. Shawon, Abdullah Aeyas & M. Ashraf Uddin. (2022) Cyclic peptides as an inhibitor of metastasis in breast cancer targeting MMP-1: Computational approach. Informatics in Medicine Unlocked 35, pages 101128.
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Giovana Maria Fioramonti Calixto, Francesca Damiani Victorelli, Michelle Franz-Montan, Fátima Baltazar & Marlus Chorilli. (2021) Innovative Mucoadhesive Precursor of Liquid Crystalline System Loading Anti-Gellatinolytic Peptide for Topical Treatment of Oral Cancer. Journal of Biomedical Nanotechnology 17:2, pages 253-262.
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Devendra Shukla, Tanima Mandal, Priyanka Saha, Deepak Kumar, Sanjay Kumar & Amit Kumar Srivastava. 2020. Cancer-Leading Proteases. Cancer-Leading Proteases 391 416 .
Juurikka, Butler, Salo, Nyberg & Åström. (2019) The Role of MMP8 in Cancer: A Systematic Review. International Journal of Molecular Sciences 20:18, pages 4506.
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Gregg B. Fields. (2019) The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma. Cells 8:9, pages 984.
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Peng Liang, Yuan Yuan Zhang, Ping Yang, Stephanie Grond, Yi Zhang & Zhong-Ji Qian. (2019) Viridicatol and viridicatin isolated from a shark-gill-derived fungus Penicilliumpolonicum AP2T1 as MMP-2 and MMP-9 inhibitors in HT1080 cells by MAPKs signaling pathway and docking studies. Medicinal Chemistry Research 28:7, pages 1039-1048.
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Thomas Fischer & Rainer Riedl. (2019) Inhibitory Antibodies Designed for Matrix Metalloproteinase Modulation. Molecules 24:12, pages 2265.
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Gregg B. Fields. (2019) Mechanisms of Action of Novel Drugs Targeting Angiogenesis-Promoting Matrix Metalloproteinases. Frontiers in Immunology 10.
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Doretta Cuffaro, Elisa Nuti, Valentina Gifford, Noriko Ito, Caterina Camodeca, Tiziano Tuccinardi, Susanna Nencetti, Elisabetta Orlandini, Yoshifumi Itoh & Armando Rossello. (2019) Design, synthesis and biological evaluation of bifunctional inhibitors of membrane type 1 matrix metalloproteinase (MT1-MMP). Bioorganic & Medicinal Chemistry 27:1, pages 196-207.
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Evette S. Radisky, Maryam Raeeszadeh‐Sarmazdeh & Derek C. Radisky. (2017) Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer. Journal of Cellular Biochemistry 118:11, pages 3531-3548.
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Aleksandra Ellert-Miklaszewska, Katarzyna Poleszak & Bozena Kaminska. (2017) Short peptides interfering with signaling pathways as new therapeutic tools for cancer treatment. Future Medicinal Chemistry 9:2, pages 199-221.
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Dong Hyun Nam, Kuili Fang, Carlos Rodriguez, Tyler Lopez & Xin Ge. (2017) Generation of inhibitory monoclonal antibodies targeting matrix metalloproteinase-14 by motif grafting and CDR optimization. Protein Engineering Design and Selection 30:2, pages 113-118.
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Valeria Arkadash, Gal Yosef, Jason Shirian, Itay Cohen, Yuval Horev, Moran Grossman, Irit Sagi, Evette S. Radisky, Julia M. Shifman & Niv Papo. (2017) Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution. Journal of Biological Chemistry 292:8, pages 3481-3495.
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Zhenfei Bi, Wenrong Liu, Ruofang Ding, Yiran Wu, Rongkun Dou, Wenwen Zhang, Xue Yuan, Xinrong Liu, Lili Xiong, Zhiyun Guo & Canquan Mao. (2017) A novel peptide, 9R-P201, strongly inhibits the viability, proliferation and migration of liver cancer HepG2 cells and induces apoptosis by down-regulation of FoxM1 expression. European Journal of Pharmacology 796, pages 175-189.
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Anna M. Knapinska, Christie-Anne Estrada & Gregg B. Fields. 2017. Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy. Matrix Metalloproteinases and Tissue Remodeling in Health and Disease: Target Tissues and Therapy 339 354 .
Zongli Ren, Juanjuan Chen & Raouf A. Khalil. 2017. Zymography. Zymography 79 102 .
Wenfeng Li, Shouzhi Li, Liang Deng, Shibin Yang, Mingzhe Li, Shuo Long, Sile Chen, Fuxiang Lin & Longbin Xiao. (2015) Decreased MT1-MMP in gastric cancer suppressed cell migration and invasion via regulating MMPs and EMT. Tumor Biology 36:9, pages 6883-6889.
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Bowen Tan, Yijie Zhou, Zhilei Song, Yinxuan Peng, Fang Wu, Yue Kang, Xiaomin Liu, Li Zeng, Tingting Huang, Zongying Liu, Lili Xiong, Zhiyun Guo, Jian Cui & Canquan Mao. (2015) Modeling and Virtual Screening of Antisense Peptides Targeting the Divergent Region of Tumor-Associated MT1-MMP Protein. Bulletin of the Korean Chemical Society 36:9, pages 2198-2207.
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Aaron C. Overland & Paul A. Insel. (2015) Heterotrimeric G Proteins Directly Regulate MMP14/Membrane Type-1 Matrix Metalloprotease. Journal of Biological Chemistry 290:16, pages 9941-9947.
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Li Cheng, Yi Ding & Hongxing Jiang. (2015) WITHDRAWN: Decreased membrane-type 1 matrix metalloproteinase in gastric cancer suppressed cell migration and invasion via regulating matrix metalloproteinases and epithelial–mesenchymal transition. Journal of Surgical Research.
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Roosmarijn E. Vandenbroucke & Claude Libert. (2014) Is there new hope for therapeutic matrix metalloproteinase inhibition?. Nature Reviews Drug Discovery 13:12, pages 904-927.
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Yu-zhou Wang, Kun-peng Wu, Ai-bing Wu, Zhi-cheng Yang, Jin-mei Li, Yan-li Mo, Meng Xu, Bin Wu & Zhi-xiong Yang. (2014) MMP-14 overexpression correlates with poor prognosis in non-small cell lung cancer. Tumor Biology 35:10, pages 9815-9821.
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Sonia Pahwa, Maciej Stawikowski & Gregg Fields. (2014) Monitoring and Inhibiting MT1-MMP during Cancer Initiation and Progression. Cancers 6:1, pages 416-435.
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Yu‑Zhou Wang. (2013) miR‑133a suppresses cell proliferation, migration and invasion in human lung cancer by targeting MMP‑14. Oncology Reports.
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Suvi-Tuuli Vilen, Tuula Salo, Timo Sorsa & Pia Nyberg. (2013) Fluctuating Roles of Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma. The Scientific World Journal 2013, pages 1-11.
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Hongwei CHEN, Sisun LIU, Lifang MIAO, Lingfang YU, Yang WANG & Fei GUO. (2013) Inhibitory effect of lanthanum chloride on migration and invasion of cervical cancer cells. Journal of Rare Earths 31:1, pages 94-100.
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Margaret Ndinguri, Manishabrata Bhowmick, Dorota Tokmina-Roszyk, Trista Robichaud & Gregg Fields. (2012) Peptide-Based Selective Inhibitors of Matrix Metalloproteinase-Mediated Activities. Molecules 17:12, pages 14230-14248.
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Lusia Sepiashvili, Angela Hui, Vladimir Ignatchenko, Willa Shi, Susie Su, Wei Xu, Shao Hui Huang, Brian O'Sullivan, John Waldron, Jonathan C. Irish, Bayardo Perez-Ordonez, Fei-Fei Liu & Thomas Kislinger. (2012) Potentially Novel Candidate Biomarkers for Head and Neck Squamous Cell Carcinoma Identified Using an Integrated Cell Line-based Discovery Strategy. Molecular & Cellular Proteomics 11:11, pages 1404-1415.
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Rugmani Padmanabhan Iyer, Nicolle L. Patterson, Gregg B. FieldsMerry L. Lindsey. (2012) The history of matrix metalloproteinases: milestones, myths, and misperceptions. American Journal of Physiology-Heart and Circulatory Physiology 303:8, pages H919-H930.
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Janine M. Wilkinson, Rose K. Davidson, Tracey E. Swingler, Eleanor R. Jones, Anthony N. Corps, Phillip Johnston, Graham P. Riley, Adrian J. Chojnowski & Ian M. Clark. (2012) MMP-14 and MMP-2 are key metalloproteases in Dupuytren's disease fibroblast-mediated contraction. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1822:6, pages 897-905.
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S.T. Oh, H.S. Kim, N.J. Yoo, W.S. Lee, B.K. Cho & J. Reichrath. (2011) Increased immunoreactivity of membrane type-1 matrix metalloproteinase (MT1-MMP) and β-catenin in high-risk basal cell carcinoma. British Journal of Dermatology 165:6, pages 1197-1204.
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Karin Golan, Yaron Vagima, Polina Goichberg, Shiri Gur-Cohen & Tsvee Lapidot. (2011) MT1-MMP and RECK: opposite and essential roles in hematopoietic stem and progenitor cell retention and migration. Journal of Molecular Medicine 89:12, pages 1167-1174.
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Darío Fernández, Susana Larrucea, Adam Nowakowski, Miguel Pericacho, Roberto Parrilla & Matilde S. Ayuso. (2011) Release of podocalyxin into the extracellular space. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1813:8, pages 1504-1510.
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Julie Decock, Sally Thirkettle, Laura Wagstaff & Dylan R. Edwards. (2011) Matrix metalloproteinases: protective roles in cancer. Journal of Cellular and Molecular Medicine 15:6, pages 1254-1265.
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Lihua Sun, Wei Yan, Yingyi Wang, Guan Sun, Hui Luo, Junxia Zhang, Xiefeng Wang, Yongping You, Zhengxiang Yang & Ning Liu. (2011) MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10. Brain Research 1389, pages 9-18.
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