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Research Paper

Involvement of glypican-3 in the recruitment of M2-polarized tumor-associated macrophages in hepatocellular carcinoma

Pages 2329-2338 | Published online: 15 Dec 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Chunlai Yin, Qiuju Han, Dongqing Xu, Bingqing Zheng, Xuemei Zhao & Jian Zhang. (2019) SALL4-mediated upregulation of exosomal miR-146a-5p drives T-cell exhaustion by M2 tumor-associated macrophages in HCC. OncoImmunology 8:7.
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Antonio Gnoni, Daniele Santini, Mario Scartozzi, Antonio Russo, Antonella Licchetta, Vincenzo Palmieri, Luigi Lupo, Luca Faloppi, Giuseppe Palasciano, Vincenzo Memeo, Gioacchino Angarano, Oronzo Brunetti, Attilio Guarini, Salvatore Pisconti, Vito Lorusso & Nicola Silvestris. (2015) Hepatocellular carcinoma treatment over sorafenib: epigenetics, microRNAs and microenvironment. Is there a light at the end of the tunnel?. Expert Opinion on Therapeutic Targets 19:12, pages 1623-1635.
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Eman A.E. Badr, Tarek E. Korah, Ashraf Abdel Ghani, Sawsan El-Sayed & Safaa Badr. (2014) Role of serum glypican-3 in the diagnosis and differentiation of small hepatocellular carcinoma from hepatitis-C virus cirrhosis. Alexandria Journal of Medicine 50:3, pages 221-226.
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Arshi Khanam & Shyam Kottilil. (2022) New Therapeutics for HCC: Does Tumor Immune Microenvironment Matter?. International Journal of Molecular Sciences 24:1, pages 437.
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Jun Liu, Jinglin Mi, Shiqian Liu, Haiqiang Chen & Li Jiang. (2022) PSMB5 overexpression is correlated with tumor proliferation and poor prognosis in hepatocellular carcinoma . FEBS Open Bio 12:11, pages 2025-2041.
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Zhuqing Li & Kaitlin M. Bratlie. (2021) The Influence of Polysaccharides‐Based Material on Macrophage Phenotypes. Macromolecular Bioscience 21:8, pages 2100031.
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Shao-Li Huang, Yu-Ming Wang, Quan-Yue Wang, Guang-Gui Feng, Fu-Qing Wu, Liu-Ming Yang, Xi-He Zhang & Hong-Wu Xin. (2021) Mechanisms and Clinical Trials of Hepatocellular Carcinoma Immunotherapy. Frontiers in Genetics 12.
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Lin Yu, Xi Yang, Nan Huang, Meng Wu, Heng Sun, Qilin He, Qiaoli Lang, Xiangang Zou, Zuohua Liu, Jianhua Wang & Liangpeng Ge. (2020) Generation of fully human anti-GPC3 antibodies with high-affinity recognition of GPC3 positive tumors. Investigational New Drugs 39:3, pages 615-626.
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Kaixin Du, Yulu Li, Juan Liu, Wei Chen, Zhizhong Wei, Yong Luo, Huisi Liu, Yonghe Qi, Fengchao Wang & Jianhua Sui. (2021) A bispecific antibody targeting GPC3 and CD47 induced enhanced antitumor efficacy against dual antigen-expressing HCC. Molecular Therapy 29:4, pages 1572-1584.
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Gao Liu, Zhang-Fu Yang, Pei-Yun Zhou, Cheng Zhou, Ruo-Yu Guan, Bao-Ye Sun, Jia Fan, Jian Zhou, Yong Yi & Shuang-Jian Qiu. (2020) ROR-α-1 inhibits the proliferation, invasion, and migration of hepatocellular carcinoma MHCC97H via downregulation of chemokine CXCL5. Cytokine 129, pages 155004.
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Lili Chen, Qianfei Zhang, Chang Yu, Fang Wang & Xiaoni Kong. (2020) Functional roles of CCL5/RANTES in liver disease. Liver Research 4:1, pages 28-34.
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Mushtaq Ahmed, Shyamala Thirunavukkarasu, Bruce A. Rosa, Kimberly A. Thomas, Shibali Das, Javier Rangel-MorenoLan LuSmriti MehraStanley Kimbung Mbandi, Larissa B. ThackrayMichael S. DiamondKenneth M. Murphy, Terry Means, John MartinDeepak Kaushal, Thomas J. Scriba, Makedonka Mitreva & Shabaana A. Khader. (2020) Immune correlates of tuberculosis disease and risk translate across species. Science Translational Medicine 12:528.
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Zhiqiang Tian, Xiaojuan Hou, Wenting Liu, Zhipeng Han & Lixin Wei. (2019) Macrophages and hepatocellular carcinoma. Cell & Bioscience 9:1.
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Sukhneeraj P. Kaur & Brian S. Cummings. (2019) Role of glypicans in regulation of the tumor microenvironment and cancer progression. Biochemical Pharmacology 168, pages 108-118.
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Chris John Weston, Henning Wolfgang Zimmermann & David H. Adams. (2019) The Role of Myeloid-Derived Cells in the Progression of Liver Disease. Frontiers in Immunology 10.
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Zi Yin, Tingting Ma, Ye Lin, Xin Lu, Chuanzhao Zhang, Sheng Chen & Zhixiang Jian. (2018) Retracted : IL‐6/STAT3 pathway intermediates M1/M2 macrophage polarization during the development of hepatocellular carcinoma . Journal of Cellular Biochemistry 119:11, pages 9419-9432.
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H. Degroote, A. Van Dierendonck, A. Geerts, H. Van Vlierberghe & L. Devisscher. (2018) Preclinical and Clinical Therapeutic Strategies Affecting Tumor-Associated Macrophages in Hepatocellular Carcinoma. Journal of Immunology Research 2018, pages 1-9.
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Fubo Zhou, Wenting Shang, Xiaoling Yu & Jie Tian. (2018) Glypican-3: A promising biomarker for hepatocellular carcinoma diagnosis and treatment. Medicinal Research Reviews 38:2, pages 741-767.
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Gong Chen, Ya-Chi Chen, Bernhard Reis, Anton Belousov, Lori Jukofsky, Christine Rossin, Axel Muehlig, Chao Xu, Laurent Essioux, Toshihiko Ohtomo, Laura Di Laurenzio, Oscar Puig & Ray Lee. (2018) Combining expression of GPC3 in tumors and CD16 on NK cells from peripheral blood to identify patients responding to codrituzumab. Oncotarget 9:12, pages 10436-10444.
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Arthur ZimmermannArthur Zimmermann. 2017. Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Tumors and Tumor-Like Lesions of the Hepatobiliary Tract 121 149 .
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Ghassan K. Abou-Alfa, Oscar Puig, Bruno Daniele, Masatoshi Kudo, Philippe Merle, Joong-Won Park, Paul Ross, Jean-Marie Peron, Oliver Ebert, Stephen Chan, Tung Ping Poon, Massimo Colombo, Takuji Okusaka, Baek-Yeol Ryoo, Beatriz Minguez, Takayoshi Tanaka, Toshihiko Ohtomo, Stacey Ukrainskyj, Frederic Boisserie, Olga Rutman, Ya-Chi Chen, Chao Xu, Eliezer Shochat, Lori Jukofsky, Bernhard Reis, Gong Chen, Laura Di Laurenzio, Ray Lee & Chia-Jui Yen. (2016) Randomized phase II placebo controlled study of codrituzumab in previously treated patients with advanced hepatocellular carcinoma. Journal of Hepatology 65:2, pages 289-295.
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Arthur ZimmermannArthur Zimmermann. 2016. Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Tumors and Tumor-Like Lesions of the Hepatobiliary Tract 1 29 .
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Yi Li, Yuhuan Zheng, Tianshu Li, Qiang Wang, Jianfei Qian, Yong Lu, Mingjun Zhang, Enguang Bi, Maojie Yang, Frederic Reu, Qing Yi & Zhen Cai. (2015) Chemokines CCL2, 3, 14 stimulate macrophage bone marrow homing, proliferation, and polarization in multiple myeloma. Oncotarget 6:27, pages 24218-24229.
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M Sadeghi, I Lahdou, H Oweira, V Daniel, P Terness, J Schmidt, K-H Weiss, T Longerich, P Schemmer, G Opelz & A Mehrabi. (2015) Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma. British Journal of Cancer 113:5, pages 756-762.
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CHENHONG LUO, KIYOSUMI SHIBATA, SHIRO SUZUKI, HIROAKI KAJIYAMA, TAKESHI SENGA, YOSHIHIRO KOYA, MINA DAIMON, MAMORU YAMASHITA & FUMITAKA KIKKAWA. (2014) GPC3 expression in mouse ovarian cancer induces GPC3-specific T cell-mediated immune response through M1 macrophages and suppresses tumor growth. Oncology Reports 32:3, pages 913-921.
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Andrea F. WiseTimothy M. WilliamsMensiena B. G. KiewietNatalie L. Payne, Christopher SiatskasChrishan S. Samuel & Sharon D. Ricardo. (2014) Human mesenchymal stem cells alter macrophage phenotype and promote regeneration via homing to the kidney following ischemia-reperfusion injury. American Journal of Physiology-Renal Physiology 306:10, pages F1222-F1235.
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Femke Heindryckx. (2014) Targeting the tumor stroma in hepatocellular carcinoma. World Journal of Hepatology 7:2, pages 165.
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Yi-feng He, Mei-ying Zhang, Xin Wu, Xiang-jun Sun, Ting Xu, Qi-zhi He & Wen Di. (2013) High MUC2 Expression in Ovarian Cancer Is Inversely Associated with the M1/M2 Ratio of Tumor-Associated Macrophages and Patient Survival Time. PLoS ONE 8:12, pages e79769.
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Jin Lee & Kye-Taek Lim. (2012) SJSZ glycoprotein (38 kDa) modulates macrophage type 1/2-related factors at hepatocarcinogenic stage in N-nitrosodiethylamine-treated Balb/c. Molecular and Cellular Biochemistry 372:1-2, pages 17-26.
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Yonghai Li, Donald L Siegel, Nathalie Scholler & David E Kaplan. (2012) Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library. BMC Biotechnology 12:1.
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Ken Shirabe, Yohei Mano, Jun Muto, Rumi Matono, Takashi Motomura, Takeo Toshima, Kazuki Takeishi, Hidekaki Uchiyama, Tomoharu Yoshizumi, Akinobu Taketomi, Masaru Morita, Shunichi Tsujitani, Yoshihisa Sakaguchi & Yoshihiko Maehara. (2011) Role of tumor-associated macrophages in the progression of hepatocellular carcinoma. Surgery Today 42:1, pages 1-7.
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Rana Chattopadhyay, Patricia de la Vega, Sun H. Paik, Yoko Murata, Earl W. Ferguson, Thomas L. Richie & Guck T. Ooi. (2011) Early Transcriptional Responses of HepG2-A16 Liver Cells to Infection by Plasmodium falciparum Sporozoites. Journal of Biological Chemistry 286:30, pages 26396-26405.
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Yanhui Xu, Hong Li, Rui Lin Gao, Oluwasayo Adeyemo, Maxim Itkin & David E. Kaplan. (2011) Expansion of interferon-gamma-producing multifunctional CD4+ T-cells and dysfunctional CD8+ T-cells by glypican-3 peptide library in hepatocellular carcinoma patients. Clinical Immunology 139:3, pages 302-313.
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Bin Yan, Jing-Jing Wei, Yi-Ming Qian, Xiang-Li Zhao, Wei-Wei Zhang, Ai-Min Xu & Shu-hui Zhang. (2011) Expression and clinicopathologic significance of glypican 3 in hepatocellular carcinoma. Annals of Diagnostic Pathology 15:3, pages 162-169.
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Jun-Wen Yang, Dong-Ye Yang, Fang-Gen Lu, Cai-Hong Li, Hui Chen, Ning Xie & Xin Zhao. (2011) GPC3 fused to an alpha epitope of HBsAg acts as an immune target against hepatocellular carcinoma associated with hepatitis B virus. Hepatobiliary & Pancreatic Diseases International 10:2, pages 164-170.
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Mitchell Ho & Heungnam Kim. (2011) Glypican-3: A new target for cancer immunotherapy. European Journal of Cancer 47:3, pages 333-338.
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James O'Beirne, Farzin Farzaneh & Phillip M Harrison. (2010) Generation of functional CD8+ T Cells by human dendritic cells expressing glypican-3 epitopes. Journal of Experimental & Clinical Cancer Research 29:1.
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