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Research Paper

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells

Pages 730-738 | Published online: 15 Apr 2009

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Inge Compter, Danielle B. P. Eekers, Ann Hoeben, Kasper M. A. Rouschop, Bart Reymen, Linda Ackermans, Jan Beckervordersantforth, Noel J. C. Bauer, Monique M. Anten, Pieter Wesseling, Alida A. Postma, Dirk De Ruysscher & Philippe Lambin. (2021) Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial. Autophagy 17:9, pages 2604-2612.
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Barry Jutten, Tom G. Keulers, Hanneke J. M. Peeters, Marco B. E. Schaaf, Kim G. M. Savelkouls, Inge Compter, Ruud Clarijs, Olaf E. M. G. Schijns, Linda Ackermans, Onno P. M. Teernstra, Marijke I. Zonneveld, Resi M. E. Colaris, Ludwig Dubois, Marc A. Vooijs, Johan Bussink, Julio Sotelo, Jan Theys, Guido Lammering & Kasper M. A. Rouschop. (2018) EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition. Autophagy 14:2, pages 283-295.
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Hai Liu, Weifang Yang, Huaping Gao, Tingting Jiang, Bengxin Gu, Qinghua Dong, Wenhong Xu, Shixiu Wu & Xiaonan Sun. (2015) Nimotuzumab abrogates acquired radioresistance of KYSE-150R esophageal cancer cells by inhibiting EGFR signaling and cellular DNA repair. OncoTargets and Therapy 8, pages 509-518.
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Barry Jutten & Kasper rouschop. (2014) EGFR signaling and autophagy dependence for growth, survival, and therapy resistance. Cell Cycle 13:1, pages 42-51.
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Brian M Alexander, Keith L Ligon & Patrick Y Wen. (2013) Enhancing radiation therapy for patients with glioblastoma. Expert Review of Anticancer Therapy 13:5, pages 569-581.
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Brian M Alexander, Eudocia Q Lee, David A Reardon & Patrick Y Wen. (2013) Current and future directions for Phase II trials in high-grade glioma. Expert Review of Neurotherapeutics 13:4, pages 369-387.
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H. Helen Lin, Xu Li, Jo-Lin Chen, Xiuzhu Sun, Fariba Norouziyan Cooper, Yun-Ru Chen, Wenyu Zhang, Yiyin Chung, Angela Li, Chun-Ting Cheng, Lixin Yang, XuTao Deng, Xiyong Liu, Yun Yen, Deborah L. Johnson, Hsiu-Ming Shih, Austin Yang & David K. Ann. (2012) Identification of an AAA ATPase VPS4B-Dependent Pathway That Modulates Epidermal Growth Factor Receptor Abundance and Signaling during Hypoxia. Molecular and Cellular Biology 32:6, pages 1124-1138.
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Sarah E. Golding & Kristoffer Valerie. (2011) MRE11 and ATM AKTivate pro-survival signaling. Cell Cycle 10:19, pages 3227-3227.
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Ashraf Khalil, Rhiannon N. Morgan, Bret R. Adams, Sarah E. Golding, Seth M. Dever, Elizabeth Rosenberg, Lawrence F. Povirk & Kristoffer Valerie. (2011) ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks. Cell Cycle 10:3, pages 481-491.
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Mechthild Krause, Kristin Gurtner, Yvonne Deuse & Michael Baumann. (2009) Heterogeneity of tumour response to combined radiotherapy and EGFR inhibitors: Differences between antibodies and TK inhibitors. International Journal of Radiation Biology 85:11, pages 943-954.
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