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MDM2 promotes SUMO-2/3 modification of p53 to modulate transcriptional activity

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Pages 3176-3188 | Received 20 Jul 2011, Accepted 28 Jul 2011, Published online: 15 Sep 2011

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Sara M Reed, Jussara Hagen, Van S Tompkins, Katie Thies, Frederick W Quelle & Dawn E Quelle. (2014) Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53. Cell Cycle 13:8, pages 1288-1298.
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Murilo TD Bueno & Stéphane Richard. (2013) SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase. Epigenetics 8:11, pages 1162-1175.
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Laura Marcos-Villar, José Pérez-Girón, Jessica Vilas, Atenea Soto, Carlos de la Cruz-Hererra, Valerie Lang, Manuel Collado, Anxo Vidal, Manuel Rodriguez, Cesar Muñoz-Fontela & Carmen Rivas. (2013) SUMOylation of p53 mediates interferon activities. Cell Cycle 12:17, pages 2809-2816.
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Orsolya Leidecker, Ivan Matic, Bidesh Mahata, Emmanuelle Pion & Dimitris P. Xirodimas. (2012) The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions. Cell Cycle 11:6, pages 1142-1150.
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Richard Bennett, Yu Pan, Jaime Christian, Teng Hui & W. Stratford May Jr.. (2012) The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G1 arrest. Cell Cycle 11:2, pages 407-417.
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Nicolas Mandel & Nitin Agarwal. (2022) Role of SUMOylation in Neurodegenerative Diseases. Cells 11:21, pages 3395.
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Nieves Lara-Ureña, Vahid Jafari & Mario García-Domínguez. (2022) Cancer-Associated Dysregulation of Sumo Regulators: Proteases and Ligases. International Journal of Molecular Sciences 23:14, pages 8012.
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Marta Gomarasca, Giovanni Lombardi & Paola Maroni. (2022) SUMOylation and NEDDylation in Primary and Metastatic Cancers to Bone. Frontiers in Cell and Developmental Biology 10.
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Xiaoxia Shi, Yixin Du, Shujing Li & Huijian Wu. (2022) The Role of SUMO E3 Ligases in Signaling Pathway of Cancer Cells. International Journal of Molecular Sciences 23:7, pages 3639.
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Ying Wang, Chenlu Zhang, Jiabao Wang & Jiang Liu. (2022) p53 regulation by ubiquitin and ubiquitin-like modifications. Genome Instability & Disease 3:4, pages 179-198.
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Che-Pei Kung & Jason D. Weber. (2022) It’s Getting Complicated—A Fresh Look at p53-MDM2-ARF Triangle in Tumorigenesis and Cancer Therapy. Frontiers in Cell and Developmental Biology 10.
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Orhi Barroso-Gomila, Fredrik Trulsson, Veronica Muratore, Iñigo Canosa, Laura Merino-Cacho, Ana Rosa Cortazar, Coralia Pérez, Mikel Azkargorta, Ibon Iloro, Arkaitz Carracedo, Ana M. Aransay, Felix Elortza, Ugo Mayor, Alfred C. O. Vertegaal, Rosa Barrio & James D. Sutherland. (2021) Identification of proximal SUMO-dependent interactors using SUMO-ID. Nature Communications 12:1.
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Alyssa M. Klein, Rafaela Muniz de Queiroz, Divya Venkatesh & Carol Prives. (2021) The roles and regulation of MDM2 and MDMX: it is not just about p53. Genes & Development 35:9-10, pages 575-601.
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Yuanyuan Qin, Hong Yuan, Xu Chen, Xinyi Yang, Zhengcao Xing, Yajie Shen, Wanying Dong, Siming An, Yitao Qi & Hongmei Wu. (2021) SUMOylation Wrestles With the Occurrence and Development of Breast Cancer. Frontiers in Oncology 11.
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Mengwu Pan & Christine Blattner. (2021) Regulation of p53 by E3s. Cancers 13:4, pages 745.
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Samir H. Barghout & Aaron D. Schimmer. (2020) E1 Enzymes as Therapeutic Targets in Cancer. Pharmacological Reviews 73:1, pages 1-56.
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Luyao Shao, Yan Liu, Wenbiao Wang, Aixin Li, Pin Wan, Weiyong Liu, Muhammad Adnan Shereen, Fang Liu, Wen Zhang, Quiping Tan, Kailang Wu, Yingle Liu & Jianguo Wu. (2019) SUMO1 SUMOylates and SENP3 deSUMOylates NLRP3 to orchestrate the inflammasome activation. The FASEB Journal 34:1, pages 1497-1515.
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Daniela Oliveira, Bjorn Johansson & Rui Oliveira. 2019. Handbook of Nutrition, Diet, and Epigenetics. Handbook of Nutrition, Diet, and Epigenetics 1997 2015 .
Carlos F. De La Cruz-Herrera, Kathy Shire, Umama Z. Siddiqi & Lori Frappier. (2018) A genome-wide screen of Epstein-Barr virus proteins that modulate host SUMOylation identifies a SUMO E3 ligase conserved in herpesviruses. PLOS Pathogens 14:7, pages e1007176.
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Liu-Zhong Jin, Ji-Shou Lu & Jian-Wen Gao. (2018) Silencing SUMO2 promotes protection against degradation and apoptosis of nucleus pulposus cells through p53 signaling pathway in intervertebral disc degeneration. Bioscience Reports 38:3.
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Teresa Cunha-Oliveira, Luciana L. Ferreira, Ana Raquel Coelho, Cláudia M. Deus & Paulo J. Oliveira. (2018) Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes. Toxicology and Applied Pharmacology 348, pages 1-13.
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Maurizio Previati, Sonia Missiroli, Mariasole Perrone, Natascia Caroccia, Federico Paliotto, Daniela Milani & Carlotta Giorgi. (2018) Functions and dys-functions of promyelocytic leukemia protein PML. Rendiconti Lincei. Scienze Fisiche e Naturali 29:2, pages 411-420.
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Andrea Princz & Nektarios Tavernarakis. (2017) The role of SUMOylation in ageing and senescent decline. Mechanisms of Ageing and Development 162, pages 85-90.
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Chittur V. Srikanth & Smriti Verma. 2017. SUMO Regulation of Cellular Processes. SUMO Regulation of Cellular Processes 389 408 .
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Yuuki Shimizu, Jonathan P. Lambert, Chad K. Nicholson, Joshua J. Kim, David W. Wolfson, Hee Cheol Cho, Ahsan Husain, Nawazish Naqvi, Li-Shen Chin, Lian Li & John W. Calvert. (2016) DJ-1 protects the heart against ischemia–reperfusion injury by regulating mitochondrial fission. Journal of Molecular and Cellular Cardiology 97, pages 56-66.
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Zara Hannoun, Ghizlane Maarifi & Mounira K. Chelbi-Alix. (2016) The implication of SUMO in intrinsic and innate immunity. Cytokine & Growth Factor Reviews 29, pages 3-16.
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Navin Chicooree, Richard D. Unwin & John R. Griffiths. (2015) The application of targeted mass spectrometry-based strategies to the detection and localization of post-translational modifications. Mass Spectrometry Reviews 34:6, pages 595-626.
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M H Stindt, P A J Muller, R L Ludwig, S Kehrloesser, V Dötsch & K H Vousden. (2014) Functional interplay between MDM2, p63/p73 and mutant p53. Oncogene 34:33, pages 4300-4310.
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Alfonso Bellacosa & Alexander C. Drohat. (2015) Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sites. DNA Repair 32, pages 33-42.
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Che-Pei Kung, Sakina Khaku, Matthew Jennis, Yan Zhou & Maureen E. Murphy. (2015) Identification of TRIML2, a Novel p53 Target, that Enhances p53 SUMOylation and Regulates the Transactivation of Proapoptotic Genes. Molecular Cancer Research 13:2, pages 250-262.
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Yun Sun Park, Jeong-Woo Kang, Dong Hun Lee, Man Sub Kim, Yesol Bak, Young Yang, Hee-Gu Lee, Jintae Hong & Do-Young Yoon. (2014) Interleukin-32α modulates promyelocytic leukemia zinc finger gene activity by inhibiting protein kinase Cɛ-dependent sumoylation. The International Journal of Biochemistry & Cell Biology 55, pages 136-143.
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Hailian Bi, Shujing Li, Miao Wang, Zhaojun Jia, Alan K. Chang, Pengsha Pang & Huijian Wu. (2014) SUMOylation of GPS2 protein regulates its transcription-suppressing function. Molecular Biology of the Cell 25:16, pages 2499-2508.
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Peipei Pan, Michael D. Treat & Frank van Breukelen. (2014) A systems-level approach to understanding transcriptional regulation by p53 during mammalian hibernation. Journal of Experimental Biology 217:14, pages 2489-2498.
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ZIYI ZHAO, LAN WU, HUIMIN SHI & CHUANFANG WU. (2014) p53 N-terminal binding and stabilisation by PIAS3 inhibits MDM2-induced p53 ubiquitination and regulates cell growth. Molecular Medicine Reports 9:5, pages 1903-1908.
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Christopher T. Coey, Megan E. Fitzgerald, Atanu Maiti, Katherine H. Reiter, Catherine M. Guzzo, Michael J. Matunis & Alexander C. Drohat. (2014) E2-mediated Small Ubiquitin-like Modifier (SUMO) Modification of Thymine DNA Glycosylase Is Efficient but Not Selective for the Enzyme-Product Complex. Journal of Biological Chemistry 289:22, pages 15810-15819.
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Valentina C. Martinelli, W. Buck Kyle, Snezana Kojic, Nicola Vitulo, Zhaohui Li, Anna Belgrano, Paolo Maiuri, Lawrence Banks, Matteo Vatta, Giorgio Valle & Georgine Faulkner. (2014) ZASP Interacts with the Mechanosensing Protein Ankrd2 and p53 in the Signalling Network of Striated Muscle. PLoS ONE 9:3, pages e92259.
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Andreas K. Hock & Karen H. Vousden. (2014) The role of ubiquitin modification in the regulation of p53. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:1, pages 137-149.
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Katrin Eckermann. (2013) SUMO and Parkinson’s Disease. NeuroMolecular Medicine 15:4, pages 737-759.
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Shuliang Chen, Xiao Yu, Quan Lei, Lixin Ma & Deyin Guo. (2013) The sumoylation of zinc-fingers and homeoboxes 1 (ZHX1) by ubc9 regulates its stability and transcriptional repression activity. Journal of Cellular Biochemistry 114:10, pages 2323-2333.
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Navin Chicooree, John R. Griffiths, Yvonne Connolly & Duncan L. Smith. (2013) Chemically facilitating the generation of diagnostic ions from SUMO(2/3) remnant isopeptides. Rapid Communications in Mass Spectrometry 27:18, pages 2108-2114.
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Aleixo Santiago, Dawei Li, Lisa Y. Zhao, Adam Godsey & Daiqing Liao. (2013) p53 SUMOylation promotes its nuclear export by facilitating its release from the nuclear export receptor CRM1. Molecular Biology of the Cell 24:17, pages 2739-2752.
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Navin Chicooree, John R. Griffiths, Yvonne Connolly, Chong-Teik Tan, Angeliki Malliri, Claire E. Eyers & Duncan L. Smith. (2013) A novel approach to the analysis of SUMOylation with the independent use of trypsin and elastase digestion followed by database searching utilising consecutive residue addition to lysine. Rapid Communications in Mass Spectrometry 27:1, pages 127-134.
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Barak Rotblat, Gerry Melino & Richard A. Knight. (2012) NRF2 and p53: Januses in cancer?. Oncotarget 3:11, pages 1272-1283.
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Luyao Shao, Wenbiao Wang, Aixin Li, Pin Wan, Weiyong Liu, Muhammad Adnan Shereen, Fang Liu, Wen Zhang, Quiping Tan, Kailang Wu, Yingle Liu & Jianguo Wu. (2018) SUMO1 Sumoylates and SENP3 DeSUMOylates NLRP3 to Orchestrate the Inflammasome Activation. SSRN Electronic Journal.
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