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Mutations in the β-tubulin binding site for peloruside A confer resistance by targeting a cleft significant in side chain binding

Pages 3387-3396 | Received 01 Jul 2011, Accepted 10 Aug 2011, Published online: 01 Oct 2011

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Yuma Kudo, Akihiro Abe, Kumiko Ito, Yuko Cho, Mari Yotsu-Yamashita & Keiichi Konoki. (2014) Expression of recombinant alpha and beta tubulins from the yew Taxus cuspidata and analysis of the microtubule assembly in the presence of taxol. Bioscience, Biotechnology, and Biochemistry 78:11, pages 1887-1894.
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Melissa J. Bennett, Gordon K. Chan, J.B. Rattner & David C. Schriemer. (2012) Low-dose laulimalide represents a novel molecular probe for investigating microtubule organization. Cell Cycle 11:16, pages 3045-3054.
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Articles from other publishers (19)

Daipeng Chen, Chunlan Wu, Chaofeng Hao, Panpan Huang, Huiquan Liu, Zhuyun Bian & Jin‐Rong Xu. (2018) Sexual specific functions of Tub1 beta‐tubulins require stage‐specific RNA processing and expression in Fusarium graminearum . Environmental Microbiology 20:11, pages 4009-4021.
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Matías A. Zúñiga, Joel B. Alderete, Gonzalo A. Jaña & Verónica A. Jiménez. (2017) Structural insight into the role of Gln293Met mutation on the Peloruside A/Laulimalide association with αβ-tubulin from molecular dynamics simulations, binding free energy calculations and weak interactions analysis. Journal of Computer-Aided Molecular Design 31:7, pages 643-652.
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Jessica Field, Peter Northcote, Ian Paterson, Karl-Heinz Altmann, J. Díaz & John Miller. (2017) Zampanolide, a Microtubule-Stabilizing Agent, Is Active in Resistant Cancer Cells and Inhibits Cell Migration. International Journal of Molecular Sciences 18:5, pages 971.
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Laura Woods, Joseph Arico, Jeffrey Frein, Dan Sackett & Richard Taylor. (2017) Synthesis and Biological Evaluation of 7-Deoxy-Epothilone Analogues. International Journal of Molecular Sciences 18:3, pages 648.
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Sarmistha Majumdar, Satyabrata Maiti & Shubhra Ghosh Dastidar. (2015) Dynamic and Static Water Molecules Complement the TN16 Conformational Heterogeneity inside the Tubulin Cavity. Biochemistry 55:2, pages 335-347.
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Arun Kanakkanthara, Peter T. Northcote & John H. Miller. (2016) Peloruside A: a lead non-taxoid-site microtubule-stabilizing agent with potential activity against cancer, neurodegeneration, and autoimmune disease. Natural Product Reports 33:4, pages 549-561.
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Arun Kanakkanthara, Matthew R. Rowe, Jessica J. Field, Peter T. Northcote, Paul H. Teesdale-Spittle & John H. Miller. (2015) βI-tubulin mutations in the laulimalide/peloruside binding site mediate drug sensitivity by altering drug–tubulin interactions and microtubule stability. Cancer Letters 365:2, pages 251-260.
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Erik M. Larsen, Matthew R. Wilson & Richard E. Taylor. (2015) Conformation–activity relationships of polyketide natural products. Natural Product Reports 32:8, pages 1183-1206.
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Cristina C. Rohena & Susan L. Mooberry. (2014) Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities. Nat. Prod. Rep. 31:3, pages 335-355.
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Reem Hanna, David R. Maass, Paul H. Atkinson, Peter T. Northcote, Paul H. Teesdale-Spittle, David S. Bellows & John H. Miller. (2014) Characterizing the laulimalide–peloruside binding site using site-directed mutagenesis of TUB2 in S. cerevisiae. Mol. BioSyst. 10:1, pages 110-116.
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Shanghua Yin, Changqing Zeng, Malathi Hari & Fernando Cabral. (2013) Paclitaxel resistance by random mutagenesis of ?-tubulin. Cytoskeleton 70:12, pages 849-862.
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Christoph W. Wullschleger, Jürg Gertsch & Karl‐Heinz Altmann. (2013) Synthesis and Biological Activity of 7,8,9‐Trideoxy‐ and 7 R DesTHP‐Peloruside A . Chemistry – A European Journal 19:39, pages 13105-13111.
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Jessica J. Field, José Fernando Díaz & John H. Miller. (2013) The Binding Sites of Microtubule-Stabilizing Agents. Chemistry & Biology 20:3, pages 301-315.
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Melissa M. Gajewski, Laleh Alisaraie & Jack A. Tuszynski. (2012) Peloruside, Laulimalide, and Noscapine Interactions with Beta-Tubulin. Pharmaceutical Research 29:11, pages 2985-2993.
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Shanghua Yin, Changqing Zeng, Malathi Hari & Fernando Cabral. (2012) Random Mutagenesis of β-Tubulin Defines a Set of Dispersed Mutations That Confer Paclitaxel Resistance. Pharmaceutical Research 29:11, pages 2994-3006.
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Soumyananda Chakraborti, Devlina Chakravarty, Suvroma Gupta, Biswa Prasun Chatterji, Gopa Dhar, Asim Poddar, Dulal Panda, Pinak Chakrabarti, Shubhra Ghosh Dastidar & Bhabatarak Bhattacharyya. (2012) Discrimination of Ligands with Different Flexibilities Resulting from the Plasticity of the Binding Site in Tubulin. Biochemistry 51:36, pages 7138-7148.
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Matthew R. Wilson & Richard E. Taylor. (2012) Toward an Enantioselective Synthesis of (−)-Zampanolide: Preparation of the C9–C20 Region. Organic Letters 14:13, pages 3408-3411.
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Zhiming Zhao & Richard E. Taylor. (2012) Rapid Access to Conformational Analogues of (+)-Peloruside A. Organic Letters 14:3, pages 669-671.
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Arun Kanakkanthara, Peter T. Northcote & John H. Miller. (2012) βII-Tubulin and βIII-Tubulin Mediate Sensitivity to Peloruside A and Laulimalide, but not Paclitaxel or Vinblastine, in Human Ovarian Carcinoma Cells. Molecular Cancer Therapeutics 11:2, pages 393-404.
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