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Cell Cycle Volume 10, 2011 - Issue 7
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The phenotype of MDM2 auto-degradation after DNA damage is due to epitope masking by phosphorylation

Qian Cheng Moffitt Cancer Center; Tampa, FL USA
&
Jiandong Chen Moffitt Cancer Center; Tampa, FL USA
Pages 1162-1166 | Published online: 01 Apr 2011

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Evgenia Gubanova, Natalia Issaeva, Camilla Gokturk, Tatjana Djureinovic & Thomas Helleday. (2013) SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways. Cell Cycle 12:24, pages 3770-3780.
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Kristina Heyne, Christine Winter, Fabian Gerten, Christina Schmidt & Klaus Roemer. (2013) A novel mechanism of crosstalk between the p53 and NFκB pathways. Cell Cycle 12:15, pages 2479-2492.
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Jihane Basbous, Dora Knani, Nathalie Bonneaud, Dominique Giorgi, Jean-Marc Brondello & Sylvie Rouquier. (2012) Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage. Cell Cycle 11:12, pages 2380-2390.
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Articles from other publishers (13)

Helge M. Magnussen, Syed F. Ahmed, Gary. J. Sibbet, Ventzislava A. Hristova, Koji Nomura, Andreas K. Hock, Lewis J. Archibald, Andrew G. Jamieson, David Fushman, Karen H. Vousden, Allan M. Weissman & Danny T. Huang. (2020) Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain. Nature Communications 11:1.
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Shahd Fouad, Owen S. Wells, Mark A. Hill & Vincenzo D’Angiolella. (2019) Cullin Ring Ubiquitin Ligases (CRLs) in Cancer: Responses to Ionizing Radiation (IR) Treatment. Frontiers in Physiology 10.
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Thuc-Nghi Duc Pham, Weili Ma, David Miller, Lidia Kazakova & Samuel Benchimol. (2019) Erythropoietin inhibits chemotherapy-induced cell death and promotes a senescence-like state in leukemia cells. Cell Death & Disease 10:1.
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J C Senturk, S Bohlman & J J Manfredi. (2017) Mdm2 selectively suppresses DNA damage arising from inhibition of topoisomerase II independent of p53. Oncogene 36:44, pages 6085-6096.
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T Liu, J Xiong, S Yi, H Zhang, S Zhou, L Gu & M Zhou. (2016) FKBP12 enhances sensitivity to chemotherapy-induced cancer cell apoptosis by inhibiting MDM2. Oncogene 36:12, pages 1678-1686.
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Haiyan WangShanbao Cai, Barbara J. BaileyM. Reza SaadatzadehJixin DingEva Tonsing-CarterTaxiarchis M. GeorgiadisT. Zachary GunterEric C. LongRobert E. MintoKevin R. GordonStephanie E. SenWenjing CaiJacob A. EitelDavid L. WaningLauren R. BringmanClark D. WellsMary E. MurrayJann N. Sarkaria, Lawrence M. GelbertDavid R. JonesAaron A. Cohen-GadolLindsey D. MayoHarlan E. ShannonKaren E. Pollok. (2017) Combination therapy in a xenograft model of glioblastoma: enhancement of the antitumor activity of temozolomide by an MDM2 antagonist. Journal of Neurosurgery 126:2, pages 446-459.
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Eva Slabáková, Gvantsa Kharaishvili, Monika Smějová, Zuzana Pernicová, Tereza Suchánková, Ján Remšík, Stanislav Lerch, Nicol Straková, Jan Bouchal, Milan Král, Zoran Culig, Alois Kozubík & Karel Souček. (2015) Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells. Oncotarget 6:34, pages 36156-36171.
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Christine M. Eischen & Guillermina Lozano. (2014) The Mdm Network and Its Regulation of p53 Activities: A Rheostat of Cancer Risk. Human Mutation 35:6, pages 728-737.
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Kristina Heyne, Juliane Förster, Roland Schüle & Klaus Roemer. (2022) Transcriptional repressor NIR interacts with the p53-inhibiting ubiquitin ligase MDM2. Nucleic Acids Research 42:6, pages 3565-3579.
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Andreas K. Hock & Karen H. Vousden. (2014) The role of ubiquitin modification in the regulation of p53. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1843:1, pages 137-149.
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Allison L. Zwingenberger, William Vernau, Changying Shi, Wensheng Yan, Xinbin Chen, Ira K. Gordon & Michael S. Kent. (2012) Development and characterization of 5 canine B-cell lymphoma cell lines. Leukemia Research 36:5, pages 601-606.
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Joshua S. Silverman, Jeffrey R. Skaar & Michele Pagano. (2012) SCF ubiquitin ligases in the maintenance of genome stability. Trends in Biochemical Sciences 37:2, pages 66-73.
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Vinod Pant, Shunbin Xiong, Tomoo Iwakuma, Alfonso Quintás-Cardama & Guillermina Lozano. (2011) Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proceedings of the National Academy of Sciences 108:29, pages 11995-12000.
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