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Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

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Pages 721-729 | Received 24 Oct 2011, Accepted 23 Dec 2011, Published online: 15 Feb 2012

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Rama K. Mallampalli, Jennifer R. Glasser, Tiffany A. Coon & Bill B. Chen. (2013) Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis. Cell Cycle 12:4, pages 663-673.
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Sun-Young Lee, Gong Rak Lee, Dong-Hyuk Woo, Neung Hwa Park, Hee Jeong Cha, Yong-Hwan Moon & In-Seob Han. (2013) Depletion of Aurora A leads to upregulation of FoxO1 to induce cell cycle arrest in hepatocellular carcinoma cells. Cell Cycle 12:1, pages 67-75.
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Articles from other publishers (39)

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Jing Zhou, Yang Lin, Xiuhua Kang, Zhicheng Liu, Juntao Zou & Fei Xu. (2023) Hypoxia-mediated promotion of glucose metabolism in non-small cell lung cancer correlates with activation of the EZH2/FBXL7/PFKFB4 axis. Cell Death & Disease 14:5.
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Yue Wang, Xiao Shen, Longyuan Gong, Yongchao Zhao & Xiufang Xiong. (2022) Functional characterization of FBXL7 as a novel player in human cancers. Cell Death Discovery 8:1.
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Fang Liu, Xuan Wang, Jianli Duan, Zhijie Hou, Zhouming Wu, Lingling Liu, Hanqi Lei, Dan Huang, Yifei Ren, Yue Wang, Xinyan Li, Junxiao Zhuo, Zijian Zhang, Bin He, Min Yan, Huiming Yuan, Lihua Zhang, Jinsong Yan, Shijun Wen, Zifeng Wang & Quentin Liu. (2022) A Temporal PROTAC Cocktail‐Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells. Advanced Science 9:22, pages 2104823.
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Diego Camuzi, Luisa Aguirre Buexm, Simone de Queiroz Chaves Lourenço, Rachele Grazziotin, Simone Guaraldi, Priscila Valverde, Davy Rapozo, Jill M. Brooks, Hisham Mehanna, Luis Felipe Ribeiro Pinto & Sheila Coelho Soares-Lima. (2022) FBXL7 Body Hypomethylation Is Frequent in Tumors from the Digestive and Respiratory Tracts and Is Associated with Risk-Factor Exposure. International Journal of Molecular Sciences 23:14, pages 7801.
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Yanping Jia, Wenqiang Liu, Dandan Bai, Yalin Zhang, Yanhe Li, Yingdong Liu, Jiqing Yin, Qiaoyu Chen, Mingming Ye, Yanhong Zhao, Xiaochen Kou, Hong Wang, Shaorong Gao, Kunming Li & Miaoxin Chen. (2021) Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring. Journal of Pineal Research.
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Eddie Luidy Imada, Diego Fernando Sanchez, Wikum Dinalankara, Thiago Vidotto, Ericka M. Ebot, Svitlana Tyekucheva, Gloria Regina Franco, Lorelei Ann Mucci, Massimo Loda, Edward Matthew Schaeffer, Tamara Lotan & Luigi Marchionni. (2021) Transcriptional landscape of PTEN loss in primary prostate cancer. BMC Cancer 21:1.
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Jianqi Ni, Lan Shen, Liu Xu, Qin Jin & Guoliang Wang. (2021) 7-Ethoxyrosmanol alleviates hyperglycemia-induced vascular endothelial dysfunction by regulating FBXL7 expression. Journal of Bioenergetics and Biomembranes 53:5, pages 553-560.
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Liang Tang, Meng Ji, Xing Liang, Danlei Chen, Anan Liu, Guang Yang, Ligang Shi, Zhiping Fu & Chenghao Shao. (2021) Downregulated F-Box/LRR-Repeat Protein 7 Facilitates Pancreatic Cancer Metastasis by Regulating Snail1 for Proteasomal Degradation. Frontiers in Genetics 12.
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Giulia Bertolin, Marie-Clotilde Alves-Guerra, Angélique Cheron, Agnès Burel, Claude Prigent, Roland Le Borgne & Marc Tramier. (2021) Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2. Life Science Alliance 4:6, pages e202000806.
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Bethany Mason & Heike Laman. (2020) The FBXL family of F-box proteins: variations on a theme. Open Biology 10:11.
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Loredana Moro, Daniele Simoneschi, Emma Kurz, Arnaldo A. Arbini, Shaowen Jang, Nicoletta Guaragnella, Sergio Giannattasio, Wei Wang, Yu-An Chen, Geoffrey Pires, Andrew Dang, Elizabeth Hernandez, Payal Kapur, Ankita Mishra, Aristotelis Tsirigos, George Miller, Jer-Tsong Hsieh & Michele Pagano. (2020) Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis. Nature Cell Biology 22:9, pages 1130-1142.
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Shiqi Kong, Yanwei Fang, Bingqian Wang, Yingxiao Cao, Runzhi He & Zongmao Zhao. (2020) miR‐152‐5p suppresses glioma progression and tumorigenesis and potentiates temozolomide sensitivity by targeting FBXL7. Journal of Cellular and Molecular Medicine 24:8, pages 4569-4579.
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Linzhi Yan, Min Lin, Shuya Pan, Yehuda G. Assaraf, Zhi-wei Wang & Xueqiong Zhu. (2020) Emerging roles of F-box proteins in cancer drug resistance. Drug Resistance Updates 49, pages 100673.
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Sang-Min Jang, Christophe E. Redon & Mirit I. Aladjem. (2018) Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy. Frontiers in Molecular Biosciences 5.
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Christian Arquint, Fabien Cubizolles, Agathe Morand, Alexander Schmidt & Erich A. Nigg. (2018) The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number. Open Biology 8:2.
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Chen Wu, Victoria G. Twort, Ross N. Crowhurst, Richard D. Newcomb & Thomas R. Buckley. (2017) Assembling large genomes: analysis of the stick insect (Clitarchus hookeri) genome reveals a high repeat content and sex-biased genes associated with reproduction. BMC Genomics 18:1.
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Chenglin Liu, Yu-Hang Zhang, Tao Huang & Yudong Cai. (2017) Identification of transcription factors that may reprogram lung adenocarcinoma. Artificial Intelligence in Medicine 83, pages 52-57.
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E Hasanov, G Chen, P Chowdhury, J Weldon, Z Ding, E Jonasch, S Sen, C L Walker & R Dere. (2017) Ubiquitination and regulation of AURKA identifies a hypoxia-independent E3 ligase activity of VHL. Oncogene 36:24, pages 3450-3463.
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M Kamran, Z-J Long, D Xu, S-S Lv, B Liu, C-L Wang, J Xu, E W-F Lam & Q Liu. (2017) Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. Oncogenesis 6:2, pages e298-e298.
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Nana Zheng, Zhiwei Wang & Wenyi Wei. (2016) Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins. The International Journal of Biochemistry & Cell Biology 73, pages 99-110.
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Jinho Heo, Rebeka Eki & Tarek Abbas. (2016) Deregulation of F-box proteins and its consequence on cancer development, progression and metastasis. Seminars in Cancer Biology 36, pages 33-51.
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Yuan Liu & Rama K. Mallampalli. (2016) Small molecule therapeutics targeting F-box proteins in cancer. Seminars in Cancer Biology 36, pages 105-119.
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Suzanne J. Randle & Heike Laman. (2016) F-box protein interactions with the hallmark pathways in cancer. Seminars in Cancer Biology 36, pages 3-17.
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Catherine Lindon, Rhys Grant & Mingwei Min. (2016) Ubiquitin-Mediated Degradation of Aurora Kinases. Frontiers in Oncology 5.
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Tiffany A. CoonAlison C. McKelveyTravis LearShristi RajbhandariSarah R. DunnWilliam ConnellyJoe Y. ZhaoSeungHye HanYuan LiuNathaniel M. WeathingtonBryan J. McVerryYingze ZhangBill B. Chen. (2015) The proinflammatory role of HECTD2 in innate immunity and experimental lung injury. Science Translational Medicine 7:295.
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Yuan Liu, Travis Lear, Olivia Iannone, Sruti Shiva, Catherine Corey, Shristi Rajbhandari, Jacob Jerome, Bill B. Chen & Rama K. Mallampalli. (2015) The Proapoptotic F-box Protein Fbxl7 Regulates Mitochondrial Function by Mediating the Ubiquitylation and Proteasomal Degradation of Survivin. Journal of Biological Chemistry 290:19, pages 11843-11852.
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Y Liu, T Lear, Y Zhao, J Zhao, C Zou, B B Chen & R K Mallampalli. (2015) F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7. Cell Death & Disease 6:2, pages e1630-e1630.
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Justin A Bosch, Taryn M Sumabat, Yassi Hafezi, Brett J Pellock, Kevin D Gandhi & Iswar K Hariharan. (2014) The Drosophila F-box protein Fbxl7 binds to the protocadherin Fat and regulates Dachs localization and Hippo signaling. eLife 3.
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Hiroyuki Inuzuka & Wenyi WeiBrian J. North, Yueyong Liu, Hiroyuki Inuzuka & Wenyi Wei. 2014. SCF and APC E3 Ubiquitin Ligases in Tumorigenesis. SCF and APC E3 Ubiquitin Ligases in Tumorigenesis 47 71 .
Satoko Yamamoto, Mutsuko Yamamoto-Ibusuki, Yutaka Yamamoto, Saori Fujiwara & Hirotaka Iwase. (2013) A comprehensive analysis of Aurora A; transcript levels are the most reliable in association with proliferation and prognosis in breast cancer. BMC Cancer 13:1.
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M. Khair ElZarrad, Partha Mukhopadhyay, Nishant Mohan, Enkui Hao, Milos Dokmanovic, Dianne S. Hirsch, Yi Shen, Pal Pacher & Wen Jin Wu. (2013) Trastuzumab Alters the Expression of Genes Essential for Cardiac Function and Induces Ultrastructural Changes of Cardiomyocytes in Mice. PLoS ONE 8:11, pages e79543.
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Wen Dui, Wei Lu, Jun Ma & Renjie Jiao. (2012) A Systematic Phenotypic Screen of F-box Genes Through a Tissue-specific RNAi-based Approach in Drosophila. Journal of Genetics and Genomics 39:8, pages 397-413.
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