1,885
Views
59
CrossRef citations to date
0
Altmetric
Review

Autophagy and cardiovascular aging

Lesson learned from rapamycin

&
Pages 2092-2099 | Published online: 01 Jun 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Dorien G De Munck, Guido RY De Meyer & Wim Martinet. (2020) Autophagy as an emerging therapeutic target for age-related vascular pathologies. Expert Opinion on Therapeutic Targets 24:2, pages 131-145.
Read now
Karla Consort Ribeiro, Roberto Perez Campelo, Daniela del Rosário Flores Rodrigues, Elisabete C. Mattos, Izaira Trincani Brandão, Célio Lopes da Silva, Eliete Bouskela, Camila Guerra Martinez & Eleonora Kurtenbach. (2018) Immunization with plasmids encoding M2 acetylcholine muscarinic receptor epitopes impairs cardiac function in mice and induces autophagy in the myocardium. Autoimmunity 51:5, pages 245-257.
Read now
Mikhail V Blagosklonny. (2013) Selective anti-cancer agents as anti-aging drugs. Cancer Biology & Therapy 14:12, pages 1092-1097.
Read now
Federico Pietrocola, Guillermo Mariño, Delphine Lissa, Erika Vacchelli, Shoaib Ahmad Malik, Mireia Niso-Santano, Naoufal Zamzami, Lorenzo Galluzzi, Maria Chiara Maiuri & Guido Kroemer. (2012) Pro-autophagic polyphenols reduce the acetylation of cytoplasmic proteins. Cell Cycle 11:20, pages 3851-3860.
Read now

Articles from other publishers (52)

Cristina Carvalho, Joana F. Pires, Paula I. Moreira & Nuno Raimundo. 2023. Aging. Aging 359 384 .
Dorien G. De Munck, Arthur J. A. Leloup, Sofie De Moudt, Guido R. Y. De Meyer, Wim Martinet & Paul Fransen. (2022) Mouse aortic biomechanics are affected by short-term defective autophagy in vascular smooth muscle cells. The Journal of Physiological Sciences 72:1.
Crossref
Wenjuan Wang, Qingjian He, Chenchen Zhuang, Haodong Zhang, Xin Fan, Qiongying Wang, Miaomiao Qi, Runmin Sun, Caie Li & Jing Yu. (2022) Apatinib Through Activating the RhoA/ROCK Signaling Pathway to Cause Dysfunction of Vascular Smooth Muscle Cells. Applied Biochemistry and Biotechnology 194:11, pages 5367-5385.
Crossref
Vanessa Dela Justina, Jéssica S. G. Miguez, Fernanda Priviero, Jennifer C. Sullivan, Fernanda R. Giachini & R. Clinton Webb. (2021) Sex Differences in Molecular Mechanisms of Cardiovascular Aging. Frontiers in Aging 2.
Crossref
Mirko Pesce, Patrizia Ballerini, Teresa Paolucci, Iris Puca, Mohammad Hosein Farzaei & Antonia Patruno. (2020) Irisin and Autophagy: First Update. International Journal of Molecular Sciences 21:20, pages 7587.
Crossref
Amir Ajoolabady, Hamid Aslkhodapasandhokmabad, Ayuob Aghanejad, Yingmei Zhang & Jun Ren. (2020) Mitophagy Receptors and Mediators: Therapeutic Targets in the Management of Cardiovascular Ageing. Ageing Research Reviews 62, pages 101129.
Crossref
Amir Ajoolabady, Ayuob Aghanejad, Yaguang Bi, Yingmei Zhang, Hamid Aslkhodapasandhukmabad, Alireza Abhari & Jun Ren. (2020) Enzyme-based autophagy in anti-neoplastic management: From molecular mechanisms to clinical therapeutics. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1874:1, pages 188366.
Crossref
Ali M. Mahran, Eman Mosad, Mohamed A. Abdel‐Raheem, Eman H. Ahmed, Amira Ali Abdel Motaleb & Eman R. Hofny. (2019) The correlation between mammalian target of rapamycin (mTOR) gene expression and sperm DNA damage among infertile patients with and without varicocele. Andrologia 51:9.
Crossref
Kurt A. Escobar, Nathan H. Cole, Christine M. Mermier & Trisha A. VanDusseldorp. (2019) Autophagy and aging: Maintaining the proteome through exercise and caloric restriction. Aging Cell 18:1, pages e12876.
Crossref
Evgeniy Panzhinskiy, Bruce Culver, Jun Ren, Debasis Bagchi & Sreejayan Nair. 2019. Nutrition and Enhanced Sports Performance. Nutrition and Enhanced Sports Performance 251 261 .
Hassan I. H. El-Sayyad. 2019. Modulation of Oxidative Stress in Heart Disease. Modulation of Oxidative Stress in Heart Disease 81 105 .
Jun Ren & Yingmei Zhang. (2018) Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases. Trends in Pharmacological Sciences 39:12, pages 1064-1076.
Crossref
C. Barbati, M. Vomero, T. Colasanti, F. Ceccarelli, M. Marcosano, F. Miranda, L. Novelli, A. Pecani, Carlo Perricone, F. R. Spinelli, S. Truglia, F. Conti, G. Valesini & C. Alessandri. (2018) Microparticles and autophagy: a new frontier in the understanding of atherosclerosis in rheumatoid arthritis. Immunologic Research 66:6, pages 655-662.
Crossref
Fu-Hui Xiao, Xiao-Qiong Chen, Qin Yu, Yunshuang Ye, Yao-Wen Liu, Dongjing Yan, Li-Qin Yang, Guijun Chen, Rong Lin, Liping Yang, Xiaoping Liao, Wen Zhang, Wei Zhang, Nelson Leung-Sang Tang, Xiao-Fan Wang, Jumin Zhou, Wang-Wei Cai, Yong-Han He & Qing-Peng Kong. (2018) Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. Genome Research 28:11, pages 1601-1610.
Crossref
Yingmei Zhang, Adam T. Whaley-Connell, James R. Sowers & Jun Ren. (2018) Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management. Pharmacology & Therapeutics 191, pages 1-22.
Crossref
Asli F. Ceylan, Shuyi Wang, Machender R. Kandadi, Jie Chen, Yinan Hua, Zhaohui Pei, Sreejayan Nair & Jun Ren. (2018) Cardiomyocyte-specific knockout of endothelin receptor a attenuates obesity cardiomyopathy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:10, pages 3339-3352.
Crossref
Na Lu, Xingxing Li, Ruolan Tan, Jing An, Zhenlu Cai, Xiaoxuan Hu, Feidi Wang, Haoruo Wang, Chengbiao Lu & Haixia Lu. (2018) HIF-1α/Beclin1-Mediated Autophagy Is Involved in Neuroprotection Induced by Hypoxic Preconditioning. Journal of Molecular Neuroscience 66:2, pages 238-250.
Crossref
Mingyi Wang, Li Zhang, Wanqu Zhu, Jing Zhang, Soo Hyuk Kim, Yushi Wang, Leng Ni, Richard Telljohann, Robert E. Monticone, Kimberly McGraw, Lijuan Liu, Rafael de Cabo & Edward G. Lakatta. (2018) Calorie Restriction Curbs Proinflammation That Accompanies Arterial Aging, Preserving a Youthful Phenotype. Journal of the American Heart Association 7:18.
Crossref
Shuyi Wang, Wei Ge, Carrie Harns, Xianzhong Meng, Yingmei Zhang & Jun Ren. (2018) Ablation of toll-like receptor 4 attenuates aging-induced myocardial remodeling and contractile dysfunction through NCoRI-HDAC1-mediated regulation of autophagy. Journal of Molecular and Cellular Cardiology 119, pages 40-50.
Crossref
Wei Yu, Wenliang Zha & Jun Ren. (2018) Exendin-4 and Liraglutide Attenuate Glucose Toxicity-Induced Cardiac Injury through mTOR/ULK1-Dependent Autophagy. Oxidative Medicine and Cellular Longevity 2018, pages 1-14.
Crossref
Pernille Hojman, Julie Gehl, Jesper F. Christensen & Bente K. Pedersen. (2018) Molecular Mechanisms Linking Exercise to Cancer Prevention and Treatment. Cell Metabolism 27:1, pages 10-21.
Crossref
Jun Ren, Lifang Yang, Li Zhu, Xihui Xu, Asli F. Ceylan, Wei Guo, Jian Yang & Yingmei Zhang. (2017) Akt2 ablation prolongs life span and improves myocardial contractile function with adaptive cardiac remodeling: role of Sirt1-mediated autophagy regulation. Aging Cell 16:5, pages 976-987.
Crossref
Nikolaos Charmpilas, Emmanouil Kyriakakis & Nektarios Tavernarakis. (2017) Small heat shock proteins in ageing and age-related diseases. Cell Stress and Chaperones 22:4, pages 481-492.
Crossref
Bing WangJing ZengQi Gu. (2017) Exercise restores bioavailability of hydrogen sulfide and promotes autophagy influx in livers of mice fed with high-fat diet. Canadian Journal of Physiology and Pharmacology 95:6, pages 667-674.
Crossref
Yubisay Mejías-Peña, Brisamar Estébanez, Paula Rodriguez-Miguelez, Rodrigo Fernandez-Gonzalo, Mar Almar, José A. de Paz, Javier González-Gallego & María J. Cuevas. (2017) Impact of resistance training on the autophagy-inflammation-apoptosis crosstalk in elderly subjects. Aging 9:2, pages 408-418.
Crossref
Francesca Tarantini, Claudia Di Serio & Luigi Ferrucci. 2017. Cardiac Management in the Frail Elderly Patient and the Oldest Old. Cardiac Management in the Frail Elderly Patient and the Oldest Old 23 40 .
N-T. Cheng, A. Guo & Y-P. Cui. (2016) Intra-articular injection of Torin 1 reduces degeneration of articular cartilage in a rabbit osteoarthritis model. Bone & Joint Research 5:6, pages 218-224.
Crossref
Shin Kyoung HurSeung Hee ParkGoo Taeg Oh. (2016) The Role of Autophagy in the Pathogenesis of Atherosclerosis. Journal of Lipid and Atherosclerosis 5:1, pages 1.
Crossref
Ming Zhang, Juan Mo & Sally S. Atherton. 2016. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging 267 279 .
Eugenia Morselli & Alfredo Criollo. 2016. Autophagy Networks in Inflammation. Autophagy Networks in Inflammation 323 343 .
J Zhang, Y Bai, L Huang, Y Qi, Q Zhang, S Li, Y Wu & X Li. (2015) Protective effect of autophagy on human retinal pigment epithelial cells against lipofuscin fluorophore A2E: implications for age-related macular degeneration. Cell Death & Disease 6:11, pages e1972-e1972.
Crossref
Ruchira Singh, David Kuai, Karina E Guziewicz, Jackelyn Meyer, Molly Wilson, Jianfeng Lu, Molly Smith, Eric Clark, Amelia Verhoeven, Gustavo D Aguirre & David M Gamm. (2015) Pharmacological Modulation of Photoreceptor Outer Segment Degradation in a Human iPS Cell Model of Inherited Macular Degeneration. Molecular Therapy 23:11, pages 1700-1711.
Crossref
Lifang Yang, Jian-Yuan Gao, Jipeng Ma, Xihui Xu, Qiurong Wang, Lize Xiong, Jian Yang & Jun Ren. (2015) Cardiac-specific overexpression of metallothionein attenuates myocardial remodeling and contractile dysfunction in l-NAME-induced experimental hypertension: Role of autophagy regulation. Toxicology Letters 237:2, pages 121-132.
Crossref
Carine Beaupere, Marie Garcia, Jerome Larghero, Bruno Fève, Jacqueline Capeau & Claire Lagathu. (2015) The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation. Aging Cell 14:4, pages 534-546.
Crossref
Jun Ren & Heinrich Taegtmeyer. (2015) Too much or not enough of a good thing — The Janus faces of autophagy in cardiac fuel and protein homeostasis. Journal of Molecular and Cellular Cardiology 84, pages 223-226.
Crossref
Changhua Wang & Xuejun Wang. (2015) The interplay between autophagy and the ubiquitin–proteasome system in cardiac proteotoxicity. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852:2, pages 188-194.
Crossref
Qijun Zheng, Kun Zhao, Xuefeng Han, Anna F. Huff, Qin Cui, Sara A. Babcock, Shiqiang Yu & Yingmei Zhang. (2015) Inhibition of AMPK accentuates prolonged caloric restriction-induced change in cardiac contractile function through disruption of compensatory autophagy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1852:2, pages 332-342.
Crossref
Guido R.Y. De MeyerMandy O.J. GrootaertCédéric F. MichielsAmmar KurdiDorien M. SchrijversWim Martinet. (2015) Autophagy in Vascular Disease. Circulation Research 116:3, pages 468-479.
Crossref
Eunbi Kim, Sam Young Yoon & Young Joo Shin. 2015. Studies on the Cornea and Lens. Studies on the Cornea and Lens 3 22 .
Xin-Yuan Luo, Shun-Lin Qu, Zhi-Han Tang, Yuan Zhang, Mi-Hua Liu, Juan Peng, Hui Tang, Kang-Lun Yu, Chi Zhang, Zhong Ren & Zhi-Sheng Jiang. (2014) SIRT1 in cardiovascular aging. Clinica Chimica Acta 437, pages 106-114.
Crossref
Yingmei Zhang, Xuefeng Han, Nan Hu, Anna F. Huff, Feng Gao & Jun Ren. (2014) Akt2 knockout alleviates prolonged caloric restriction-induced change in cardiac contractile function through regulation of autophagy. Journal of Molecular and Cellular Cardiology 71, pages 81-91.
Crossref
Hongyu Zhang, Yongsheng Gong, Zhouguang Wang, Liping Jiang, Ran Chen, Xiaofang Fan, Huanmian Zhu, Liping Han, Xiaokun Li, Jian Xiao & Xiaoxia Kong. (2014) Apelin inhibits the proliferation and migration of rat PASMC s via the activation of PI3K/Akt/m TOR signal and the inhibition of autophagy under hypoxia . Journal of Cellular and Molecular Medicine 18:3, pages 542-553.
Crossref
Guido R. Y. De Meyer, Dorien M. Schrijvers & Wim Martinet. 2014. Aging and Heart Failure. Aging and Heart Failure 339 349 .
M V Blagosklonny. (2013) TOR-centric view on insulin resistance and diabetic complications: perspective for endocrinologists and gerontologists. Cell Death & Disease 4:12, pages e964-e964.
Crossref
D. U. Akasheva, E. V. Plokhova, I. D. Strazhesko, E. N. Dudinskaya & O. N. Tkacheva. (2013) HEART AND AGE (PART III): MODIFYING AGEING PROCESSES. Cardiovascular Therapy and Prevention 12:5, pages 91-96.
Crossref
Asli F. Ceylan-Isik, Machender R. Kandadi, Xihui Xu, Yinan Hua, Adam J. Chicco, Jun Ren & Sreejayan Nair. (2013) Apelin administration ameliorates high fat diet-induced cardiac hypertrophy and contractile dysfunction. Journal of Molecular and Cellular Cardiology 63, pages 4-13.
Crossref
Emanuele MarzettiAnna CsiszarDebapriya Dutta, Gauthami Balagopal, Riccardo Calvani & Christiaan Leeuwenburgh. (2013) Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics. American Journal of Physiology-Heart and Circulatory Physiology 305:4, pages H459-H476.
Crossref
J. BowersJ. TerrienM. S. Clerget-FroidevauxJ. D. GothiéM. P. Rozing, R. G. J. Westendorp, D. van Heemst & B. A. Demeneix. (2013) Thyroid Hormone Signaling and Homeostasis During Aging. Endocrine Reviews 34:4, pages 556-589.
Crossref
Wei Ge, Nan Hu, Lindsey A. George, Stephen P. Ford, Peter W. Nathanielsz, Xiao-Ming Wang & Jun Ren. (2013) Maternal nutrient restriction predisposes ventricular remodeling in adult sheep offspring. The Journal of Nutritional Biochemistry 24:7, pages 1258-1265.
Crossref
Robert C. Lyon, Stephan Lange & Farah Sheikh. (2013) Breaking down protein degradation mechanisms in cardiac muscle. Trends in Molecular Medicine 19:4, pages 239-249.
Crossref
Ka Wai Mok, Dolores D. Mruk & C. Yan Cheng. 2013. 291 358 .
Evgeniy Panzhinskiy, Bruce Culver, Jun Ren, Debasis Bagchi & Sreejayan Nair. 2013. Nutrition and Enhanced Sports Performance. Nutrition and Enhanced Sports Performance 217 227 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.