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Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

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Pages 3019-3035 | Received 02 Jul 2012, Accepted 06 Jul 2012, Published online: 09 Aug 2012

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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
Ting Jiang, Xisha Chen, Xingcong Ren, Jin-Ming Yang & Yan Cheng. (2021) Emerging role of autophagy in anti-tumor immunity: Implications for the modulation of immunotherapy resistance. Drug Resistance Updates 56, pages 100752.
Crossref
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Crossref
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Crossref
Rushikesh S. Joshi, Samanvi S. Kanugula, Sweta Sudhir, Matheus P. Pereira, Saket Jain & Manish K. Aghi. (2021) The Role of Cancer-Associated Fibroblasts in Tumor Progression. Cancers 13:6, pages 1399.
Crossref
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Barbara Bellei, Emilia Migliano & Mauro Picardo. (2020) A Framework of Major Tumor-Promoting Signal Transduction Pathways Implicated in Melanoma-Fibroblast Dialogue. Cancers 12:11, pages 3400.
Crossref
Young-Ho Ahn & Jeong Seon Kim. (2020) Long Non-Coding RNAs as Regulators of Interactions between Cancer-Associated Fibroblasts and Cancer Cells in the Tumor Microenvironment. International Journal of Molecular Sciences 21:20, pages 7484.
Crossref
Venkadesaperumal Gopu, Liang Fan, Rashmi S. Shetty, M.R. Nagaraja & Sreerama Shetty. (2020) Caveolin-1 scaffolding domain peptide regulates glucose metabolism in lung fibrosis. JCI Insight 5:19.
Crossref
Wen-Wei Zhu, Ming Lu, Xiang-Yu Wang, Xu Zhou, Chao Gao & Lun-Xiu Qin. (2020) The fuel and engine: The roles of reprogrammed metabolism in metastasis of primary liver cancer. Genes & Diseases 7:3, pages 299-307.
Crossref
Pingping Hou, Avnish Kapoor, Qiang Zhang, Jiexi Li, Chang-Jiun Wu, Jun Li, Zhengdao Lan, Ming Tang, Xingdi Ma, Jeffrey J. Ackroyd, Raghu Kalluri, Jianhua Zhang, Shan Jiang, Denise J. Spring, Y. Alan Wang & Ronald A. DePinho. (2020) Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer. Cancer Discovery 10:7, pages 1058-1077.
Crossref
Shoujie Feng, Li Zhang, Xiucheng Liu, Guangbin Li, Biao Zhang, Ziwen Wang, Hao Zhang & Haitao Ma. (2020) Low levels of AMPK promote epithelial‐mesenchymal transition in lung cancer primarily through HDAC4‐ and HDAC5‐mediated metabolic reprogramming. Journal of Cellular and Molecular Medicine 24:14, pages 7789-7801.
Crossref
Cesar A. Martinez & Claudio Scafoglio. (2020) Heterogeneity of Glucose Transport in Lung Cancer. Biomolecules 10:6, pages 868.
Crossref
Teresa Dean, Nancy T. Li, Jose L. Cadavid, Laurie Ailles & Alison P. McGuigan. (2020) A TRACER culture invasion assay to probe the impact of cancer associated fibroblasts on head and neck squamous cell carcinoma cell invasiveness. Biomaterials Science 8:11, pages 3078-3094.
Crossref
Kevin DzoboCollet Dandara. (2020) Architecture of Cancer-Associated Fibroblasts in Tumor Microenvironment: Mapping Their Origins, Heterogeneity, and Role in Cancer Therapy Resistance. OMICS: A Journal of Integrative Biology 24:6, pages 314-339.
Crossref
Lisa M. Becker, Joyce T. O’Connell, Annie P. Vo, Margo P. Cain, Desiree Tampe, Lauren Bizarro, Hikaru Sugimoto, Anna K. McGow, John M. Asara, Sara Lovisa, Kathleen M. McAndrews, Rafal Zielinski, Philip L. Lorenzi, Michael Zeisberg, Sughra Raza, Valerie S. LeBleu & Raghu Kalluri. (2020) Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer. Cell Reports 31:9, pages 107701.
Crossref
Sevda Salimifard, Ali Masjedi, Mohammad Hojjat-Farsangi, Ghasem Ghalamfarsa, Mahzad Irandoust, Gholamreza Azizi, Hamed Mohammadi, Mohammad Reza Keramati & Farhad Jadidi-Niaragh. (2020) Cancer associated fibroblasts as novel promising therapeutic targets in breast cancer. Pathology - Research and Practice 216:5, pages 152915.
Crossref
Jin Gong, Yiyun Lin, Huaqin Zhang, Chunqi Liu, Zhong Cheng, Xiaowei Yang, Jiamei Zhang, Yuanyuan Xiao, Na Sang, Xinying Qian, Liang Wang, Xiaobo Cen, Xiao Du & Yinglan Zhao. (2020) Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells. Cell Death & Disease 11:4.
Crossref
Ebbe BoedtkjerStine F. Pedersen. (2020) The Acidic Tumor Microenvironment as a Driver of Cancer. Annual Review of Physiology 82:1, pages 103-126.
Crossref
Marta Truffi, Luca Sorrentino & Fabio Corsi. 2020. Tumor Microenvironment. Tumor Microenvironment 15 29 .
Sascha Rahn, Philippe Dänzer Barbosa, Julia Luisa Möller, Nourhane Ammar, Tobias Demetrowitsch, Ole Helm, Daniela Wesch, Bence Sipos, Christoph Röcken, Karin Schwarz, Heiner Schäfer & Susanne Sebens. (2019) Inflammation Associated Pancreatic Tumorigenesis: Upregulation of Succinate Dehydrogenase (Subunit B) Reduces Cell Growth of Pancreatic Ductal Epithelial Cells. Cancers 12:1, pages 42.
Crossref
Thomas Lindner, Anastasia Loktev, Frederik Giesel, Clemens Kratochwil, Annette Altmann & Uwe Haberkorn. (2019) Targeting of activated fibroblasts for imaging and therapy. EJNMMI Radiopharmacy and Chemistry 4:1.
Crossref
Juan Zhang, Hui Li, Dan Yi, Chuntian Lai, Haiyan Wang, Wenda Zou & Bei Cao. (2019) Knockdown of vascular cell adhesion molecule 1 impedes transforming growth factor beta 1-mediated proliferation, migration, and invasion of endometriotic cyst stromal cells. Reproductive Biology and Endocrinology 17:1.
Crossref
Xuanling Du, Qiping Xu, Duyi Pan, Dongke Xu, Baolin Niu, Wenting Hong, Rui Zhang, Xiaobo Li & Shiyao Chen. (2019) HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression. Cell Death & Disease 10:12.
Crossref
Masoud Najafi, Keywan Mortezaee & Jamal Majidpoor. (2019) Stromal reprogramming: A target for tumor therapy. Life Sciences 239, pages 117049.
Crossref
Kshitiz, Junaid Afzal, Jamie D. Maziarz, Archer Hamidzadeh, Cong Liang, Eric M. Erkenbrack, Hong Nam Kim, Jan-Dirk Haeger, Christiane Pfarrer, Thomas Hoang, Troy Ott, Thomas Spencer, Mihaela Pavličev, Douglas F. Antczak, Andre Levchenko & Günter P. Wagner. (2019) Evolution of placental invasion and cancer metastasis are causally linked. Nature Ecology & Evolution 3:12, pages 1743-1753.
Crossref
Brooke A. Pereira, Claire Vennin, Michael Papanicolaou, Cecilia R. Chambers, David Herrmann, Jennifer P. Morton, Thomas R. Cox & Paul Timpson. (2019) CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer. Trends in Cancer 5:11, pages 724-741.
Crossref
Jingfang Sun, Ran Tao, Tianxiao Mao, Zhi Feng, Qinglong Guo & Xiaobo Zhang. (2019) The involvement of lipid raft pathway in suppression of TGFβ-mediated metastasis by tolfenamic acid in hepatocellular carcinoma cells. Toxicology and Applied Pharmacology 380, pages 114696.
Crossref
Francois Faitot, Elisa Ruhland, Constantin Oncioiu, Camille Besch, Pietro Addeo, A. Ercument Cicek, Philippe Bachellier & Izzie-Jacques Namer. (2019) Metabolomic profiling highlights the metabolic bases of acute-on-chronic and post-hepatectomy liver failure. HPB 21:10, pages 1354-1361.
Crossref
Sarah DimeloePatrick GubserJordan Loeliger, Corina FrickLeyla DeveliogluMarco Fischer, Florian MarquardsenGlenn R. BantugDaniela Thommen, Yannic LecoultreAlfred ZippeliusAnja Langenkamp & Christoph Hess. (2019) Tumor-derived TGF-β inhibits mitochondrial respiration to suppress IFN-γ production by human CD4 + T cells . Science Signaling 12:599.
Crossref
Rachel H. ParkStephen J. PollockRichard P. PhippsHoward N. LangsteinCollynn F. Woeller. (2019) Discovery of Novel Small Molecules that Block Myofibroblast Formation: Implications for Capsular Contracture Treatment. Plastic and Reconstructive Surgery - Global Open 7:9, pages e2430.
Crossref
Zhengtao Xiao, Ziwei Dai & Jason W. Locasale. (2019) Metabolic landscape of the tumor microenvironment at single cell resolution. Nature Communications 10:1.
Crossref
Bethany R. Mordhorst, Karl C. Kerns, Martin Schauflinger, Michal Zigo, Stephanie L. Murphy, Renee M. Ross, Kevin D. Wells, Jonathan A. Green, Peter Sutovsky & Randall S. Prather. (2019) Pharmacologic treatment with CPI-613 and PS48 decreases mitochondrial membrane potential and increases quantity of autolysosomes in porcine fibroblasts. Scientific Reports 9:1.
Crossref
Alexander Fabian, Simon Stegner, Lauritz Miarka, Johannes Zimmermann, Lennart Lenk, Sascha Rahn, Jann Buttlar, Fabrice Viol, Hendrike Knaack, Daniela Esser, Sascha Schäuble, Peter Großmann, Georgios Marinos, Robert Häsler, Wolfgang Mikulits, Dieter Saur, Christoph Kaleta, Heiner Schäfer & Susanne Sebens. (2019) Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells. Cancer Letters 453, pages 95-106.
Crossref
Luke Bu, Hideo Baba, Naoya Yoshida, Keisuke Miyake, Tadahito Yasuda, Tomoyuki Uchihara, Patrick Tan & Takatsugu Ishimoto. (2019) Biological heterogeneity and versatility of cancer-associated fibroblasts in the tumor microenvironment. Oncogene 38:25, pages 4887-4901.
Crossref
Hongjun Zheng, Jin Liu, Eric Tycksen, Ryan Nunley & Audrey McAlinden. (2019) MicroRNA-181a/b-1 over-expression enhances osteogenesis by modulating PTEN/PI3K/AKT signaling and mitochondrial metabolism. Bone 123, pages 92-102.
Crossref
Xuegang Yuan, Timothy M. Logan & Teng Ma. (2019) Metabolism in Human Mesenchymal Stromal Cells: A Missing Link Between hMSC Biomanufacturing and Therapy?. Frontiers in Immunology 10.
Crossref
Go J. Yoshida, Arata Azuma, Yukiko Miura & Akira Orimo. (2019) Activated Fibroblast Program Orchestrates Tumor Initiation and Progression; Molecular Mechanisms and the Associated Therapeutic Strategies. International Journal of Molecular Sciences 20:9, pages 2256.
Crossref
Hannah Sanford-Crane, Jaime Abrego & Mara H. Sherman. (2019) Fibroblasts as Modulators of Local and Systemic Cancer Metabolism. Cancers 11:5, pages 619.
Crossref
Heng Sow, Jiang Ren, Marcel Camps, Ferry Ossendorp & Peter ten Dijke. (2019) Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models. Cells 8:4, pages 320.
Crossref
Barbara Bassani, Denisa Baci, Matteo Gallazzi, Alessandro Poggi, Antonino Bruno & Lorenzo Mortara. (2019) Natural Killer Cells as Key Players of Tumor Progression and Angiogenesis: Old and Novel Tools to Divert Their Pro-Tumor Activities into Potent Anti-Tumor Effects. Cancers 11:4, pages 461.
Crossref
Ali Salaritabar, Ioana Berindan-Neagoe, Behrad Darvish, Farzaneh Hadjiakhoondi, Azadeh Manayi, Kasi Pandima Devi, Davide Barreca, Ilkay Erdogan Orhan, Ipek Süntar, Ammad Ahmad Farooqi, Diana Gulei, Seyed Fazel Nabavi, Antoni Sureda, Maria Daglia, Ahmad R. Dehpour, Seyed Mohammad Nabavi & Samira Shirooie. (2019) Targeting Hedgehog signaling pathway: Paving the road for cancer therapy. Pharmacological Research 141, pages 466-480.
Crossref
Chiara Ricca, Alessia Aillon, Marta Viano, Loredana Bergandi, Elisabetta Aldieri & Francesca Silvagno. (2019) Vitamin D inhibits the epithelial-mesenchymal transition by a negative feedback regulation of TGF-β activity. The Journal of Steroid Biochemistry and Molecular Biology 187, pages 97-105.
Crossref
Simon Schwörer, Santosha A. Vardhana & Craig B. Thompson. (2019) Cancer Metabolism Drives a Stromal Regenerative Response. Cell Metabolism 29:3, pages 576-591.
Crossref
Shengnan Xu, Kathryn Ware, Yuantong Ding, So Kim, Maya Sheth, Sneha Rao, Wesley Chan, Andrew Armstrong, William Eward, Mohit Jolly & Jason Somarelli. (2019) An Integrative Systems Biology and Experimental Approach Identifies Convergence of Epithelial Plasticity, Metabolism, and Autophagy to Promote Chemoresistance. Journal of Clinical Medicine 8:2, pages 205.
Crossref
Xueman Chen & Erwei Song. (2018) Turning foes to friends: targeting cancer-associated fibroblasts. Nature Reviews Drug Discovery 18:2, pages 99-115.
Crossref
Fang‑Tao Wang, Wei Sun, Jing‑Tao Zhang & Yue‑Zu Fan. (2019) Cancer‑associated fibroblast regulation of tumor neo‑angiogenesis as a therapeutic target in cancer (Review). Oncology Letters.
Crossref
Alberto Cruz-Bermúdez, Raquel Laza-Briviesca, Ramiro J. Vicente-Blanco, Aránzazu García-Grande, Maria José Coronado, Sara Laine-Menéndez, Cristina Alfaro, Juan Cristobal Sanchez, Fernando Franco, Virginia Calvo, Atocha Romero, Paloma Martin-Acosta, Clara Salas, José Miguel Garcia & Mariano Provencio. (2019) Cancer-associated fibroblasts modify lung cancer metabolism involving ROS and TGF-β signaling. Free Radical Biology and Medicine 130, pages 163-173.
Crossref
Marion Curtis, Hilary A. Kenny, Bradley Ashcroft, Abir Mukherjee, Alyssa Johnson, Yilin Zhang, Ynes Helou, Raquel Batlle, Xiaojing Liu, Nuria Gutierrez, Xia Gao, S. Diane Yamada, Ricardo Lastra, Anthony Montag, Nagib Ahsan, Jason W. Locasale, Arthur R. Salomon, Angel R. Nebreda & Ernst Lengyel. (2019) Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. Cell Metabolism 29:1, pages 141-155.e9.
Crossref
Yu Ren, Huan-huan Jia, Yi-qi Xu, Xuan Zhou, Xiao-hui Zhao, Yun-fei Wang, Xin Song, Zhi-yan Zhu, Ting Sun, Yan Dou, Wei-ping Tian, Xiu-lan Zhao, Chun-sheng Kang & Mei Mei. (2018) Paracrine and epigenetic control of CAF-induced metastasis: the role of HOTAIR stimulated by TGF-ß1 secretion. Molecular Cancer 17:1.
Crossref
Nuzhat Ahmed, Ruth Escalona, Dilys Leung, Emily Chan & George Kannourakis. (2018) Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: Perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells. Seminars in Cancer Biology 53, pages 265-281.
Crossref
Arseniy E. Yuzhalin, Su Yin Lim, Anton G. Kutikhin & Alex N. Gordon-Weeks. (2018) Dynamic matrisome: ECM remodeling factors licensing cancer progression and metastasis. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1870:2, pages 207-228.
Crossref
J. M. Houthuijzen & J. Jonkers. (2018) Cancer-associated fibroblasts as key regulators of the breast cancer tumor microenvironment. Cancer and Metastasis Reviews 37:4, pages 577-597.
Crossref
Qing Zhang, Xiaonan Hou, Bradley Evans, Jamison VanBlaricom, Saravut Weroha & William Cliby. (2018) LY2157299 Monohydrate, a TGF-βR1 Inhibitor, Suppresses Tumor Growth and Ascites Development in Ovarian Cancer. Cancers 10:8, pages 260.
Crossref
Chanitra Thuwajit, Alessandra Ferraresi, Rossella Titone, Peti Thuwajit & Ciro Isidoro. (2018) The metabolic cross-talk between epithelial cancer cells and stromal fibroblasts in ovarian cancer progression: Autophagy plays a role. Medicinal Research Reviews 38:4, pages 1235-1254.
Crossref
Angelica Avagliano, Giuseppina Granato, Maria Rosaria Ruocco, Veronica Romano, Immacolata Belviso, Antonia Carfora, Stefania Montagnani & Alessandro Arcucci. (2018) Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts. BioMed Research International 2018, pages 1-12.
Crossref
Malini Visweswaran, Kevin N. Keane, Frank Arfuso, Rodney J. Dilley, Philip Newsholme & Arun Dharmarajan. (2018) The Influence of Breast Tumour-Derived Factors and Wnt Antagonism on the Transformation of Adipose-Derived Mesenchymal Stem Cells into Tumour-Associated Fibroblasts. Cancer Microenvironment 11:1, pages 71-84.
Crossref
Ernestina M. De FrancescoFederica SotgiaMichael P. Lisanti. (2018) Cancer stem cells (CSCs): metabolic strategies for their identification and eradication. Biochemical Journal 475:9, pages 1611-1634.
Crossref
Laia Caja, Francesco Dituri, Serena Mancarella, Daniel Caballero-Diaz, Aristidis Moustakas, Gianluigi Giannelli & Isabel Fabregat. (2018) TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer. International Journal of Molecular Sciences 19:5, pages 1294.
Crossref
Yusuke Shimoyama, Keiichi Tamai, Rie Shibuya, Mao Nakamura, Mai Mochizuki, Kazunori Yamaguchi, Yoichi Kakuta, Yoshitaka Kinouchi, Ikuro Sato, Akira Kudo, Tooru Shimosegawa & Kennichi Satoh. (2018) Periostin attenuates tumor growth by inducing apoptosis in colitis-related colorectal cancer. Oncotarget 9:28, pages 20008-20017.
Crossref
Kurt R Stenmark, Maria G Frid, Brian B Graham & Rubin M Tuder. (2018) Dynamic and diverse changes in the functional properties of vascular smooth muscle cells in pulmonary hypertension. Cardiovascular Research 114:4, pages 551-564.
Crossref
Marissa D. Rybstein, José Manuel Bravo-San Pedro, Guido Kroemer & Lorenzo Galluzzi. (2018) The autophagic network and cancer. Nature Cell Biology 20:3, pages 243-251.
Crossref
Yan Lan, Dong Zhang, Chunxiao Xu, Kenneth W. Hance, Bo Marelli, Jin Qi, Huakui Yu, Guozhong Qin, Aroop Sircar, Vivian M. HernándezMolly H. JenkinsRachel E. FontanaAmit DeshpandeGeorge Locke, Helen SabzevariLaszlo RadvanyiKin-Ming Lo. (2018) Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β. Science Translational Medicine 10:424.
Crossref
Amy Pei-Ling Chiu, Denise Bierende, Nathaniel Lal, Fulong Wang, Andrea Wan, Israel Vlodavsky, Bahira Hussein & Brian Rodrigues. (2018) Dual effects of hyperglycemia on endothelial cells and cardiomyocytes to enhance coronary LPL activity. American Journal of Physiology-Heart and Circulatory Physiology 314:1, pages H82-H94.
Crossref
Christos Sazeides & Anne Le. 2018. The Heterogeneity of Cancer Metabolism. The Heterogeneity of Cancer Metabolism 149 165 .
Fumihiko Urabe, Nobuyoshi Kosaka, Yusuke Yoshioka, Shin Egawa & Takahiro Ochiya. (2017) The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment. Clinical and Translational Medicine 6:1.
Crossref
Ana Rodríguez-García, Paula Samsó, Pere Fontova, Helga Simon-Molas, Anna Manzano, Esther Castaño, Jose Luis Rosa, Ubaldo Martinez-Outshoorn, Francesc Ventura, Àurea Navarro-Sabaté & Ramon Bartrons. (2017) TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells. The FEBS Journal 284:20, pages 3437-3454.
Crossref
Vicky J. Young, S.F. Ahmad, W. Colin Duncan & Andrew W. Horne. (2017) The role of TGF-β in the pathophysiology of peritoneal endometriosis. Human Reproduction Update 23:5, pages 548-559.
Crossref
Yaojie Fu, Shanshan Liu, Shanghelin Yin, Weihong Niu, Wei Xiong, Ming Tan, Guiyuan Li & Ming Zhou. (2017) The reverse Warburg effect is likely to be an Achilles' heel of cancer that can be exploited for cancer therapy. Oncotarget 8:34, pages 57813-57825.
Crossref
Shanmugasundaram Ganapathy-Kanniappan. (2017) Linking tumor glycolysis and immune evasion in cancer: Emerging concepts and therapeutic opportunities. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1868:1, pages 212-220.
Crossref
Aline C. Gomes, Angélica L. Mello, Manuel G. Ribeiro, Diogo G. Garcia, Clovis O. Da Fonseca, Marcela D’Alincourt Salazar, Axel H. Schönthal & Thereza Quirico-Santos. (2017) Perillyl alcohol, a pleiotropic natural compound suitable for brain tumor therapy, targets free radicals. Archivum Immunologiae et Therapiae Experimentalis 65:4, pages 285-297.
Crossref
R J Seager, Cynthia Hajal, Fabian Spill, Roger D Kamm & Muhammad H Zaman. (2017) Dynamic interplay between tumour, stroma and immune system can drive or prevent tumour progression. Convergent Science Physical Oncology 3:3, pages 034002.
Crossref
Hyoji Kim, Hisashi Iizasa, Yuichi Kanehiro, Sintayehu Fekadu & Hironori Yoshiyama. (2017) Herpesviral microRNAs in Cellular Metabolism and Immune Responses. Frontiers in Microbiology 8.
Crossref
Wenbing Dai, Xiaoyou Wang, Ge Song, Tongzhou Liu, Bing He, Hua Zhang, Xueqing Wang & Qiang Zhang. (2017) Combination antitumor therapy with targeted dual-nanomedicines. Advanced Drug Delivery Reviews 115, pages 23-45.
Crossref
Hacer Ezgi Karakas, Junyoung Kim, Juhee Park, Jung Min Oh, Yongjun Choi, Devrim Gozuacik & Yoon-Kyoung Cho. (2017) A microfluidic chip for screening individual cancer cells via eavesdropping on autophagy-inducing crosstalk in the stroma niche. Scientific Reports 7:1.
Crossref
Xingchun Wang, Minjie Li, Mengyao Hu, Ping Wei & Wei Zhu. (2017) BAMBI overexpression together with β-sitosterol ameliorates NSCLC via inhibiting autophagy and inactivating TGF-β/Smad2/3 pathway. Oncology Reports 37:5, pages 3046-3054.
Crossref
Seema Gupta, Amrita Roy & Bilikere S. Dwarakanath. (2017) Metabolic Cooperation and Competition in the Tumor Microenvironment: Implications for Therapy. Frontiers in Oncology 7.
Crossref
Fabricio Loayza‐Puch, Koos Rooijers, Jelle Zijlstra, Behzad Moumbeini, Esther A Zaal, Joachim F Oude Vrielink, Rui Lopes, Alejandro P Ugalde, Celia R Berkers & Reuven Agami. (2017) TGF β1‐induced leucine limitation uncovered by differential ribosome codon reading . EMBO reports 18:4, pages 549-557.
Crossref
Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Sandra Demaria, Silvia Chiara Formenti & Guido Kroemer. (2016) Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy. Nature Reviews Clinical Oncology 14:4, pages 247-258.
Crossref
Duojiao Wu, Leying Zhuo & Xiangdong Wang. (2017) Metabolic reprogramming of carcinoma-associated fibroblasts and its impact on metabolic heterogeneity of tumors. Seminars in Cell & Developmental Biology 64, pages 125-131.
Crossref
Abdullah Yalcin, Tugba H. Solakoglu, Selahattin C. Ozcan, Saime Guzel, Sabire Peker, Serap Celikler, Basak D. Balaban, Elif Sevinc, Yunus Gurpinar & Jason A. Chesney. (2017) 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor β1-enhanced invasion of Panc1 cells in vitro. Biochemical and Biophysical Research Communications 484:3, pages 687-693.
Crossref
Joe Yeong, Aye Aye Thike, Puay Hoon Tan & Jabed Iqbal. (2017) Identifying progression predictors of breast ductal carcinoma in situ. Journal of Clinical Pathology 70:2, pages 102-108.
Crossref
Brunella Costanza, Ijeoma Umelo, Justine Bellier, Vincent Castronovo & Andrei Turtoi. (2017) Stromal Modulators of TGF-β in Cancer. Journal of Clinical Medicine 6:1, pages 7.
Crossref
Wei Wen, Ge Liu, Ke Jin & Xiang Hu. (2017) TGF-β1 induces PGP9.5 expression in CAFs to promote the growth of colorectal cancer cells. Oncology Reports 37:1, pages 115-122.
Crossref
Zhicheng Huang, Changliang Yang, Shuangyan Sun, Yingji Nan, Zhiguo Lang, Xiu Wang, Jihong Zhao & Ying Liu. (2017) Heat Shock Protein 27, a Novel Regulator of Transforming Growth Factor β Induced Resistance to Cisplatin in A549 Cell. Pharmacology 100:5-6, pages 283-291.
Crossref
Torcato Martins, Nadia Eusebio, Andreia Correia, Joana Marinho, Fernando Casares & Paulo S. Pereira. (2017) TGFβ/Activin signalling is required for ribosome biogenesis and cell growth in Drosophila salivary glands . Open Biology 7:1, pages 160258.
Crossref
Maria Peiris-Pagès, Ubaldo E. Martinez-Outschoorn, Richard G. Pestell, Federica Sotgia & Michael P. Lisanti. (2016) Cancer stem cell metabolism. Breast Cancer Research 18:1.
Crossref
Andrea Morandi, Elisa Giannoni & Paola Chiarugi. (2016) Nutrient Exploitation within the Tumor–Stroma Metabolic Crosstalk. Trends in Cancer 2:12, pages 736-746.
Crossref
Judith Penkert, Tim Ripperger, Maximilian Schieck, Brigitte Schlegelberger, Doris Steinemann & Thomas Illig. (2016) On metabolic reprogramming and tumor biology: A comprehensive survey of metabolism in breast cancer. Oncotarget 7:41, pages 67626-67649.
Crossref
Raghu Kalluri. (2016) The biology and function of fibroblasts in cancer. Nature Reviews Cancer 16:9, pages 582-598.
Crossref
Claudia Bellomo, Laia Caja & Aristidis Moustakas. (2016) Transforming growth factor β as regulator of cancer stemness and metastasis. British Journal of Cancer 115:7, pages 761-769.
Crossref
Yoshihiro Mezawa & Akira Orimo. (2016) The roles of tumor- and metastasis-promoting carcinoma-associated fibroblasts in human carcinomas. Cell and Tissue Research 365:3, pages 675-689.
Crossref
Mary C. Regier, Lindsey J. Maccoux, Emma M. Weinberger, Keil J. Regehr, Scott M. Berry, David J. Beebe & Elaine T. Alarid. (2016) Transitions from mono- to co- to tri-culture uniquely affect gene expression in breast cancer, stromal, and immune compartments. Biomedical Microdevices 18:4.
Crossref
Zeribe C. Nwosu, Hamed Alborzinia, Stefan Wölfl, Steven Dooley & Yan Liu. (2016) Evolving Insights on Metabolism, Autophagy, and Epigenetics in Liver Myofibroblasts. Frontiers in Physiology 7.
Crossref
Maria LukinaMarina ShirmanovaVarvara DudenkovaIrina DruzhkovaAnastasia ShumilovaElena Zagaynova. Analysis of energy metabolism of HeLa cancer cells in vitro and in vivo using fluorescence lifetime microscopy . Analysis of energy metabolism of HeLa cancer cells in vitro and in vivo using fluorescence lifetime microscopy .
Jason P. Webber, Lisa K. Spary, Malcolm D. Mason, Zsuzsanna Tabi, Ian A. Brewis & Aled Clayton. (2016) Prostate stromal cell proteomics analysis discriminates normal from tumour reactive stromal phenotypes. Oncotarget 7:15, pages 20124-20139.
Crossref
Anthony D. Whetton, Norhaida Che Azmi, Stella Pearson, Ewa Jaworska, Liqun Zhang, Rognvald Blance, Alexandra C. Kendall, Anna Nicolaou, Samuel Taylor, Andrew J.K. Williamson & Andrew Pierce. (2016) MPL W515L expression induces TGFβ secretion and leads to an increase in chemokinesis via phosphorylation of THOC5 . Oncotarget 7:10, pages 10739-10755.
Crossref
Rachel Buchsbaum & Sun Oh. (2016) Breast Cancer-Associated Fibroblasts: Where We Are and Where We Need to Go. Cancers 8:2, pages 19.
Crossref
Alessandro Arcucci, Maria Rosaria Ruocco, Giuseppina Granato, Anna Maria Sacco & Stefania Montagnani. (2016) Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts. BioMed Research International 2016, pages 1-7.
Crossref
Xiaofang Ma, Jiaxiu Deng, Ning Cao, Zhenzhen Guo, Yaqiu Zheng, Shengnan Geng, Mingjing Meng, Haihong Lin, Yongjian Duan & Gangjun Du. (2016) Lasting glycolytic stress governs susceptibility to urethane-induced lung carcinogenesis in vivo and in vitro. Toxicology Letters 240:1, pages 130-139.
Crossref
Lei Miao, C. Michael Lin & Leaf Huang. (2015) Stromal barriers and strategies for the delivery of nanomedicine to desmoplastic tumors. Journal of Controlled Release 219, pages 192-204.
Crossref
Rita Nahta, Fahd Al-Mulla, Rabeah Al-Temaimi, Amedeo Amedei, Rafaela Andrade-Vieira, Sarah N. Bay, Dustin G. Brown, Gloria M. Calaf, Robert C. Castellino, Karine A. Cohen-Solal, Anna Maria Colacci, Nichola Cruickshanks, Paul Dent, Riccardo Di Fiore, Stefano Forte, Gary S. Goldberg, Roslida A. Hamid, Harini Krishnan, Dale W. Laird, Ahmed Lasfar, Paola A. Marignani, Lorenzo Memeo, Chiara Mondello, Christian C. Naus, Richard Ponce-Cusi, Jayadev Raju, Debasish Roy, Rabindra Roy, Elizabeth P. Ryan, Hosni K. Salem, A.Ivana Scovassi, Neetu Singh, Monica Vaccari, Renza Vento, Jan Vondráček, Mark Wade, Jordan Woodrick & William H. Bisson. (2015) Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression. Carcinogenesis 36:Suppl 1, pages S2-S18.
Crossref
Haojun Luo, Gang Tu, Zhimin Liu & Manran Liu. (2015) Cancer-associated fibroblasts: A multifaceted driver of breast cancer progression. Cancer Letters 361:2, pages 155-163.
Crossref
Giuseppe S. Sica, Cristina Fiorani, Carmine Stolfi, Giovanni Monteleone, Eleonora Candi, Ivano Amelio, Valeria Catani, Simone Sibio, Andrea Divizia, Giorgia Tema, Edoardo Iaculli & Achille L. Gaspari. (2015) Peritoneal expression of matrilysin helps identify early post-operative recurrence of colorectal cancer. Oncotarget 6:15, pages 13402-13415.
Crossref
Maria Peiris-Pagès, Federica Sotgia & Michael P. Lisanti. (2015) Chemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cells. Oncotarget 6:13, pages 10728-10745.
Crossref
Akiko Takahashi, Genichiro Ishii, Shinya Neri, Tatsuya Yoshida, Hiroko Hashimoto, Shigeki Suzuki, Shigeki Umemura, Shingo Matsumoto, Kiyotaka Yoh, Seiji Niho, Koichi Goto, Hironobu Ohmatsu, Kanji Nagai, Akihiko Gemma, Yuichiro Ohe & Atsushi Ochiai. (2015) Podoplanin-expressing cancer-associated fibroblasts inhibit small cell lung cancer growth. Oncotarget 6:11, pages 9531-9541.
Crossref
Ubaldo E. Martinez-Outschoorn, Federica Sotgia & Michael P. Lisanti. (2015) Caveolae and signalling in cancer. Nature Reviews Cancer 15:4, pages 225-237.
Crossref
H.H. Nienhuis, S.B.M. Gaykema, H. Timmer-Bosscha, M. Jalving, A.H. Brouwers, M.N. Lub-de Hooge, B. van der Vegt, B. Overmoyer, E.G.E. de Vries & C.P. Schröder. (2015) Targeting breast cancer through its microenvironment: Current status of preclinical and clinical research in finding relevant targets. Pharmacology & Therapeutics 147, pages 63-79.
Crossref
Michael Groessl, Astrid Slany, Andrea Bileck, Kerstin Gloessmann, Dominique Kreutz, Walter Jaeger, Georg Pfeiler & Christopher Gerner. (2014) Proteome Profiling of Breast Cancer Biopsies Reveals a Wound Healing Signature of Cancer-Associated Fibroblasts. Journal of Proteome Research 13:11, pages 4773-4782.
Crossref

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