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Cell Cycle Volume 13, 2014 - Issue 4
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JNK1 stress signaling is hyper-activated in high breast density and the tumor stroma: Connecting fibrosis, inflammation, and stemness for cancer prevention

Michael P Lisanti Breakthrough Breast Cancer Research Unit and the Manchester Breast Centre; Institute of Cancer Sciences; University of Manchester; Manchester, UK; Manchester Centre for Cellular Metabolism (MCCM); University of Manchester; Manchester, UKCorrespondence[email protected]
,
Kimberly Reeves Breakthrough Breast Cancer Research Unit and the Manchester Breast Centre; Institute of Cancer Sciences; University of Manchester; Manchester, UK; Manchester Centre for Cellular Metabolism (MCCM); University of Manchester; Manchester, UK
,
Maria Peiris-Pagès Breakthrough Breast Cancer Research Unit and the Manchester Breast Centre; Institute of Cancer Sciences; University of Manchester; Manchester, UK; Manchester Centre for Cellular Metabolism (MCCM); University of Manchester; Manchester, UK
,
Amy L Chadwick Breakthrough Breast Cancer Research Unit and the Manchester Breast Centre; Institute of Cancer Sciences; University of Manchester; Manchester, UK; Manchester Centre for Cellular Metabolism (MCCM); University of Manchester; Manchester, UK
,
Rosa Sanchez-Alvarez Breakthrough Breast Cancer Research Unit and the Manchester Breast Centre; Institute of Cancer Sciences; University of Manchester; Manchester, UK; Manchester Centre for Cellular Metabolism (MCCM); University of Manchester; Manchester, UK
,
Anthony Howell Breakthrough Breast Cancer Research Unit and the Manchester Breast Centre; Institute of Cancer Sciences; University of Manchester; Manchester, UK
,
Ubaldo E. Martinez-Outschoorn Kimmel Cancer Center; Thomas Jefferson University; Philadelphia, PA USA
&
Federica Sotgia Breakthrough Breast Cancer Research Unit and the Manchester Breast Centre; Institute of Cancer Sciences; University of Manchester; Manchester, UK; Manchester Centre for Cellular Metabolism (MCCM); University of Manchester; Manchester, UKCorrespondence[email protected]
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Pages 580-599 | Received 15 Nov 2013, Accepted 28 Nov 2013, Published online: 05 Dec 2013

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Abubaker Mansur Hamad & Hussain Gadelkarim Ahmed. (2018) Association of some carbohydrates with estrogen expression in breast lesions among Sudanese females. Journal of Histotechnology 41:1, pages 2-9.
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Marina Pajic, David Herrmann, Claire Vennin, James RW Conway, Venessa T Chin, Anna-Karin E Johnsson, Heidi CE Welch & Paul Timpson. (2015) The dynamics of Rho GTPase signaling and implications for targeting cancer and the tumor microenvironment. Small GTPases 6:2, pages 123-133.
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Articles from other publishers (40)

Qian Pu & Haidong Gao. (2023) The Role of the Tumor Microenvironment in Triple-Positive Breast Cancer Progression and Therapeutic Resistance. Cancers 15:22, pages 5493.
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Öykü Boraka, Marie Klintman, Johan Vallon-Christersson, Sophia Zackrisson, Per Hall, Signe Borgquist & Ann H. Rosendahl. (2023) FGF/FGFR1 system in paired breast tumor-adjacent and tumor tissues, associations with mammographic breast density and tumor characteristics. Frontiers in Oncology 13.
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Palanisamy Nallasamy, Rama Krishna Nimmakayala, Seema Parte, Abhirup C. Are, Surinder K. Batra & Moorthy P. Ponnusamy. (2022) Tumor microenvironment enriches the stemness features: the architectural event of therapy resistance and metastasis. Molecular Cancer 21:1.
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I. V. Kuznetsova. (2022) Herbal remedies as a way to treat benign pathology of the mammary gland. Medical alphabet:24, pages 31-37.
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Elaine F. Harkness & Sue M. Astley. 2022. Digital Mammography. Digital Mammography 41 49 .
Iván P. Uray & Karen Uray. (2021) Mechanotransduction at the Plasma Membrane-Cytoskeleton Interface. International Journal of Molecular Sciences 22:21, pages 11566.
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Ho-Sung Lee, In-Hee Lee, Kyungrae Kang, Sang-In Park, Minho Jung, Seung Gu Yang, Tae-Wook Kwon & Dae-Yeon Lee. (2021) Network Pharmacology-Based Dissection of the Comprehensive Molecular Mechanisms of the Herbal Prescription FDY003 Against Estrogen Receptor-Positive Breast Cancer. Natural Product Communications 16:9, pages 1934578X2110443.
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Т. N. Leikht, G. I. Bratnikova, Р. S. Gomina, N. S. Kosolapova, К. A. Tihaya, L. D. Kotova, N. А. Samosyuk, I. А. Repyanskaya & К. G. Utin. (2021) Difficulties of radiological diagnosis оf small breast cancers. Ural Medical Journal 20:2, pages 49-53.
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Mireia Berdiel-Acer, Ana Maia, Zhivka Hristova, Simone Borgoni, Martina Vetter, Sara Burmester, Corinna Becki, Birgitta Michels, Khalid Abnaof, Ilona Binenbaum, Daniel Bethmann, Aristotelis Chatziioannou, Max Hasmann, Christoph Thomssen, Elisa Espinet & Stefan Wiemann. (2021) Stromal NRG1 in luminal breast cancer defines pro-fibrotic and migratory cancer-associated fibroblasts. Oncogene 40:15, pages 2651-2666.
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N. I. Rozhkova, I. I. Burdina, S. B. Zapirova, P. G. Labazanova, M. L. Mazo, S. Yu. Mikushin, S. P. Prokopenko & O. E. Jacobs. (2021) Diversity of non-palpable breast cancer. Timely diagnosis, adequate treatment and prevention. Medical alphabet:38, pages 34-40.
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Alexandra Giatromanolaki, Avgi Tsolou, Eleftheria Daridou, Maria Kouroupi, Katerina Chlichlia & Michael I. Koukourakis. (2020) iNOS Expression by Tumor-Infiltrating Lymphocytes, PD-L1 and Prognosis in Non-Small-Cell Lung Cancer. Cancers 12:11, pages 3276.
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Kara L. Britt, Jack Cuzick & Kelly-Anne Phillips. (2020) Key steps for effective breast cancer prevention. Nature Reviews Cancer 20:8, pages 417-436.
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L. V. Pokul, O. S. Sacultsan, M. R. Orazov & M. G. Lebedeva. (2020) Benign dysplasia of remaining contralateral breast in patients with breast cancer. Expanding opportunities of phytoprophylaxis and phytotherapy. Medical alphabet 4:33, pages 31-37.
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Agnieszka Jezierska-Drutel, Shireen Attaran, Barbara L. Hopkins, John J. Skoko, Steven A. Rosenzweig & Carola A. Neumann. (2019) The peroxidase PRDX1 inhibits the activated phenotype in mammary fibroblasts through regulating c-Jun N-terminal kinases. BMC Cancer 19:1.
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E. L. Muyzhnek, V. I. KiselevO. E. JakobsN. I. Rozhkova, A. D. Kaprin, I. I. Burdina, S. B. Zapirova, M. L. MazoS. P. ProkopenkoP. G. Labazanova. (2019) FIBROSCLEROSIS AND SCLEROSING ADENOSIS WITH MICROCALCIFICATIONS IN THE BREAST. MOLECULAR PATHOGENESIS, TIMELY DIAGNOSIS AND TREATMENT. Research'n Practical Medicine Journal 6:2, pages 75-85.
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Sharon A Glynn. (2019) Emerging novel mechanisms of action for nitric oxide in cancer progression. Current Opinion in Physiology 9, pages 18-25.
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Norman Boyd, Hal Berman, Jie Zhu, Lisa J. Martin, Martin J. Yaffe, Sofia Chavez, Greg Stanisz, Greg Hislop, Anna M. Chiarelli, Salomon Minkin & Andrew D. Paterson. (2018) The origins of breast cancer associated with mammographic density: a testable biological hypothesis. Breast Cancer Research 20:1.
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Shiheng Lu, Ke Zhao, Xuefei Wang, Hui Liu, Xiamuxiya Ainiwaer, Yan Xu & Min Ye. (2018) Use of Laplacian Heat Diffusion Algorithm to Infer Novel Genes With Functions Related to Uveitis. Frontiers in Genetics 9.
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Feibiao Yang, Zhangsheng Xiao & Songze Zhang. (2018) Knockdown of miR-194-5p inhibits cell proliferation, migration and invasion in breast cancer by regulating the Wnt/β-catenin signaling pathway. International Journal of Molecular Medicine.
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Bixiao Wang, Chunfang Xi, Mingwei Liu, Haichen Sun, Shuang Liu, Lei Song & Hua Kang. (2018) Breast fibroblasts in both cancer and normal tissues induce phenotypic transformation of breast cancer stem cells: a preliminary study. PeerJ 6, pages e4805.
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Toni Roeke, Marcelo Sobral-Leite, Tim J. A. Dekker, Jelle Wesseling, Vincent T. H. B. M. Smit, Rob A. E. M. Tollenaar, Marjanka K. Schmidt & Wilma E. Mesker. (2017) The prognostic value of the tumour-stroma ratio in primary operable invasive cancer of the breast: a validation study. Breast Cancer Research and Treatment 166:2, pages 435-445.
Crossref
Anisha M. Hammer, Gina M. Sizemore, Vasudha C. Shukla, Alex Avendano, Steven T. Sizemore, Jonathan J. Chang, Raleigh D. Kladney, Maria C. Cuitiño, Katie A. Thies, Quinn Verfurth, Arnab Chakravarti, Lisa D. Yee, Gustavo Leone, Jonathan W. Song, Samir N. Ghadiali & Michael C. Ostrowski. (2017) Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth. Neoplasia 19:6, pages 496-508.
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Alyssa D. Throckmorton, Deborah J. Rhodes, Kevin S. Hughes, Amy C. Degnim & Diana Dickson-Witmer. (2016) Dense Breasts: What Do Our Patients Need to Be Told and Why?. Annals of Surgical Oncology 23:10, pages 3119-3127.
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Abubaker M Hamad. (2016) Association of Connective Tissue Fibers with Estrogen Expression in Breast Lesions among Sudanese Females. International Clinical Pathology Journal 2:4.
Crossref
Alastair J. Ironside & J. Louise Jones. (2016) Stromal characteristics may hold the key to mammographic density: the evidence to date. Oncotarget 7:21, pages 31550-31562.
Crossref
Gabriel Gruionu, Despina Bazou, Nir Maimon, Mara Onita-Lenco, Lucian G. Gruionu, Peigen Huang & Lance L. Munn. (2016) Implantable tissue isolation chambers for analyzing tumor dynamics in vivo. Lab on a Chip 16:10, pages 1840-1851.
Crossref
Qing YanQing Yan. 2016. Psychoneuroimmunology. Psychoneuroimmunology 97 108 .
Federica Vannini, Khosrow Kashfi & Niharika Nath. (2015) The dual role of iNOS in cancer. Redox Biology 6, pages 334-343.
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Michael S. Shawky, Carmela Ricciardelli, Megan Lord, John Whitelock, Vito Ferro, Kara Britt & Erik W. Thompson. (2015) Proteoglycans: Potential Agents in Mammographic Density and the Associated Breast Cancer Risk. Journal of Mammary Gland Biology and Neoplasia 20:3-4, pages 121-131.
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Venessa T. Chin, Adnan M. Nagrial, Angela Chou, Andrew V. Biankin, Anthony J. Gill, Paul Timpson & Marina Pajic. (2015) Rho-associated kinase signalling and the cancer microenvironment: novel biological implications and therapeutic opportunities. Expert Reviews in Molecular Medicine 17.
Crossref
Solveig S. H. Hofvind, Gunvor Gipling Waade & Sue Astley. 2015. Digital Mammography. Digital Mammography 163 167 .
Anthony Howell, Annie S Anderson, Robert B Clarke, Stephen W Duffy, D Gareth Evans, Montserat Garcia-Closas, Andy J Gescher, Timothy J Key, John M Saxton & Michelle N Harvie. (2014) Risk determination and prevention of breast cancer. Breast Cancer Research 16:5.
Crossref
Andreas Pettersson & Rulla M. Tamimi. (2014) Breast Density and Breast Cancer Risk: Understanding of Biology and Risk. Current Epidemiology Reports 1:3, pages 120-129.
Crossref

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