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Cell Cycle Volume 13, 2014 - Issue 4
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The reciprocal interaction between autophagic dysfunction and ER stress in adipose insulin resistance

Huixia Li First Affiliated Hospital of Medical School of Xi’an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases; Ministry of Education; Medical School of Xi′an Jiaotong University; Xi′an, Shaanxi, China
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Bo Zhou First Affiliated Hospital of Medical School of Xi’an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases; Ministry of Education; Medical School of Xi′an Jiaotong University; Xi′an, Shaanxi, China
,
Lin Xu First Affiliated Hospital of Medical School of Xi’an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases; Ministry of Education; Medical School of Xi′an Jiaotong University; Xi′an, Shaanxi, China
,
Jiali Liu First Affiliated Hospital of Medical School of Xi’an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases; Ministry of Education; Medical School of Xi′an Jiaotong University; Xi′an, Shaanxi, China
,
Weijin Zang First Affiliated Hospital of Medical School of Xi’an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases; Ministry of Education; Medical School of Xi′an Jiaotong University; Xi′an, Shaanxi, China
,
Shufang Wu First Affiliated Hospital of Medical School of Xi’an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases; Ministry of Education; Medical School of Xi′an Jiaotong University; Xi′an, Shaanxi, ChinaCorrespondence[email protected]
&
Hongzhi Sun First Affiliated Hospital of Medical School of Xi’an Jiaotong University; Key Laboratory of Environment and Genes Related to Diseases; Ministry of Education; Medical School of Xi′an Jiaotong University; Xi′an, Shaanxi, ChinaCorrespondence[email protected]
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Pages 565-579 | Received 30 Sep 2013, Accepted 02 Dec 2013, Published online: 05 Dec 2013

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Jiali Liu & Qian He. (2023) Ca2+/calmodulin-dependent protein kinase IV attenuates inflammation and mitochondrial dysfunction under insulin resistance in C2C12 cells. Archives of Physiology and Biochemistry 129:3, pages 690-699.
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Fang Li, Huixia Li, Xinxin Jin, Ying Zhang, Xiaomin Kang, Zhuanmin Zhang, Mao Xu, Zhuang Qian, Zhengmin Ma, Xin Gao, Liting Zhao, Shufang Wu & Hongzhi Sun. (2019) Adipose-specific knockdown of Sirt1 results in obesity and insulin resistance by promoting exosomes release. Cell Cycle 18:17, pages 2067-2082.
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Nir Goldstein, Yulia Haim, Pamela Mattar, Sapir Hadadi-Bechor, Nitzan Maixner, Peter Kovacs, Matthias Blüher & Assaf Rudich. (2019) Leptin stimulates autophagy/lysosome-related degradation of long-lived proteins in adipocytes. Adipocyte 8:1, pages 51-60.
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Roberto B Bazotte, Lorena G Silva & Fabiana PM Schiavon. (2014) Insulin resistance in the liver: Deficiency or excess of insulin?. Cell Cycle 13:16, pages 2494-2500.
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Asie Sadeghi, Maryam Niknam, Mohammad Amin Momeni-Moghaddam, Maryam Shabani, Hamid Aria, Alireza Bastin, Maryam Teimouri, Reza Meshkani & Hamed Akbari. (2023) Crosstalk between autophagy and insulin resistance: evidence from different tissues. European Journal of Medical Research 28:1.
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Li Jia, Zhu Jingzhen, Yang Xinliang, Sun Bishao, Luo Xin, Zheng Ji & Fang Zhenqiang. (2023) 4-PBA inhibits endoplasmic reticulum stress to improve autophagic flux in the treatment of protamine/lipopolysaccharide-induced interstitial cystitis in rats. Scientific Reports 13:1.
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Rong Cao, Huimin Tian, Yu Zhang, Geng Liu, Haixia Xu, Guocheng Rao, Yan Tian & Xianghui Fu. (2023) Signaling pathways and intervention for therapy of type 2 diabetes mellitus. MedComm 4:3.
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Julian Meyer Berger & Gerard Karsenty. (2022) Osteocalcin and the physiology of danger. FEBS Letters 596:5, pages 665-680.
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Jiali Liu, Yue Li, Ning Gao, Jing Ji & Qian He. (2021) Calcium/calmodulin-dependent protein kinase IV regulates vascular autophagy and insulin signaling through Akt/mTOR/CREB pathway in ob/ob mice. Journal of Physiology and Biochemistry 78:1, pages 199-211.
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Xueqiong Yao, Rui Liu, Xiu Li, Yan Li, Zhen Zhang, Shanshan Huang, Yanyan Ge, Xiuzhi Chen & Xuefeng Yang. (2021) Zinc, selenium and chromium co-supplementation improves insulin resistance by preventing hepatic endoplasmic reticulum stress in diet-induced gestational diabetes rats. The Journal of Nutritional Biochemistry 96, pages 108810.
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Yao Zhang, Kongdong Li, Anqi Kong, Yang Zhou, Dongfeng Chen, Jie Gu & Haifeng Shi. (2021) Dysregulation of autophagy acts as a pathogenic mechanism of non-alcoholic fatty liver disease (NAFLD) induced by common environmental pollutants. Ecotoxicology and Environmental Safety 217, pages 112256.
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Jiali Liu, Ruihua Yang, Hao Meng, Ting Zhou & Qian He. (2020) In vitro treatment of 3 T3-L1 adipocytes with recombinant Calcium/calmodulin-dependent Protein Kinase IV (CaMKIV) limits ER stress and improves insulin sensitivity through inhibition of autophagy via the mTOR/CREB signaling pathway. BMC Endocrine Disorders 20:1.
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Gerard Karsenty. (2020) The facts of the matter: What is a hormone?. PLOS Genetics 16:6, pages e1008938.
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Hong-guang Chen, Huan-zhi Han, Yuan Li, Yong-hao Yu & Ke-liang Xie. (2020) Hydrogen alleviated organ injury and dysfunction in sepsis: The role of cross-talk between autophagy and endoplasmic reticulum stress: Experimental research. International Immunopharmacology 78, pages 106049.
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Daina Zhao, Shuangxi Zhang, Xueqiang Wang, Dan Gao, Jing Liu, Ke Cao, Lei Chen, Run Liu, Jiankang Liu & Jiangang Long. (2019) ATG7 regulates hepatic Akt phosphorylation through the c‐JUN/PTEN pathway in high fat diet‐induced metabolic disorder. The FASEB Journal 33:12, pages 14296-14306.
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Roberto Villalobos-Labra, Mario Subiabre, Fernando Toledo, Fabián Pardo & Luis Sobrevia. (2019) Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity. Molecular Aspects of Medicine 66, pages 49-61.
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Xuzhu Lin, Alan Hayes, Glenn McConell, Gustavo Duque, Tara C. Brennan-Speranza & Itamar Levinger. 2019. Osteosarcopenia: Bone, Muscle and Fat Interactions. Osteosarcopenia: Bone, Muscle and Fat Interactions 145 171 .
A. Burgeiro, A.C. Fonseca, D. Espinoza, L. Carvalho, N. Lourenço, M. Antunes & E. Carvalho. (2018) Proteostasis in epicardial versus subcutaneous adipose tissue in heart failure subjects with and without diabetes. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:6, pages 2183-2198.
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Yingmei Zhang. 2018. Autophagy and Cardiometabolic Diseases. Autophagy and Cardiometabolic Diseases 83 90 .
Amiya K. Ghosh, Martin O’Brien, Theresa Mau & Raymond Yung. (2017) Toll-like receptor 4 (TLR4) deficient mice are protected from adipose tissue inflammation in aging. Aging 9:9, pages 1971-1982.
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Rohit A. SinhaBrijesh K. SinghPaul M. Yen. (2017) Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis. Endocrine Reviews 38:1, pages 69-102.
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JIAJING YIN, YUFAN WANG, LIPING GU, NENGGUANG FAN, YUHANG MA & YONGDE PENG. (2015) Palmitate induces endoplasmic reticulum stress and autophagy in mature adipocytes: Implications for apoptosis and inflammation. International Journal of Molecular Medicine 35:4, pages 932-940.
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Adam D. BarlowDavid C. Thomas. (2015) Autophagy in Diabetes: β-Cell Dysfunction, Insulin Resistance, and Complications. DNA and Cell Biology 34:4, pages 252-260.
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Yemin Zhang, Mao Ye, Leyuan Jack Chen, Mingxin Li, Zhao Tang & Changhua Wang. (2015) Role of the ubiquitin-proteasome system and autophagy in regulation of insulin sensitivity in serum-starved 3T3-L1 adipocytes. Endocrine Journal 62:8, pages 673-686.
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Jiajing Yin, Liping Gu, Yufan Wang, Nengguang Fan, Yuhang Ma & Yongde Peng. (2015) Rapamycin Improves Palmitate-Induced ER Stress/NF κ B Pathways Associated with Stimulating Autophagy in Adipocytes . Mediators of Inflammation 2015, pages 1-12.
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Aowen Zhuang & Josephine M Forbes. (2014) Stress in the kidney is the road to pERdition: is endoplasmic reticulum stress a pathogenic mediator of diabetic nephropathy?. Journal of Endocrinology 222:3, pages R97-R111.
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Huixia Li, Bo Zhou, Lin Xu, Jiali Liu, Weijin Zang, Shufang Wu & Hongzhi Sun. (2014) Circulating PGRN Is Significantly Associated With Systemic Insulin Sensitivity and Autophagic Activity in Metabolic Syndrome. Endocrinology 155:9, pages 3493-3507.
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