Advanced search
Publication Cover
Cell Cycle Volume 13, 2014 - Issue 9
Submit an article Journal homepage
1,344
Views
22
CrossRef citations to date
0
Altmetric
Report

The RNA helicase/transcriptional co-regulator, p68 (DDX5), stimulates expression of oncogenic protein kinase, Polo-like kinase-1 (PLK1), and is associated with elevated PLK1 levels in human breast cancers

R Sumanth Iyer Division of Cancer Research; University of Dundee; Ninewells Hospital & Medical School; Dundee, UK
,
Samantha M Nicol Division of Cancer Research; University of Dundee; Ninewells Hospital & Medical School; Dundee, UK
,
Philip R Quinlan Division of Cancer Research; University of Dundee; Ninewells Hospital & Medical School; Dundee, UK
,
Alastair M Thompson Division of Cancer Research; University of Dundee; Ninewells Hospital & Medical School; Dundee, UK
,
David W Meek Division of Cancer Research; University of Dundee; Ninewells Hospital & Medical School; Dundee, UKCorrespondence[email protected]
&
Frances V Fuller-Pace Division of Cancer Research; University of Dundee; Ninewells Hospital & Medical School; Dundee, UK
Pages 1413-1423 | Received 11 Feb 2014, Accepted 03 Mar 2014, Published online: 06 Mar 2014

Citations (22)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Vanessa Meier-Stephenson, Tyler Mrozowich, Mimi Pham & Trushar R. Patel. (2018) DEAD-box helicases: the Yin and Yang roles in viral infections. Biotechnology and Genetic Engineering Reviews 34:1, pages 3-32.
Read now

Articles from other publishers (21)

Priyanka Dey Talukdar & Urmi Chatterji. (2023) Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases. Signal Transduction and Targeted Therapy 8:1.
Crossref
Shaheda Tabassum & Mrinal K. Ghosh. (2023) DEAD-box RNA helicases with special reference to p68: Unwinding their biology, versatility, and therapeutic opportunity in cancer. Genes & Diseases 10:4, pages 1220-1241.
Crossref
Xin Zhou, Zhihong Liu, Tengfei He, Cuifeng Zhang, Manman Jiang, Yuxiao Jin, Ziyu Wu, Changji Gu, Wei Zhang & Xiaodong Yang. (2022) DDX10 promotes the proliferation and metastasis of colorectal cancer cells via splicing RPL35. Cancer Cell International 22:1.
Crossref
Meng Cheng, Qingmiao Yang, Yafei Liu, Meng-Jie Zhao, Xinyuan Du, Jiaqi Sun, Wen-Jie Shu, Zan Huang, Jianping Bi, Ximing Xu & Hai-Ning Du. (2022) SETD3 Methyltransferase Regulates PLK1 Expression to Promote In Situ Hepatic Carcinogenesis. Frontiers in Oncology 12.
Crossref
Kai Li, Gang Zhao, Hang Yuan, Jie Zhang, Qin Li, Di Gong & Ping Lin. (2022) Upregulated expression of DDX5 predicts recurrence and poor prognosis in breast cancer. Pathology - Research and Practice 229, pages 153736.
Crossref
Lu Zhang & Xiaogang Li. (2021) DEAD-Box RNA Helicases in Cell Cycle Control and Clinical Therapy. Cells 10:6, pages 1540.
Crossref
Mohamed A. M. Ali. (2021) The DEAD-box protein family of RNA helicases: sentinels for a myriad of cellular functions with emerging roles in tumorigenesis. International Journal of Clinical Oncology 26:5, pages 795-825.
Crossref
Mingzhu Zong, Wanting Feng, Li Wan, Xiaojuan Yu & Weiyong Yu. (2020) LncRNA TUG1 promotes esophageal cancer development through regulating PLK1 expression by sponging miR-1294. Biotechnology Letters 42:12, pages 2537-2549.
Crossref
Vida Hashemi, Armin Ahmadi, Farinaz Malakotikhah, Mitra Ghasemi Chaleshtari, Mahdi Baghi Moornani, Ali Masjedi, Mozhdeh Sojoodi, Fatemeh Atyabi, Afshin Nikkhoo, Narges Rostami, Behzad Baradaran, Gholamreza Azizi, Bahman Yousefi, Ghasem Ghalamfarsa & Farhad Jadidi-Niaragh. (2020) Silencing of p68 and STAT3 synergistically diminishes cancer progression. Life Sciences 249, pages 117499.
Crossref
Yu‑Bo Zhang, Yuhan Jiang, Jiao Wang, Jing Ma & Shiyu Han. (2019) Evaluation of core serous epithelial ovarian cancer genes as potential prognostic markers and indicators of the underlying molecular mechanisms using an integrated bioinformatics analysis. Oncology Letters.
Crossref
Gang Wang, Jian Lv, Xiaoxin Qiu & Yujun An. (2019) Integrating genome-wide association and eQTLs studies identifies the genes associated with age at menarche and age at natural menopause. PLOS ONE 14:6, pages e0213953.
Crossref
Ye Fan, Yikuan ChenJing Zhang, Feng YangYanhua HuLi ZhangChunyu Zeng & Qingbo Xu. (2019) Protective Role of RNA Helicase DEAD-Box Protein 5 in Smooth Muscle Cell Proliferation and Vascular Remodeling. Circulation Research 124:10.
Crossref
Vida Hashemi, Ali Masjedi, Bita Hazhir‐karzar, Asghar Tanomand, Siamak Sandoghchian Shotorbani, Mohammad Hojjat‐Farsangi, Ghasem Ghalamfarsa, Gholamreza Azizi, Enayat Anvari, Behzad Baradaran & Farhad Jadidi‐Niaragh. (2018) The role of DEAD‐box RNA helicase p68 (DDX5) in the development and treatment of breast cancer. Journal of Cellular Physiology 234:5, pages 5478-5487.
Crossref
Yanchun Chen, Qiaozhen Wang, Qing Wang, Jinmeng Liu, Xin Jiang, Yawen Zhang, Yongxin Liu, Fenghua Zhou & Huancai Liu. (2019) DEAD-Box Helicase 5 Interacts With Transcription Factor 12 and Promotes the Progression of Osteosarcoma by Stimulating Cell Cycle Progression. Frontiers in Pharmacology 9.
Crossref
Rose Magoma Nyamao, Jing Wu, Li Yu, Xiao Xiao & Feng-Min Zhang. (2019) Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1871:1, pages 85-98.
Crossref
Ying Xue, Xuebing Jia, Lei Li, Xiao Dong, Jing Ling, Jian Yuan & Qi Li. (2018) DDX5 promotes hepatocellular carcinoma tumorigenesis via Akt signaling pathway. Biochemical and Biophysical Research Communications 503:4, pages 2885-2891.
Crossref
Yunbao Pan, Guohong Liu, Yufen Yuan, Jin Zhao, Yong Yang & Yirong Li. (2017) Analysis of differential gene expression profile identifies novel biomarkers for breast cancer. Oncotarget 8:70, pages 114613-114625.
Crossref
Sheng-Hong Shi, Wei Zhang, Jing Jiang & Long Sun. (2017) Identification of altered pathways in breast cancer based on individualized pathway aberrance score. Oncology Letters 14:2, pages 1287-1294.
Crossref
Nirmalya Dasgupta, Bhupesh Kumar Thakur, Atri Ta, Sayan Das, George Banik & Santasabuj Das. (2017) Polo-like kinase 1 expression is suppressed by CCAAT/enhancer-binding protein α to mediate colon carcinoma cell differentiation and apoptosis. Biochimica et Biophysica Acta (BBA) - General Subjects 1861:7, pages 1777-1787.
Crossref
Song Qing, Wuniqiemu Tulake, Mingfang Ru, Xiaohong Li, Reziwanguli Yuemaier, Dilare Lidifu, Aierken Rouzibilali, Axiangu Hasimu, Yun Yang, Reziya Rouziahong, Halmurat Upur & Abulizi Abudula. (2017) Proteomic identification of potential biomarkers for cervical squamous cell carcinoma and human papillomavirus infection. Tumor Biology 39:4, pages 101042831769754.
Crossref
Hao Zhang, Zheng Xing, Saravana Kumar Kailasam Mani, Brigitte Bancel, David Durantel, Fabien Zoulim, Elizabeth J. Tran, Philippe Merle & Ourania Andrisani. (2016) RNA helicase DEAD box protein 5 regulates Polycomb repressive complex 2/Hox transcript antisense intergenic RNA function in hepatitis B virus infection and hepatocarcinogenesis. Hepatology 64:4, pages 1033-1048.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.