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Cell Cycle Volume 13, 2014 - Issue 9
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Reversing deleterious protein aggregation with re-engineered protein disaggregases

Meredith E Jackrel Department of Biochemistry and Biophysics; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA USA
&
James Shorter Department of Biochemistry and Biophysics; Perelman School of Medicine at the University of Pennsylvania; Philadelphia, PA USACorrespondence[email protected]
Pages 1379-1383 | Received 19 Mar 2014, Accepted 30 Mar 2014, Published online: 02 Apr 2014

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Yiran Wang & Rickie Patani. (2020) Novel therapeutic targets for amyotrophic lateral sclerosis: ribonucleoproteins and cellular autonomy. Expert Opinion on Therapeutic Targets 24:10, pages 971-984.
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Meredith E Jackrel & James Shorter. (2015) Engineering enhanced protein disaggregases for neurodegenerative disease. Prion 9:2, pages 90-109.
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Articles from other publishers (29)

Korrie L. Mack, Hanna Kim, Edward M. Barbieri, JiaBei Lin, Sylvanne Braganza, Meredith E. Jackrel, Jamie E. DeNizio, Xiaohui Yan, Edward Chuang, Amber Tariq, Ryan R. Cupo, Laura M. Castellano, Kim A. Caldwell, Guy A. Caldwell & James Shorter. (2023) Tuning Hsp104 specificity to selectively detoxify α-synuclein. Molecular Cell 83:18, pages 3314-3332.e9.
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Matthew K. Howard, Karlie R. Miller, Brian S. Sohn, Jeremy J. Ryan, Andy Xu & Meredith E. Jackrel. (2023) Probing the drivers of Staphylococcus aureus biofilm protein amyloidogenesis and disrupting biofilms with engineered protein disaggregases . mBio.
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Macy L. Sprunger, Ken Lee, Brian S. Sohn & Meredith E. Jackrel. (2022) Molecular determinants and modifiers of Matrin-3 toxicity, condensate dynamics, and droplet morphology. iScience 25:3, pages 103900.
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Jeremy J. Ryan, Aaron Bao, Braxton Bell, Cendi Ling & Meredith E. Jackrel. (2021) Drivers of Hsp104 potentiation revealed by scanning mutagenesis of the middle domain. Protein Science 30:8, pages 1667-1685.
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Macy L. Sprunger & Meredith E. Jackrel. (2021) Prion-Like Proteins in Phase Separation and Their Link to Disease. Biomolecules 11:7, pages 1014.
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Daniel A. Solomon, Rebekah Smikle, Matthew J. Reid & Sarah Mizielinska. (2021) Altered Phase Separation and Cellular Impact in C9orf72-Linked ALS/FTD. Frontiers in Cellular Neuroscience 15.
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Heike J. Wobst, Korrie L. Mack, Dean G. Brown, Nicholas J. Brandon & James Shorter. (2020) The clinical trial landscape in amyotrophic lateral sclerosis—Past, present, and future. Medicinal Research Reviews 40:4, pages 1352-1384.
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Matthew K. Howard, Brian S. Sohn, Julius von Borcke, Andy Xu & Meredith E. Jackrel. (2020) Functional analysis of proposed substrate-binding residues of Hsp104. PLOS ONE 15:3, pages e0230198.
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Shamini Vijayakumaran, Yasuko Nakamura, Jeremy M. Henley & Dean L. Pountney. (2019) Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates. Molecular and Cellular Neuroscience 101, pages 103416.
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James Shorter & Daniel R. Southworth. (2019) Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase. Cold Spring Harbor Perspectives in Biology 11:8, pages a034033.
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Jeremy J. Ryan, Macy L. Sprunger, Kayla Holthaus, James Shorter & Meredith E. Jackrel. (2019) Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma. Journal of Biological Chemistry 294:29, pages 11286-11296.
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Alexandrea N. Rizo, JiaBei Lin, Stephanie N. Gates, Eric Tse, Stephen M. Bart, Laura M. Castellano, Frank DiMaio, James Shorter & Daniel R. Southworth. (2019) Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase. Nature Communications 10:1.
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Amber Tariq, JiaBei Lin, Megan M Noll, Mariana P Torrente, Korrie L Mack, Oscar Hernandez Murillo, Meredith E Jackrel & James Shorter. (2018) Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain. FEMS Yeast Research 18:5.
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Lin Guo & James Shorter. (2017) Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies. Cold Spring Harbor Perspectives in Medicine 7:9, pages a024554.
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Alice Ford HarrisonJames Shorter. (2017) RNA-binding proteins with prion-like domains in health and disease. Biochemical Journal 474:8, pages 1417-1438.
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Meredith E. Jackrel & James Shorter. (2017) Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease. Frontiers in Neuroscience 11.
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Borislav Angelov & Angelina Angelova. (2017) Nanoscale clustering of the neurotrophin receptor TrkB revealed by super-resolution STED microscopy. Nanoscale 9:28, pages 9797-9804.
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Adam L Yokom, Stephanie N Gates, Meredith E Jackrel, Korrie L Mack, Min Su, James Shorter & Daniel R Southworth. (2016) Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation. Nature Structural & Molecular Biology 23:9, pages 830-837.
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Zachary M. March, Oliver D. King & James Shorter. (2016) Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease. Brain Research 1647, pages 9-18.
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Elizabeth A. Sweeny & James Shorter. (2016) Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104. Journal of Molecular Biology 428:9, pages 1870-1885.
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Korrie L. Mack & James Shorter. (2016) Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity. Frontiers in Molecular Biosciences 3.
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Mariana P. Torrente, Edward Chuang, Megan M. Noll, Meredith E. Jackrel, Michelle S. Go & James Shorter. (2016) Mechanistic Insights into Hsp104 Potentiation. Journal of Biological Chemistry 291:10, pages 5101-5115.
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Juan I. Castrillo & Stephen G. Oliver. 2016. Systems Biology of Alzheimer's Disease. Systems Biology of Alzheimer's Disease 3 48 .
Meredith E. Jackrel, Keolamau Yee, Amber Tariq, Annie I. Chen & James Shorter. (2015) Disparate Mutations Confer Therapeutic Gain of Hsp104 Function. ACS Chemical Biology 10:12, pages 2672-2679.
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Yvonne S. Eisele, Cecilia Monteiro, Colleen Fearns, Sandra E. Encalada, R. Luke Wiseman, Evan T. Powers & Jeffery W. Kelly. (2015) Targeting protein aggregation for the treatment of degenerative diseases. Nature Reviews Drug Discovery 14:11, pages 759-780.
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Jay Kardani & Ipsita Roy. (2015) Understanding Caffeine’s Role in Attenuating the Toxicity of α-Synuclein Aggregates: Implications for Risk of Parkinson’s Disease. ACS Chemical Neuroscience 6:9, pages 1613-1625.
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Shamini Vijayakumaran, Mathew Wong, Helma Antony & Dean Pountney. (2015) Direct and/or Indirect Roles for SUMO in Modulating Alpha-Synuclein Toxicity. Biomolecules 5:3, pages 1697-1716.
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Mariana P. Torrente, Laura M. Castellano & James Shorter. (2014) Suramin Inhibits Hsp104 ATPase and Disaggregase Activity. PLoS ONE 9:10, pages e110115.
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Meredith E. Jackrel & James Shorter. (2014) Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins. Disease Models & Mechanisms.
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