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ATR and ATM-Dependent Movement of BLM Helicase during Replication Stress Ensures Optimal ATM Activation and 53BP1 Focus Formation

Pages 1579-1586 | Published online: 05 Oct 2004

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Jay Yang, Lara O'Donnell, Daniel Durocher & Grant W. Brown. (2012) RMI1 Promotes DNA Replication Fork Progression and Recovery from Replication Fork Stress. Molecular and Cellular Biology 32:15, pages 3054-3064.
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Alessia Errico & Vincenzo Costanzo. (2012) Mechanisms of replication fork protection: a safeguard for genome stability. Critical Reviews in Biochemistry and Molecular Biology 47:3, pages 222-235.
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Benjamin Orsburn, Beatriz Escudero, Mansi Prakash, Silvia Gesheva, Guosheng Liu, David L. Huso & Sonia Franco. (2010) Differential Requirement for H2AX and 53BP1 in Organismal Development and Genome Maintenance in the Absence of Poly(ADP)ribosyl Polymerase 1. Molecular and Cellular Biology 30:10, pages 2341-2352.
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Saravanabhavan Thangavel, Ramiro Mendoza-Maldonado, Erika Tissino, Julia M. Sidorova, Jinhu Yin, Weidong Wang, Raymond J. Monnat$suffix/text()$suffix/text(), Arturo Falaschi & Alessandro Vindigni. (2010) Human RECQ1 and RECQ4 Helicases Play Distinct Roles in DNA Replication Initiation. Molecular and Cellular Biology 30:6, pages 1382-1396.
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Leslie L. Woo, Kenan Onel & Nathan A. Ellis. (2007) The broken genome: Genetic and pharmacologic approaches to breaking DNA. Annals of Medicine 39:3, pages 208-218.
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V. Ashutosh Rao, Angela M. Fan, LingHua Meng, Christopher F. Doe, Phillip S. North, Ian D. Hickson & Yves Pommier. (2005) Phosphorylation of BLM, Dissociation from Topoisomerase IIIα, and Colocalization with γ-H2AX after Topoisomerase I-Induced Replication Damage. Molecular and Cellular Biology 25:20, pages 8925-8937.
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Articles from other publishers (39)

Takamitsu A. Kato. 2023. Chromosome Analysis. Chromosome Analysis 93 98 .
Jyotirindra Maity, Sachi Horibata, Grant Zurcher & Jung-Min Lee. (2022) Targeting of RecQ Helicases as a Novel Therapeutic Strategy for Ovarian Cancer. Cancers 14:5, pages 1219.
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Jolee M Ruchert, Morgan M Brady, Susan McMahan, Karly J Lacey, Leigh C Latta, Jeff Sekelsky & Eric P Stoffregen. (2022) Blm helicase facilitates rapid replication of repetitive DNA sequences in early Drosophila development . Genetics 220:1.
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Melanie Rall-Scharpf, Thomas W.P. Friedl, Shahar Biechonski, Michael Denkinger, Michael Milyavsky & Lisa Wiesmüller. (2021) Sex-specific differences in DNA double-strand break repair of cycling human lymphocytes during aging. Aging 13:17, pages 21066-21089.
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Nafees Ahamad, Saman Khan, Alaa Taha A. Mahdi & Yong-jie Xu. (2021) Checkpoint functions of RecQ helicases at perturbed DNA replication fork. Current Genetics 67:3, pages 369-382.
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Therese Wilhelm, Maha Said & Valeria Naim. (2020) DNA Replication Stress and Chromosomal Instability: Dangerous Liaisons. Genes 11:6, pages 642.
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Mohammad Mirza-Aghazadeh-Attari, Amir Mohammadzadeh, Bahman Yousefi, Ainaz Mihanfar, Ansar Karimian & Maryam Majidinia. (2019) 53BP1: A key player of DNA damage response with critical functions in cancer. DNA Repair 73, pages 110-119.
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Vivek Tripathi, Himanshi Agarwal, Swati Priya, Harish Batra, Priyanka Modi, Monica Pandey, Dhurjhoti Saha, Sathees C. Raghavan & Sagar Sengupta. (2018) MRN complex-dependent recruitment of ubiquitylated BLM helicase to DSBs negatively regulates DNA repair pathways. Nature Communications 9:1.
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Christelle de Renty & Nathan A. Ellis. (2017) Bloom’s syndrome: Why not premature aging?. Ageing Research Reviews 33, pages 36-51.
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Chen Ling, Jing Huang, Zhijiang Yan, Yongjiang Li, Mioko Ohzeki, Masamichi Ishiai, Dongyi Xu, Minoru Takata, Michael Seidman & Weidong Wang. (2016) Bloom syndrome complex promotes FANCM recruitment to stalled replication forks and facilitates both repair and traverse of DNA interstrand crosslinks. Cell Discovery 2:1.
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Larissa Tangeman, Michael McIlhatton, Patrick Grierson, Joanna Groden & Samir Acharya. (2016) Regulation of BLM Nucleolar Localization. Genes 7:9, pages 69.
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N Kanu, T Zhang, R A Burrell, A Chakraborty, J Cronshaw, C DaCosta, E Grönroos, H N Pemberton, E Anderton, L Gonzalez, S Sabbioneda, H D Ulrich, C Swanton & A Behrens. (2015) RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress. Oncogene 35:30, pages 4009-4019.
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R Kwakman, E M V de Cuba, J P de Winter, I H J T de Hingh, P M Delis-van Diemen, M Tijssen, M A Rooimans, O Krijgsman, B Carvalho, G J Peters, H J Bonjer, G A Meijer & E A te Velde. (2015) Tailoring heated intraperitoneal mitomycin C for peritoneal metastases originating from colorectal carcinoma: a translational approach to improve survival. British Journal of Cancer 112:5, pages 851-856.
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Stefanie Böhm, Michael Joseph Mihalevic, Morgan Alexandra Casal & Kara Anne Bernstein. (2015) Disruption of SUMO-targeted ubiquitin ligases Slx5–Slx8/RNF4 alters RecQ-like helicase Sgs1/BLM localization in yeast and human cells. DNA Repair 26, pages 1-14.
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Abdelghani Mazouzi, Georgia Velimezi & Joanna I. Loizou. (2014) DNA replication stress: Causes, resolution and disease. Experimental Cell Research 329:1, pages 85-93.
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Yosef Shiloh. (2014) ATM: Expanding roles as a chief guardian of genome stability. Experimental Cell Research 329:1, pages 154-161.
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Stefanie Böhm & Kara Anne Bernstein. (2014) The role of post-translational modifications in fine-tuning BLM helicase function during DNA repair. DNA Repair 22, pages 123-132.
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Anastazja Grabarz, Josée Guirouilh-Barbat, Aurélia Barascu, Gaëlle Pennarun, Diane Genet, Emilie Rass, Susanne M. Germann, Pascale Bertrand, Ian D. Hickson & Bernard S. Lopez. (2013) A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining. Cell Reports 5:1, pages 21-28.
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Yosef Shiloh & Yael Ziv. (2013) The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nature Reviews Molecular Cell Biology 14:4, pages 197-210.
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Anna Maria Hegnauer, Nicole Hustedt, Kenji Shimada, Brietta L Pike, Markus Vogel, Philipp Amsler, Seth M Rubin, Fred van Leeuwen, Aude Guénolé, Haico van Attikum, Nicolas H Thomä & Susan M Gasser. (2012) An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks. The EMBO Journal 31:18, pages 3768-3783.
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Dharmendra Kumar Singh, Avik K. Ghosh, Deborah L. Croteau & Vilhelm A. Bohr. (2012) RecQ helicases in DNA double strand break repair and telomere maintenance. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 736:1-2, pages 15-24.
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H. Chen, M.J. You, Y. Jiang, W. Wang & L. Li. (2011) RMI1 attenuates tumor development and is essential for early embryonic survival. Molecular Carcinogenesis 50:2, pages 80-88.
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Krystal L. Bergeron, Eileen L. Murphy, Lily W. Brown & Karen H. Almeida. (2010) Critical Interaction Domains between Bloom Syndrome Protein and RAD51. The Protein Journal 30:1, pages 1-8.
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Karen J. Ouyang, Leslie L. Woo, Jianmei Zhu, Dezheng Huo, Michael J. Matunis & Nathan A. Ellis. (2009) SUMO Modification Regulates BLM and RAD51 Interaction at Damaged Replication Forks. PLoS Biology 7:12, pages e1000252.
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Yih-Lin Chung & Tzung-Yuan Tsai. (2009) Promyelocytic Leukemia Nuclear Bodies Link the DNA Damage Repair Pathway with Hepatitis B Virus Replication: Implications for Hepatitis B Virus Exacerbation during Chemotherapy and Radiotherapy. Molecular Cancer Research 7:10, pages 1672-1685.
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Dharmendra Kumar Singh, Byungchan Ahn & Vilhelm A. Bohr. (2008) Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging. Biogerontology 10:3, pages 235-252.
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Rebecca A. Chanoux, Bu Yin, Karen A. Urtishak, Amma Asare, Craig H. Bassing & Eric J. Brown. (2009) ATR and H2AX Cooperate in Maintaining Genome Stability under Replication Stress. Journal of Biological Chemistry 284:9, pages 5994-6003.
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Dongyi Xu, Rong Guo, Alexandra Sobeck, Csanad Z. Bachrati, Jay Yang, Takemi Enomoto, Grant W. Brown, Maureen E. Hoatlin, Ian D. Hickson & Weidong Wang. (2008) RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability. Genes & Development 22:20, pages 2843-2855.
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Wen-Hsing ChengDiana Muftic, Meltem Muftuoglu, Lale Dawut, Christa MorrisThomas Helleday, Yosef Shiloh & Vilhelm A. Bohr. (2008) WRN Is Required for ATM Activation and the S-Phase Checkpoint in Response to Interstrand Cross-Link–Induced DNA Double-Strand Breaks. Molecular Biology of the Cell 19:9, pages 3923-3933.
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Karen J. Ouyang, Leslie L. Woo & Nathan A. Ellis. (2008) Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases. Mechanisms of Ageing and Development 129:7-8, pages 425-440.
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Csanád Z. Bachrati & Ian D. Hickson. (2008) RecQ helicases: guardian angels of the DNA replication fork. Chromosoma 117:3, pages 219-233.
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L. C. Riches, A. M. Lynch & N. J. Gooderham. (2008) Early events in the mammalian response to DNA double-strand breaks. Mutagenesis 23:5, pages 331-339.
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Wen-Hsing Cheng, Meltem Muftuoglu & Vilhelm A. Bohr. (2007) Werner syndrome protein: Functions in the response to DNA damage and replication stress in S-phase. Experimental Gerontology 42:9, pages 871-878.
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Laurence Tartier, Stuart Gilchrist, Susanne Burdak-Rothkamm, Melvyn Folkard & Kevin M. Prise. (2007) Cytoplasmic Irradiation Induces Mitochondrial-Dependent 53BP1 Protein Relocalization in Irradiated and Bystander Cells. Cancer Research 67:12, pages 5872-5879.
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S A Gatz & L Wiesmüller. (2006) p53 in recombination and repair. Cell Death & Differentiation 13:6, pages 1003-1016.
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Roger D. Everett. (2006) Interactions between DNA viruses, ND10 and the DNA damage response. Cellular Microbiology 8:3, pages 365-374.
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Maja Petkovic, Tobias Dietschy, Raimundo Freire, Renjie Jiao & Igor Stagljar. (2005) The human Rothmund-Thomson syndrome gene product, RECQL4, localizes to distinct nuclear foci that coincide with proteins involved in the maintenance of genome stability. Journal of Cell Science 118:18, pages 4261-4269.
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Simone Difilippantonio, Arkady Celeste, Oscar Fernandez-Capetillo, Hua-Tang Chen, Bernardo Reina San Martin, Francois Van Laethem, Yong-Ping Yang, Galina V. Petukhova, Michael Eckhaus, Lionel Feigenbaum, Katia Manova, Michael Kruhlak, R. Daniel Camerini-Otero, Shyam Sharan, Michel Nussenzweig & André Nussenzweig. (2005) Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nature Cell Biology 7:7, pages 675-685.
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Sonia Eladad, Tian-Zhang Ye, Peng Hu, Margaret Leversha, Sergey Beresten, Michael J. Matunis & Nathan A. Ellis. (2005) Intra-nuclear trafficking of the BLM helicase to DNA damage-induced foci is regulated by SUMO modification. Human Molecular Genetics 14:10, pages 1351-1365.
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