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Flavopiridol inhibits the Growth of GL261 Gliomas In Vivo: Implications for Malignant Glioma Therapy

Pages 218-222 | Published online: 03 Dec 2003

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Andrei Shchebet, Oleksandra Karpiuk, Elisabeth Kremmer, Dirk Eick & Steven A. Johnsen. (2012) Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function. Cell Cycle 11:11, pages 2122-2127.
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Junfang Wu, Bogdan A. Stoica, Michael Dinizo, Ahdeah Pajoohesh-Ganji, Chunshu Piao & Alan I. Faden. (2012) Delayed cell cycle pathway modulation facilitates recovery after spinal cord injury. Cell Cycle 11:9, pages 1782-1795.
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Sergiy V Kushchayev, Tejas Sankar, Laura L Eggink, Yevgeniya S Kushchayeva, Philip C Wiener, J Kenneth Hoober, Jennifer Eschbacher, Ruolan Liu, Fu-Dong Shi, Mohammed G Abdelwahab, Adrienne C Scheck & Mark C Preul. (2012) Monocyte galactose/N-acetylgalactosamine-specific C-type lectin receptor stimulant immunotherapy of an experimental glioma. Part II: combination with external radiation improves survival. Cancer Management and Research 4, pages 325-334.
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Marta Penas-Prado & Mark R Gilbert. (2007) Molecularly targeted therapies for malignant gliomas: advances and challenges. Expert Review of Anticancer Therapy 7:5, pages 641-661.
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Andrew S Chi & Patrick Y Wen. (2007) Inhibiting kinases in malignant gliomas. Expert Opinion on Therapeutic Targets 11:4, pages 473-496.
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Patrick Y Wen, Santosh Kesari & Jan Drappatz. (2006) Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment. Expert Review of Anticancer Therapy 6:5, pages 733-754.
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Qingxia Wei, Olivia Singh, Can Ekinci, Jaspreet Gill, Mira Li, Yasin Mamatjan, Shirin Karimi, Severa Bunda, Sheila Mansouri, Kenneth Aldape & Gelareh Zadeh. (2021) TNFα secreted by glioma associated macrophages promotes endothelial activation and resistance against anti-angiogenic therapy. Acta Neuropathologica Communications 9:1.
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Victoria E. Sanchez, John P. Lynes, Stuart Walbridge, Xiang Wang, Nancy A. Edwards, Anthony K. Nwankwo, Hannah P. Sur, Gifty A. Dominah, Arnold Obungu, Nicholas Adamstein, Pradeep K. Dagur, Dragan Maric, Jeeva Munasinghe, John D. Heiss & Edjah K. Nduom. (2020) GL261 luciferase-expressing cells elicit an anti-tumor immune response: an evaluation of murine glioma models. Scientific Reports 10:1.
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Saowaluk Saisomboon, Ryusho Kariya, Kulthida Vaeteewoottacharn, Sopit Wongkham, Kanlayanee Sawanyawisuth & Seiji Okada. (2019) Antitumor effects of flavopiridol, a cyclin-dependent kinase inhibitor, on human cholangiocarcinoma in vitro and in an in vivo xenograft model. Heliyon 5:5, pages e01675.
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Isabelle Ferry, Claudia M. Kuzan-Fischer, Emilie Ernoult & James T. Rutka. 2018. Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy. Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy 271 290 .
Timothy P. Heffron. (2016) Small Molecule Kinase Inhibitors for the Treatment of Brain Cancer. Journal of Medicinal Chemistry 59:22, pages 10030-10066.
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Jenny L. Pokorny, Gaspar J. Kitange & Daniel J. Ma. 2016. Resistance to Targeted Therapies Against Adult Brain Cancers. Resistance to Targeted Therapies Against Adult Brain Cancers 145 174 .
Hao Ren, Min Han, Jing Zhou, Ze-Feng Zheng, Ping Lu, Jun-Juan Wang, Jia-Qiu Wang, Qi-Jiang Mao, Jian-Qing Gao & Hong Wei Ouyang. (2014) Repair of spinal cord injury by inhibition of astrocyte growth and inflammatory factor synthesis through local delivery of flavopiridol in PLGA nanoparticles. Biomaterials 35:24, pages 6585-6594.
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Yujie Huang, Caitlin Hoffman, Prajwal Rajappa, Joon-Hyung Kim, Wenhuo Hu, Jason Huse, Zhongshu Tang, Xuri Li, Babette Weksler, Jacqueline Bromberg, David C. Lyden & Jeffrey P. Greenfield. (2014) Oligodendrocyte Progenitor Cells Promote Neovascularization in Glioma by Disrupting the Blood–Brain Barrier. Cancer Research 74:4, pages 1011-1021.
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Steven A. Johnsen. (2012) The enigmatic role of H2Bub1 in cancer. FEBS Letters 586:11, pages 1592-1601.
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Junfang Wu, Bogdan A. Stoica & Alan I. Faden. (2011) Cell Cycle Activation and Spinal Cord Injury. Neurotherapeutics 8:2, pages 221-228.
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Phillip Stafford, Mohammed G Abdelwahab, Do Young Kim, Mark C Preul, Jong M Rho & Adrienne C Scheck. (2010) The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma. Nutrition & Metabolism 7:1.
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Olga Méndez, Jiri Zavadil, Mine Esencay, Yevgeniy Lukyanov, Daniel Santovasi, Shu-Chi Wang, Elizabeth W Newcomb & David Zagzag. (2010) Knock down of HIF-1α in glioma cells reduces migration in vitro and invasion in vivo and impairs their ability to form tumor spheres. Molecular Cancer 9:1.
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David J. Matthews & Mary E. Gerritsen. 2010. Targeting Protein Kinases for Cancer Therapy. Targeting Protein Kinases for Cancer Therapy 327 390 .
Abdelilah IbrahimiGreetje Vande VeldeVeerle ReumersJaan ToelenIrina ThiryCaroline VandeputteSofie VetsChristophe DerooseGuy BormansVeerle BaekelandtZeger DebyserRik Gijsbers. (2009) Highly Efficient Multicistronic Lentiviral Vectors with Peptide 2A Sequences. Human Gene Therapy 20:8, pages 845-860.
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Elizabeth W. Newcomb & David Zagzag. 2009. CNS Cancer. CNS Cancer 227 241 .
Anhua WuSeunguk OhStephen M. WiesnerKatya EricsonLisa ChenWalter A. HallPaul E. ChampouxWalter C. LowJohn R. Ohlfest. (2008) Persistence of CD133 + Cells in Human and Mouse Glioma Cell Lines: Detailed Characterization of GL261 Glioma Cells with Cancer Stem Cell-Like Properties . Stem Cells and Development 17:1, pages 173-184.
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Kimberly R. Byrnes & Alan I. Faden. (2007) Role of Cell Cycle Proteins in CNS Injury. Neurochemical Research 32:10, pages 1799-1807.
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Elizabeth W. Newcomb, Yevgeniy Lukyanov, Tona Schnee, Mine Esencay, Ingeborg Fischer, David Hong, Yongzhao Shao & David Zagzag. (2007) The geldanamycin analogue 17-allylamino-17-demethoxygeldanamycin inhibits the growth of GL261 glioma cells in vitro and in vivo. Anti-Cancer Drugs 18:8, pages 875-882.
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Elizabeth W. Newcomb, Sandra Demaria, Yevgeniy Lukyanov, Yongzhao Shao, Tona Schnee, Noriko Kawashima, Li Lan, J. Keith Dewyngaert, David Zagzag, William H. McBride & Silvia C. Formenti. (2006) The Combination of Ionizing Radiation and Peripheral Vaccination Produces Long-term Survival of Mice Bearing Established Invasive GL261 Gliomas. Clinical Cancer Research 12:15, pages 4730-4737.
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Santosh Kesari, Naren Ramakrishna, Claire Sauvageot, Charles D. Stiles & Patrick Y. Wen. (2006) Targeted molecular therapy of malignant gliomas. Current Oncology Reports 8:1, pages 58-70.
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Santosh Kesari, Naren Ramakrishna, Claire Sauvageot, Charles D. Stiles & Patrick Y. Wen. (2005) Targeted molecular therapy of malignant gliomas. Current Neurology and Neuroscience Reports 5:3, pages 186-197.
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Elizabeth W. Newcomb. (2004) Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity. Anti-Cancer Drugs 15:5, pages 411-419.
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Zoya N. Demidenko & Mikhail V. Blagosklonny. (2004) Flavopiridol Induces p53 via Initial Inhibition of Mdm2 and p21 and, Independently of p53, Sensitizes Apoptosis-Reluctant Cells to Tumor Necrosis Factor. Cancer Research 64:10, pages 3653-3660.
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