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Akt-Dependent T198 Phosphorylation of Cyclin-Dependent Kinase Inhibitor p27kip1 in Breast Cancer

Pages 1072-1078 | Published online: 21 May 2004

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Fernanda De Vita, Miriam Riccardi, Donatella Malanga, Marianna Scrima, Carmela De Marco & Giuseppe Viglietto. (2012) PKC-dependent phosphorylation of p27 at T198 contributes to p27 stabilization and cell cycle arrest. Cell Cycle 11:8, pages 1583-1592.
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Michelle D. Larrea, Jiyong Liang, Thiago Da Silva, Feng Hong, Shan H. Shao, Kathy Han, D. Dumont & Joyce M. Slingerland. (2008) Phosphorylation of p27Kip1 Regulates Assembly and Activation of Cyclin D1-Cdk4. Molecular and Cellular Biology 28:20, pages 6462-6472.
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D Zhao, A H Besser, S A Wander, J Sun, W Zhou, B Wang, T Ince, M A Durante, W Guo, G Mills, D Theodorescu & J Slingerland. (2015) Cytoplasmic p27 promotes epithelial–mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation. Oncogene 34:43, pages 5447-5459.
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D Raina, Y Uchida, A Kharbanda, H Rajabi, G Panchamoorthy, C Jin, S Kharbanda, M Scaltriti, J Baselga & D Kufe. (2013) Targeting the MUC1-C oncoprotein downregulates HER2 activation and abrogates trastuzumab resistance in breast cancer cells. Oncogene 33:26, pages 3422-3431.
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Yves Nzengue, Serge M. Candéias, Sylvie Sauvaigo, Thierry Douki, Alain Favier, Walid Rachidi & Pascale Guiraud. (2011) The toxicity redox mechanisms of cadmium alone or together with copper and zinc homeostasis alteration: Its redox biomarkers. Journal of Trace Elements in Medicine and Biology 25:3, pages 171-180.
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Monica Schiappacassi, Sara Lovisa, Francesca Lovat, Linda Fabris, Alfonso Colombatti, Barbara Belletti & Gustavo Baldassarre. (2011) Role of T198 Modification in the Regulation of p27Kip1 Protein Stability and Function. PLoS ONE 6:3, pages e17673.
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Simone Diermeier-Daucher, Stefanie Breindl, Stefan Buchholz, Olaf Ortmann & Gero Brockhoff. (2011) Modular anti-EGFR and anti-Her2 targeting of SK-BR-3 and BT474 breast cancer cell lines in the presence of ErbB receptor-specific growth factors. Cytometry Part A, pages n/a-n/a.
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K S Kelly-Spratt, J Philipp-Staheli, K E Gurley, K Hoon-Kim, S Knoblaugh & C J Kemp. (2009) Inhibition of PI-3K restores nuclear p27Kip1 expression in a mouse model of Kras-driven lung cancer. Oncogene 28:41, pages 3652-3662.
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Michelle D. Larrea, Feng Hong, Seth A. Wander, Thiago G. da Silva, David Helfman, Deborah Lannigan, Jeffrey A. Smith & Joyce M. Slingerland. (2009) RSK1 drives p27 Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility . Proceedings of the National Academy of Sciences 106:23, pages 9268-9273.
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Dana-Lynn T. Koomoa, Lisette P. Yco, Tamas Borsics, Christopher J. Wallick & André S. Bachmann. (2008) Ornithine Decarboxylase Inhibition by α-Difluoromethylornithine Activates Opposing Signaling Pathways via Phosphorylation of Both Akt/Protein Kinase B and p27Kip1 in Neuroblastoma. Cancer Research 68:23, pages 9825-9831.
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Satoki Nakamura, Keiji Okinaka, Isao Hirano, Takaaki Ono, Yuya Sugimoto, Kazuyuki Shigeno, Shinya Fujisawa, Kaori Shinjo & Kazunori Ohnishi. (2008) KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells. Leukemia Research 32:9, pages 1358-1365.
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Isabel M. Chu, Ludger Hengst & Joyce M. Slingerland. (2008) The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nature Reviews Cancer 8:4, pages 253-267.
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Danielle Caron, Pierre E. Savard, Charles J. Doillon, Martin Olivier, Eric Shink, Jacques G. Lussier & Robert L. Faure. (2008) Protein tyrosine phosphatase inhibition induces anti-tumor activity: Evidence of Cdk2/p27kip1 and Cdk2/SHP-1 complex formation in human ovarian cancer cells. Cancer Letters 262:2, pages 265-275.
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Elena A. Ostrakhovitch, Per-Erik Olsson, Jonas von Hofsten & M. George Cherian. (2007) P53 mediated regulation of metallothionein transcription in breast cancer cells. Journal of Cellular Biochemistry 102:6, pages 1571-1583.
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Margit Rosner, Angelika Freilinger, Michaela Hanneder, Naoya Fujita, Gert Lubec, Takashi Tsuruo & Markus Hengstschläger. (2007) p27 Kip1 localization depends on the tumor suppressor protein tuberin. Human Molecular Genetics 16:13, pages 1541-1556.
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Uta Kossatz, Jörg Vervoorts, Irina Nickeleit, Holly A Sundberg, J Simon C Arthur, Michael P Manns & Nisar P Malek. (2006) C-terminal phosphorylation controls the stability and function of p27kip1. The EMBO Journal 25:21, pages 5159-5170.
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Frederick Y. Wu, Shizhen Emily Wang, Melinda E. Sanders, Incheol Shin, Federico Rojo, Jose Baselga & Carlos L. Arteaga. (2006) Reduction of Cytosolic p27Kip1 Inhibits Cancer Cell Motility, Survival, and Tumorigenicity. Cancer Research 66:4, pages 2162-2172.
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Motoyasu Saji, Vasily Vasko, Faiza Kada, Elena Hardy Allbritton, Kenneth D. Burman & Matthew D. Ringel. (2005) Akt1 contains a functional leucine-rich nuclear export sequence. Biochemical and Biophysical Research Communications 332:1, pages 167-173.
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Cheryl A. PickettS. Nicholas AgoffTravis J. WidmanMary P. Bronner. (2005) Altered Expression of Cyclins and Cell Cycle Inhibitors in Papillary Thyroid Cancer: Prognostic Implications. Thyroid 15:5, pages 461-473.
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