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Cell Cycle Volume 3, 2004 - Issue 8
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Perspectives

Oxygen Sensing by H+: Implications for HIF and Hypoxic Cell Memory

Karim Mekhail
,
Mireille Khacho
,
Lakshman Gunaratnam
&
Stephen Lee
Pages 1025-1027 | Published online: 21 May 2004

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Jianling Xie, Halina Mikolajek, Craig R. Pigott, Kelly J. Hooper, Toby Mellows, Claire E. Moore, Hafeez Mohammed, Jörn M. Werner, Gareth J. Thomas & Christopher G. Proud. (2015) Molecular Mechanism for the Control of Eukaryotic Elongation Factor 2 Kinase by pH: Role in Cancer Cell Survival. Molecular and Cellular Biology 35:10, pages 1805-1824.
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Matthias Kappler, Helge Taubert, Johannes Schubert, Dirk Vordermark & Alexander W. Eckert. (2012) The real face of HIF1α in the tumor process. Cell Cycle 11:21, pages 3932-3936.
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Mathieu D. Jacob, Timothy E. Audas, Sahra-Taylor Mullineux & Stephen Lee. (2012) Where no RNA polymerase has gone before. Nucleus 3:4, pages 315-319.
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Aaishwarya B. Deshmukh, Jayvadan K. Patel, Ashish R. Prajapati & Shreya Shah. (2012) Perspective in Chronic Kidney Disease: Targeting Hypoxia-Inducible Factor (HIF) as Potential Therapeutic Approach. Renal Failure 34:4, pages 521-532.
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Mireille Khacho, Karim Mekhail, Karine Pilon-Larose, Josianne Payette & Stephen Lee. (2008) Cancer-Causing Mutations in a Novel Transcription-Dependent Nuclear Export Motif of VHL Abrogate Oxygen-Dependent Degradation of Hypoxia-Inducible Factor. Molecular and Cellular Biology 28:1, pages 302-314.
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Articles from other publishers (21)

Hao Zhao, Yachun Han, Na Jiang, Chenrui Li, Ming Yang, Ying Xiao, Ling Wei, Xiaofen Xiong, Jinfei Yang, Chengyuan Tang, Li Xiao, Fuyou Liu, Yu Liu & Lin Sun. (2021) Effects of HIF-1α on renal fibrosis in cisplatin-induced chronic kidney disease. Clinical Science 135:10, pages 1273-1288.
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Oliver Thews & Anne Riemann. (2019) Tumor pH and metastasis: a malignant process beyond hypoxia. Cancer and Metastasis Reviews 38:1-2, pages 113-129.
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Joris Paris, Joëlle Tobaly-Tapiero, Marie-Lou Giron, Julien Burlaud-Gaillard, Florence Buseyne, Philippe Roingeard, Pascale Lesage, Alessia Zamborlini & Ali Saïb. (2018) The invariant arginine within the chromatin-binding motif regulates both nucleolar localization and chromatin binding of Foamy virus Gag. Retrovirology 15:1.
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Mathieu D. Jacob, Timothy E. Audas, James Uniacke, Laura Trinkle-Mulcahy & Stephen Lee. (2013) Environmental cues induce a long noncoding RNA–dependent remodeling of the nucleolus. Molecular Biology of the Cell 24:18, pages 2943-2953.
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Krzysztof Staroń & Agnieszka Girstun. 2013. Proteins of the Nucleolus. Proteins of the Nucleolus 209 247 .
Y Bertrand, J-C Currie, J Poirier, M Demeule, A Abulrob, D Fatehi, D Stanimirovic, H Sartelet, J-P Castaigne & R Béliveau. (2011) Influence of glioma tumour microenvironment on the transport of ANG1005 via low-density lipoprotein receptor-related protein 1. British Journal of Cancer 105:11, pages 1697-1707.
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Maike Glitsch. (2011) Protons and Ca 2+ : Ionic Allies in Tumor Progression? . Physiology 26:4, pages 252-265.
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Yonglei Liu, Xianrang Song, Xingwu Wang, Ling Wei, Xiuju Liu, Shuanghu Yuan & Liyan Lv. (2010) Effect of chronic intermittent hypoxia on biological behavior and hypoxia-associated gene expression in lung cancer cells. Journal of Cellular Biochemistry 111:3, pages 554-563.
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Elizabeth A. Mazzio, Bruce Smith & Karam F. A. Soliman. (2009) Evaluation of endogenous acidic metabolic products associated with carbohydrate metabolism in tumor cells. Cell Biology and Toxicology 26:3, pages 177-188.
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Lakshman Gunaratnam & Joseph V. Bonventre. (2009) HIF in Kidney Disease and Development. Journal of the American Society of Nephrology 20:9, pages 1877-1887.
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Mireille Khacho & Stephen Lee. (2009) Subcellular dynamics of the VHL tumor suppressor: on the move for HIF degradation. Future Oncology 5:1, pages 85-95.
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Pasquale Fasanaro, Yuri D'Alessandra, Valeria Di Stefano, Roberta Melchionna, Sveva Romani, Giulio Pompilio, Maurizio C. Capogrossi & Fabio Martelli. (2008) MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3. Journal of Biological Chemistry 283:23, pages 15878-15883.
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Anna S. Kocincova, Sergey M. Borisov, Christian Krause & Otto S. Wolfbeis. (2007) Fiber-Optic Microsensors for Simultaneous Sensing of Oxygen and pH, and of Oxygen and Temperature. Analytical Chemistry 79:22, pages 8486-8493.
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Karim Mekhail, Luis Rivero-Lopez, Ahmad Al-Masri, Caroline Brandon, Mireille Khacho & Stephen Lee. (2007) Identification of a Common Subnuclear Localization Signal. Molecular Biology of the Cell 18:10, pages 3966-3977.
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Peter Vaupel & Arnulf Mayer. (2007) Hypoxia in cancer: significance and impact on clinical outcome. Cancer and Metastasis Reviews 26:2, pages 225-239.
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Sergey V. Novoselov, Gregory V. Kryukov, Xue-Ming Xu, Bradley A. Carlson, Dolph L. Hatfield & Vadim N. Gladyshev. (2007) Selenoprotein H Is a Nucleolar Thioredoxin-like Protein with a Unique Expression Pattern. Journal of Biological Chemistry 282:16, pages 11960-11968.
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Anna S. Vasylevska, Alexander A. Karasyov, Sergey M. Borisov & Christian Krause. (2007) Novel coumarin-based fluorescent pH indicators, probes and membranes covering a broad pH range. Analytical and Bioanalytical Chemistry 387:6, pages 2131-2141.
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Henry N. Hulter & Reto Krapf. (2006) Interrelationships Among Hypoxia-Inducible Factor Biology and Acid-Base Equilibrium. Seminars in Nephrology 26:6, pages 454-465.
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Ganna S. Vasylevska, Sergey M. Borisov, Christian Krause & Otto S. Wolfbeis. (2006) Indicator-Loaded Permeation-Selective Microbeads for Use in Fiber Optic Simultaneous Sensing of pH and Dissolved Oxygen. Chemistry of Materials 18:19, pages 4609-4616.
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Kenneth R. Cutroneo, Sheryl L. White, Jen-Fu Chiu & H. Paul Ehrlich. (2006) Tissue fibrosis and carcinogenesis: Divergent or successive pathways dictate multiple molecular therapeutic targets for oligo decoy therapies. Journal of Cellular Biochemistry 97:6, pages 1161-1174.
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Karim Mekhail, Mireille Khacho, Amanda Carrigan, Robert R.J. Hache, Lakshman Gunaratnam & Stephen Lee. (2005) Regulation of ubiquitin ligase dynamics by the nucleolus. Journal of Cell Biology 170:5, pages 733-744.
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