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Loss of Caveolin-1 Causes the Hyper-Proliferation of Intestinal Crypt Stem Cells, with Increased Sensitivity to Whole Body ?-Radiation

Pages 1817-1825 | Published online: 09 Nov 2005

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Read on this site (7)

Javed Mahmood, Sarthak R. Zaveri, Stephanie C. Murti, Allen A. Alexander, Caroline Q. Connors, Hem D. Shukla & Zeljko Vujaskovic. (2016) Caveolin-1: a novel prognostic biomarker of radioresistance in cancer. International Journal of Radiation Biology 92:12, pages 747-753.
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Rosa Sanchez-Alvarez, Ubaldo E. Martinez-Outschoorn, Zhao Lin, Rebecca Lamb, James Hulit, Anthony Howell, Federica Sotgia, Emanuel Rubin & Michael P. Lisanti. (2013) Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism. Cell Cycle 12:2, pages 289-301.
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Zaki A. Sherif & Ahmed S. Sultan. (2013) Divergent control of Cav-1 expression in non-cancerous Li-Fraumeni syndrome and human cancer cell lines. Cancer Biology & Therapy 14:1, pages 29-38.
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Elke Burgermeister, Teresa Friedrich, Ivana Hitkova, Ivonne Regel, Henrik Einwächter, Wolfgang Zimmermann, Christoph Röcken, Aurel Perren, Matthew B. Wright, Roland M. Schmid, Rony Seger & Matthias P. A. Ebert. (2011) The Ras Inhibitors Caveolin-1 and Docking Protein 1 Activate Peroxisome Proliferator-Activated Receptor γ through Spatial Relocalization at Helix 7 of Its Ligand-Binding Domain. Molecular and Cellular Biology 31:16, pages 3497-3510.
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Richard C. Crist, Jacquelyn J. Roth, Michael P Lisanti, Linda D. Siracusa & Arthur M. Buchberg. (2011) Identification of Mom12 and Mom13, two novel modifier loci of Apc-mediated intestinal tumorigenesis. Cell Cycle 10:7, pages 1092-1099.
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Maria Shatz & Mordechai Liscovitch. (2008) Caveolin-1: A tumor-promoting role in human cancer. International Journal of Radiation Biology 84:3, pages 177-189.
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Vicente A. Torres, Julio C. Tapia, Diego A. Rodriguez, Alvaro Lladser, Cristian Arredondo, Lisette Leyton & Andrew F. G. Quest. (2007) E-Cadherin Is Required for Caveolin-1-Mediated Down-Regulation of the Inhibitor of Apoptosis Protein Survivin via Reduced β-Catenin-Tcf/Lef-Dependent Transcription. Molecular and Cellular Biology 27:21, pages 7703-7717.
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Articles from other publishers (42)

Feng Luo, Jinbang Li, Jihong Liu & Kunping Liu. (2022) Stabilizing and upregulating Axin with tankyrase inhibitor reverses 5-fluorouracil chemoresistance and proliferation by targeting the WNT/caveolin-1 axis in colorectal cancer cells. Cancer Gene Therapy 29:11, pages 1707-1719.
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Xingning Lai, Yiling Guo, Miaomiao Chen, Yuxuan Wei, Wanting Yi, Yubo Shi & Lixia Xiong. (2021) Caveolin1: its roles in normal and cancer stem cells. Journal of Cancer Research and Clinical Oncology 147:12, pages 3459-3475.
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Heba A. Mohamed & Riham S. Said. (2021) Coenzyme Q10 attenuates inflammation and fibrosis implicated in radiation enteropathy through suppression of NF-kB/TGF-β/MMP-9 pathways. International Immunopharmacology 92, pages 107347.
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Paola Serrano Martinez, Lorena Giuranno, Marc Vooijs & Robert P. Coppes. (2021) The Radiation-Induced Regenerative Response of Adult Tissue-Specific Stem Cells: Models and Signaling Pathways. Cancers 13:4, pages 855.
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Ronghua Yang, Jingru Wang, Ziheng Zhou, Shaohai Qi, Shubin Ruan, Zepeng Lin, Qi Xin, Yan Lin, Xiaodong Chen & Julin Xie. (2019) Curcumin promotes burn wound healing in mice by upregulating caveolin-1 in epidermal stem cells. Phytotherapy Research 33:2, pages 422-430.
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Ronghua Yang, Jingru Wang, Ziheng Zhou, Shaohai Qi, Shubin Ruan, Zepeng Lin, Qi Xin, Yan Lin, Xiaodong Chen & Julin Xie. (2019) Role of caveolin-1 in epidermal stem cells during burn wound healing in rats. Developmental Biology 445:2, pages 271-279.
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Ying Chen, Chunxia Wang, Qiang Huang, Dan Wu, Jianing Cao, Xin Xu, Chengjian Yang & Xun Li. (2017) Caveolin-1 Plays an Important Role in the Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells into Cardiomyocytes. Cardiology 136:1, pages 40-48.
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Der Sheng Sun, Soon Auck Hong, Hye Sung Won, Su Hyun Yoo, Han Hong Lee, Okran Kim & Yoon Ho Ko. (2017) Prognostic Value of Metastatic Tumoral Caveolin-1 Expression in Patients with Resected Gastric Cancer. Gastroenterology Research and Practice 2017, pages 1-10.
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Csaba Tóth, Jeannine Meinrath, Esther Herpel, Jutta Derix, Jochen Fries, Reinhard Buettner, Peter Schirmacher & Sebastian Heikaus. (2015) Expression of the apoptosis repressor with caspase recruitment domain (ARC) in liver metastasis of colorectal cancer and its correlation with DNA mismatch repair proteins and p53. Journal of Cancer Research and Clinical Oncology 142:5, pages 927-935.
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Zhiyu Wang, Neng Wang, Pengxi Liu, Fu Peng, Hailin Tang, Qianjun Chen, Rui Xu, Yan Dai, Yi Lin, Xiaoming Xie, Cheng Peng & Honglin Situ. (2015) Caveolin-1, a stress-related oncotarget, in drug resistance. Oncotarget 6:35, pages 37135-37150.
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Daniel Talmasov, Xinjun Zhang, Bing Yu, Mandayam O. Nandan, Agnieszka B. Bialkowska, Enas Elkarim, Jes Kuruvilla, Vincent W. Yang & Amr M. Ghaleb. (2015) Krüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology 308:2, pages G121-G138.
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Katelyn M. Atkins, Laura L. Thomas, Jonathan Barroso-González, Laurel Thomas, Sylvain Auclair, Jun Yin, Hyeog Kang, Jay H. Chung, Jimmy D. Dikeakos & Gary Thomas. (2014) The Multifunctional Sorting Protein PACS-2 Regulates SIRT1-Mediated Deacetylation of p53 to Modulate p21-Dependent Cell-Cycle Arrest. Cell Reports 8:5, pages 1545-1557.
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B.-S. Moon, Y. H. Cho, W.-J. Jeong & K.-Y. Choi. (2014) Response. JNCI Journal of the National Cancer Institute 106:8, pages dju197-dju197.
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I. Cristobal, R. Rincon, R. Manso, F. Rojo & J. Garcia-Foncillas. (2014) Re: Role of Oncogenic K-Ras in Cancer Stem Cell Activation by Aberrant Wnt/ -Catenin Signaling. JNCI Journal of the National Cancer Institute 106:8, pages dju196-dju196.
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Yuan Zhang, Wei Zou, Fenggong Cui, Nan Wang, Dongyan Zhang, Yuying Cui, Peng Liu & Jing Liu. (2013) Protective Effect of Phosphatidylcholine on Restoration of Ethanol-Injured Hepatocytes Related with Caveolin-1. The Journal of Membrane Biology 247:1, pages 73-80.
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Natasha Baker & Rocky S Tuan. (2013) The less-often-traveled surface of stem cells: caveolin-1 and caveolae in stem cells, tissue repair and regeneration. Stem Cell Research & Therapy 4:4.
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Rebecca Senetta, Giulia Stella, Ernesto Pozzi, Niccolo Sturli, Daniela Massi & Paola Cassoni. (2013) Caveolin‐1 as a promoter of tumour spreading: when, how, where and why. Journal of Cellular and Molecular Medicine 17:3, pages 325-336.
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Gregory Lyng, Richard Logan & Maria Mancini. 2013. Pathobiology of Cancer Regimen-Related Toxicities. Pathobiology of Cancer Regimen-Related Toxicities 75 95 .
Natasha Baker, Guofeng Zhang, Yang You & Rocky S. Tuan. (2012) Caveolin-1 regulates proliferation and osteogenic differentiation of human mesenchymal stem cells. Journal of Cellular Biochemistry 113:12, pages 3773-3787.
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Neill Patani, Lesley-Ann Martin, Jorge S. Reis-Filho & Mitch Dowsett. (2011) The role of caveolin-1 in human breast cancer. Breast Cancer Research and Treatment 131:1, pages 1-15.
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Andrew F. G. Quest, Vicente A. Torres, Diego A. Rodriguez, Jorge Gutierrez-Pajares & Julio C. Tapia. 2012. Caveolins in Cancer Pathogenesis, Prevention and Therapy. Caveolins in Cancer Pathogenesis, Prevention and Therapy 17 41 .
Ayako Makino, Amy L. Firth & Jason X.‐J. Yuan. 2011. Comprehensive Physiology. Comprehensive Physiology 1555 1602 .
Chhinder Sodhi, Ryan Levy, Roop Gill, Matthew D. Neal, Ward Richardson, Maria BrancaAnthony RussoThomas PrindleTimothy R. Billiar & David J. Hackam. (2011) DNA attenuates enterocyte Toll-like receptor 4-mediated intestinal mucosal injury after remote trauma. American Journal of Physiology-Gastrointestinal and Liver Physiology 300:5, pages G862-G873.
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Giuseppe Maria de PeppoSara SvenssonMaria LenneråsJane SynnergrenJohan StenbergRaimund StrehlJohan HyllnerPeter ThomsenCamilla Karlsson. (2010) Human Embryonic Mesodermal Progenitors Highly Resemble Human Mesenchymal Stem Cells and Display High Potential for Tissue Engineering Applications. Tissue Engineering Part A 16:7, pages 2161-2182.
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Lurong Zhang, Weimin Sun, Jianjun Wang, Mei Zhang, Shanmin Yang, Yeping Tian, Sadasivan Vidyasagar, Louis A. Peña, Kunzhong Zhang, Yongbing Cao, Liangjie Yin, Wei Wang, Lei Zhang, Katherine L. Schaefer, Lawrence J. Saubermann, Steven G. Swarts, Bruce M. Fenton, Peter C. Keng & Paul Okunieff. (2010) Mitigation Effect of an FGF-2 Peptide on Acute Gastrointestinal Syndrome After High-Dose Ionizing Radiation. International Journal of Radiation Oncology*Biology*Physics 77:1, pages 261-268.
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David Barzan, Patrick Maier, W. Jens Zeller, Frederik Wenz & Carsten Herskind. (2010) Overexpression of Caveolin-1 in Lymphoblastoid TK6 Cells Enhances Proliferation After Irradiation with Clinically Relevant DosesÜberexpression von Caveolin-1 in lymphoblastoiden TK6-Zellen erhöht die Proliferation nach Bestrahlung mit klinisch relevanten Dosen. Strahlentherapie und Onkologie 186:2, pages 99-106.
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Chhinder P. Sodhi, Xia–Hua Shi, Ward M. Richardson, Zachary S. Grant, Richard A. Shapiro, Thomas PrindleJrJr, Maria Branca, Anthony Russo, Steven C. Gribar, Congrong Ma & David J. Hackam. (2010) Toll-Like Receptor-4 Inhibits Enterocyte Proliferation via Impaired β-Catenin Signaling in Necrotizing Enterocolitis. Gastroenterology 138:1, pages 185-196.
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Vicente Notario, Silvia Mateo-Lozano, Joaquín Villar & Oscar M. Tirado. 2010. Handbook of Cell Signaling. Handbook of Cell Signaling 2859 2871 .
S. Ya. Proskuryakov, A. G. Konoplyannikov, L. P. Ulyanova, D. Yu. Logunov, B. S. Narodicky & A. L. Gincburg. (2009) Stem cells of intestinal epithelium. The mechanisms of survival and the role of microbiota. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 3:3, pages 221-236.
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Stephanie Hehlgans, Iris Eke, Katja Storch, Michael Haase, Gustavo B. Baretton & Nils Cordes. (2009) Caveolin-1 mediated radioresistance of 3D grown pancreatic cancer cells. Radiotherapy and Oncology 92:3, pages 362-370.
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Isabelle Mercier, Jean-Francois Jasmin, Stephanos Pavlides, Carlo Minetti, Neal Flomenberg, Richard G Pestell, Philippe G Frank, Federica Sotgia & Michael P Lisanti. (2009) Clinical and translational implications of the caveolin gene family: lessons from mouse models and human genetic disorders. Laboratory Investigation 89:6, pages 614-623.
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Federica Sotgia, Francesco Del Galdo, Mathew C. Casimiro, Gloria Bonuccelli, Isabelle Mercier, Diana Whitaker-Menezes, Kristin M. Daumer, Jie Zhou, Chenguang Wang, Sanjay Katiyar, Huan Xu, Emily Bosco, Andrew A. Quong, Bruce Aronow, Agnieszka K. Witkiewicz, Carlo Minetti, Philippe G. Frank, Sergio A. Jimenez, Erik S. Knudsen, Richard G. Pestell & Michael P. Lisanti. (2009) Caveolin-1−/− Null Mammary Stromal Fibroblasts Share Characteristics with Human Breast Cancer-Associated Fibroblasts. The American Journal of Pathology 174:3, pages 746-761.
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Franz Rödel, Gianni Capalbo, Claus Rödel & Christian Weiss. (2009) Caveolin-1 as a Prognostic Marker for Local Control After Preoperative Chemoradiation Therapy in Rectal Cancer. International Journal of Radiation Oncology*Biology*Physics 73:3, pages 846-852.
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Jia Chen, Franco Capozza, An Wu, Tiziana deAngelis, Hongzhi Sun, Michael Lisanti & Renato Baserga. (2008) Regulation of insulin receptor substrate-1 expression levels by caveolin-1. Journal of Cellular Physiology 217:1, pages 281-289.
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Elke Burgermeister, Mordechai Liscovitch, Christoph Röcken, Roland M. Schmid & Matthias P.A. Ebert. (2008) Caveats of caveolin-1 in cancer progression. Cancer Letters 268:2, pages 187-201.
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Andrew F. G. Quest, Jorge L. Gutierrez-Pajares & Vicente A. Torres. (2008) Caveolin-1: an ambiguous partner in cell signalling and cancer. Journal of Cellular and Molecular Medicine 12:4, pages 1130-1150.
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Kay-Uwe Wagner & Hallgeir Rui. (2008) Jak2/Stat5 Signaling in Mammogenesis, Breast Cancer Initiation and Progression. Journal of Mammary Gland Biology and Neoplasia 13:1, pages 93-103.
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N Cordes, S Frick, T B Brunner, C Pilarsky, R Grützmann, B Sipos, G Klöppel, W G McKenna & E J Bernhard. (2007) Human pancreatic tumor cells are sensitized to ionizing radiation by knockdown of caveolin-1. Oncogene 26:48, pages 6851-6862.
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Hugo Garneau, Laetitia Alvarez, Marie-Christine Paquin, Carine Lussier, Claudine Rancourt, Éric Tremblay, Jean-Francois Beaulieu & Nathalie Rivard. (2007) Nuclear expression of E2F4 induces cell death via multiple pathways in normal human intestinal epithelial crypt cells but not in colon cancer cells. American Journal of Physiology-Gastrointestinal and Liver Physiology 293:4, pages G758-G772.
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Elke Burgermeister, Xiangbin Xing, Christoph Röcken, Mark Juhasz, Jie Chen, Michaela Hiber, Katrin Mair, Maria Shatz, Moti Liscovitch, Roland M. Schmid & Matthias P.A. Ebert. (2007) Differential Expression and Function of Caveolin-1 in Human Gastric Cancer Progression. Cancer Research 67:18, pages 8519-8526.
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P A Insel & H H Patel. (2007) Do studies in caveolin-knockouts teach us about physiology and pharmacology or instead, the ways mice compensate for ‘lost proteins’?. British Journal of Pharmacology 150:3, pages 251-254.
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Vicente A. Torres, Julio C. Tapia, Diego A. Rodríguez, Mario Párraga, Pamela Lisboa, Margarita Montoya, Lisette Leyton & Andrew F. G. Quest. (2006) Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin. Journal of Cell Science 119:9, pages 1812-1823.
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