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H2AX post-translational modifications in the ionizing radiation response and homologous recombination

Pages 3602-3610 | Published online: 01 Sep 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Jae Jin Kim, Seo Yun Lee & Kyle M. Miller. (2019) Preserving genome integrity and function: the DNA damage response and histone modifications. Critical Reviews in Biochemistry and Molecular Biology 54:3, pages 208-241.
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Wei-Ta Chen, Amir Alpert, Courtney Leiter, Fade Gong, Stephen P. Jackson & Kyle M. Miller. (2013) Systematic Identification of Functional Residues in Mammalian Histone H2AX. Molecular and Cellular Biology 33:1, pages 111-126.
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Sameer Mirza, Bryan J. Katafiasz, Rakesh Kumar, Jun Wang, Shakur Mohibi, Smrati Jain, Channabasavaiah Basavaraju Gurumurthy, Tej K. Pandita, Bhavana J. Dave, Hamid Band & Vimla Band. (2012) Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability. Cell Cycle 11:22, pages 4266-4274.
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Adva Levy-Barda, Yaniv Lerenthal, Anthony J. Davis, Young Min Chung, Jeroen Essers, Zhengping Shao, Nicole van Vliet, David J. Chen, Mickey C-T. Hu, Roland Kanaar, Yael Ziv & Yosef Shiloh. (2011) Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks. Cell Cycle 10:24, pages 4300-4310.
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Zhewei Zhang, Zhiming Yang, Sari Jäämaa, Hester Liu, Laxmi G. Pellakuru, Tsuyoshi Iwata, Taija M. af Hällström, Angelo M. De Marzo & Marikki Laiho. (2011) Differential epithelium DNA damage response to ATM and DNA-PK pathway inhibition in human prostate tissue culture. Cell Cycle 10:20, pages 3545-3553.
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Amy DeMicco & Craig H. Bassing. (2010) Deciphering the DNA damage histone code . Cell Cycle 9:19, pages 3842-3847.
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Articles from other publishers (33)

Philipp Oberdoerffer & Kyle M. Miller. (2023) Histone H2A variants: Diversifying chromatin to ensure genome integrity. Seminars in Cell & Developmental Biology 135, pages 59-72.
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Atsushi Kuno, Ryusuke Hosoda, Miki Tsukamoto, Tatsuya Sato, Hiromi Sakuragi, Nami Ajima, Yukika Saga, Kouhei Tada, Yoshiki Taniguchi, Naotoshi Iwahara & Yoshiyuki Horio. (2022) SIRT1 in the cardiomyocyte counteracts doxorubicin-induced cardiotoxicity via regulating histone H2AX. Cardiovascular Research 118:17, pages 3360-3373.
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Matthew Day, Antony W. Oliver & Laurence H. Pearl. (2021) Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1. DNA Repair 108, pages 103232.
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Lauge Hjorth Mikkelsen. (2020) Molecular biology in conjunctival melanoma and the relationship to mucosal melanoma. Acta Ophthalmologica 98, pages 1-27.
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Hironori Abe, Kris G. Alavattam, Yueh-Chiang Hu, Qishen Pang, Paul R. Andreassen, Rashmi S. Hegde & Satoshi H. Namekawa. (2020) The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Current Biology 30:3, pages 408-420.e5.
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Alex N. Zelensky, Mascha Schoonakker, Inger Brandsma, Marcel Tijsterman, Dik C. van Gent, Jeroen Essers & Roland Kanaar. (2020) Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner. PLOS Genetics 16:1, pages e1008550.
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Nealia CM House, Erica J Polleys, Ishtiaque Quasem, Marjorie De la Rosa Mejia, Cailin E Joyce, Oliver Takacsi-Nagy, Jocelyn E Krebs, Stephen M Fuchs & Catherine H Freudenreich. (2019) Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126. eLife 8.
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Pérez-Gélvez, Unger, Gutiérrez-Sánchez, Bridger, RhodesJr.Jr. & Bergmann. (2019) An Effective Protocol for Proteome Analysis of Medaka (Oryzias latipes) after Acute Exposure to Ionizing Radiation. Methods and Protocols 2:3, pages 66.
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Hong Zhao, Xuan Huang, H. Dorota Halicka & Zbigniew Darzynkiewicz. (2019) Detection of Histone H2AX Phosphorylation on Ser‐139 as an Indicator of DNA Damage. Current Protocols in Cytometry 89:1.
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Christine E. Hellweg, Arif Ali Chishti, Sebastian Diegeler, Luis F. Spitta, Bernd Henschenmacher & Christa Baumstark-Khan. (2018) Molecular Signaling in Response to Charged Particle Exposures and its Importance in Particle Therapy. International Journal of Particle Therapy 5:1, pages 60-73.
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David Corujo & Marcus Buschbeck. (2018) Post-Translational Modifications of H2A Histone Variants and Their Role in Cancer. Cancers 10:3, pages 59.
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Erika Testa, Daniela Nardozi, Cristina Antinozzi, Monica Faieta, Stefano Di Cecca, Cinzia Caggiano, Tomoyuki Fukuda, Elena Bonanno, Lou Zhenkun, Andros Maldonado, Ignasi Roig, Monica Di Giacomo & Marco Barchi. (2018) H2AFX and MDC1 promote maintenance of genomic integrity in male germ cells. Journal of Cell Science.
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Chao Chen, Si Cong Zhao, Wen Zheng Yang, Zong Ping Chen & Yong Yan. (2017) Potential biological process of X‑linked inhibitor of apoptosis protein in renal cell carcinoma based upon differential protein expression analysis. Oncology Letters.
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Yi-Li Feng, Ji-Feng Xiang, Si-Cheng Liu, Tao Guo, Guo-Fang Yan, Ye Feng, Na Kong, Hao- Dan Li, Yang Huang, Hui Lin, Xiu-Jun Cai & An-Yong Xie. (2017) H2AX facilitates classical non-homologous end joining at the expense of limited nucleotide loss at repair junctions. Nucleic Acids Research 45:18, pages 10614-10633.
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Alo Ray, Chessica Blevins, Gulzar Wani & Altaf A. Wani. (2016) ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle. PLOS ONE 11:7, pages e0159344.
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Lin-Lin Cao, Changchun Shen & Wei-Guo Zhu. (2016) Histone modifications in DNA damage response. Science China Life Sciences 59:3, pages 257-270.
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Abubakar A. Hatimy, Martin J.G. Browne, Andrew Flaus & Steve M.M. Sweet. (2015) Histone H2AX Y142 phosphorylation is a low abundance modification. International Journal of Mass Spectrometry 391, pages 139-145.
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Li Wang, Ling Xie, Srinivas Ramachandran, YuanYu Lee, Zhen Yan, Li Zhou, Krzysztof Krajewski, Feng Liu, Cheng Zhu, David J. Chen, Brian D. Strahl, Jian Jin, Nikolay V. Dokholyan & Xian Chen. (2015) Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX. Chemistry & Biology 22:7, pages 849-861.
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Yuichiro Saito, Hui Zhou & Junya Kobayashi. (2015) Chromatin modification and NBS1: their relationship in DNA double-strand break repair. Genes & Genetic Systems 90:4, pages 195-208.
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Nealia C. M. House, Melissa R. Koch & Catherine H. Freudenreich. (2014) Chromatin modifications and DNA repair: beyond double-strand breaks. Frontiers in Genetics 5.
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Fátima Liliana Monteiro, Tiago Baptista, Francisco Amado, Rui Vitorino, Carmen Jerónimo & Luisa A. Helguero. (2014) Expression and functionality of histone H2A variants in cancer. Oncotarget 5:11, pages 3428-3443.
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Ralph Scully & Anyong Xie. (2013) Double strand break repair functions of histone H2AX. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 750:1-2, pages 5-14.
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Fade Gong & Kyle M. Miller. (2013) Mammalian DNA repair: HATs and HDACs make their mark through histone acetylation. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 750:1-2, pages 23-30.
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Emmanuel Tadjuidje & Rashmi S. Hegde. (2012) The Eyes Absent proteins in development and disease. Cellular and Molecular Life Sciences 70:11, pages 1897-1913.
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Alo Ray, Keisha Milum, Aruna Battu, Gulzar Wani & Altaf A. Wani. (2013) NER initiation factors, DDB2 and XPC, regulate UV radiation response by recruiting ATR and ATM kinases to DNA damage sites. DNA Repair 12:4, pages 273-283.
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Tae Moon Kim, Vivienne I Rebel & Paul Hasty. (2013) Defining a genotoxic profile with mouse embryonic stem cells. Experimental Biology and Medicine 238:3, pages 285-293.
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Emilie Rass, Gurushankar Chandramouly, Shan Zha, Frederick W. Alt & Anyong Xie. (2013) Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells. Journal of Biological Chemistry 288:10, pages 7086-7095.
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Wei WANG, Zhi-Qi MENG & Fang-Xiong SHI. (2012) Modification and biological role of histone. Hereditas (Beijing) 34:7, pages 810-818.
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Kyle M. MillerStephen P. Jackson. (2012) Histone marks: repairing DNA breaks within the context of chromatin. Biochemical Society Transactions 40:2, pages 370-376.
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James A.L. Brown, John K. Eykelenboom & Noel F. Lowndes. (2012) Co-mutation of histone H2AX S139A with Y142A rescues Y142A-induced ionising radiation sensitivity. FEBS Open Bio 2:1, pages 313-317.
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Alexander A. Goldberg, Adam Beach, Gerald F. Davies, Troy A. A. Harkness, Andréa LeBlanc & Vladimir I. Titorenko. (2011) Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget 2:10, pages 761-782.
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Lavinia C Dumitrache, Lingchuan Hu, Mi Young Son, Han Li, Austin Wesevich, Ralph Scully, Jeremy Stark & Paul Hasty. (2011) Trex2 Enables Spontaneous Sister Chromatid Exchanges Without Facilitating DNA Double-Strand Break Repair. Genetics 188:4, pages 787-797.
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Ari Barzilai. (2011) The neuro-glial-vascular interrelations in genomic instability symptoms. Mechanisms of Ageing and Development 132:8-9, pages 395-404.
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