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Review

Targeting the checkpoint kinase Chk1 in cancer therapy

Pages 279-283 | Published online: 15 Jan 2010

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Xinwei Zou, Chenjie Zhu, Lin Zhang, Yi Zhang, Fengqing Fu, Youguo Chen & Jinhua Zhou. (2020) MicroRNA-708 Suppresses Cell Proliferation and Enhances Chemosensitivity of Cervical Cancer Cells to cDDP by Negatively Targeting Timeless. OncoTargets and Therapy 13, pages 225-235.
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A. Balupuri, P.K. Balasubramanian, C.G. Gadhe & S.J. Cho. (2014) Docking-based 3D-QSAR study of pyridyl aminothiazole derivatives as checkpoint kinase 1 inhibitors. SAR and QSAR in Environmental Research 25:8, pages 651-671.
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Laura Carrassa, Rosaria Chilà, Monica Lupi, Francesca Ricci, Cinzia Celenza, Marco Mazzoletti, Massimo Broggini & Giovanna Damia. (2012) Combined inhibition of Chk1 and Wee1: In vitro synergistic effect translates to tumor growth inhibition in vivo. Cell Cycle 11:13, pages 2507-2517.
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Lei Chen, Shi-Bin Chao, Zhen-Bo Wang, Shu-Tao Qi, Xiu-Lan Zhu, Shang-Wu Yang, Cai-Rong Yang, Qing-Hua Zhang, Ying-Chun Ouyang, Yi Hou, Heide Schatten & Qing-Yuan Sun. (2012) Checkpoint kinase 1 is essential for meiotic cell cycle regulation in mouse oocytes. Cell Cycle 11:10, pages 1948-1955.
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Jac A. Nickoloff. (2017) Paths from DNA damage and signaling to genome rearrangements via homologous recombination. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 806, pages 64-74.
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M M Al-kaabi, A T Alshareeda, D A Jerjees, A A Muftah, A R Green, N H Alsubhi, C C Nolan, S Chan, E Cornford, S Madhusudan, I O Ellis & E A Rakha. (2015) Checkpoint kinase1 (CHK1) is an important biomarker in breast cancer having a role in chemotherapy response. British Journal of Cancer 112:5, pages 901-911.
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JIAN GONG, LIANG LV & JIRONG HUO. (2014) Roles of F-box proteins in human digestive system tumors (Review). International Journal of Oncology 45:6, pages 2199-2207.
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IRENE QUATTRINI, AMALIA CONTI, LAURA PAZZAGLIA, CHIARA NOVELLO, STEFANO FERRARI, PIERO PICCI & MARIA SERENA BENASSI. (2014) Metformin inhibits growth and sensitizes osteosarcoma cell lines to cisplatin through cell cycle modulation. Oncology Reports 31:1, pages 370-375.
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Enrique Hernández-Lemus. 2014. Omics Approaches in Breast Cancer. Omics Approaches in Breast Cancer 333 352 .
Hiroyuki Inuzuka & Wenyi WeiJianping Guo, Brian J. North, Adriana E. Tron, Hiroyuki Inuzuka & Wenyi Wei. 2014. SCF and APC E3 Ubiquitin Ligases in Tumorigenesis. SCF and APC E3 Ubiquitin Ligases in Tumorigenesis 73 87 .
Hiroyuki Inuzuka & Wenyi WeiBrian J. North, Yueyong Liu, Hiroyuki Inuzuka & Wenyi Wei. 2014. SCF and APC E3 Ubiquitin Ligases in Tumorigenesis. SCF and APC E3 Ubiquitin Ligases in Tumorigenesis 47 71 .
Elizabeth Blackwood, Jennifer Epler, Ivana Yen, Michael Flagella, Tom O'Brien, Marie Evangelista, Stephen Schmidt, Yang Xiao, Jonathan Choi, Kaska Kowanetz, Judi Ramiscal, Kenton Wong, Diana Jakubiak, Sharon Yee, Gary Cain, Lewis Gazzard, Karen Williams, Jason Halladay, Peter K. Jackson & Shiva Malek. (2013) Combination Drug Scheduling Defines a “Window of Opportunity” for Chemopotentiation of Gemcitabine by an Orally Bioavailable, Selective ChK1 Inhibitor, GNE-900. Molecular Cancer Therapeutics 12:10, pages 1968-1980.
Crossref
A.M. Gonzalez-Angulo, S. Liu, H. Chen, M. Chavez-MacGregor, A. Sahin, G.N. Hortobagyi, G.B. Mills, K.-A. Do & F. Meric-Bernstam. (2013) Functional proteomics characterization of residual breast cancer after neoadjuvant systemic chemotherapy. Annals of Oncology 24:4, pages 909-916.
Crossref
Glen J. Weiss, Ross C. Donehower, Tara Iyengar, Ramesh K. Ramanathan, Karen Lewandowski, Eric Westin, Karla Hurt, Scott M. Hynes, Stephen P. Anthony & Scott McKane. (2012) Phase I dose-escalation study to examine the safety and tolerability of LY2603618, a checkpoint 1 kinase inhibitor, administered 1 day after pemetrexed 500 mg/m2 every 21 days in patients with cancer. Investigational New Drugs 31:1, pages 136-144.
Crossref
Inken Wierstra. 2013. 97 398 .
XIAOBIN WANG, ZHIKUN MA, ZHENG XIAO, HUI LIU, ZHONGLING DOU, XIAOSHAN FENG & HAIJUN SHI. (2012) Chk1 knockdown confers radiosensitization in prostate cancer stem cells. Oncology Reports 28:6, pages 2247-2254.
Crossref
S. Liu, S. O. Opiyo, K. Manthey, J. G. Glanzer, A. K. Ashley, C. Amerin, K. Troksa, M. Shrivastav, J. A. Nickoloff & G. G. Oakley. (2012) Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress. Nucleic Acids Research 40:21, pages 10780-10794.
Crossref
James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Giuseppe Montalto, Melchiorre Cervello, Massimo Libra, Saverio Candido, Grazia Malaponte, Maria C. Mazzarino, Paolo Fagone, Ferdinando Nicoletti, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Francesca Chiarini, Camilla Evangelisti, Lucio Cocco & Alberto M. Martelli. (2012) Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance. Oncotarget 3:10, pages 1068-1111.
Crossref
Jian Hong, Kaishun Hu, Yunfei Yuan, Yi Sang, Qiangui Bu, Guihua Chen, Longjun Yang, Binkui Li, Pinzhu Huang, Dongtai Chen, Yi Liang, Ruhua Zhang, Jingxuan Pan, Yi-Xin Zeng & Tiebang Kang. (2012) CHK1 targets spleen tyrosine kinase (L) for proteolysis in hepatocellular carcinoma. Journal of Clinical Investigation 122:6, pages 2165-2175.
Crossref
M Bartucci, S Svensson, P Romania, R Dattilo, M Patrizii, M Signore, S Navarra, F Lotti, M Biffoni, E Pilozzi, E Duranti, S Martinelli, C Rinaldo, A Zeuner, M Maugeri-Saccà, A Eramo & R De Maria. (2011) Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy. Cell Death & Differentiation 19:5, pages 768-778.
Crossref
Bin Liu, Ying Zheng, Tong-Dan Wang, Han-Zhang Xu, Li Xia, Jian Zhang, Ying-Li Wu, Guo-Qiang Chen & Li-Shun Wang. (2012) Proteomic Identification of Common SCF Ubiquitin Ligase FBXO6-Interacting Glycoproteins in Three kinds of Cells. Journal of Proteome Research 11:3, pages 1773-1781.
Crossref
Hsing-Chen Tsai, Huili Li, Leander Van Neste, Yi Cai, Carine Robert, Feyruz V. Rassool, James J. Shin, Kirsten M. Harbom, Robert Beaty, Emmanouil Pappou, James Harris, Ray-Whay Chiu Yen, Nita Ahuja, Malcolm V. Brock, Vered Stearns, David Feller-Kopman, Lonny B. Yarmus, Yi-Chun Lin, Alana L. Welm, Jean-Pierre Issa, Il Minn, William Matsui, Yoon-Young Jang, Saul J. Sharkis, Stephen B. Baylin & Cynthia A. Zahnow. (2012) Transient Low Doses of DNA-Demethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor Cells. Cancer Cell 21:3, pages 430-446.
Crossref
Kaiji Hu, Jennifer H Law, Abbas Fotovati & Sandra E Dunn. (2012) Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells. Breast Cancer Research 14:1.
Crossref
Joshua S. Silverman, Jeffrey R. Skaar & Michele Pagano. (2012) SCF ubiquitin ligases in the maintenance of genome stability. Trends in Biochemical Sciences 37:2, pages 66-73.
Crossref
Navjotsingh Pabla, Kirti Bhatt & Zheng Dong. (2011) Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints. Proceedings of the National Academy of Sciences 109:1, pages 197-202.
Crossref
Anren Song, Jean Wu, Emily Whitaker & Nadarajah Vigneswaran. (2012) Gemcitabine Inhibits Murine Head and Neck Squamous Cell Carcinoma Growth via Proteasome-Dependent Degradation of Chk1 Leading to Cell Cycle Arrest and Apoptosis. Journal of Cancer Therapy 03:05, pages 562-574.
Crossref
G Lossaint, E Besnard, D Fisher, J Piette & V Dulić. (2011) Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional. Oncogene 30:41, pages 4261-4274.
Crossref
LiFeng Ning, HuiPing Wang, Dan San & JianLi Sang. (2011) C-terminal domain of Chk1 regulates its subcellular location and kinase activity for DNA repair. Chinese Science Bulletin 56:30.
Crossref
Ariel Bensimon, Ruedi Aebersold & Yosef Shiloh. (2011) Beyond ATM: The protein kinase landscape of the DNA damage response. FEBS Letters 585:11, pages 1625-1639.
Crossref
Wonil Koh, Soo-Jin Jeong, Hyo-Jung Lee, Ho-Geon Ryu, Eun-Ok Lee, Kyoo Seok Ahn, Hyunsu Bae & Sung-Hoon Kim. (2011) Melatonin promotes puromycin-induced apoptosis with activation of caspase-3 and 5′-adenosine monophosphate-activated kinase-alpha in human leukemia HL-60 cells. Journal of Pineal Research 50:4, pages 367-373.
Crossref
Dorota Rybaczek & Magdalena Kowalewicz-Kulbat. (2011) Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements. Histochemistry and Cell Biology 135:3, pages 263-280.
Crossref
Cynthia X. Ma, James W. Janetka & Helen Piwnica-Worms. (2011) Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics. Trends in Molecular Medicine 17:2, pages 88-96.
Crossref
Ernest K. Boamah, Angelika Brekman, Maria Tomasz, Natura Myeku, Maria Figueiredo-Pereira, Senyene Hunter, Joel Meyer, Rahul C. Bhosle & Jill Bargonetti. (2010) DNA Adducts of Decarbamoyl Mitomycin C Efficiently Kill Cells without Wild-Type p53 Resulting from Proteasome-Mediated Degradation of Checkpoint Protein 1. Chemical Research in Toxicology 23:7, pages 1151-1162.
Crossref

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