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Special Feature on Interdisciplinary Research

Shifting senescence into quiescence by turning up p53

Pages 4256-4257 | Published online: 01 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Lu-Zhe Pan, Dae-Gyun Ahn, Tanveer Sharif, Derek Clements, Shashi Gujar & Patrick W.K. Lee. (2014) The NAD+ synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target. Cell Cycle 13:6, pages 1041-1048.
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Tatyana V. Pospelova, Tatiana V Bykova, Svetlana G Zubova, Natalia V Katolikova, Natalia M Yartzeva & Valery A Pospelov. (2013) Rapamycin induces pluripotent genes associated with avoidance of replicative senescence. Cell Cycle 12:24, pages 3841-3851.
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Mikhail V Blagosklonny. (2013) Aging is not programmed. Cell Cycle 12:24, pages 3736-3742.
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Mikhail V. Blagosklonny. (2012) Rapalogs in cancer prevention. Cancer Biology & Therapy 13:14, pages 1349-1354.
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Articles from other publishers (30)

Yi-Ping Tao, Heng-Yan Zhu, Qian-Yuan Shi, Cai-Xia Wang, Yu-Xin Hua, Han-Yin Hu, Qi-Yin Zhou, Zi-Lu Zhou, Ying Sun, Xiao-Min Wang, Yu Wang, Ya-Ling Zhang, Yan-Jun Guo, Zi-Ying Wang, Xuan Che, Chun-Wei Xu, Xian-Chao Zhang, Michal Heger, Su-Ping Tao, Xin Zheng, Ying Xu, Lei Ao, Ai-Jun Liu, Sheng-Bing Liu, Shu-Qun Cheng & Wei-Wei Pan. (2023) S1PR1 regulates ovarian cancer cell senescence through the PDK1-LATS1/2-YAP pathway. Oncogene 42:47, pages 3491-3502.
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Lorne J. Hofseth, Ainsley Weston & Curtis C. Harris. 2017. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine 1 23 .
Mikhail V. Blagosklonny. (2022) As expected, based on rapamycin-like p53-mediated gerosuppression, mTOR inhibition acts as a checkpoint in p53-mediated tumor suppression. Oncoscience 9, pages 38-41.
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Angel Cayo, Raúl Segovia, Whitney Venturini, Rodrigo Moore-Carrasco, Claudio Valenzuela & Nelson Brown. (2021) mTOR Activity and Autophagy in Senescent Cells, a Complex Partnership. International Journal of Molecular Sciences 22:15, pages 8149.
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Valentino Bezzerri, Francesco Piacenza, Nicole Caporelli, Marco Malavolta, Mauro Provinciali & Marco Cipolli. (2019) Is cellular senescence involved in cystic fibrosis?. Respiratory Research 20:1.
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Fernando M. Simabuco, Mirian G. Morale, Isadora C.B. Pavan, Ana P. Morelli, Fernando R. Silva & Rodrigo E. Tamura. (2018) p53 and metabolism: from mechanism to therapeutics. Oncotarget 9:34, pages 23780-23823.
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Muzeyyen Izmirli. 2005. Encyclopedia of Life Sciences. Encyclopedia of Life Sciences 1 10 .
Lorne J. Hofseth, Ainsley Weston & Curtis C. Harris. 2016. Holland‐Frei Cancer Medicine. Holland‐Frei Cancer Medicine 1 25 .
Rebekka Harary Søndergaard, Bjarke Follin, Lisbeth Drozd Lund, Morten Juhl, Annette Ekblond, Jens Kastrup & Mandana Haack-Sørensen. (2017) Senescence and quiescence in adipose-derived stromal cells: Effects of human platelet lysate, fetal bovine serum and hypoxia. Cytotherapy 19:1, pages 95-106.
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Menderes Yusuf Terzi, Muzeyyen Izmirli & Bulent Gogebakan. (2016) The cell fate: senescence or quiescence. Molecular Biology Reports 43:11, pages 1213-1220.
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XINBING SUI, YONG FANG, HAIZHOU LOU, KAIFENG WANG, YU ZHENG, FANG LOU, WEI JIN, YINGHUA XU, WEI CHEN, HONGMING PAN, XIAN WANG & WEIDONG HAN. (2015) p53 suppresses stress-induced cellular senescence via regulation of autophagy under the deprivation of serum. Molecular Medicine Reports 11:2, pages 1214-1220.
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Anne Marie Nyholm, Catharina M Lerche, Valentina Manfé, Edyta Biskup, Peter Johansen, Niels Morling, Birthe Mørk Thomsen, Martin Glud & Robert Gniadecki. (2014) miR-125b induces cellular senescence in malignant melanoma. BMC Dermatology 14:1.
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James A. McCubrey, Linda S. Steelman, William H. Chappell, Lin Sun, Nicole M. Davis, Stephen L. Abrams, Richard A. Franklin, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto M. Martelli, Massimo Libra, Saverio Candido, Giovanni Ligresti, Grazia Malaponte, Maria C. Mazzarino, Paolo Fagone, Marco Donia, Ferdinando Nicoletti, Jerry Polesel, Renato Talamini, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Joanna Dulińska-Litewka, Piotr Laidler, Antonio B. D’Assoro, Lyudmyla Drobot, Kazuo Umezawa, Giuseppe Montalto, Melchiorre Cervello & Zoya N. Demidenko. (2012) Advances in Targeting Signal Transduction Pathways. Oncotarget 3:12, pages 1505-1521.
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Mikhail V. Blagosklonny. (2012) Answering the ultimate question “What is the Proximal Cause of Aging?”. Aging 4:12, pages 861-877.
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James A. McCubrey & Zoya N. Demidenko. (2012) Recent discoveries in the cycling, growing and aging of the p53 field. Aging 4:12, pages 887-893.
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Olga V. Leontieva, Geraldine M. Paszkiewicz & Mikhail V. Blagosklonny. (2012) Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging. Aging 4:12, pages 899-916.
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James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria C. Mazzarino, Saverio Candido, Massimo Libra, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini & Alberto M. Martelli. (2012) Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response.. Oncotarget 3:9, pages 954-987.
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Sébastien L. Floor, Jacques E. Dumont, Carine Maenhaut & Eric Raspe. (2012) Hallmarks of cancer: of all cancer cells, all the time?. Trends in Molecular Medicine 18:9, pages 509-515.
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Mikhail V. Blagosklonny. (2012) Wt p53 impairs response to chemotherapy: make lemonade to spare normal cells. Oncotarget 3:6, pages 601-607.
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E Diaz-Rodriguez, M García-Lavandeira, S Perez-Romero, A Senra, C Cañibano, I Palmero, M G Borrello, C Dieguez & C V Alvarez. (2011) Direct promoter induction of p19Arf by Pit-1 explains the dependence receptor RET/Pit-1/p53-induced apoptosis in the pituitary somatotroph cells. Oncogene 31:23, pages 2824-2835.
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Mikhail V. Blagosklonny. (2012) Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging. Aging 4:3, pages 159-165.
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Mattia Frontini & Luca Proietti-De-Santis. (2012) Interaction between the Cockayne syndrome B and p53 proteins: implications for aging. Aging 4:2, pages 89-97.
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Mikhail V. Blagosklonny. (2011) Molecular damage in cancer: an argument for mTOR-driven aging. Aging 3:12, pages 1130-1141.
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Robi Tacutu, Arie Budovsky, Hagai Yanai & Vadim E. Fraifeld. (2011) Molecular links between cellular senescence, longevity and age-related diseases – a systems biology perspective. Aging 3:12, pages 1178-1191.
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Olga V. Leontieva & Mikhail V. Blagosklonny. (2011) Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. Aging 3:11, pages 1078-1091.
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Mikhail V. Blagosklonny. (2011) Hormesis does not make sense except in the light of TOR-driven aging. Aging 3:11, pages 1051-1062.
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Jackson R. Taylor, Brian D. Lehmann, William H. Chappell, Stephen L. Abrams, Linda S. Steelman & James A. McCubrey. (2011) Cooperative Effects of Akt-1 and Raf-1 on the Induction of Cellular Senescence in Doxorubicin or Tamoxifen Treated Breast Cancer Cells. Oncotarget 2:8, pages 610-626.
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Mikhail V. Blagosklonny. (2011) Progeria, rapamycin and normal aging: recent breakthrough. Aging 3:7, pages 685-691.
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Ruth Villalonga-Planells, Lloren? Coll-Mulet, Fina Mart?nez-Soler, Esther Casta?o, Juan-Jose Acebes, Pepita Gim?nez-Bonaf?Joan Gil & Avelina Tortosa. (2011) Activation of p53 by Nutlin-3a Induces Apoptosis and Cellular Senescence in Human Glioblastoma Multiforme. PLoS ONE 6:4, pages e18588.
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Mikhail V. Blagosklonny. (2011) Cell cycle arrest is not senescence. Aging 3:2, pages 94-101.
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