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Nek6 overexpression antagonizes p53-induced senescence in human cancer cells

Pages 4703-4710 | Published online: 01 Dec 2010

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Tatyana V. Pospelova, Tatiana V Bykova, Svetlana G Zubova, Natalia V Katolikova, Natalia M Yartzeva & Valery A Pospelov. (2013) Rapamycin induces pluripotent genes associated with avoidance of replicative senescence. Cell Cycle 12:24, pages 3841-3851.
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Derek C. Radisky. (2011) Function following form. Cell Cycle 10:1, pages 15-22.
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Articles from other publishers (51)

Xiaoyan Wu, Ke‐Qiong Deng, Huan‐Huan Cai, Ziyue Zeng, Jian‐Lei Cao, Lin Zhang, Zhibing Lu & Wen‐Lin Cheng. (2023) Nek6 knockdown polarized macrophages into a pro‐inflammatory phenotype via inhibiting STAT3 expression . International Journal of Experimental Pathology.
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Hao Zhang & Bo Li. (2023) NIMA-related kinase 6 as an effective target inhibits the hepatocarcinogenesis and progression of hepatocellular carcinoma. Heliyon 9:6, pages e15971.
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Shuangyin Shao, Lili Xiao, Meng Jia, Chuyang Zhang, Guojun Zhao, Rui Yao, Xiaofang Wang & Lu Gao. (2023) Never in mitosis gene A-related kinase-6 deficiency deteriorates diabetic cardiomyopathy via regulating heat shock protein 72. Journal of Molecular Medicine 101:4, pages 419-430.
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Nagesh Kishan Panchal, Shruti Mohanty & Sabina Evan Prince. (2022) NIMA-related kinase-6 (NEK6) as an executable target in cancer. Clinical and Translational Oncology 25:1, pages 66-77.
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Ayça NABİOĞLU, Pelin MUTLU, Serap YALÇIN & Ufuk GÜNDÜZ. (2022) NEK6 gene silencing using siRNA for overcome multidrug resistance in chronic myeloid leukemia cells. Bulletin of Biotechnology 3:1, pages 1-6.
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Braveen B. Joseph, Phillip T. Edeen, Sarina Meadows, Shaonil Binti & David S. Fay. (2022) An unexpected role for the conserved ADAM-family metalloprotease ADM-2 in Caenorhabditis elegans molting. PLOS Genetics 18:5, pages e1010249.
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Luiz Gustavo de Almeida Chuffa, Milena Cremer de Souza, Ellen Mayara Souza Cruz, Francielle Belinelli Ferreira, Juliana Maria Bitencourt de Morais & Fábio Rodrigues Ferreira Seiva. (2022) Hepatocellular carcinoma and miRNAs: An in silico approach revealing potential therapeutic targets for polyphenols. Phytomedicine Plus 2:2, pages 100259.
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Scott Bachus, Drayson Graves, Lauren Fulham, Nikolas Akkerman, Caelan Stephanson, Jessica Shieh & Peter Pelka. (2022) In Mitosis You Are Not: The NIMA Family of Kinases in Aspergillus, Yeast, and Mammals. International Journal of Molecular Sciences 23:7, pages 4041.
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Mengxia Yang, Yikun Guo, Xiaofei Guo, Yun Mao, Shijie Zhu, Ningjun Wang & Dianrong Lu. (2022) Analysis of the effect of NEKs on the prognosis of patients with non-small-cell lung carcinoma based on bioinformatics. Scientific Reports 12:1.
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Ying Yu, Tianjin Shen, Xiaoling Zhong, Lei‐Lei Wang, Wenjiao Tai, Yuhua Zou, Jun Qin, Zhaohui Zhang & Chun‐Li Zhang. (2021) NEK6 is an injury‐responsive kinase cooperating with STAT3 in regulation of reactive astrogliosis . Glia 70:2, pages 273-286.
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Yang-Yang Ding, Hannah Kim, Kellyn Madden, Joseph P. Loftus, Gregory M. Chen, David Hottman Allen, Ruitao Zhang, Jason Xu, Chia-Hui Chen, Yuxuan Hu, Sarah K. Tasian & Kai Tan. (2021) Network Analysis Reveals Synergistic Genetic Dependencies for Rational Combination Therapy in Philadelphia Chromosome–Like Acute Lymphoblastic Leukemia. Clinical Cancer Research 27:18, pages 5109-5122.
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Meng Xiao, Chaoyang Du, Chuanbo Zhang, Xinzhong Zhang, Shaomin Li, Dainan Zhang & Wang Jia. (2021) Bioinformatics analysis of the prognostic value of NEK8 and its effects on immune cell infiltration in glioma. Journal of Cellular and Molecular Medicine 25:18, pages 8748-8763.
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Isadora Carolina Betim Pavan, Andressa Peres de Oliveira, Pedro Rafael Firmino Dias, Fernanda Luisa Basei, Luidy Kazuo Issayama, Camila de Castro Ferezin, Fernando Riback Silva, Ana Luisa Rodrigues de Oliveira, Lívia Alves dos Reis Moura, Mariana Bonjiorno Martins, Fernando Moreira Simabuco & Jörg Kobarg. (2021) On Broken Ne(c)ks and Broken DNA: The Role of Human NEKs in the DNA Damage Response. Cells 10:3, pages 507.
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Xiaowen Xu, Meifeng Li, Zeyuan Deng, Jihuan Hu, Zeyin Jiang, Yapeng Liu, Kaile Chang & Chengyu Hu. (2021) Grass Carp (Ctenopharyngodon idellus) NIMA-Related Kinase 6 Blocks dsRNA-Induced IFN I Response by Targeting IRF3. Frontiers in Immunology 11.
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心桐 刘. (2021) The Localization of NEK6 in HepG2 Cell Line and Its Expression and Clinical Significance in HCC. World Journal of Cancer Research 11:03, pages 67-75.
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Victoria Roberts, Barry Main, Nicholas J. Timpson & Simon Haworth. (2020) Genome-Wide Association Study Identifies Genetic Associations with Perceived Age. Journal of Investigative Dermatology 140:12, pages 2380-2385.
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Nasir Haider, Previn Dutt, Bert van de Kooij, Jason Ho, Luis Palomero, Miquel Angel Pujana, Michael Yaffe & Vuk Stambolic. (2020) NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity. Oncogene 39:30, pages 5252-5266.
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Nektarios Barabutis. (2020) Regulation of lung endothelial permeability by NEK kinases. IUBMB Life 72:4, pages 801-804.
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Young Yeon Kim, Jee‐Hyun Um, Jeong‐Hyun Yoon, Da‐Ye Lee, Yoon Jung Lee, Dong Hyun Kim, Joo‐In Park & Jeanho Yun. (2019) p53 regulates mitochondrial dynamics by inhibiting Drp1 translocation into mitochondria during cellular senescence. The FASEB Journal 34:2, pages 2451-2464.
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Chaohe Zhang, Jiyao Sheng, Guangquan Li, Lihong Zhao, Yicun Wang, Wei Yang, Xiaoxiao Yao, Lihuan Sun, Zhuo Zhang & Ranji Cui. (2020) Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review. Frontiers in Pharmacology 10.
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Cigir Biray Avci, Bakiye Goker Bagca, Asli Tetik Vardarli, Guray Saydam & Cumhur Gunduz. (2018) Epigenetic modifications in chronic myeloid leukemia cells through ruxolitinib treatment. Journal of Cellular Biochemistry 120:3, pages 4555-4563.
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Zhixian He, Xiaojian Ni, Liuwan Xia & Zhimin Shao. (2018) Overexpression of NIMA-related kinase 6 (NEK6) contributes to malignant growth and dismal prognosis in Human Breast Cancer. Pathology - Research and Practice 214:10, pages 1648-1654.
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Marco Malavolta, Massimo Bracci, Lory Santarelli, Md Abu Sayeed, Elisa Pierpaoli, Robertina Giacconi, Laura Costarelli, Francesco Piacenza, Andrea Basso, Maurizio Cardelli & Mauro Provinciali. (2018) Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy. Mediators of Inflammation 2018, pages 1-32.
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Andrew M. Fry, Richard Bayliss & Joan Roig. (2017) Mitotic Regulation by NEK Kinase Networks. Frontiers in Cell and Developmental Biology 5.
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Young Yeon Kim, Hye Jin Jee, Jee-Hyun Um, Young Mi Kim, Sun Sik Bae & Jeanho Yun. (2017) Cooperation between p21 and Akt is required for p53-dependent cellular senescence. Aging Cell 16:5, pages 1094-1103.
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James A. McCubrey, Kvin Lertpiriyapong, Linda S. Steelman, Steve L. Abrams, Li V. Yang, Ramiro M. Murata, Pedro L. Rosalen, Aurora Scalisi, Luca M. Neri, Lucio Cocco, Stefano Ratti, Alberto M. Martelli, Piotr Laidler, Joanna Dulińska-Litewka, Dariusz Rakus, Agnieszka Gizak, Paolo Lombardi, Ferdinando Nicoletti, Saverio Candido, Massimo Libra, Giuseppe Montalto & Melchiorre Cervello. (2017) Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs. Aging 9:6, pages 1477-1536.
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C-Q Li, G-W Huang, Z-Y Wu, Y-J Xu, X-C Li, Y-J Xue, Y Zhu, J-M Zhao, M Li, J Zhang, J-Y Wu, F Lei, Q-Y Wang, S Li, C-P Zheng, B Ai, Z-D Tang, C-C Feng, L-D Liao, S-H Wang, J-H Shen, Y-J Liu, X-F Bai, J-Z He, H-H Cao, B-L Wu, M-R Wang, D-C Lin, H P Koeffler, L-D Wang, X Li, E-M Li & L-Y Xu. (2017) Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma. Oncogenesis 6:2, pages e297-e297.
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Atish D. Choudhury, Anna C. Schinzel, Maura B. Cotter, Rosina T. Lis, Katherine Labella, Ying Jie Lock, Francesca Izzo, Isil Guney, Michaela Bowden, Yvonne Y. Li, Jinal Patel, Emily Hartman, Steven A. Carr, Monica Schenone, Jacob D. Jaffe, Philip W. Kantoff, Peter S. Hammerman & William C. Hahn. (2017) Castration Resistance in Prostate Cancer Is Mediated by the Kinase NEK6. Cancer Research 77:3, pages 753-765.
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Irsan E. Kooi, Berber M. Mol, Maarten P. G. Massink, Marcus C. de Jong, Pim de Graaf, Paul van der Valk, Hanne Meijers-Heijboer, Gertjan J. L. Kaspers, Annette C. Moll, Hein te Riele, Jacqueline Cloos & Josephine C. Dorsman. (2016) A Meta-Analysis of Retinoblastoma Copy Numbers Refines the List of Possible Driver Genes Involved in Tumor Progression. PLOS ONE 11:4, pages e0153323.
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Elmas Kasap, Emre Gerceker, Seda Örenay Boyacıoglu, Hakan Yuceyar, Hatice Yıldırm, Semin Ayhan & Mehmet Korkmaz. (2015) The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma. Tumor Biology 37:3, pages 3071-3080.
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Carmen Dominguez-Brauer, Kelsie L. Thu, Jacqueline M. Mason, Heiko Blaser, Mark R. Bray & Tak W. Mak. (2015) Targeting Mitosis in Cancer: Emerging Strategies. Molecular Cell 60:4, pages 524-536.
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EMRE GERÇEKER, SEDA ORENAY BOYACIOGLU, ELMAS KASAP, AHMED BAYKAN, HAKAN YUCEYAR, HATICE YILDIRIM, SEMIN AYHAN, ENDER ELLIDOKUZ & MEHMET KORKMAZ. (2015) Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer. Oncology Reports 34:4, pages 1905-1914.
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Jie Zuo, Haijie Ma, Hao Cai, Yanhua Wu, Wei Jiang & Long Yu. (2015) An inhibitory role of NEK6 in TGFβ/Smad signaling pathway. BMB Reports 48:8, pages 473-478.
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John Yochem, Vladimir Lažetić, Leslie Bell, Lihsia Chen & David Fay. (2015) C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting. Developmental Biology 398:2, pages 255-266.
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Ning Wang, Meifen Zhu, Xuanbin Wang, Hor-Yue Tan, Sai-wah Tsao & Yibin Feng. (2014) Berberine-induced tumor suppressor p53 up-regulation gets involved in the regulatory network of MIR-23a in hepatocellular carcinoma. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 1839:9, pages 849-857.
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Xin Li, Ling Lian, Daixi Zhang, Lujiang Qu & Ning Yang. (2014) gga-miR-26a targets NEK6 and suppresses Marek's disease lymphoma cell proliferation. Poultry Science 93:5, pages 1097-1105.
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Ki-Yeol Kim, Xianglan Zhang & In-Ho Cha. (2014) Combined genomic expressions as a diagnostic factor for oral squamous cell carcinoma. Genomics 103:5-6, pages 317-322.
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Zhouyan Bian, Haihan Liao, Yan Zhang, Qingqing Wu, Heng Zhou, Zheng Yang, Jinrong Fu, Teng Wang, Ling Yan, Difei Shen, Hongliang Li & Qizhu Tang. (2014) Never in Mitosis Gene A Related Kinase-6 Attenuates Pressure Overload-Induced Activation of the Protein Kinase B Pathway and Cardiac Hypertrophy. PLoS ONE 9:4, pages e96095.
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P. Srinivasan, P. Chella Perumal & A. Sudha. (2014) Discovery of Novel Inhibitors for Nek6 Protein through Homology Model Assisted Structure Based Virtual Screening and Molecular Docking Approaches. The Scientific World Journal 2014, pages 1-9.
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Hye Jin Jee, Hyun-Ju Kim, Ae Jeong Kim, Naree Song, Minjee Kim, Hye-Jeong Lee & Jeanho Yun. (2013) The inhibition of Nek6 function sensitizes human cancer cells to premature senescence upon serum reduction or anticancer drug treatment. Cancer Letters 335:1, pages 175-182.
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James A. McCubrey & Zoya N. Demidenko. (2012) Recent discoveries in the cycling, growing and aging of the p53 field. Aging 4:12, pages 887-893.
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ELMAS KASAP, SEDA ÖRENAY BOYACIOGLU, MEHMET KORKMAZ, ELIF SARITAS YUKSEL, BELKIS ÜNSAL, ERKAN KAHRAMAN, ÖMER ÖZÜTEMIZ & HAKAN YUCEYAR. (2012) Aurora kinase A (AURKA) and never in mitosis gene A-related kinase 6 (NEK6) genes are upregulated in erosive esophagitis and esophageal adenocarcinoma. Experimental and Therapeutic Medicine 4:1, pages 33-42.
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Zhongyi Hu, Yuanyuan Gu, Bo Han, Jinsan Zhang, Zunling Li, Keli Tian, Charles Y.F. Young & Huiqing Yuan. (2012) Knockdown of AGR2 induces cellular senescence in prostate cancer cells. Carcinogenesis 33:6, pages 1178-1186.
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