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Cell Cycle News & Views

Targeting Chk1 in the replicative stress response

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Pages 1025-1030 | Published online: 15 Mar 2010

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Stela S. Palii, Yuxia Cui, Cynthia L. Innes & Richard S. Paules. (2013) Dissecting cellular responses to irradiation via targeted disruptions of the ATM-CHK1-PP2A circuit. Cell Cycle 12:7, pages 1105-1118.
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Articles from other publishers (18)

Ching-Ni Njauw, Zhenyu Ji, Duc Minh Pham, Antoine Simoneau, Raj Kumar, Keith T. Flaherty, Lee Zou & Hensin Tsao. (2022) Oncogenic KIT Induces Replication Stress and Confers Cell Cycle Checkpoint Vulnerability in Melanoma. Journal of Investigative Dermatology 142:5, pages 1413-1424.e6.
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Liang Zhou, Xinyan Pei, Yu Zhang, Yanxia Ning, Lin Li, Xiaoyan Hu, Sri Lakshmi Chalasani, Kanika Sharma, Jewel Nkwocha, Jonathan Yu, Dipankar Bandyopadhyay, Said M. Sebti & Steven Grant. (2022) Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells. Molecular Cancer Research 20:3, pages 456-467.
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Manish Charan, Ajeet K. Verma, Shahid Hussain, Swati Misri, Sanjay Mishra, Sarmila Majumder, Bhuvaneswari Ramaswamy, Dinesh Ahirwar & Ramesh K. Ganju. (2020) Molecular and Cellular Factors Associated with Racial Disparity in Breast Cancer. International Journal of Molecular Sciences 21:16, pages 5936.
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Chang-Sheng Chang, Eiko Kitamura, Joan Johnson, Roni Bollag & Lesleyann Hawthorn. (2019) Genomic analysis of racial differences in triple negative breast cancer. Genomics 111:6, pages 1529-1542.
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Michalis Fragkos, Viviana Barra, Tom Egger, Benoit Bordignon, Delphine Lemacon, Valeria Naim & Arnaud Coquelle. (2019) Dicer prevents genome instability in response to replication stress. Oncotarget 10:43, pages 4407-4423.
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Clara C. Geneste & Andrew J. Massey. (2018) Cell Density Affects the Detection of Chk1 Target Engagement by the Selective Inhibitor V158411. SLAS Discovery 23:2, pages 144-153.
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Kelli L. Goss, Stacia L. Koppenhafer, Kathryn M. Harmoney, William W. Terry & David J. Gordon. (2017) Inhibition of CHK1 sensitizes Ewing sarcoma cells to the ribonucleotide reductase inhibitor gemcitabine. Oncotarget 8:50, pages 87016-87032.
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Nikolas K. Haass & Brian Gabrielli. (2017) Cell cycle-tailored targeting of metastatic melanoma: Challenges and opportunities. Experimental Dermatology 26:7, pages 649-655.
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Andrew J. Massey. (2017) Modification of tumour cell metabolism modulates sensitivity to Chk1 inhibitor-induced DNA damage. Scientific Reports 7:1.
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Joanne Wayne, Teresa Brooks & Andrew J. Massey. (2016) Inhibition of Chk1 with the small molecule inhibitor V158411 induces DNA damage and cell death in an unperturbed S-phase. Oncotarget 7:51, pages 85033-85048.
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Andrew J. Massey. (2016) Tumour growth environment modulates Chk1 signalling pathways and Chk1 inhibitor sensitivity. Scientific Reports 6:1.
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John Paul Shen, Rohith Srivas, Andrew Gross, Jianfeng Li, Eric J. Jaehnig, Su Ming Sun, Ana Bojorquez-Gomez, Katherine Licon, Vignesh Sivaganesh, Jia L. Xu, Kristin Klepper, Huwate Yeerna, Daniel Pekin, Chu Ping Qiu, Haico van Attikum, Robert W. Sobol & Trey Ideker. (2015) Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition . Oncotarget 6:34, pages 35755-35769.
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Marieke Aarts, Ilirjana Bajrami, Maria T. Herrera-Abreu, Richard Elliott, Rachel Brough, Alan Ashworth, Christopher J. Lord & Nicholas C. Turner. (2015) Functional Genetic Screen Identifies Increased Sensitivity to WEE1 Inhibition in Cells with Defects in Fanconi Anemia and HR Pathways. Molecular Cancer Therapeutics 14:4, pages 865-876.
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Christopher Bryant, Kirsten Scriven & Andrew J Massey. (2014) Inhibition of the checkpoint kinase Chk1 induces DNA damage and cell death in human Leukemia and Lymphoma cells. Molecular Cancer 13:1.
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P. O. Carminati, F. S. Donaires, M. M. Marques, E. A. Donadi, G. A. S. Passos & E. T. Sakamoto-Hojo. (2013) Cisplatin associated with LY294002 increases cytotoxicity and induces changes in transcript profiles of glioblastoma cells. Molecular Biology Reports 41:1, pages 165-177.
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John M. Furgason & El Mustapha Bahassi. (2013) Targeting DNA repair mechanisms in cancer. Pharmacology & Therapeutics 137:3, pages 298-308.
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Yun Dai, Shuang Chen, Liang Yi & Minhui Xu. 2013. Trends in Stem Cell Proliferation and Cancer Research. Trends in Stem Cell Proliferation and Cancer Research 591 654 .
James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Giuseppe Montalto, Melchiorre Cervello, Massimo Libra, Saverio Candido, Grazia Malaponte, Maria C. Mazzarino, Paolo Fagone, Ferdinando Nicoletti, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Francesca Chiarini, Camilla Evangelisti, Lucio Cocco & Alberto M. Martelli. (2012) Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance. Oncotarget 3:10, pages 1068-1111.
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