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Editorials: Cell Cycle Features

mTOR signaling in the control of activation of primordial follicles

Pages 1673-1674 | Published online: 14 May 2010

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Mutian Han, Hongbo Cheng, Jiaxiong Wang, Yi Yu, Fuxin Wang, Rui Zhu, Wei Wang, Shenmin Yang & Hong Li. (2019) Abnormal aggregation of myeloid-derived suppressor cells in a mouse model of cyclophosphamide-induced premature ovarian failure. Gynecological Endocrinology 35:11, pages 985-990.
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Mikhail V Blagosklonny. (2013) Aging is not programmed. Cell Cycle 12:24, pages 3736-3742.
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Kate Mowrey, Hope Northrup, Syed Shahrukh Hashmi & David Rodriguez-Buritica. (2022) Expanding Our Knowledge of Menstrual Irregularities Reported by Females With Tuberous Sclerosis Complex. Frontiers in Reproductive Health 4.
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Xiuying CHEN, Zhijing TANG, Haiyun GUAN, Hexia XIA, Chao GU, Yan XU, Bin LI & Wei ZHANG. (2022) Rapamycin maintains the primordial follicle pool and protects ovarian reserve against cyclophosphamide-induced damage. Journal of Reproduction and Development 68:4, pages 287-294.
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M. O. Verhoeven & C. B. Lambalk. 2018. Principles of Endocrinology and Hormone Action. Principles of Endocrinology and Hormone Action 493 514 .
Julia Rehnitz, Diego D. Alcoba, Ilma S. Brum, Katrin Hinderhofer, Berthe Youness, Thomas Strowitzki & Peter H. Vogt. (2017) FMR1 and AKT/mTOR signalling pathways: potential functional interactions controlling folliculogenesis in human granulosa cells. Reproductive BioMedicine Online 35:5, pages 485-493.
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Crossref
Debabrata Das & Swathi Arur. (2017) Conserved insulin signaling in the regulation of oocyte growth, development, and maturation. Molecular Reproduction and Development 84:6, pages 444-459.
Crossref
Chao Zhang, Xiao-Ran Liu, Yong-Chun Cao, Jin-Ling Tian, Di Zhen, Xiao-Fei Luo, Xin-Mei Wang, Jian-Hui Tian & Jian-Ming Gao. (2017) Mammalian target of rapamycin/eukaryotic initiation factor 4F pathway regulates follicle growth and development of theca cells in mice. Reproduction, Fertility and Development 29:4, pages 768.
Crossref
Jelena Danilović Luković, Aleksandra Korać, Ivan Milošević, Tijana Lužajić, Nela Puškaš, Milica Kovačević Filipović & Anita Radovanović. (2016) Altered state of primordial follicles in neonatal and early infantile rats due to maternal hypothyroidism: Light and electron microscopy approach. Micron 90, pages 33-42.
Crossref
Kazuhiro Kawamura, Nanami Kawamura & Aaron J.W. Hsueh. (2016) Activation of dormant follicles. Current Opinion in Obstetrics & Gynecology 28:3, pages 217-222.
Crossref
Preety Bajwa, Prathima B. Nagendra, Sarah Nielsen, Subhransu S. Sahoo, Amanda Bielanowicz, Janine M. Lombard, J. Erby Wilkinson, Richard A. Miller & Pradeep S. Tanwar. (2016) Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium. Oncotarget 7:15, pages 19214-19227.
Crossref
M. O. Verhoeven & C. B. Lambalk. 2016. Principles of Endocrinology and Hormone Action. Principles of Endocrinology and Hormone Action 1 22 .
Yuan Cheng, Jaehong Kim, Xiao Xiao Li & Aaron J. Hsueh. (2015) Promotion of Ovarian Follicle Growth following mTOR Activation: Synergistic Effects of AKT Stimulators. PLOS ONE 10:2, pages e0117769.
Crossref
Aaron J. W. HsuehKazuhiro KawamuraYuan ChengBart C. J. M. Fauser. (2015) Intraovarian Control of Early Folliculogenesis. Endocrine Reviews 36:1, pages 1-24.
Crossref
Stephanie A. Pangas & Aleksandar Rajkovic. 2015. Knobil and Neill's Physiology of Reproduction. Knobil and Neill's Physiology of Reproduction 947 995 .
Stephanie L Sherman, Eliza C Curnow, Charles A Easley, Peng Jin, Renate K Hukema, Maria Isabel Tejada, Rob Willemsen & Karen Usdin. (2014) Use of model systems to understand the etiology of fragile X-associated primary ovarian insufficiency (FXPOI). Journal of Neurodevelopmental Disorders 6:1.
Crossref
Hua Zhang, Deepak Adhikari, Wenjing Zheng & Kui Liu. (2013) Combating ovarian aging depends on the use of existing ovarian follicles, not on putative oogonial stem cells. REPRODUCTION 146:6, pages R229-R233.
Crossref
Shuhong Yang, Shuo Wang, Aiyue Luo, Ting Ding, Zhiwen Lai, Wei Shen, Xiangyi Ma, Chen Cao, Liangyan Shi, Jingjing Jiang, Fangfang Rong, Lanfang Ma, Yong Tian, Xiaofang Du, Yunping Lu, Ya Li & Shixuan Wang. (2013) Expression Patterns and Regulatory Functions of MicroRNAs During the Initiation of Primordial Follicle Development in the Neonatal Mouse Ovary1. Biology of Reproduction 89:5.
Crossref
Lital Kalich-PhilosophHadassa RonessAlon CarmelyMichal Fishel-BartalHagai LigumskyShoshana PaglinIdo WolfHannah KanetyBenjamin SredniDror Meirow. (2013) Cyclophosphamide Triggers Follicle Activation and “Burnout”; AS101 Prevents Follicle Loss and Preserves Fertility. Science Translational Medicine 5:185.
Crossref
Evelyn E. Telfer & Mary B. Zelinski. (2013) Ovarian follicle culture: advances and challenges for human and nonhuman primates. Fertility and Sterility 99:6, pages 1523-1533.
Crossref
Deepak Adhikari, Sanjiv Risal, Kui Liu & Yan Shen. (2013) Pharmacological Inhibition of mTORC1 Prevents Over-Activation of the Primordial Follicle Pool in Response to Elevated PI3K Signaling. PLoS ONE 8:1, pages e53810.
Crossref
Deepak Adhikari. 2013. Oocyte Biology in Fertility Preservation. Oocyte Biology in Fertility Preservation 29 42 .
Yuichi Niikura & Joshua Johnson. 2012. Fertility Preservation in Females. Fertility Preservation in Females 33 51 .
Deepak Adhikari & Kui Liu. 2013. Oogenesis. Oogenesis 49 62 .
James A. McCubrey, Linda S. Steelman, William H. Chappell, Lin Sun, Nicole M. Davis, Stephen L. Abrams, Richard A. Franklin, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini, Alberto M. Martelli, Massimo Libra, Saverio Candido, Giovanni Ligresti, Grazia Malaponte, Maria C. Mazzarino, Paolo Fagone, Marco Donia, Ferdinando Nicoletti, Jerry Polesel, Renato Talamini, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Joanna Dulińska-Litewka, Piotr Laidler, Antonio B. D’Assoro, Lyudmyla Drobot, Kazuo Umezawa, Giuseppe Montalto, Melchiorre Cervello & Zoya N. Demidenko. (2012) Advances in Targeting Signal Transduction Pathways. Oncotarget 3:12, pages 1505-1521.
Crossref
Mikhail V. Blagosklonny. (2012) Answering the ultimate question “What is the Proximal Cause of Aging?”. Aging 4:12, pages 861-877.
Crossref
Flor Sánchez & Johan Smitz. (2012) Molecular control of oogenesis. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1822:12, pages 1896-1912.
Crossref
James A. McCubrey, Linda S. Steelman, William H. Chappell, Stephen L. Abrams, Giuseppe Montalto, Melchiorre Cervello, Ferdinando Nicoletti, Paolo Fagone, Grazia Malaponte, Maria C. Mazzarino, Saverio Candido, Massimo Libra, Jörg Bäsecke, Sanja Mijatovic, Danijela Maksimovic-Ivanic, Michele Milella, Agostino Tafuri, Lucio Cocco, Camilla Evangelisti, Francesca Chiarini & Alberto M. Martelli. (2012) Mutations and Deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascades Which Alter Therapy Response.. Oncotarget 3:9, pages 954-987.
Crossref
Krishna Jagarlamudi & Aleksandar Rajkovic. (2012) Oogenesis: Transcriptional regulators and mouse models. Molecular and Cellular Endocrinology 356:1-2, pages 31-39.
Crossref
Yuichi Niikura & Joshua Johnson. 2012. Fertility Preservation. Fertility Preservation 29 43 .
Toshifumi Takahashi, Hideki Igarashi, Mitsuyoshi Amita, Shuichiro Hara & Hirohisa Kurachi. (2011) Cellular and molecular mechanisms of various types of oocyte aging. Reproductive Medicine and Biology 10:4, pages 239-249.
Crossref
A. Gougeon. (2011) Régulation de l’initiation de la croissance folliculaire. Gynécologie Obstétrique & Fertilité 39:9, pages 511-513.
Crossref
Joshua Johnson & Pasquale Patrizio. (2011) Ovarian cryopreservation strategies and the fine control of ovarian follicle development in vitro. Annals of the New York Academy of Sciences 1221:1, pages 40-46.
Crossref
Evelyn E. Telfer & Marie McLaughlin. 2011. Principles and Practice of Fertility Preservation. Principles and Practice of Fertility Preservation 397 408 .
. 2011. Principles and Practice of Fertility Preservation. Principles and Practice of Fertility Preservation 389 439 .

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