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Research Paper

Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen

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Pages 701-709 | Published online: 01 Jul 2012

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Subhojit Sen, Kirsten F. Block, Alice Pasini, Stephen B. Baylin & Hariharan Easwaran. (2016) Genome-wide positioning of bivalent mononucleosomes. BMC Medical Genomics 9:1.
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Vera Kloten, Martin Schlensog, Julian Eschenbruch, Janina Gasthaus, Janina Tiedemann, Jolein Mijnes, Timon Heide, Till Braunschweig, Ruth Knüchel & Edgar Dahl. (2016) Abundant NDRG2 Expression Is Associated with Aggressiveness and Unfavorable Patients’ Outcome in Basal-Like Breast Cancer. PLOS ONE 11:7, pages e0159073.
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Wei Hu, Chongxi Fan, Peng Jiang, Zhiqiang Ma, Xiaolong Yan, Shouyin Di, Shuai Jiang, Tian Li, Yedong Cheng & Yang Yang. (2015) Emerging role of N-myc downstream-regulated gene 2 (NDRG2) in cancer. Oncotarget 7:1, pages 209-223.
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Crossref
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Crossref
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Crossref
Leander Van Neste & Wim Van Criekinge. (2014) We are all individuals… bioinformatics in the personalized medicine era. Cellular Oncology 38:1, pages 29-37.
Crossref
Mukesh Verma. 2015. Advances in Cancer Biomarkers. Advances in Cancer Biomarkers 59 80 .
CHIN MINNING, NORFILZA MOHD MOKHTAR, NORLIA ABDULLAH, ROHAIZAK MUHAMMAD, NOR AINA EMRAN, SITI AISHAH MD ALI, ROSLAN HARUN & RAHMAN JAMAL. (2014) Exploring breast carcinogenesis through integrative genomics and epigenomics analyses. International Journal of Oncology 45:5, pages 1959-1968.
Crossref
Mika Takarada-Iemata, Dai Kezuka, Toshiaki Takeichi, Masahito Ikawa, Tsuyoshi Hattori, Yasuko Kitao & Osamu Hori. (2014) Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury. Journal of Neurochemistry 130:3, pages 374-387.
Crossref
Jolien S. de Groot, Xiaojuan Pan, Jan Meeldijk, Elsken van der Wall, Paul J. van Diest & Cathy B. Moelans. (2014) Validation of DNA promoter hypermethylation biomarkers in breast cancer — a short report. Cellular Oncology 37:4, pages 297-303.
Crossref
Mandana VeisehDaniel H. KwonAlexander D. BorowskyCornelia TolgHon S. LeongJohn D. Lewis, Eva A. Turley & Mina J. Bissell. (2014) Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset. Proceedings of the National Academy of Sciences 111:17.
Crossref
John Wrangle, Emi Ota Machida, Ludmila Danilova, Alicia Hulbert, Noreli Franco, Wei Zhang, Sabine C. Glöckner, Mathewos Tessema, Leander Van Neste, Hariharan Easwaran, Kornel E. Schuebel, Julien Licchesi, Craig M. Hooker, Nita Ahuja, Jun Amano, Steven A. Belinsky, Stephen B. Baylin, James G. Herman & Malcolm V. Brock. (2014) Functional Identification of Cancer-Specific Methylation of CDO1 , HOXA9 , and TAC1 for the Diagnosis of Lung Cancer . Clinical Cancer Research 20:7, pages 1856-1864.
Crossref
XIAOYUN ZENG, FUQIANG YIN, XIA LIU, JIANWEN XU, YANG XU, JINMEI HUANG, YUELI NAN & XIAOQIANG QIU. (2014) Upregulation of E2F transcription factor 3 is associated with poor prognosis in hepatocellular carcinoma. Oncology Reports 31:3, pages 1139-1146.
Crossref
Huili Li, Katherine B. Chiappinelli, Angela A. Guzzetta, Hariharan Easwaran, Ray-Whay Chiu Yen, Rajita Vatapalli, Michael J. Topper, Jianjun Luo, Roisin M. Connolly, Nilofer S. Azad, Vered Stearns, Drew M. Pardoll, Nancy Davidson, Peter A. Jones, Dennis J. Slamon, Stephen B. Baylin, Cynthia A. Zahnow & Nita Ahuja. (2014) Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget 5:3, pages 587-598.
Crossref
Haona Xie, Hao Li, Yue Huang, Xiaoying Wang, Yongmei Yin & Genxi Li. (2013) Combining Peptide and DNA for Protein Assay: CRIP1 Detection for Breast Cancer Staging. ACS Applied Materials & Interfaces 6:1, pages 459-463.
Crossref
Mohammed ShakerKara M. PascarelliMatthew J. PlantingaMiles A. LoveAlexander J. LazarDavis R. IngramMargaret Von MehrenDina LevDavid KiplingDominique Broccoli. (2014) Differential Expression of Cysteine Dioxygenase 1 in Complex Karyotype Liposarcomas. Biomarkers in Cancer 6, pages BIC.S14683.
Crossref
Natalie Ludyga, Sonja Englert, Kerstin Pflieger, Sandra Rauser, Herbert Braselmann, Axel Walch, Gert Auer, Heinz Höfler & Michaela Aubele. (2013) The impact of Cysteine-Rich Intestinal Protein 1 (CRIP1) in human breast cancer. Molecular Cancer 12:1.
Crossref
Jovana Klajic, Thomas Fleischer, Emelyne Dejeux, Hege Edvardsen, Fredrik Warnberg, Ida Bukholm, Per Eystein Lønning, Hiroko Solvang, Anne-Lise Børresen-Dale, Jörg Tost & Vessela N Kristensen. (2013) Quantitative DNA methylation analyses reveal stage dependent DNA methylation and association to clinico-pathological factors in breast tumors. BMC Cancer 13:1.
Crossref
Joo Mi Yi, Angela A. Guzzetta, Vasudev J. Bailey, Stephanie R. Downing, Leander Van Neste, Katherine B. Chiappinelli, Brian P. Keeley, Alejandro Stark, Alexander Herrera, Christopher Wolfgang, Emmanouil P. Pappou, Christine A. Iacobuzio-Donahue, Michael G. Goggins, James G. Herman, Tza-Huei Wang, Stephen B. Baylin & Nita Ahuja. (2013) Novel Methylation Biomarker Panel for the Early Detection of Pancreatic Cancer. Clinical Cancer Research 19:23, pages 6544-6555.
Crossref
SEONGEUN KANG, BYUNGTAK KIM, SUNG-BIN PARK, GOOKJOO JEONG, HAN-SUNG KANG, RAN LIU & SUN JUNG KIM. (2013) Stage-specific methylome screen identifies that NEFL is downregulated by promoter hypermethylation in breast cancer. International Journal of Oncology 43:5, pages 1659-1665.
Crossref
Jana Jeschke, Heather M. O'Hagan, Wei Zhang, Rajita Vatapalli, Marilia Freitas Calmon, Ludmila Danilova, Claudia Nelkenbrecher, Leander Van Neste, Ingrid T.G.W. Bijsmans, Manon Van Engeland, Edward Gabrielson, Kornel E. Schuebel, Andreas Winterpacht, Stephen B. Baylin, James G. Herman & Nita Ahuja. (2013) Frequent Inactivation of Cysteine Dioxygenase Type 1 Contributes to Survival of Breast Cancer Cells and Resistance to Anthracyclines . Clinical Cancer Research 19:12, pages 3201-3211.
Crossref
Cai Chen, Christoph Bartenhagen, Michael Gombert, Vera Okpanyi, Vera Binder, Silja Röttgers, Jutta Bradtke, Andrea Teigler‐Schlegel, Jochen Harbott, Sebastian Ginzel, Ralf Thiele, Ute Fischer, Martin Dugas, Jianda Hu & Arndt Borkhardt. (2013) Next‐generation‐sequencing‐based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia. Genes, Chromosomes and Cancer 52:6, pages 564-579.
Crossref
Kiyoshi Misawa, Takeharu Kanazawa, Yuki Misawa, Atsushi Imai, Takayuki Uehara, Daiki Mochizuki, Shiori Endo, Goro Takahashi & Hiroyuki Mineta. (2013) Frequent promoter hypermethylation of tachykinin-1 and tachykinin receptor type 1 is a potential biomarker for head and neck cancer. Journal of Cancer Research and Clinical Oncology 139:5, pages 879-889.
Crossref
H El Sheikh Saad, A Toullec, S Vacher, M Pocard, I Bieche & M Perrot-Applanat. (2013) In utero and lactational exposure to vinclozolin and genistein induces genomic changes in the rat mammary gland. Journal of Endocrinology 216:2, pages 245-263.
Crossref
Rosalia C. M. Simmen, Omar M. Rahal, Maria Theresa E. Montales, John Mark P. Pabona, Melissa E. Heard, Ahmed Al-Dwairi, Adam R. Brown & Frank A. Simmen. 2013. Cancer Chemoprevention and Treatment by Diet Therapy. Cancer Chemoprevention and Treatment by Diet Therapy 121 140 .

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