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Brief Report

Supra-physiological folic acid concentrations induce aberrant DNA methylation in normal human cells in vitro

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Pages 689-694 | Published online: 01 Jul 2012

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Leo J. Schouten, Ivette A. G. Deckers, Piet A. van den Brandt, Marcella M. L. L. Baldewijns & Manon van Engeland. (2016) Alcohol and Dietary Folate Intake and Promoter CpG Island Methylation in Clear-Cell Renal Cell Cancer. Nutrition and Cancer 68:7, pages 1097-1107.
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Sajin Bae, Cornelia M Ulrich, Lynn B Bailey, Olga Malysheva, Elissa C Brown, David R Maneval, Marian L Neuhouser, Ting-Yuan David Cheng, Joshua W Miller, Yingye Zheng, Liren Xiao, Lifang Hou, Xiaoling Song, Katharina Buck, Shirley AA Beresford & Marie A Caudill. (2014) Impact of folic acid fortification on global DNA methylation and one-carbon biomarkers in the Women's Health Initiative Observational Study cohort. Epigenetics 9:3, pages 396-403.
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Ali M. Fardous & Ahmad R. Heydari. (2023) Uncovering the Hidden Dangers and Molecular Mechanisms of Excess Folate: A Narrative Review. Nutrients 15:21, pages 4699.
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Khadijah I. Alnabbat, Ali M. Fardous, Aiman Shahab, Andrew A. James, Manhel R. Bahry & Ahmad R. Heydari. (2022) High Dietary Folic Acid Intake Is Associated with Genomic Instability in Peripheral Lymphocytes of Healthy Adults. Nutrients 14:19, pages 3944.
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J. Jory. (2022) Red cell folate status among a subset of Canadian children with Down Syndrome post‐fortification. Journal of Intellectual Disability Research 66:5, pages 471-482.
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Khadijah I. Alnabbat, Ali M. Fardous, Diane C. Cabelof & Ahmad R. Heydari. (2022) Excessive Folic Acid Mimics Folate Deficiency in Human Lymphocytes. Current Issues in Molecular Biology 44:4, pages 1452-1462.
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Elina V. García, Mariano J. Mansilla, Jean Guy LeBlanc & Antonio D. Barrera. (2020) Impact of extracellular folic acid levels on oviductal gene expression. Theriogenology 154, pages 161-170.
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Josiane Steluti, Cecília Zanin Palchetti, Andreia Machado Miranda, Regina Mara Fisberg & Dirce Maria Marchioni. (2019) DNA methylation and one-carbon metabolism related nutrients and polymorphisms: analysis after mandatory flour fortification with folic acid. British Journal of Nutrition 123:1, pages 23-29.
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Birgit Niemann, Anke Nemitz, Josephine Werner, Ha Dong Mai, Pablo Steinberg, Alfonso Lampen & Anke Ehlers. (2017) Folic acid modulates cancer‐associated micro RNAs and inflammatory mediators in neoplastic and non‐neoplastic colonic cells in a different way. Molecular Nutrition & Food Research 61:12, pages 1700260.
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Ankuri Desai, Jeffrey M. Sequeira & Edward V. Quadros. (2016) The metabolic basis for developmental disorders due to defective folate transport. Biochimie 126, pages 31-42.
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A. Kumar, N.A. Butt & A.S. Levenson. 2016. Medical Epigenetics. Medical Epigenetics 747 798 .
J.P. Lallès, C. Michel, V. Theodorou & J.P. Segain. 2016. The Epigenome and Developmental Origins of Health and Disease. The Epigenome and Developmental Origins of Health and Disease 337 360 .
Kathleen L. Hefferon & Abdullah Makhzoum. 2015. Advances in Food Biotechnology. Advances in Food Biotechnology 1 12 .
Can-Ze HuangTao YuQi-Kui Chen. (2015) DNA Methylation Dynamics During Differentiation, Proliferation, and Tumorigenesis in the Intestinal Tract. Stem Cells and Development 24:23, pages 2733-2739.
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Nathan Farias, Nelson Ho, Stacey Butler, Leanne Delaney, Jodi Morrison, Siranoush Shahrzad & Brenda L. Coomber. (2015) The effects of folic acid on global DNA methylation and colonosphere formation in colon cancer cell lines. The Journal of Nutritional Biochemistry 26:8, pages 818-826.
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R. Jordan Price, Karen A. Lillycrop & Graham C. Burdge. (2015) Folic acid supplementation in vitro induces cell type–specific changes in BRCA1 and BRCA 2 mRNA expression, but does not alter DNA methylation of their promoters or DNA repair. Nutrition Research 35:6, pages 532-544.
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M. Muñoz, G. Penarossa, J. N. Caamaño, C. Díez, T. A. L. Brevini & E. Gómez. (2015) Research with parthenogenetic stem cells will help decide whether a safer clinical use is possible. Journal of Tissue Engineering and Regenerative Medicine 9:4, pages 325-331.
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I. T. Johnson & N. J. Belshaw. (2014) Nutrition and epigenetics: An emerging field. Nutrition Bulletin 39:4, pages 313-321.
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S. Alvarado, R. D. Fernald, K. B. Storey & M. Szyf. (2014) The Dynamic Nature of DNA Methylation: A Role in Response to Social and Seasonal Variation. Integrative and Comparative Biology 54:1, pages 68-76.
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Ian T Johnson & Nigel J Belshaw. (2014) The effect of diet on the intestinal epigenome. Epigenomics 6:2, pages 239-251.
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Martin Tio, Juliana Andrici, Michael R Cox & Guy D Eslick. (2014) Folate intake and the risk of upper gastrointestinal cancers: A systematic review and meta-analysis. Journal of Gastroenterology and Hepatology 29:2, pages 250-258.
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Y. Luo, M. Yu & W. M. Grady. (2014) Field cancerization in the colon: a role for aberrant DNA methylation?. Gastroenterology Report 2:1, pages 16-20.
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Shannon Masih, Lesley A. Plumptre & Young-In Kim. 2014. Molecular mechanisms and physiology of disease. Molecular mechanisms and physiology of disease 277 353 .
Pratiksha S. Sable, Anvita A. Kale & Sadhana R. Joshi. (2013) Prenatal omega 3 fatty acid supplementation to a micronutrient imbalanced diet protects brain neurotrophins in both the cortex and hippocampus in the adult rat offspring. Metabolism 62:11, pages 1607-1622.
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Kjetil H. Løland, Øyvind Bleie, Heidi Borgeraas, Elin Strand, Per M. Ueland, Asbjørn Svardal, Jan E. Nordrehaug & Ottar Nygård. (2013) The Association between Progression of Atherosclerosis and the Methylated Amino Acids Asymmetric Dimethylarginine and Trimethyllysine. PLoS ONE 8:5, pages e64774.
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