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Epigenetics Volume 7, 2012 - Issue 1
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Research Paper

The 3D tissue microenvironment modulates DNA methylation and E-cadherin expression in squamous cell carcinoma

Teresa M. DesRochers Department of Anatomy; Sackler School of Graduate Biomedical Sciences; Tufts University School of Medicine; Boston, MA USA; Division of Cancer Biology and Tissue Engineering; Department of Oral and Maxillofacial Pathology; Tufts University School of Dental Medicine; Boston, MA USA
,
Yulia Shamis Department of Anatomy; Sackler School of Graduate Biomedical Sciences; Tufts University School of Medicine; Boston, MA USA; Division of Cancer Biology and Tissue Engineering; Department of Oral and Maxillofacial Pathology; Tufts University School of Dental Medicine; Boston, MA USA
,
Addy Alt-Holland Department of Endodontics; Tufts University School of Dental Medicine; Boston, MA USA
,
Yasusei Kudo Department of Oral and Maxillofacial Pathology; Graduate School of Biomedical Sciences; Hiroshima University; Hiroshima, Japan
,
Takashi Takata Department of Oral and Maxillofacial Pathology; Graduate School of Biomedical Sciences; Hiroshima University; Hiroshima, Japan
,
Guangwen Wang Children’s Hospital; Harvard Medical School; Boston, MA USA
,
Laurie Jackson-Grusby Children’s Hospital; Harvard Medical School; Boston, MA USA
&
Jonathan A. Garlick Department of Anatomy; Sackler School of Graduate Biomedical Sciences; Tufts University School of Medicine; Boston, MA USA; Division of Cancer Biology and Tissue Engineering; Department of Oral and Maxillofacial Pathology; Tufts University School of Dental Medicine; Boston, MA USACorrespondence[email protected]
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Pages 34-46 | Received 20 Sep 2011, Accepted 27 Oct 2011, Published online: 01 Jan 2012

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R. Alan Harris, Dorottya Nagy-Szakal & Richard Kellermayer. (2013) Human metastable epiallele candidates link to common disorders. Epigenetics 8:2, pages 157-163.
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Jie Qi, Yue Shi, Yezhen Tan, Qi Zhang, Jianye Zhang, Jilu Wang, Cong Huang & Weimin Ci. (2022) Regional gain and global loss of 5-hydroxymethylcytosine coexist in genitourinary cancers and regulate different oncogenic pathways. Clinical Epigenetics 14:1.
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Shalini Raik, Reetu Thakur, Vidya Rattan, Navin Kumar, Arnab Pal & Shalmoli Bhattacharyya. (2022) Temporal Modulation of DNA Methylation and Gene Expression in Monolayer and 3D Spheroids of Dental Pulp Stem Cells during Osteogenic Differentiation: A Comparative Study. Tissue Engineering and Regenerative Medicine 19:6, pages 1267-1282.
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Shibao Wang, Yinghui Huang, Xupeng Mu, Tianyang Qi, Sha Qiao, Zhenxia Lu & Hongjun Li. (2018) DNA methylation is a common molecular alteration in colorectal cancer cells and culture method has no influence on DNA methylation. Experimental and Therapeutic Medicine.
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Olga Kashpur, Avi Smith, Nailia Mukhamedshina, Jeremy Baskin, Yulia Shamis, Kyle Hewitt, Behzad Gerami-Naini & Jonathan A. Garlick. 2018. Skin Tissue Models for Regenerative Medicine. Skin Tissue Models for Regenerative Medicine 399 419 .
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Masaru Miyano, Rosalyn W. Sayaman, Marcus H. Stoiber, Chun-Han Lin, Martha R. Stampfer, James B. Brown & Mark A. LaBarge. (2017) Age-related gene expression in luminal epithelial cells is driven by a microenvironment made from myoepithelial cells. Aging 9:10, pages 2026-2051.
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Maddaly Ravi, Aarthi Ramesh & Aishwarya Pattabhi. (2017) Contributions of 3D Cell Cultures for Cancer Research. Journal of Cellular Physiology 232:10, pages 2679-2697.
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Brittany L. Carpenter, Jinpeng Liu, Lei Qi, Chi Wang & Kathleen L. O’Connor. (2017) Integrin α6β4 Upregulates Amphiregulin and Epiregulin through Base Excision Repair-Mediated DNA Demethylation and Promotes Genome-wide DNA Hypomethylation. Scientific Reports 7:1.
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Maddaly Ravi, S. R. Kaviya & V. Paramesh. (2014) Culture phases, cytotoxicity and protein expressions of agarose hydrogel induced Sp2/0, A549, MCF-7 cell line 3D cultures. Cytotechnology 68:3, pages 429-441.
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Silvia M Sirchia, Alice Faversani, Davide Rovina, Maria V Russo, Leda Paganini, Federica Savi, Claudia Augello, Lorenzo Rosso, Alessandro Del Gobbo, Silvia Tabano, Silvano Bosari & Monica Miozzo. (2016) Epigenetic effects of chromatin remodeling agents on organotypic cultures. Epigenomics 8:3, pages 341-358.
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Constantin Pixberg, Wolfgang Schulz, Nikolas Stoecklein & Rui Neves. (2015) Characterization of DNA Methylation in Circulating Tumor Cells. Genes 6:4, pages 1053-1075.
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Teresa M. DesRochers, Erica Palma Kimmerling, Dakshina M. Jandhyala, Wassim El-Jouni, Jing Zhou, Cheleste M. Thorpe, John M. Leong & David L. Kaplan. (2015) Effects of Shiga Toxin Type 2 on a Bioengineered Three-Dimensional Model of Human Renal Tissue. Infection and Immunity 83:1, pages 28-38.
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Rebecca F. Lowdon, Bo Zhang, Misha Bilenky, Thea Mauro, Daofeng Li, Philippe Gascard, Mahvash Sigaroudinia, Peggy J. Farnham, Boris C. Bastian, Thea D. Tlsty, Marco A. Marra, Martin Hirst, Joseph F. Costello, Ting Wang & Jeffrey B. Cheng. (2014) Regulatory network decoded from epigenomes of surface ectoderm-derived cell types. Nature Communications 5:1.
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Teresa M. DesRochers, Erica Palma & David L. Kaplan. (2014) Tissue-engineered kidney disease models. Advanced Drug Delivery Reviews 69-70, pages 67-80.
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Anna A Bulysheva, Gary L Bowlin, Stella P Petrova & W Andrew Yeudall. (2013) Enhanced chemoresistance of squamous carcinoma cells grown in 3D cryogenic electrospun scaffolds. Biomedical Materials 8:5, pages 055009.
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M.A. González-Moles, M. Bravo, I. Ruiz-Avila, J.A. Gil-Montoya, F. Acebal & F. Esteban. (2013) E-cadherin in non-tumor epithelium adjacent to oral cancer as risk marker for the development of multiple tumors. British Journal of Oral and Maxillofacial Surgery 51:2, pages 157-163.
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Gary G. Meadows. (2012) Diet, nutrients, phytochemicals, and cancer metastasis suppressor genes. Cancer and Metastasis Reviews 31:3-4, pages 441-454.
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Peter Tolias. (2012) The need to assess drugs selected from cancer genomic data prior to patient treatment. Personalized Medicine 9:5, pages 463-466.
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Katja Storch & Nils Cordes. (2012) Focal Adhesion-Chromatin Linkage Controls Tumor Cell Resistance to Radio- and Chemotherapy. Chemotherapy Research and Practice 2012, pages 1-10.
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