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Research Paper

Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children

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Pages 799-805 | Received 30 Dec 2011, Accepted 26 Feb 2012, Published online: 12 Apr 2012

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Read on this site (9)

Dabin Ren, Peter Bajorski, Timothy F. Murphy, Eric R. Lafontaine & Michael E. Pichichero. (2020) Synchrony in serum antibody response to conserved proteins of Moraxella catarrhalis in young children. Human Vaccines & Immunotherapeutics 16:12, pages 3194-3200.
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Theano Lagousi, Paraskevi Basdeki, Marien I De Jonge & Vana Spoulou. (2020) Understanding host immune responses to pneumococcal proteins in the upper respiratory tract to develop serotype-independent pneumococcal vaccines. Expert Review of Vaccines 19:10, pages 959-972.
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Dafne C. Andrade, Igor C. Borges, Maiara L. Bouzas, Juliana R. Oliveira, Helena Käyhty, Olli Ruuskanen & Cristiana Nascimento-Carvalho. (2018) Antibody responses against Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in children with acute respiratory infection with or without nasopharyngeal bacterial carriage. Infectious Diseases 50:9, pages 705-713.
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Michael E. Pichichero. (2017) Pneumococcal whole-cell and protein-based vaccines: changing the paradigm. Expert Review of Vaccines 16:12, pages 1181-1190.
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M. Nadeem Khan, Dabin Ren, Ravinder Kaur, Saleem Basha, Robert Zagursky & Michael E. Pichichero. (2016) Developing a vaccine to prevent otitis media caused by nontypeable Haemophilus influenzae. Expert Review of Vaccines 15:7, pages 863-878.
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Michael E Pichichero, M Nadeem Khan & Qingfu Xu. (2016) Next generation protein based Streptococcus pneumoniae vaccines. Human Vaccines & Immunotherapeutics 12:1, pages 194-205.
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Dabin Ren, Anthony L Almudevar & Michael E Pichichero. (2015) Synchrony in serum antibody response to conserved proteins of Streptococcus pneumoniae in young children . Human Vaccines & Immunotherapeutics 11:2, pages 489-497.
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M Nadeem Khan & Michael E Pichichero. (2014) The host immune dynamics of pneumococcal colonization: Implications for novel vaccine development. Human Vaccines & Immunotherapeutics 10:12, pages 3688-3699.
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Articles from other publishers (38)

Ravinder Kaur, Eduardo Gonzalez, Minh Pham & Michael Pichichero. (2023) Naturally-induced serum antibody levels in children to pneumococcal polysaccharide 15B that correlate with protection from nasopharyngeal colonization but anti-serotype 15B antibody has low functional cross-reactivity with serotype 15C. Vaccine 41:48, pages 7265-7273.
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Michael Shaffer, Katharine Best, Catherine Tang, Xue Liang, Steven Schulz, Eduardo Gonzalez, Cory H. White, Thomas P. Wyche, John Kang, Hendrik Wesseling, Begüm D. Topçuoğlu, Thomas Cairns, Theodore R. Sana, Robin M. Kaufhold, Julia M. Maritz, Christopher H. Woelk, Gokul Swaminathan, James E. NortonJr.Jr. & Michael E. Pichichero. (2023) Very early life microbiome and metabolome correlates with primary vaccination variability in children. mSystems 8:5.
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Lisa Ciacchi, Martijn D.B. van de Garde, Kristin Ladell, Carine Farenc, Martien C.M. Poelen, Kelly L. Miners, Carmen Llerena, Hugh H. Reid, Jan Petersen, David A. Price, Jamie Rossjohn & Cécile A.C.M. van Els. (2023) CD4+ T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity. Immunity 56:5, pages 1082-1097.e6.
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Ravinder Kaur & Michael Pichichero. (2023) Colonization, Density, and Antibiotic Resistance of Streptococcus pneumoniae , Haemophilus Influenzae , and Moraxella catarrhalis among PCV13-Vaccinated Infants in the First Six Months of Life in Rochester, New York: A Cohort Study . Journal of the Pediatric Infectious Diseases Society 12:3, pages 135-142.
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Ravinder Kaur, Minh Pham & Michael Pichichero. (2021) Serum antibody levels to pneumococcal polysaccharides 22F, 33F, 19A and 6A that correlate with protection from colonization and acute otitis media in children. Vaccine 39:29, pages 3900-3906.
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I. M. Gruber, O. M. Kukina, N. B Egorova, & O. V. Zhigunova. (2021) Different Technologies for Obtaining Pneumococcal Immunogens. Epidemiology and Vaccinal Prevention 20:1, pages 76-91.
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Yanling Liu, Wenhui Li, Qian Dong, Minqi Chen, Wenyu Li, Xulin Wang, Jinjian Fu & Xiaohua Ye. (2021) Non-linear relationships between children age and pneumococcal vaccine coverage: Important implications for vaccine prevention strategies. Vaccine 39:9, pages 1392-1401.
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Mirian Domenech & Ernesto García. (2020) The N -Acetylglucosaminidase LytB of Streptococcus pneumoniae Is Involved in the Structure and Formation of Biofilms . Applied and Environmental Microbiology 86:10.
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Dabin Ren, Anthony L. Almudevar, Timothy F. Murphy, Eric R. Lafontaine, Anthony A. Campagnari, Nicole Luke-Marshall & Michael E. Pichichero. (2019) Serum antibody response to Moraxella catarrhalis proteins in stringently defined otitis prone children. Vaccine 37:32, pages 4637-4645.
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A-Yeung Jang, Ki Bum Ahn, Yong Zhi, Hyun-Jung Ji, Jing Zhang, Seung Hyun Han, Huichen Guo, Sangyong Lim, Joon Yong Song, Jae Hyang Lim & Ho Seong Seo. (2019) Serotype-Independent Protection Against Invasive Pneumococcal Infections Conferred by Live Vaccine With lgt Deletion. Frontiers in Immunology 10.
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Dabin Ren, Qingfu Xu, Anthony L Almudevar & Michael E Pichichero. (2019) Impaired Proinflammatory Response in Stringently Defined Otitis-prone Children During Viral Upper Respiratory Infections. Clinical Infectious Diseases 68:9, pages 1566-1574.
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Yu-Kun Ma, Yu-Bin Chen & Peng Li. (2018) Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKα/NF-κB and MAPK signaling pathways in otitis media. International Journal of Molecular Medicine.
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Matthew C Morris & Michael E Pichichero. (2017) Streptococcus pneumoniae burden and nasopharyngeal inflammation during acute otitis media . Innate Immunity 23:8, pages 667-677.
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Dabin Ren, Timothy F. Murphy, Eric R. Lafontaine & Michael E. Pichichero. (2017) Stringently Defined Otitis Prone Children Demonstrate Deficient Naturally Induced Mucosal Antibody Response to Moraxella catarrhalis Proteins. Frontiers in Immunology 8.
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Q. Xu, J.R. Casey, A. Almudevar & M.E. Pichichero. (2017) Correlation of higher antibody levels to pneumococcal proteins with protection from pneumococcal acute otitis media but not protection from nasopharyngeal colonization in young children. Clinical Microbiology and Infection 23:7, pages 487.e1-487.e6.
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Ruth B. Thornton, Lea-Ann S. Kirkham, Karli J. Corscadden, Selma P. Wiertsema, Angela Fuery, B. Jan Jones, Harvey L. Coates, Shyan Vijayasekaran, Guicheng Zhang, Anthony Keil & Peter C. Richmond. (2017) Australian Aboriginal Children with Otitis Media Have Reduced Antibody Titers to Specific Nontypeable Haemophilus influenzae Vaccine Antigens. Clinical and Vaccine Immunology 24:4.
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Lea-Ann S. Kirkham, Selma P. Wiertsema, Karli J. Corscadden, Tulia Mateus, Gemma L. Mullaney, Guicheng Zhang, Peter C. Richmond & Ruth B. Thornton. (2017) Otitis-Prone Children Produce Functional Antibodies to Pneumolysin and Pneumococcal Polysaccharides. Clinical and Vaccine Immunology 24:3.
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Carolina Lessa-Aquino, Janet C. Lindow, Arlo Randall, Elsio Wunder, Jozelyn Pablo, Rie Nakajima, Algis Jasinskas, Jaqueline S. Cruz, Alcineia O. Dami?o, N?vison Nery, Guilherme S. Ribeiro, Federico Costa, Jos? E. Hagan, Mitermayer Galv?o Reis, Albert I. Ko, Marco Alberto Medeiros & Philip L. Felgner. (2017) Distinct antibody responses of patients with mild and severe leptospirosis determined by whole proteome microarray analysis. PLOS Neglected Tropical Diseases 11:1, pages e0005349.
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Qingfu Xu, Karin Pryharski & Michael E. Pichichero. (2017) Trivalent pneumococcal protein vaccine protects against experimental acute otitis media caused by Streptococcus pneumoniae in an infant murine model. Vaccine 35:2, pages 337-344.
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Michael E. Pichichero. (2016) Ten-Year Study of Acute Otitis Media in Rochester, NY. Pediatric Infectious Disease Journal 35:9, pages 1027-1032.
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Michael E. Pichichero & Anthony Almudevar. (2016) Inflammation-associated cytokine analysis identifies presence of respiratory bacterial pathogens in the nasopharynx. Pathogens and Disease 74:6, pages ftw064.
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Michael E. Pichichero, Janet R. Casey, Anthony Almudevar, Saleem Basha, Naveen Surendran, Ravinder Kaur, Matthew Morris, Alexandra M. Livingstone & Tim R. Mosmann. (2016) Functional Immune Cell Differences Associated With Low Vaccine Responses in Infants. Journal of Infectious Diseases 213:12, pages 2014-2019.
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Dafne C. Andrade, Igor C. Borges, Peter V. Adrian, Andreas Meinke, Aldina Barral, Olli Ruuskanen, Helena K?yhty & Cristiana M. Nascimento-Carvalho. (2016) Effect of Pneumococcal Conjugate Vaccine on the Natural Antibodies and Antibody Responses Against Protein Antigens From Streptococcus pneumoniae, Haemophilus influenzae and Moraxella catarrhalis in Children With Community-acquired Pneumonia. The Pediatric Infectious Disease Journal 35:6, pages 683-689.
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Qingfu Xu, Janet R. Casey, Emily Newman & Michael E. Pichichero. (2016) Otitis-prone Children Have Immunologic Deficiencies in Naturally Acquired Nasopharyngeal Mucosal Antibody Response after Streptococcus pneumoniae Colonization. Pediatric Infectious Disease Journal 35:1, pages 54-60.
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Matthew C. Morris, Anthony L. Almudevar, Janet R. Casey & Michael E. Pichichero. (2015) Familial and microbiological contribution to the otitis?prone condition. International Journal of Pediatric Otorhinolaryngology 79:12, pages 2174-2177.
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S Basha & M E Pichichero. (2015) Poor memory B cell generation contributes to non-protective responses to DTaP vaccine antigens in otitis-prone children. Clinical and Experimental Immunology 182:3, pages 314-322.
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Dabin Ren, Anthony L. Almudevar, Timothy F. Murphy, Eric R. Lafontaine, Anthony A. Campagnari, Nicole Luke-Marshall, Janet R. Casey & Michael E. Pichichero. (2015) Serum antibody response to Moraxella catarrhalis proteins OMP CD, OppA, Msp22, Hag, and PilA2 after nasopharyngeal colonization and acute otitis media in children. Vaccine 33:43, pages 5809-5814.
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Q Xu, J R Casey & M E Pichichero. (2015) Higher levels of mucosal antibody to pneumococcal vaccine candidate proteins are associated with reduced acute otitis media caused by Streptococcus pneumoniae in young children. Mucosal Immunology 8:5, pages 1110-1117.
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Abiodun D. Ogunniyi & James C. Paton. 2015. Streptococcus Pneumoniae. Streptococcus Pneumoniae 59 78 .
Ravinder Kaur, Naveen Surendran, Martina Ochs & Michael E. Pichichero. (2014) Human Antibodies to PhtD, PcpA, and Ply Reduce Adherence to Human Lung Epithelial Cells and Murine Nasopharyngeal Colonization by Streptococcus pneumoniae. Infection and Immunity 82:12, pages 5069-5075.
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Geert Leroux-Roels, Cathy Maes, Fien De Boever, Magali Traskine, Jens U. Rüggeberg & Dorota Borys. (2014) Safety, reactogenicity and immunogenicity of a novel pneumococcal protein-based vaccine in adults: A phase I/II randomized clinical study. Vaccine 32:50, pages 6838-6846.
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D Verhoeven & M E Pichichero. (2014) Divergent mucosal and systemic responses in children in response to acute otitis media. Clinical and Experimental Immunology 178:1, pages 94-101.
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David Verhoeven, Sheldon Perry & Michael E. Pichichero. (2014) Contributions to Protection from Streptococcus pneumoniae Infection Using the Monovalent Recombinant Protein Vaccine Candidates PcpA, PhtD, and PlyD1 in an Infant Murine Model during Challenge. Clinical and Vaccine Immunology 21:8, pages 1037-1045.
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Roman Prymula, Petr Pazdiora, Magali Traskine, Jens U. Rüggeberg & Dorota Borys. (2014) Safety and immunogenicity of an investigational vaccine containing two common pneumococcal proteins in toddlers: A phase II randomized clinical trial. Vaccine 32:25, pages 3025-3034.
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Qingfu Xu & Michael E. Pichichero. (2014) Co-colonization by Haemophilus influenzae with Streptococcus pneumoniae enhances pneumococcal-specific antibody response in young children. Vaccine 32:6, pages 706-711.
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Charles D. Plumptre, Abiodun D. Ogunniyi & James C. Paton. (2013) Surface Association of Pht Proteins of Streptococcus pneumoniae. Infection and Immunity 81:10, pages 3644-3651.
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Sharad K. Sharma & Michael E. Pichichero. (2013) Cellular Immune Response in Young Children Accounts for Recurrent Acute Otitis Media. Current Allergy and Asthma Reports 13:5, pages 495-500.
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Sulman Shafeeq, Oscar P. Kuipers & Tomas G. Kloosterman. (2013) The role of zinc in the interplay between pathogenic streptococci and their hosts. Molecular Microbiology 88:6, pages 1047-1057.
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