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Human Vaccines & Immunotherapeutics Volume 10, 2014 - Issue 8
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Research Paper

A nonhuman primate toxicology and immunogenicity study evaluating aerosol delivery of AERAS-402/Ad35 vaccine

Evidence for transient t cell responses in peripheral blood and robust sustained responses in the lungs

David A Hokey Aeras; Rockville, MD USACorrespondence[email protected]
,
Robert Wachholder Aeras; Rockville, MD USA
,
Patricia A Darrah Vaccine Research Center; NIAID; NIH; Bethesda, MD USA
,
Diane L Bolton US Military HIV Research Program; Silver Spring, MD USA
,
Dan H Barouch Center for Virology and Vaccine Research; Beth Israel Deaconess Medical Center; Boston, MA USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA
,
Krystal Hill Aeras; Rockville, MD USA
,
Veerabadran Dheenadhayalan Aeras; Rockville, MD USA
,
Stephan Schwander Rutgers School of Public Health; Piscataway, NJ USA
,
C Steven Godin Smithers Avanza; Gaithersburg, MD USA
,
Macaya Douoguih Crucell Holland BV; Leiden, The Netherlands
,
Maria Grazia Pau Crucell Holland BV; Leiden, The Netherlands
,
Robert A Seder Vaccine Research Center; NIAID; NIH; Bethesda, MD USA
,
Mario Roederer Vaccine Research Center; NIAID; NIH; Bethesda, MD USA
,
Jerald C Sadoff Crucell Holland BV; Leiden, The Netherlands
&
Donata Sizemore USAMRIID; Ft. Detrick, MD USA
 show all
Pages 2199-2210 | Received 17 Jan 2014, Accepted 04 May 2014, Published online: 08 May 2014

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AJ Graves & DA Hokey. (2015) Tuberculosis vaccine development: Shifting focus amid increasing development challenges. Human Vaccines & Immunotherapeutics 11:8, pages 1910-1916.
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Lewis K. Schrager, Rebecca C. Harris & Johan Vekemans. (2019) Research and development of new tuberculosis vaccines: a review. F1000Research 7, pages 1732.
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Lewis K. Schrager, Rebecca C. Harris & Johan Vekemans. (2018) Research and development of new tuberculosis vaccines: a review. F1000Research 7, pages 1732.
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J Wolf. 2018. Comprehensive Toxicology. Comprehensive Toxicology 852 872 .
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Taylor W Foreman, Smriti Mehra, Andrew A Lackner & Deepak Kaushal. (2017) Translational Research in the Nonhuman Primate Model of Tuberculosis. ILAR Journal 58:2, pages 151-159.
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Deborah A. Lewinsohn, David M. Lewinsohn & Thomas J. Scriba. (2017) Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination. Frontiers in Immunology 8.
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Diane L. Bolton, Kaimei Song, Georgia D. Tomaras, Srinivas Rao & Mario Roederer. (2017) Unique cellular and humoral immunogenicity profiles generated by aerosol, intranasal, or parenteral vaccination in rhesus macaques. Vaccine 35:4, pages 639-646.
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Nnamdi Nwachukwu. (2016) Comparative Effectiveness of Vaccines for Tuberculosis in Endemic Countries: A Systematic Review and Meta-analysis. International Journal of Vaccines & Vaccination 3:1.
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Ellen F. Young, Anthony J. Hickey & Miriam Braunstein. 2016. Drug Delivery Systems for Tuberculosis Prevention and Treatment. Drug Delivery Systems for Tuberculosis Prevention and Treatment 111 130 .
Sam Afkhami, Yushi Yao & Zhou Xing. (2016) Methods and clinical development of adenovirus-vectored vaccines against mucosal pathogens. Molecular Therapy - Methods & Clinical Development 3, pages 16030.
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A. D. White, C. Sarfas, K. West, L. S. Sibley, A. S. Wareham, S. Clark, M. J. Dennis, A. Williams, P. D. Marsh & S. A. Sharpe. (2015) Evaluation of the Immunogenicity of Mycobacterium bovis BCG Delivered by Aerosol to the Lungs of Macaques. Clinical and Vaccine Immunology 22:9, pages 992-1003.
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. (2015) Developing aerosol vaccines for Mycobacterium tuberculosis: Workshop proceedings. Vaccine 33:26, pages 3038-3046.
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Nicola Principi & Susanna Esposito. (2015) The present and future of tuberculosis vaccinations. Tuberculosis 95:1, pages 6-13.
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Patricia A. Darrah, Diane L. Bolton, Andrew A. Lackner, Deepak Kaushal, Pyone Pyone Aye, Smriti Mehra, James L. Blanchard, Peter J. Didier, Chad J. Roy, Srinivas S. Rao, David A. Hokey, Charles A. Scanga, Donata R. Sizemore, Jerald C. Sadoff, Mario Roederer & Robert A. Seder. (2014) Aerosol Vaccination with AERAS-402 Elicits Robust Cellular Immune Responses in the Lungs of Rhesus Macaques but Fails To Protect against High-Dose Mycobacterium tuberculosis Challenge . The Journal of Immunology 193:4, pages 1799-1811.
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